DE69317411D1 - Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen - Google Patents

Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen

Info

Publication number
DE69317411D1
DE69317411D1 DE69317411T DE69317411T DE69317411D1 DE 69317411 D1 DE69317411 D1 DE 69317411D1 DE 69317411 T DE69317411 T DE 69317411T DE 69317411 T DE69317411 T DE 69317411T DE 69317411 D1 DE69317411 D1 DE 69317411D1
Authority
DE
Germany
Prior art keywords
phenyl
treatment
neurodegenerative disorders
enantiomere
ethylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69317411T
Other languages
English (en)
Other versions
DE69317411T2 (de
Inventor
Ronald Griffith
Robert Murray
Michael Balestra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929207339A external-priority patent/GB9207339D0/en
Priority claimed from GB929208290A external-priority patent/GB9208290D0/en
Application filed by Astra AB filed Critical Astra AB
Publication of DE69317411D1 publication Critical patent/DE69317411D1/de
Application granted granted Critical
Publication of DE69317411T2 publication Critical patent/DE69317411T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE69317411T 1992-04-03 1993-04-01 Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen Expired - Lifetime DE69317411T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929207339A GB9207339D0 (en) 1992-04-03 1992-04-03 Pharmaceutical compound
GB929208290A GB9208290D0 (en) 1992-04-15 1992-04-15 Pharmaceutical compound having neuroprotective properties
PCT/GB1993/000689 WO1993020052A1 (en) 1992-04-03 1993-04-01 Enantiomeric 1-phenyl-2-(2-pyridinyl)ethylamine for the treatment of neurodegenerative disorders

Publications (2)

Publication Number Publication Date
DE69317411D1 true DE69317411D1 (de) 1998-04-16
DE69317411T2 DE69317411T2 (de) 1998-07-30

Family

ID=26300643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69317411T Expired - Lifetime DE69317411T2 (de) 1992-04-03 1993-04-01 Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen

Country Status (29)

Country Link
EP (1) EP0633879B1 (de)
JP (2) JP3120810B2 (de)
KR (1) KR100259567B1 (de)
CN (1) CN1044367C (de)
AT (1) ATE163925T1 (de)
AU (2) AU3897693A (de)
CA (1) CA2133427C (de)
CZ (1) CZ288519B6 (de)
DE (1) DE69317411T2 (de)
DK (1) DK0633879T3 (de)
DZ (1) DZ1677A1 (de)
ES (1) ES2115055T3 (de)
FI (1) FI105025B (de)
HK (1) HK1009331A1 (de)
HU (1) HU211529A9 (de)
IL (1) IL105276A (de)
MA (1) MA22866A1 (de)
MX (1) MX9301935A (de)
MY (1) MY110149A (de)
NO (1) NO302170B1 (de)
NZ (1) NZ251384A (de)
PL (1) PL180014B1 (de)
RU (1) RU2128650C1 (de)
SG (1) SG47948A1 (de)
SK (1) SK281258B6 (de)
TW (1) TW282455B (de)
UA (1) UA29437C2 (de)
WO (1) WO1993020052A1 (de)
ZA (1) ZA932415B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320273D0 (en) * 1993-04-01 1993-11-17 Fisons Corp Compound useful in therapy
SG52662A1 (en) * 1988-08-12 1998-09-28 Astra Ab Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
ZA942140B (en) * 1993-04-01 1994-10-03 Fisons Corp Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy
SE9901077D0 (sv) * 1999-03-23 1999-03-23 Astra Ab Novel use
SE9901237D0 (sv) * 1999-04-06 1999-04-06 Astra Ab Novel use
SE9901340D0 (sv) 1999-04-15 1999-04-15 Astra Pharma Prod Novel process
WO2007017652A2 (en) * 2005-08-10 2007-02-15 Astrazeneca Ab Arylakylamines for the treatment of cancer
CN102333762B (zh) * 2008-12-24 2014-06-11 阿斯利康(瑞典)有限公司 乙胺类化合物及其在治疗抑郁症中的用途
WO2013088135A1 (en) * 2011-12-14 2013-06-20 Astrazeneca Ab Gabr-a2 diagnostic
PT3066091T (pt) 2013-11-05 2019-07-11 Astrazeneca Ab Pro-farmacos de antagonista de nmda
JP2023531918A (ja) * 2020-06-23 2023-07-26 バイオヘイブン・セラピューティクス・リミテッド （１ｓ）－１－フェニル－２－ピリジン－２－イルエタンアミンの局所製剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG52662A1 (en) * 1988-08-12 1998-09-28 Astra Ab Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties

Also Published As

Publication number Publication date
JP3120810B2 (ja) 2000-12-25
NZ251384A (en) 1996-10-28
IL105276A0 (en) 1993-08-18
JPH07505385A (ja) 1995-06-15
DZ1677A1 (fr) 2002-02-17
CA2133427C (en) 2003-06-10
AU705419B2 (en) 1999-05-20
SG47948A1 (en) 1998-04-17
AU3897693A (en) 1993-11-08
FI944546A (fi) 1994-09-30
CA2133427A1 (en) 1993-10-14
DK0633879T3 (da) 1998-09-28
ES2115055T3 (es) 1998-06-16
FI105025B (fi) 2000-05-31
ZA932415B (en) 1993-10-22
ATE163925T1 (de) 1998-03-15
KR100259567B1 (ko) 2000-07-01
AU7545696A (en) 1997-02-13
CN1044367C (zh) 1999-07-28
EP0633879A1 (de) 1995-01-18
MX9301935A (es) 1994-08-31
DE69317411T2 (de) 1998-07-30
MY110149A (en) 1998-02-28
HU211529A9 (en) 1995-11-28
NO302170B1 (no) 1998-02-02
PL180014B1 (pl) 2000-11-30
NO943645L (no) 1994-11-16
FI944546A0 (fi) 1994-09-30
CN1081669A (zh) 1994-02-09
SK281258B6 (sk) 2001-01-18
IL105276A (en) 1997-06-10
HK1009331A1 (en) 1999-05-28
RU94042465A (ru) 1996-07-20
EP0633879B1 (de) 1998-03-11
SK117794A3 (en) 1995-05-10
RU2128650C1 (ru) 1999-04-10
MA22866A1 (fr) 1993-12-31
TW282455B (de) 1996-08-01
CZ240994A3 (en) 1995-12-13
CZ288519B6 (cs) 2001-07-11
JP2000319259A (ja) 2000-11-21
NO943645D0 (no) 1994-09-30
WO1993020052A1 (en) 1993-10-14
UA29437C2 (uk) 2000-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition