DE69329804D1 - Dioxolanzwischenprodukte - Google Patents

Dioxolanzwischenprodukte

Info

Publication number
DE69329804D1
DE69329804D1 DE69329804T DE69329804T DE69329804D1 DE 69329804 D1 DE69329804 D1 DE 69329804D1 DE 69329804 T DE69329804 T DE 69329804T DE 69329804 T DE69329804 T DE 69329804T DE 69329804 D1 DE69329804 D1 DE 69329804D1
Authority
DE
Germany
Prior art keywords
intermediates
substituted phenyl
hydrogen
phenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69329804T
Other languages
English (en)
Other versions
DE69329804T2 (de
Inventor
Jonathan Philip Dickens
Michael John Crimmin
Raymond Paul Beckett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of DE69329804D1 publication Critical patent/DE69329804D1/de
Application granted granted Critical
Publication of DE69329804T2 publication Critical patent/DE69329804T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
DE69329804T 1992-07-23 1993-07-23 Dioxolanzwischenprodukte Expired - Fee Related DE69329804T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929215665A GB9215665D0 (en) 1992-07-23 1992-07-23 Compounds

Publications (2)

Publication Number Publication Date
DE69329804D1 true DE69329804D1 (de) 2001-02-01
DE69329804T2 DE69329804T2 (de) 2001-05-31

Family

ID=10719178

Family Applications (5)

Application Number Title Priority Date Filing Date
DE69329804T Expired - Fee Related DE69329804T2 (de) 1992-07-23 1993-07-23 Dioxolanzwischenprodukte
DE9321495U Expired - Lifetime DE9321495U1 (de) 1992-07-23 1993-07-23 Hydroxaminsäure-Derivat als Metalloproteinase-Inhibitor
DE69309686T Expired - Fee Related DE69309686T2 (de) 1992-07-23 1993-07-23 Hydroxamsaürederivate als mettalloproteinase-inhibitoren
DE4393452T Ceased DE4393452T1 (de) 1992-07-23 1993-07-23 Hydroxaminsäure-Derivate als Metalloproteinase-Inhibitoren
DE69316367T Expired - Fee Related DE69316367T2 (de) 1992-07-23 1993-07-23 Natürliche aminosäurederivate als metalloproteinase-inhibitoren

Family Applications After (4)

Application Number Title Priority Date Filing Date
DE9321495U Expired - Lifetime DE9321495U1 (de) 1992-07-23 1993-07-23 Hydroxaminsäure-Derivat als Metalloproteinase-Inhibitor
DE69309686T Expired - Fee Related DE69309686T2 (de) 1992-07-23 1993-07-23 Hydroxamsaürederivate als mettalloproteinase-inhibitoren
DE4393452T Ceased DE4393452T1 (de) 1992-07-23 1993-07-23 Hydroxaminsäure-Derivate als Metalloproteinase-Inhibitoren
DE69316367T Expired - Fee Related DE69316367T2 (de) 1992-07-23 1993-07-23 Natürliche aminosäurederivate als metalloproteinase-inhibitoren

Country Status (26)

Country Link
US (3) US5643964A (de)
EP (3) EP0651739B1 (de)
JP (3) JP2768554B2 (de)
KR (1) KR100205710B1 (de)
AT (3) ATE162183T1 (de)
AU (2) AU661410B2 (de)
CA (1) CA2140626C (de)
CY (1) CY1944A (de)
CZ (1) CZ285896B6 (de)
DE (5) DE69329804T2 (de)
DK (2) DK0651739T3 (de)
ES (1) ES2153927T3 (de)
FI (1) FI114549B (de)
GB (4) GB9215665D0 (de)
GR (2) GR3023522T3 (de)
HK (1) HK149396A (de)
HU (2) HU220625B1 (de)
NO (1) NO303221B1 (de)
NZ (1) NZ254862A (de)
PL (1) PL174279B1 (de)
PT (1) PT754688E (de)
RU (1) RU2126791C1 (de)
SK (1) SK281240B6 (de)
UA (1) UA29450C2 (de)
WO (2) WO1994002447A1 (de)
ZA (2) ZA935352B (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307956D0 (en) * 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
ES2075797B1 (es) * 1993-08-18 1996-05-16 British Bio Technology Derivados de acidos hidroxamicos terapeuticamente activos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina.
ES2075798B1 (es) * 1993-08-18 1996-03-01 British Bio Technology Derivados de aminoacidos naturales como inhibidores de metaloproteinasas, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina.
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
CA2170158A1 (en) * 1993-08-23 1995-03-02 Roy A. Black Inhibitors of tnf-alpha secretion
GB9401129D0 (en) * 1994-01-21 1994-03-16 British Bio Technology Hydroxamic acid derivatives as metalloproteinase inhibitors
GB2299335B (en) * 1994-01-21 1997-12-17 British Biotech Pharm Hydroxamic acid derivatives as metalloproteinase inhibitors
CA2181709A1 (en) * 1994-01-22 1995-07-27 Raymond Paul Beckett Hydroxamic acid derivatives as metalloproteinase inhibitors
GB9404046D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Corp Novel compounds
GB9411088D0 (en) * 1994-06-03 1994-07-27 Hoffmann La Roche Hydroxylamine derivatives
GB9416897D0 (en) * 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
AU5002196A (en) * 1995-03-28 1996-10-16 Novo Nordisk A/S Immunosuppressive agents
GB9507799D0 (en) * 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US5691381A (en) * 1995-04-18 1997-11-25 The Dupont Merck Pharmaceutical Company Hydroxamic and carbocyclic acids as metalloprotease inhibitors
EP0832875B1 (de) 1995-04-25 2004-06-30 Daiichi Fine Chemical Co., Ltd. In wasser hochlöslicher metalloproteinase-inhibitor
WO1996035687A1 (en) * 1995-05-10 1996-11-14 Chiroscience Limited Peptidyl compounds and their therapeutic use
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
GB9513331D0 (en) * 1995-06-30 1995-09-06 British Biotech Pharm Matrix metalloproteinase inhibitors
WO1997003966A1 (en) * 1995-07-19 1997-02-06 British Biotech Pharmaceuticals Limited N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors
GB9514867D0 (en) * 1995-07-20 1995-09-20 British Biotech Pharm Metalloproteinase inhibitors
GB2318353B (en) * 1995-07-20 1999-10-06 British Biotech Pharm Metalloproteinase inhibitors
US6281352B1 (en) 1995-11-14 2001-08-28 Dupont Pharmaceuticals Company Macrocyclic compounds as metalloprotease inhibitors
GB9523637D0 (en) * 1995-11-18 1996-01-17 British Biotech Pharm Synthesis of carboxylic acid derivatives
WO1997019075A1 (en) * 1995-11-22 1997-05-29 Darwin Discovery Limited Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf)
US6127427A (en) 1995-11-23 2000-10-03 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
GB9609702D0 (en) 1996-05-09 1996-07-10 Royal Free Hosp School Med Anticoagulant peptides
GB9609794D0 (en) * 1996-05-10 1996-07-17 Smithkline Beecham Plc Novel compounds
NZ334257A (en) * 1996-08-28 2000-11-24 Procter & Gamble Spirocyclic metalloprotease inhibitors
PL331854A1 (en) * 1996-08-28 1999-08-16 Procter & Gamble Phosphinamides as inhibitors of metaloprotease matrix
EP0923561B1 (de) * 1996-08-28 2002-10-23 The Procter & Gamble Company Heterozyklische metalloproteaseinhibitoren
CN1228773A (zh) * 1996-08-28 1999-09-15 普罗克特和甘保尔公司 杂环金属蛋白酶抑制剂
IL128661A (en) * 1996-08-28 2001-10-31 Procter & Gamble Teleprotease inhibitors 1, 3 - diethocycles and pharmaceutical preparations containing them
ATE220660T1 (de) 1996-09-10 2002-08-15 British Biotech Pharm Cytostatische hydroxamsäurederivate
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
EP0971895A1 (de) 1997-03-28 2000-01-19 AstraZeneca AB Hydroxamsäuren substituiert durch heterocyclen verwenbar für die inhibition von tumor necrosis factor
EP0971881A1 (de) * 1997-03-28 2000-01-19 AstraZeneca AB Verfahren zur herstellung von n-(3-hydroxy-succinyl) amino säure derivaten
US5883131A (en) * 1997-07-09 1999-03-16 Pfizer Inc. Cyclic sulfone derivatives
WO1999006340A2 (en) 1997-07-31 1999-02-11 The Procter & Gamble Company Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
US6576664B1 (en) * 1997-08-18 2003-06-10 Bristol-Myers Squibb Pharma Company Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
EP0897908A1 (de) 1997-08-19 1999-02-24 Roche Diagnostics GmbH 3-Aryl-Succinamido-Hydroxamsäuren, Prozesse zu ihrer Herstellung und diese Substanzen enthaltende Medikamente
ZA988967B (en) * 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
US6403632B1 (en) 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
JP4948702B2 (ja) † 1997-11-14 2012-06-06 ザ プロクター アンド ギャンブル カンパニー 孔あきトップシート上にスキンケア組成物を有する使い捨て吸収性製品
AU736511B2 (en) 1998-01-09 2001-07-26 Pfizer Inc. Matrix metalloprotease inhibitors
WO1999041246A1 (en) 1998-02-11 1999-08-19 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
ATE231122T1 (de) * 1998-03-12 2003-02-15 British Biotech Pharm Cytostatika
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
CA2347632A1 (en) 1998-10-21 2000-04-27 W.R. Grace & Co.-Conn. Slurries of abrasive inorganic oxide particles and method for adjusting the abrasiveness of the particles
US6447693B1 (en) 1998-10-21 2002-09-10 W. R. Grace & Co.-Conn. Slurries of abrasive inorganic oxide particles and method for polishing copper containing surfaces
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
MXPA01008855A (es) 1999-03-03 2002-07-02 Procter & Gamble Inhibidores de metaloproteasa que contienen alquenilo y alquinilo.
JP2002541138A (ja) 1999-04-02 2002-12-03 デュポン ファーマシューティカルズ カンパニー マトリックスメタロプロテアーゼ、ＴＮＦ−α、およびアグレカナーゼの阻害剤としての新規アミド誘導体
AU4181000A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US6297337B1 (en) 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
JP2001055327A (ja) * 1999-06-11 2001-02-27 Fuji Chemical Industries Ltd 新規なヒドロキサム酸誘導体を含む医薬
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
GB9929527D0 (en) * 1999-12-14 2000-02-09 Smithkline Beecham Plc Novel compounds
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
BR0109328A (pt) 2000-03-21 2003-06-10 Procter & Gamble Inibidores de metaloprotease n-substituìdos, contendo cadeia lateral heterocìclica
IL151250A0 (en) 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
US6620823B2 (en) 2000-07-11 2003-09-16 Bristol-Myers Squibb Pharme Company Lactam metalloprotease inhibitors
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
CN1512991A (zh) 2001-06-15 2004-07-14 ά����ҩ�﹫˾ 吡咯烷双环化合物
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
DE60331367D1 (de) 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
JP2006517960A (ja) * 2003-02-18 2006-08-03 ファイザー インコーポレイテッド Ｃ型肝炎ウイルスの阻害剤、それを使用する組成物および治療法
US7846963B2 (en) 2003-05-17 2010-12-07 Korea Research Institute Of Bioscience And Biotechnology 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
US7923467B2 (en) 2003-05-30 2011-04-12 Ranbaxy Laboratories, Inc. Substituted pyrrole derivatives and their use as HMG-CO inhibitors
AU2004263900A1 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
CA2559062A1 (en) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
PL1771421T3 (pl) 2004-07-26 2009-08-31 Serono Lab Pochodne N-hydroksyamidowe i ich zastosowanie
DE102005021806A1 (de) * 2005-05-04 2006-11-16 Lancaster Group Gmbh Verwendung von radikalfangenden Substanzen zur Behandlung von Zuständen mit erhöhter Hauttemperatur, insbesondere zur antipyretischen Behandlung
MX2008002073A (es) 2005-08-12 2008-04-16 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios.
WO2007054896A1 (en) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
DE102007027772A1 (de) * 2007-06-16 2008-12-24 Ab Skf Anodnung zur Lagerung eines Maschinenteils
DE102007062199A1 (de) * 2007-12-21 2009-06-25 Evonik Degussa Gmbh 2-Methylthioethyl-substituierte Heterocyclen als Futtermitteladditive
IT1401253B1 (it) 2010-04-23 2013-07-18 Uni Degli Studi Carlo Bo Urbino Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.
FR3010076B1 (fr) * 2013-09-02 2016-12-23 Centre Nat De La Rech Scient - Cnrs - Inhibiteurs de metalloproteases, leurs procedes de preparation et leurs utilisations therapeutiques
WO2015107139A1 (en) * 2014-01-17 2015-07-23 Proyecto De Biomedicina Cima, S.L. Compounds for use as antifibrinolytic agents
CN113194954A (zh) 2018-10-04 2021-07-30 国家医疗保健研究所 用于治疗角皮病的egfr抑制剂
IT202100023357A1 (it) 2021-09-09 2023-03-09 Cheirontech S R L Peptidi con attività anti-angiogenica

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL122359C (de) * 1964-03-06
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
IT1198237B (it) * 1986-12-23 1988-12-21 Zambon Spa Intermedi per la sintesi di composti organici
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
GB9307956D0 (en) * 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives

Also Published As

Publication number Publication date
EP0651739A1 (de) 1995-05-10
ZA935352B (en) 1994-05-16
FI950262A0 (fi) 1995-01-20
EP0651738A1 (de) 1995-05-10
ATE198331T1 (de) 2001-01-15
EP0754688B1 (de) 2000-12-27
DE4393452T1 (de) 1995-06-01
DE69316367T2 (de) 1998-06-10
FI950262A (fi) 1995-01-20
GB2287023B (en) 1996-02-14
AU661410B2 (en) 1995-07-20
PL174279B1 (pl) 1998-07-31
GB9315222D0 (en) 1993-09-08
RU2126791C1 (ru) 1999-02-27
HU211287A9 (en) 1995-11-28
GB2268934B (en) 1996-01-24
JP2768554B2 (ja) 1998-06-25
AU4715293A (en) 1994-02-14
DK0754688T3 (da) 2001-03-05
US5700838A (en) 1997-12-23
ZA935351B (en) 1994-02-14
GB2268934A (en) 1994-01-26
NO303221B1 (no) 1998-06-15
KR950702525A (ko) 1995-07-29
NZ254862A (en) 1996-02-27
NO950226D0 (no) 1995-01-20
EP0651739B1 (de) 1997-04-09
ATE151414T1 (de) 1997-04-15
HK149396A (en) 1996-08-16
HU9500202D0 (en) 1995-03-28
GR3035510T3 (en) 2001-06-29
GB9315206D0 (en) 1993-09-08
PT754688E (pt) 2001-04-30
US5643964A (en) 1997-07-01
CA2140626A1 (en) 1994-02-03
US5912360A (en) 1999-06-15
RU95109920A (ru) 1996-10-27
DK0651739T3 (da) 1997-08-18
EP0754688A3 (de) 1997-07-30
KR100205710B1 (ko) 1999-07-01
EP0754688A2 (de) 1997-01-22
NO950226L (no) 1995-01-20
GB9215665D0 (en) 1992-09-09
CY1944A (en) 1997-05-16
UA29450C2 (uk) 2000-11-15
DE69309686T2 (de) 1997-07-24
JPH10204081A (ja) 1998-08-04
GB9500722D0 (en) 1995-03-08
GB2268933A (en) 1994-01-26
GB2287023A (en) 1995-09-06
DE69316367D1 (de) 1998-02-19
WO1994002447A1 (en) 1994-02-03
CZ15795A3 (en) 1995-10-18
AU4715393A (en) 1994-02-14
ES2153927T3 (es) 2001-03-16
HUT70552A (en) 1995-10-30
HU220625B1 (hu) 2002-03-28
GB2268933B (en) 1996-04-10
DE69329804T2 (de) 2001-05-31
JP2971053B2 (ja) 1999-11-02
JPH07509460A (ja) 1995-10-19
ATE162183T1 (de) 1998-01-15
WO1994002446A1 (en) 1994-02-03
PL307171A1 (en) 1995-05-15
CZ285896B6 (cs) 1999-11-17
SK281240B6 (sk) 2001-01-18
DE69309686D1 (de) 1997-05-15
CA2140626C (en) 2002-09-03
EP0651738B1 (de) 1998-01-14
DE9321495U1 (de) 1998-09-10
SK7895A3 (en) 1995-07-11
FI114549B (fi) 2004-11-15
GR3023522T3 (en) 1997-08-29
JPH07509459A (ja) 1995-10-19

Similar Documents

Publication Publication Date Title
DE69329804D1 (de) Dioxolanzwischenprodukte
CY1109863T1 (el) Παραγωγα θειαζολης για χρηση ως αντιφλεγμονωδη
LV10076A (lv) Aizvietoti beta- diketoni
DK0478173T3 (da) 4,5-polymethylen-4-isothiazolin-3-onderivater og anvendelse heraf som biocider
DK0413278T3 (da) Anvendelse af xanthinderivater mod mavesår

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee