DE69317139T2 - Retinoid enthaltende, wässrige, gelartige Darreichungsform - Google Patents

Retinoid enthaltende, wässrige, gelartige Darreichungsform

Info

Publication number
DE69317139T2
DE69317139T2 DE69317139T DE69317139T DE69317139T2 DE 69317139 T2 DE69317139 T2 DE 69317139T2 DE 69317139 T DE69317139 T DE 69317139T DE 69317139 T DE69317139 T DE 69317139T DE 69317139 T2 DE69317139 T2 DE 69317139T2
Authority
DE
Germany
Prior art keywords
aqueous
gel
dosage form
form containing
aqueous gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69317139T
Other languages
English (en)
Other versions
DE69317139D1 (de
Inventor
Richard K Farng
Shirley M Ng
Gerard J Gendimenico
Stanley B Wrobel
James A Mezick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of DE69317139D1 publication Critical patent/DE69317139D1/de
Publication of DE69317139T2 publication Critical patent/DE69317139T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69317139T 1992-04-16 1993-04-15 Retinoid enthaltende, wässrige, gelartige Darreichungsform Expired - Lifetime DE69317139T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86968492A 1992-04-16 1992-04-16

Publications (2)

Publication Number Publication Date
DE69317139D1 DE69317139D1 (de) 1998-04-09
DE69317139T2 true DE69317139T2 (de) 1998-08-20

Family

ID=25354073

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69317139T Expired - Lifetime DE69317139T2 (de) 1992-04-16 1993-04-15 Retinoid enthaltende, wässrige, gelartige Darreichungsform

Country Status (21)

Country Link
US (1) US5643584A (de)
EP (1) EP0566405B1 (de)
JP (1) JP2779303B2 (de)
KR (1) KR970007901B1 (de)
AT (1) ATE163540T1 (de)
AU (1) AU670777B2 (de)
CA (1) CA2094084C (de)
DE (1) DE69317139T2 (de)
DK (1) DK0566405T3 (de)
ES (1) ES2114588T3 (de)
FI (1) FI931717A (de)
GR (1) GR3026597T3 (de)
HU (1) HUT64468A (de)
IL (1) IL105413A (de)
MX (1) MX9302244A (de)
MY (1) MY111791A (de)
NO (1) NO303816B1 (de)
NZ (1) NZ247387A (de)
SG (1) SG52276A1 (de)
TW (1) TW429152B (de)
ZA (1) ZA932653B (de)

Families Citing this family (51)

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EP0481007B1 (de) * 1989-06-07 1997-01-22 BAZZANO, Gail S VEHIKEL MIT LANGSAMER FREISETZUNG ZUR VERMINDERUNG DER HAUTREIZUNG TOPISCHER retinoidhaltiger MITTEL
AU688757B2 (en) * 1993-05-27 1998-03-19 Johnson & Johnson Consumer Products, Inc. Retinoid composition
US5646186A (en) * 1994-05-17 1997-07-08 Johnson & Johnson Consumer Products, Inc. Retinoid composition
FR2718021B1 (fr) * 1994-04-05 1996-06-28 Fabre Pierre Cosmetique Composition topique à base de rétinal.
ZA954599B (en) * 1994-06-07 1996-01-26 Allergan Inc Stable gel formulation for topical treatment of skin conditions
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
JP3940209B2 (ja) 1996-11-14 2007-07-04 株式会社資生堂 可溶化化粧料
US6008254A (en) 1997-05-09 1999-12-28 Kligman; Douglas E. Method of treating skin disorders with high-strength tretinoin
SE9801647D0 (sv) * 1998-05-12 1998-05-12 Interhealth Ab Therapeutic composition
FR2781371B1 (fr) * 1998-07-21 2001-04-27 Oreal Composition cosmetique aqueuse transparente a une seule phase
US20020006418A1 (en) * 1998-10-13 2002-01-17 John Kung Composition to enhance permeation of topical skin agents
US6656456B2 (en) 1998-11-23 2003-12-02 The Procter & Gamble Company Skin deodorizing compositions
WO2000030599A1 (en) * 1998-11-23 2000-06-02 The Procter & Gamble Company Skin deodorizing and sanitizing compositions
US6262117B1 (en) * 1999-02-18 2001-07-17 Allergan Sales, Inc. Method and composition for treating acne
US6114348A (en) * 1999-03-10 2000-09-05 Weber; Paul J. Method of treating warts using tazarotene
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
FR2807662A1 (fr) * 2000-04-12 2001-10-19 Cll Pharma Procede pour stabiliser la granulometrie d'un principe actif verulent disperse dans un liquide et ses applications
WO2001080796A1 (en) * 2000-04-26 2001-11-01 Watson Pharmaceuticals, Inc. Minimizing adverse experience associated with oxybutynin therapy
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
US20040087520A1 (en) * 2002-10-25 2004-05-06 Chowdhury Dipak K. Compositions and methods for delivery of therapeutic agents
EP1572176A2 (de) * 2002-12-12 2005-09-14 Galderma Research & Development, S.N.C. Wässrige-alkoholische depigmentierungsgel enthaltend ein phenol derivat und ein retinoid
MXPA05012632A (es) * 2003-05-20 2006-02-22 Ranbaxy Lab Ltd Composiciones farmaceuticas de acitretin.
US20050112078A1 (en) * 2003-11-13 2005-05-26 Sekhar Boddupalli Plant-derived protein extract compositions and methods
JP2007536259A (ja) * 2004-05-06 2007-12-13 イヴレア ファーマスーティカルズ インコーポレイテッド 活性薬剤の送達のための粒子
US20060141046A1 (en) * 2004-05-06 2006-06-29 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
US7662855B2 (en) 2004-05-11 2010-02-16 Imaginative Research Associates, Inc. Retinoid solutions and formulations made therefrom
US20080132580A1 (en) * 2004-12-17 2008-06-05 Mandavilli Sarveswara Rao Srir Dispersion For Delivering Active Agents
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
WO2006068232A1 (ja) * 2004-12-22 2006-06-29 Sapporo Medical University 線維化抑制のための薬物担体および薬物担体キット
FR2879459B1 (fr) * 2004-12-22 2007-02-16 Galderma Res & Dev Composition comprenant de l'adapalene solubilise avec des cyclodextrines
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US7803357B2 (en) * 2006-10-30 2010-09-28 John V Cappello Topical and transdermal treatments using urea formulation
US20090098191A1 (en) * 2007-10-16 2009-04-16 Anderson Christopher G Use of bases to stabilize transdermal formulations
EP2214661A4 (de) * 2007-10-18 2012-10-03 Medicis Pharmaceutical Corp Wässriges retinoid- und benzoylperoxid-gel
US20100029765A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Labortories Limited Topical aqueous composition comprising tretinoin
US10022348B2 (en) 2009-05-20 2018-07-17 Sun Pharmaceutical Industries Limited Topical solution of isotretinoin
SG176097A1 (en) 2009-05-20 2011-12-29 Ranbaxy Lab Ltd Topical retinoid solutions
US20110117182A1 (en) * 2009-07-30 2011-05-19 Allergan, Inc. Combination of dapsone with other anti-acne agents
US11419329B2 (en) 2010-03-12 2022-08-23 Monsanto Technology Llc Agrochemical gel compositions
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
SG11201405783VA (en) 2012-03-17 2014-10-30 Univ California Fast diagnosis and personalized treatments for acne
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
EP3065702B1 (de) 2013-10-31 2023-06-07 Sun Pharmaceutical Industries Ltd Topische pharmazeutische zusammensetzung von acitretin
WO2015152332A1 (ja) 2014-04-02 2015-10-08 日東電工株式会社 標的化分子およびその使用
RU2676680C2 (ru) 2014-04-07 2019-01-10 Нитто Денко Корпорейшн Новые гидротропы на основе полимера для доставки гидрофобного лекарственного средства
EP3108875A1 (de) * 2015-06-23 2016-12-28 Galderma Research & Development Zusammensetzungen mit wasserdispergierbaren nanoteilchen einer retinoid-verbindung

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US3729568A (en) * 1969-09-23 1973-04-24 Johnson & Johnson Acne treatment
US3906108A (en) * 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
IN142640B (de) * 1975-01-17 1977-08-06 Johnson & Johnson
US4247547A (en) * 1979-03-19 1981-01-27 Johnson & Johnson Tretinoin in a gel vehicle for acne treatment
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
US4826871A (en) * 1985-03-13 1989-05-02 Gressel Philip D Topical ophthalmic compositions containing one or more retinoids
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
MY105521A (en) * 1989-04-17 1994-10-31 Healthpoint Ltd Moisturizing vehicle for topical application of vitamin a acid.
US5476852A (en) * 1989-05-03 1995-12-19 Janssen Pharmaceutica N.V. Method of topically treating acne vulgaris, hyperkeratotic dermatoses, and photo-aging of the skin
FR2647015B1 (fr) * 1989-05-17 1994-05-06 Cird Gel aqueux a base d'acide retinoique et son utilisation en medecine humaine et en cosmetique
EP0481007B1 (de) * 1989-06-07 1997-01-22 BAZZANO, Gail S VEHIKEL MIT LANGSAMER FREISETZUNG ZUR VERMINDERUNG DER HAUTREIZUNG TOPISCHER retinoidhaltiger MITTEL

Also Published As

Publication number Publication date
KR970007901B1 (ko) 1997-05-17
SG52276A1 (en) 1998-09-28
NO303816B1 (no) 1998-09-07
TW429152B (en) 2001-04-11
NO931390D0 (no) 1993-04-15
NZ247387A (en) 1996-02-27
ES2114588T3 (es) 1998-06-01
AU670777B2 (en) 1996-08-01
DK0566405T3 (da) 1998-09-28
FI931717A (fi) 1993-10-17
AU3685893A (en) 1993-10-21
IL105413A0 (en) 1993-08-18
HUT64468A (en) 1994-01-28
EP0566405A3 (en) 1993-12-15
ZA932653B (en) 1994-10-15
GR3026597T3 (en) 1998-07-31
EP0566405A2 (de) 1993-10-20
JPH06100443A (ja) 1994-04-12
US5643584A (en) 1997-07-01
EP0566405B1 (de) 1998-03-04
ATE163540T1 (de) 1998-03-15
CA2094084C (en) 1998-06-30
JP2779303B2 (ja) 1998-07-23
CA2094084A1 (en) 1993-10-17
FI931717A0 (fi) 1993-04-15
KR930021210A (ko) 1993-11-22
HU9301114D0 (en) 1993-07-28
NO931390L (no) 1993-10-18
DE69317139D1 (de) 1998-04-09
IL105413A (en) 1999-09-22
MX9302244A (es) 1994-05-31
MY111791A (en) 2001-01-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN