DE69325698D1 - Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols - Google Patents

Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols

Info

Publication number
DE69325698D1
DE69325698D1 DE69325698T DE69325698T DE69325698D1 DE 69325698 D1 DE69325698 D1 DE 69325698D1 DE 69325698 T DE69325698 T DE 69325698T DE 69325698 T DE69325698 T DE 69325698T DE 69325698 D1 DE69325698 D1 DE 69325698D1
Authority
DE
Germany
Prior art keywords
enantiomer
enzymatic process
bicyclic alcohol
stereoselective production
hetero bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69325698T
Other languages
English (en)
Other versions
DE69325698T2 (de
Inventor
Nicolaas Buizer
Chris G Kruse
Der Laan Melle Van
Georges Langrand
Scharrenburg Gustaaf J M Van
Maria C Snoek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of DE69325698D1 publication Critical patent/DE69325698D1/de
Application granted granted Critical
Publication of DE69325698T2 publication Critical patent/DE69325698T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69325698T 1992-12-21 1993-12-09 Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols Expired - Fee Related DE69325698T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92204043 1992-12-21

Publications (2)

Publication Number Publication Date
DE69325698D1 true DE69325698D1 (de) 1999-08-26
DE69325698T2 DE69325698T2 (de) 2000-01-27

Family

ID=8211159

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325698T Expired - Fee Related DE69325698T2 (de) 1992-12-21 1993-12-09 Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols

Country Status (24)

Country Link
US (1) US5914263A (de)
EP (2) EP0939135A1 (de)
JP (1) JPH06237790A (de)
KR (1) KR940014808A (de)
CN (1) CN1255496A (de)
AT (1) ATE182367T1 (de)
AU (1) AU674547B2 (de)
BG (1) BG61511B1 (de)
CA (1) CA2111607A1 (de)
CZ (2) CZ286077B6 (de)
DE (1) DE69325698T2 (de)
DK (1) DK0605033T3 (de)
ES (1) ES2134241T3 (de)
FI (1) FI935676A (de)
GR (1) GR3031446T3 (de)
IL (1) IL108090A (de)
NO (1) NO934652L (de)
NZ (1) NZ250478A (de)
PL (2) PL177831B1 (de)
RO (1) RO112517B1 (de)
RU (1) RU2124506C1 (de)
SK (1) SK143793A3 (de)
TW (1) TW381120B (de)
ZA (1) ZA939435B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724184B1 (fr) * 1994-09-05 1997-01-03 Rhone Poulenc Chimie Procede de resolution d'un melange d'alcools stereoisomeres
AU701883B2 (en) * 1996-01-25 1999-02-11 Duphar International Research B.V. Process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer
DE19706337A1 (de) * 1997-02-19 1998-08-20 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Estern
EP2036547A3 (de) 2001-07-20 2009-12-23 Psychogenics Inc. Behandlung von Hyperaktivitätsstörungen mit Aufmerksamkeitsdefiziten
FR2853327B1 (fr) 2003-04-04 2012-07-27 Solvay Procede pour la fabrication de derives de beta-aminoacides enantiopurs et derives de beta-aminoacides enantiopurs
KR100527231B1 (ko) * 2003-06-03 2005-11-08 엔자이텍 주식회사 무수숙신산에 의한 광학활성 1,2-디올 유도체와 이의 에스테르 제조방법
GT200400218A (es) 2003-10-29 2005-06-06 Formulaciones de liberacion sostenida.
DE102004004719A1 (de) * 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
TW200811182A (en) * 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
CZ302204B6 (cs) * 2009-10-21 2010-12-15 Mikrobiologický ústav AV CR, v.v.i. Zpusob výroby opticky cistých stereomeru silybinu A a silybinu B
MX2016007140A (es) * 2013-12-11 2016-07-21 Hoffmann La Roche Proceso para la preparacion de 2-aril morfolinas quirales.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692775A (en) * 1969-03-17 1972-09-19 Allied Chem Racemization of d-or l-{60 -amino-caprolactam in the presence of metal ions
GB1389217A (en) * 1971-06-02 1975-04-03 Glaxo Lab Ltd Phenylglycine derivatives
FR2479825A1 (fr) * 1980-04-04 1981-10-09 Fabre Sa Pierre Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments
FR2523961B1 (fr) * 1982-03-23 1985-08-30 Centre Nat Rech Scient Procede de preparation d'un alpha-amino-acide libre l
US4659671A (en) * 1983-07-01 1987-04-21 Massachusetts Institute Of Technology Enzymatic separation of racemic mixtures of hydroxy compounds
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
IT1201408B (it) * 1985-03-22 1989-02-02 Montedison Spa Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
IE74200B1 (en) * 1987-09-11 1997-07-16 Duphar Int Res Anxiolytically active piperazine derivatives
NZ231631A (en) * 1988-12-08 1992-07-28 Duphar Int Res Heterocyclically-substituted piperazine and diazepine derivatives and anxiolytic compositions
US5166062A (en) * 1990-01-26 1992-11-24 University Of New Mexico Methods for separating diol and triol stereoisomers from a stereoisomer mixture

Also Published As

Publication number Publication date
CZ286162B6 (cs) 2000-01-12
CN1255496A (zh) 2000-06-07
CA2111607A1 (en) 1994-06-22
AU5250293A (en) 1994-06-30
FI935676A (fi) 1994-06-22
GR3031446T3 (en) 2000-01-31
RU2124506C1 (ru) 1999-01-10
BG98305A (bg) 1994-07-29
TW381120B (en) 2000-02-01
KR940014808A (ko) 1994-07-19
ATE182367T1 (de) 1999-08-15
PL177831B1 (pl) 2000-01-31
CZ278493A3 (en) 1994-07-13
AU674547B2 (en) 1997-01-02
RO112517B1 (ro) 1997-10-30
DK0605033T3 (da) 2000-02-07
US5914263A (en) 1999-06-22
DE69325698T2 (de) 2000-01-27
ZA939435B (en) 1994-08-09
NO934652D0 (no) 1993-12-16
EP0605033B1 (de) 1999-07-21
NZ250478A (en) 1995-03-28
BG61511B1 (bg) 1997-10-31
IL108090A (en) 1998-10-30
PL301539A1 (en) 1994-06-27
CZ286077B6 (cs) 2000-01-12
FI935676A0 (fi) 1993-12-16
ES2134241T3 (es) 1999-10-01
EP0939135A1 (de) 1999-09-01
IL108090A0 (en) 1994-04-12
PL178517B1 (pl) 2000-05-31
EP0605033A1 (de) 1994-07-06
SK143793A3 (en) 1994-09-07
JPH06237790A (ja) 1994-08-30
NO934652L (no) 1994-06-22

Similar Documents

Publication Publication Date Title
TW359670B (en) Process for producing quinazolin-4-one derivatives
HUP9802694A1 (hu) Benzamidszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0104167A2 (hu) 2-Ureido-tiazol-származékok, eljárás előállításukra és tumorellenes szerekként történő felhasználásuk
DE69325698T2 (de) Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols
ATE163012T1 (de) N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
PE20010482A1 (es) Derivados de 3-ureido-pirazol y procedimiento para su preparacion
HUP0203548A2 (hu) Új spirooxindolszármazékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
PT91580A (pt) Processo para a preparacao de compostos de nicotinamida n-substituida antidepressivos
HUP0301514A2 (hu) Benzimidazol származékok, elżállításuk és ezeket tartalmazó gyógyszerkészítmények
HUP0004628A1 (hu) Kamptotecinek új tetraciklusos analógjai, eljárás előállításukra, és ilyen vegyületeket tartalmazó gyógyászati készítmények
WO2004004730A3 (en) 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders
ATE250060T1 (de) O6-substituierte guaninederivate, verfahren zu ihre herstellung und ihre anwendung für behandlung von tumorzellen
DE3678469D1 (de) Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels.
MEP37508A (en) Process for the preparation of mesylates of piperazine derivatives
RU93055675A (ru) Способ стереоизбирательного получения гетеробициклического спиртового энантиомера, существенно чистый спиртовой энантиомер, способ получения производного пиперазина
NO20013912D0 (no) Fremgangsmate for rasemisering av optisk aktive aminer
MXPA04000978A (es) Procedimiento para la produccion de 4-amino-2,5-bisheterociclilquinazolinas.
EA200100816A1 (ru) 2-аминопиридины, содержащие конденсированные кольца в качестве заместителей
DE69810107D1 (de) Azacyclooktan- und heptan-derivate, ihre herstellung und ihre therapeutische verwendung
EA200400469A1 (ru) Замещенные производные алкиламинопиридазинона, способ их получения и содержащие их фармацевтические композиции
NO970281D0 (no) Fremgangsmåte for stereoselektiv fremstilling av heterobicyklisk alkohol enantiomer
HUP0204444A2 (en) Phenyl- and pyridyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them
NO844780L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive indolderivater
FI902775A0 (fi) Aryloxi-, aryltio-, heteroaryloxi-, heteroaryltio-alkylenderivat av aminer.
ATE346845T1 (de) Ein verfahren zur herstellung substituierter alkylamin-derivate

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee