ATE137263T1 - Erhöhung der katalytischen aktivität von ribozymen mit einem benachbartem oligonukleotid als heffer - Google Patents
Erhöhung der katalytischen aktivität von ribozymen mit einem benachbartem oligonukleotid als hefferInfo
- Publication number
- ATE137263T1 ATE137263T1 AT93904711T AT93904711T ATE137263T1 AT E137263 T1 ATE137263 T1 AT E137263T1 AT 93904711 T AT93904711 T AT 93904711T AT 93904711 T AT93904711 T AT 93904711T AT E137263 T1 ATE137263 T1 AT E137263T1
- Authority
- AT
- Austria
- Prior art keywords
- increasing
- catalytic activity
- ribozyme
- heffer
- ribozymes
- Prior art date
Links
- 102000053642 Catalytic RNA Human genes 0.000 title abstract 5
- 108090000994 Catalytic RNA Proteins 0.000 title abstract 5
- 108091092562 ribozyme Proteins 0.000 title abstract 5
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 3
- 230000003197 catalytic effect Effects 0.000 title abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83071392A | 1992-02-04 | 1992-02-04 | |
| PCT/US1993/000783 WO1993015194A1 (en) | 1992-02-04 | 1993-02-04 | Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide |
| CA002106015A CA2106015A1 (en) | 1992-02-04 | 1993-09-13 | Ribozymes having 2'-0 substituted nucleotides in the flanking sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE137263T1 true ATE137263T1 (de) | 1996-05-15 |
Family
ID=25676634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93904711T ATE137263T1 (de) | 1992-02-04 | 1993-02-04 | Erhöhung der katalytischen aktivität von ribozymen mit einem benachbartem oligonukleotid als heffer |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0625194B1 (de) |
| JP (1) | JPH07508638A (de) |
| AT (1) | ATE137263T1 (de) |
| AU (1) | AU661124B2 (de) |
| CA (2) | CA2117428A1 (de) |
| DE (1) | DE69302369T2 (de) |
| DK (1) | DK0625194T3 (de) |
| ES (1) | ES2085767T3 (de) |
| GR (1) | GR3019911T3 (de) |
| WO (1) | WO1993015194A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3933384A1 (de) * | 1989-10-06 | 1991-04-18 | Hoechst Ag | Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung |
| US5739309A (en) * | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
| KR960704034A (ko) * | 1993-07-19 | 1996-08-31 | 다니엘 엘. 캐시앙 | 단백질 생산, 세포 증식 및(또는) 전염병 병원균의 증식에 대한 올리고뉴클레오티드 저해의 향상법(Enhancement of Oligonucleotide Inhibition of Protein Production, Cell Proliferation, and/or Multiplication of Infectious Disease Pathogens) |
| US5998193A (en) * | 1994-06-24 | 1999-12-07 | Gene Shears Pty., Ltd. | Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof |
| US5700923A (en) * | 1994-09-29 | 1997-12-23 | Hybridon, Inc. | Finderons and methods of their preparation and use |
| US5650502A (en) * | 1994-11-09 | 1997-07-22 | Hybridon, Inc. | Ribozyme analogs having rigid non-nucleotidic linkers |
| US5545729A (en) * | 1994-12-22 | 1996-08-13 | Hybridon, Inc. | Stabilized ribozyme analogs |
| US20060182949A1 (en) * | 2005-02-17 | 2006-08-17 | 3M Innovative Properties Company | Surfacing and/or joining method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3933384A1 (de) * | 1989-10-06 | 1991-04-18 | Hoechst Ag | Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung |
-
1993
- 1993-02-04 AT AT93904711T patent/ATE137263T1/de not_active IP Right Cessation
- 1993-02-04 AU AU35977/93A patent/AU661124B2/en not_active Ceased
- 1993-02-04 CA CA002117428A patent/CA2117428A1/en not_active Abandoned
- 1993-02-04 DE DE69302369T patent/DE69302369T2/de not_active Expired - Fee Related
- 1993-02-04 DK DK93904711.4T patent/DK0625194T3/da active
- 1993-02-04 ES ES93904711T patent/ES2085767T3/es not_active Expired - Lifetime
- 1993-02-04 WO PCT/US1993/000783 patent/WO1993015194A1/en not_active Ceased
- 1993-02-04 EP EP93904711A patent/EP0625194B1/de not_active Expired - Lifetime
- 1993-02-04 JP JP5513431A patent/JPH07508638A/ja active Pending
- 1993-09-13 CA CA002106015A patent/CA2106015A1/en not_active Abandoned
-
1996
- 1996-05-15 GR GR960400751T patent/GR3019911T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2106015A1 (en) | 1995-03-14 |
| DE69302369D1 (de) | 1996-05-30 |
| ES2085767T3 (es) | 1996-06-01 |
| EP0625194A1 (de) | 1994-11-23 |
| CA2117428A1 (en) | 1993-08-05 |
| AU3597793A (en) | 1993-09-01 |
| AU661124B2 (en) | 1995-07-13 |
| EP0625194B1 (de) | 1996-04-24 |
| JPH07508638A (ja) | 1995-09-28 |
| DE69302369T2 (de) | 1996-09-05 |
| GR3019911T3 (en) | 1996-08-31 |
| WO1993015194A1 (en) | 1993-08-05 |
| DK0625194T3 (da) | 1996-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |