DE69331075T2 - Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung - Google Patents
Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer StrömungInfo
- Publication number
- DE69331075T2 DE69331075T2 DE69331075T DE69331075T DE69331075T2 DE 69331075 T2 DE69331075 T2 DE 69331075T2 DE 69331075 T DE69331075 T DE 69331075T DE 69331075 T DE69331075 T DE 69331075T DE 69331075 T2 DE69331075 T2 DE 69331075T2
- Authority
- DE
- Germany
- Prior art keywords
- sample
- liquid
- analysis
- sample liquid
- line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims description 339
- 230000002441 reversible effect Effects 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 21
- 238000012360 testing method Methods 0.000 claims description 360
- 239000012530 fluid Substances 0.000 claims description 277
- 238000004458 analytical method Methods 0.000 claims description 246
- 239000003153 chemical reaction reagent Substances 0.000 claims description 67
- 238000006243 chemical reaction Methods 0.000 claims description 66
- 238000006073 displacement reaction Methods 0.000 claims description 54
- 238000001514 detection method Methods 0.000 claims description 33
- 238000011144 upstream manufacturing Methods 0.000 claims description 18
- 230000007717 exclusion Effects 0.000 claims description 5
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- 101800002712 p27 Proteins 0.000 claims 1
- 239000000523 sample Substances 0.000 description 509
- 210000004027 cell Anatomy 0.000 description 75
- 239000003570 air Substances 0.000 description 51
- 239000000872 buffer Substances 0.000 description 37
- 238000012546 transfer Methods 0.000 description 37
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- 230000015572 biosynthetic process Effects 0.000 description 16
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- 230000009471 action Effects 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 230000033001 locomotion Effects 0.000 description 10
- 238000000926 separation method Methods 0.000 description 10
- 239000012080 ambient air Substances 0.000 description 9
- 239000002775 capsule Substances 0.000 description 9
- 230000006870 function Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/846,269 US5268147A (en) | 1992-02-26 | 1992-02-26 | Reversible direction capsule chemistry sample liquid analysis system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69331075D1 DE69331075D1 (de) | 2001-12-13 |
| DE69331075T2 true DE69331075T2 (de) | 2002-03-21 |
Family
ID=25297402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69331075T Expired - Fee Related DE69331075T2 (de) | 1992-02-26 | 1993-02-15 | Vorrichtung und Verfahren zur Analyse von Probenflüssigkeiten mit umkehrbarer Strömung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5268147A (enExample) |
| EP (1) | EP0562260B1 (enExample) |
| JP (1) | JP3256818B2 (enExample) |
| AU (1) | AU653486B2 (enExample) |
| CA (1) | CA2083322C (enExample) |
| DE (1) | DE69331075T2 (enExample) |
| DK (1) | DK0562260T3 (enExample) |
| ES (1) | ES2164647T3 (enExample) |
| IL (1) | IL103782A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10322942A1 (de) * | 2003-05-19 | 2004-12-09 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten |
| DE10322893A1 (de) * | 2003-05-19 | 2004-12-16 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399497A (en) * | 1992-02-26 | 1995-03-21 | Miles, Inc. | Capsule chemistry sample liquid analysis system and method |
| JP3115501B2 (ja) * | 1994-06-15 | 2000-12-11 | プレシジョン・システム・サイエンス株式会社 | 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置 |
| US5840254A (en) | 1995-06-02 | 1998-11-24 | Cdc Technologies, Inc. | Apparatus for mixing fluids for analysis |
| US5631167A (en) * | 1995-07-31 | 1997-05-20 | Bayer Corporation | Capsule chemistry analytical methods employing dioxetane chemiluminescence |
| US5714388A (en) * | 1996-08-14 | 1998-02-03 | Bayer Corporation | Apparatus and method for detecting chemiluminescent light |
| AU1874099A (en) * | 1997-11-19 | 1999-06-07 | Elena Gromakovskaja | Device for sequential discharge of flowable reagents |
| US6348354B1 (en) | 1998-07-06 | 2002-02-19 | Bayer Corporation | Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system |
| US6022747A (en) * | 1998-07-10 | 2000-02-08 | Bayer Corporation | Blood clot detector |
| US6261847B1 (en) * | 1998-07-10 | 2001-07-17 | Bayer Corporation | Sample dilution module with offset mixing chamber |
| US6315952B1 (en) | 1998-10-05 | 2001-11-13 | The University Of New Mexico | Plug flow cytometry for high throughput screening and drug discovery |
| US6623971B2 (en) * | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
| US7416903B2 (en) * | 1999-09-30 | 2008-08-26 | Stc.Unm | Wavy interface mixer |
| US6890487B1 (en) * | 1999-09-30 | 2005-05-10 | Science & Technology Corporation ©UNM | Flow cytometry for high throughput screening |
| JP2004518106A (ja) * | 2000-04-03 | 2004-06-17 | パラボル テクノロジー エス アー | 正確に制御された少量の液体の分配装置 |
| US6610499B1 (en) * | 2000-08-31 | 2003-08-26 | The Regents Of The University Of California | Capillary array and related methods |
| US6902938B1 (en) * | 2000-10-10 | 2005-06-07 | Jeol Usa, Inc. | Chemical analysis method for multiplexed samples |
| WO2002037079A2 (en) * | 2000-11-06 | 2002-05-10 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services | Sample delivery system with laminar mixing for microvolume biosensing |
| US6689621B2 (en) | 2000-11-29 | 2004-02-10 | Liquid Logic, Llc | Fluid dispensing system and valve control |
| US7198956B2 (en) | 2001-06-13 | 2007-04-03 | Uffenheimer Kenneth F | Automated fluid handling system and method |
| US20040028559A1 (en) * | 2001-11-06 | 2004-02-12 | Peter Schuck | Sample delivery system with laminar mixing for microvolume biosensing |
| US7514270B2 (en) | 2002-04-12 | 2009-04-07 | Instrumentation Laboratory Company | Immunoassay probe |
| US7488309B2 (en) | 2002-07-03 | 2009-02-10 | Bioanalytical Systems, Inc. | Device and method for drug delivery to animals |
| GB0307999D0 (en) * | 2003-04-07 | 2003-05-14 | Glaxo Group Ltd | A system |
| JP2004317420A (ja) * | 2003-04-18 | 2004-11-11 | Hitachi Software Eng Co Ltd | キャピラリー利用測定装置 |
| CA2564211C (en) | 2004-01-26 | 2010-08-03 | President And Fellows Of Harvard College | Fluid delivery system and method |
| US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
| US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| US7338804B2 (en) * | 2004-11-24 | 2008-03-04 | Siemens Healthcare Diagnostics Inc. | Automated clinical analyzer reagent formulation |
| US20060172425A1 (en) * | 2005-02-01 | 2006-08-03 | Bayer Healthcare, Llc | Colored buffer solution for automated clinical analyzer |
| RU2287145C1 (ru) * | 2005-04-11 | 2006-11-10 | Закрытое акционерное общество Научно-производственное объединение "Гранит-НЭМП" | Способ инжекционного анализа и устройство для его осуществления |
| WO2007024800A2 (en) * | 2005-08-22 | 2007-03-01 | Applera Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| US7704457B2 (en) * | 2005-11-18 | 2010-04-27 | Patton Charles J | Automatic, field portable analyzer using discrete sample aliquots |
| US20080080302A1 (en) * | 2006-09-29 | 2008-04-03 | Fujifilm Corporation | Droplet mixing method and apparatus |
| US8202492B2 (en) | 2007-05-04 | 2012-06-19 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
| DE102007032951B4 (de) | 2007-07-14 | 2010-09-02 | Karlsruher Institut für Technologie | Vorrichtung und Verfahren zur Zuführung eines Flüssigkeitsstroms aus mindestens zwei Flüssigkeitsabschnitten in eine Messzelle |
| US7980905B2 (en) * | 2007-11-25 | 2011-07-19 | C-Mar Holdings, Ltd. | Method and apparatus for providing power to a marine vessel |
| US8591829B2 (en) | 2008-12-18 | 2013-11-26 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
| EP3278877B1 (en) | 2009-02-02 | 2020-06-03 | Opko Diagnostics, LLC | Structures for controlling light interaction with microfluidic devices |
| JP5340760B2 (ja) * | 2009-02-12 | 2013-11-13 | 倉敷紡績株式会社 | 流体制御方法及び流体制御装置 |
| EP2432869B1 (en) | 2009-05-21 | 2020-08-12 | Essen Instruments, Inc. d/b/a Essen BioScience, Inc. | System and method for separating samples in a continuous flow |
| US9752964B1 (en) | 2009-06-22 | 2017-09-05 | Stc.Unm | Flow cytometry apparatus pulling sample stream through observation chamber |
| EA024999B1 (ru) | 2009-11-24 | 2016-11-30 | Опкоу Дайагностикс, Ллк. | Смешивание и доставка текучих сред в микрофлюидных системах |
| CN102939160B (zh) | 2010-04-16 | 2016-10-12 | 欧普科诊断有限责任公司 | 用于样本分析的系统和装置 |
| USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
| TWI596494B (zh) | 2012-03-05 | 2017-08-21 | Ｏｐｋｏ診斷法有限責任公司 | 預測前列腺癌風險及前列腺腺體體積之方法及裝置 |
| CA2900708C (en) | 2013-03-13 | 2021-06-15 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
| CA3009218C (en) * | 2013-08-08 | 2020-10-27 | Illumina, Inc. | Fluidic system for reagent delivery to a flow cell |
| WO2015116978A1 (en) * | 2014-01-31 | 2015-08-06 | Carnegie Mellon University | Device and method for clinical data sampling and specimen banking |
| TWI728963B (zh) | 2014-12-12 | 2021-06-01 | 美商Ｏｐｋｏ診斷法有限責任公司 | 包含培養通道之流體系統，包括成型而成的流體系統及與其相關聯之方法 |
| EP3256255B1 (en) | 2015-02-13 | 2022-11-09 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus providing reduced carryover during pipetting operations |
| USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
| EP3387447A4 (en) | 2015-12-11 | 2019-08-28 | Opko Diagnostics, LLC | FLUID SYSTEMS WITH INCUBATION SAMPLES AND / OR REAGENTS |
| GB201704760D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Reagent nozzle sipper mixing system and method |
| WO2018208448A1 (en) * | 2017-05-11 | 2018-11-15 | Emd Millipore Corporation | Method of maintaining narrow residence time distributions in continuous flow systems |
| IT201800004630A1 (it) * | 2018-04-17 | 2019-10-17 | Apparato e procedimento per la determinazione della velocita' di sedimentazione del sangue e di altri parametri ad essa correlati | |
| EP3586964A1 (en) | 2018-06-27 | 2020-01-01 | Inorevia | Method of manipulating droplets in a channel |
| JP7269869B2 (ja) * | 2019-12-05 | 2023-05-09 | 株式会社日立ハイテク | 自動分析装置及び分注方法 |
| JP7417463B2 (ja) * | 2020-04-24 | 2024-01-18 | 株式会社日立ハイテク | 分注装置、自動分析装置、分注方法 |
| WO2025030122A1 (en) * | 2023-08-03 | 2025-02-06 | Life Technologies Corporation | Systems and methods for off-axis bubble detection |
| CN118777293B (zh) * | 2024-09-10 | 2024-11-19 | 中铁二局集团建筑有限公司 | 一种混合沙的氯离子检测装置及系统和方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3418053A (en) * | 1964-08-28 | 1968-12-24 | Technicon Instr | Colorimeter flow cell |
| DE1252428B (enExample) * | 1965-12-03 | 1900-01-01 | ||
| US3600953A (en) * | 1969-07-25 | 1971-08-24 | Technicon Corp | Method and apparatus for the introduction of auxiliary separating fluid in fluid sample analyses means |
| US3831618A (en) * | 1972-12-22 | 1974-08-27 | Abbott Lab | Apparatus for the precision metering of fluids |
| US3876374A (en) * | 1974-03-22 | 1975-04-08 | Technicon Instr | Method and apparatus for automated quantitative fluid analysis |
| US4259291A (en) * | 1979-07-13 | 1981-03-31 | Technicon Instruments Corporation | Metering device |
| US4253846A (en) * | 1979-11-21 | 1981-03-03 | Technicon Instruments Corporation | Method and apparatus for automated analysis of fluid samples |
| JPS5876734A (ja) * | 1981-10-31 | 1983-05-09 | Shimadzu Corp | 流液形分析計 |
| US4526754A (en) * | 1982-07-30 | 1985-07-02 | Technicon Instruments Corporation | Sample transport system |
| US4853336A (en) * | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
| US4517302A (en) * | 1982-11-15 | 1985-05-14 | Technicon Instruments Corporation | Continuous flow metering apparatus |
| US5045473A (en) * | 1987-07-14 | 1991-09-03 | Technicon Instruments Corporation | Apparatus and method for the separation and/or formation of immicible liquid streams |
| DK374889D0 (da) * | 1989-07-28 | 1989-07-28 | Koege Kemisk Vaerk | Fremgangsmaade til procesovervaagning |
-
1992
- 1992-02-26 US US07/846,269 patent/US5268147A/en not_active Expired - Lifetime
- 1992-11-18 IL IL10378292A patent/IL103782A/en not_active IP Right Cessation
- 1992-11-19 CA CA002083322A patent/CA2083322C/en not_active Expired - Fee Related
- 1992-12-02 AU AU29840/92A patent/AU653486B2/en not_active Ceased
-
1993
- 1993-02-15 DK DK93102323T patent/DK0562260T3/da active
- 1993-02-15 DE DE69331075T patent/DE69331075T2/de not_active Expired - Fee Related
- 1993-02-15 ES ES93102323T patent/ES2164647T3/es not_active Expired - Lifetime
- 1993-02-15 EP EP93102323A patent/EP0562260B1/en not_active Expired - Lifetime
- 1993-02-26 JP JP06134593A patent/JP3256818B2/ja not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10322942A1 (de) * | 2003-05-19 | 2004-12-09 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung zum Positionieren und Ausschleusen von in Separationsmedium eingebetteten Fluidkompartimenten |
| DE10322893A1 (de) * | 2003-05-19 | 2004-12-16 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2083322C (en) | 2004-04-13 |
| IL103782A (en) | 1994-06-24 |
| DK0562260T3 (da) | 2002-02-25 |
| AU2984092A (en) | 1993-09-02 |
| EP0562260B1 (en) | 2001-11-07 |
| US5268147A (en) | 1993-12-07 |
| DE69331075D1 (de) | 2001-12-13 |
| ES2164647T3 (es) | 2002-03-01 |
| AU653486B2 (en) | 1994-09-29 |
| JPH0658942A (ja) | 1994-03-04 |
| EP0562260A2 (en) | 1993-09-29 |
| JP3256818B2 (ja) | 2002-02-18 |
| EP0562260A3 (enExample) | 1994-02-23 |
| IL103782A0 (en) | 1993-04-04 |
| CA2083322A1 (en) | 1993-08-27 |
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