ZA939435B - Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer - Google Patents

Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer

Info

Publication number
ZA939435B
ZA939435B ZA939435A ZA939435A ZA939435B ZA 939435 B ZA939435 B ZA 939435B ZA 939435 A ZA939435 A ZA 939435A ZA 939435 A ZA939435 A ZA 939435A ZA 939435 B ZA939435 B ZA 939435B
Authority
ZA
South Africa
Prior art keywords
hetero
enzymatic process
bicyclic alcohol
stereoselective preparation
alcohol enantiomer
Prior art date
Application number
ZA939435A
Other languages
English (en)
Inventor
Nicolaas Buizer
Chris G Kruse
Der Laan Melle Van
Georges Langrand
Scharrenburg Gustaaf J Van
Maria C Snoek
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of ZA939435B publication Critical patent/ZA939435B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D327/00Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA939435A 1992-12-21 1993-12-15 Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer ZA939435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92204043 1992-12-21

Publications (1)

Publication Number Publication Date
ZA939435B true ZA939435B (en) 1994-08-09

Family

ID=8211159

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA939435A ZA939435B (en) 1992-12-21 1993-12-15 Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer

Country Status (24)

Country Link
US (1) US5914263A (xx)
EP (2) EP0939135A1 (xx)
JP (1) JPH06237790A (xx)
KR (1) KR940014808A (xx)
CN (1) CN1255496A (xx)
AT (1) ATE182367T1 (xx)
AU (1) AU674547B2 (xx)
BG (1) BG61511B1 (xx)
CA (1) CA2111607A1 (xx)
CZ (2) CZ286077B6 (xx)
DE (1) DE69325698T2 (xx)
DK (1) DK0605033T3 (xx)
ES (1) ES2134241T3 (xx)
FI (1) FI935676A (xx)
GR (1) GR3031446T3 (xx)
IL (1) IL108090A (xx)
NO (1) NO934652L (xx)
NZ (1) NZ250478A (xx)
PL (2) PL177831B1 (xx)
RO (1) RO112517B1 (xx)
RU (1) RU2124506C1 (xx)
SK (1) SK143793A3 (xx)
TW (1) TW381120B (xx)
ZA (1) ZA939435B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724184B1 (fr) * 1994-09-05 1997-01-03 Rhone Poulenc Chimie Procede de resolution d'un melange d'alcools stereoisomeres
AU701883B2 (en) * 1996-01-25 1999-02-11 Duphar International Research B.V. Process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer
DE19706337A1 (de) * 1997-02-19 1998-08-20 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Estern
EP2036547A3 (en) 2001-07-20 2009-12-23 Psychogenics Inc. Treatment for Attention-Deficit Hyperactivity Disorder
FR2853327B1 (fr) 2003-04-04 2012-07-27 Solvay Procede pour la fabrication de derives de beta-aminoacides enantiopurs et derives de beta-aminoacides enantiopurs
KR100527231B1 (ko) * 2003-06-03 2005-11-08 엔자이텍 주식회사 무수숙신산에 의한 광학활성 1,2-디올 유도체와 이의 에스테르 제조방법
GT200400218A (es) 2003-10-29 2005-06-06 Formulaciones de liberacion sostenida.
DE102004004719A1 (de) * 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
TW200811182A (en) * 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
CZ302204B6 (cs) * 2009-10-21 2010-12-15 Mikrobiologický ústav AV CR, v.v.i. Zpusob výroby opticky cistých stereomeru silybinu A a silybinu B
MX2016007140A (es) * 2013-12-11 2016-07-21 Hoffmann La Roche Proceso para la preparacion de 2-aril morfolinas quirales.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692775A (en) * 1969-03-17 1972-09-19 Allied Chem Racemization of d-or l-{60 -amino-caprolactam in the presence of metal ions
GB1389217A (en) * 1971-06-02 1975-04-03 Glaxo Lab Ltd Phenylglycine derivatives
FR2479825A1 (fr) * 1980-04-04 1981-10-09 Fabre Sa Pierre Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments
FR2523961B1 (fr) * 1982-03-23 1985-08-30 Centre Nat Rech Scient Procede de preparation d'un alpha-amino-acide libre l
US4659671A (en) * 1983-07-01 1987-04-21 Massachusetts Institute Of Technology Enzymatic separation of racemic mixtures of hydroxy compounds
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
ATE81975T1 (de) * 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
IT1201408B (it) * 1985-03-22 1989-02-02 Montedison Spa Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
IE74200B1 (en) * 1987-09-11 1997-07-16 Duphar Int Res Anxiolytically active piperazine derivatives
NZ231631A (en) * 1988-12-08 1992-07-28 Duphar Int Res Heterocyclically-substituted piperazine and diazepine derivatives and anxiolytic compositions
US5166062A (en) * 1990-01-26 1992-11-24 University Of New Mexico Methods for separating diol and triol stereoisomers from a stereoisomer mixture

Also Published As

Publication number Publication date
CZ286162B6 (cs) 2000-01-12
CN1255496A (zh) 2000-06-07
CA2111607A1 (en) 1994-06-22
AU5250293A (en) 1994-06-30
FI935676A (fi) 1994-06-22
GR3031446T3 (en) 2000-01-31
RU2124506C1 (ru) 1999-01-10
BG98305A (bg) 1994-07-29
TW381120B (en) 2000-02-01
KR940014808A (ko) 1994-07-19
ATE182367T1 (de) 1999-08-15
PL177831B1 (pl) 2000-01-31
CZ278493A3 (en) 1994-07-13
AU674547B2 (en) 1997-01-02
RO112517B1 (ro) 1997-10-30
DK0605033T3 (da) 2000-02-07
DE69325698D1 (de) 1999-08-26
US5914263A (en) 1999-06-22
DE69325698T2 (de) 2000-01-27
NO934652D0 (no) 1993-12-16
EP0605033B1 (en) 1999-07-21
NZ250478A (en) 1995-03-28
BG61511B1 (bg) 1997-10-31
IL108090A (en) 1998-10-30
PL301539A1 (en) 1994-06-27
CZ286077B6 (cs) 2000-01-12
FI935676A0 (fi) 1993-12-16
ES2134241T3 (es) 1999-10-01
EP0939135A1 (en) 1999-09-01
IL108090A0 (en) 1994-04-12
PL178517B1 (pl) 2000-05-31
EP0605033A1 (en) 1994-07-06
SK143793A3 (en) 1994-09-07
JPH06237790A (ja) 1994-08-30
NO934652L (no) 1994-06-22

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