DE69231546T2 - Endothelin Antagonisten - Google Patents

Endothelin Antagonisten

Info

Publication number
DE69231546T2
DE69231546T2 DE69231546T DE69231546T DE69231546T2 DE 69231546 T2 DE69231546 T2 DE 69231546T2 DE 69231546 T DE69231546 T DE 69231546T DE 69231546 T DE69231546 T DE 69231546T DE 69231546 T2 DE69231546 T2 DE 69231546T2
Authority
DE
Germany
Prior art keywords
group
formula
lower alkyl
atom
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231546T
Other languages
German (de)
English (en)
Other versions
DE69231546D1 (de
Inventor
Takehiro Fukami
Masaki Ihara
Kiyofumi Ishikawa
Toshiaki Mase
Toshio Nagase
Masaru Nishikibe
Mitsuo Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of DE69231546D1 publication Critical patent/DE69231546D1/de
Publication of DE69231546T2 publication Critical patent/DE69231546T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69231546T 1991-12-04 1992-11-26 Endothelin Antagonisten Expired - Lifetime DE69231546T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34767091 1991-12-04
JP35373891 1991-12-18
JP23420792 1992-08-10

Publications (2)

Publication Number Publication Date
DE69231546D1 DE69231546D1 (de) 2000-12-07
DE69231546T2 true DE69231546T2 (de) 2001-05-31

Family

ID=27332096

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231546T Expired - Lifetime DE69231546T2 (de) 1991-12-04 1992-11-26 Endothelin Antagonisten

Country Status (6)

Country Link
EP (1) EP0555537B1 (enExample)
AT (1) ATE197305T1 (enExample)
AU (1) AU657585B2 (enExample)
CA (1) CA2084163C (enExample)
DE (1) DE69231546T2 (enExample)
TW (1) TW217417B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0626174A3 (en) 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Method and composition for the prophylaxis and / or treatment of underactive organs.
CA2135151A1 (en) * 1993-11-08 1995-05-09 Mitsuhiro Wakimasu Cyclic hexapeptides, their production and use
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
CA2218716A1 (en) * 1995-04-21 1996-10-24 Novartis Ag N-aroylamino acid amides as endothelin inhibitors
AU7095696A (en) * 1995-09-26 1997-04-17 Takeda Chemical Industries Ltd. Peptide derivatives having endothelin receptor antagonistic activity
AU2001239896A1 (en) 2000-03-16 2001-10-03 Sepracor, Inc. Peptidomimetic ligands for cellular receptors and ion channels
DE10105077A1 (de) * 2001-02-05 2002-08-08 Febit Ferrarius Biotech Gmbh Hybrid-Schutzgruppe
PT1243262E (pt) 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
DE60100055T2 (de) 2001-03-21 2003-07-24 Schwarz Pharma Ag Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
ATE428413T1 (de) 2003-12-02 2009-05-15 Sanol Arznei Schwarz Gmbh Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen
KR20070007931A (ko) 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
EA014055B1 (ru) 2004-08-27 2010-08-30 Шварц Фарма Аг Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами
WO2007144195A2 (en) 2006-06-15 2007-12-21 Schwarz Pharma Ag Pharmaceutical composition with synergistic anticonvulsant effect
CA2994544C (en) 2015-08-03 2021-03-30 Enb Therapeutics, Llc Compositions and methods for treating cancers associated with etbr activation
GB201712282D0 (en) * 2017-07-31 2017-09-13 Nodthera Ltd Selective inhibitors of NLRP3 inflammasome
US10435434B2 (en) 2018-01-12 2019-10-08 Enb Therapeutics, Inc. Deuterated compounds, compositions, and methods for treating cancers associated with ETBR activation
EP3746110A4 (en) * 2018-03-30 2022-03-02 ENB Therapeutics, Inc. ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS AND USES
EP4089102A1 (en) * 2021-05-14 2022-11-16 Insusense ApS Modulators of sortilin activity
CN120271660B (zh) * 2025-06-09 2025-08-19 杭州肽佳生物科技有限公司 一种高效选择性拮抗剂bq-788的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284828A (en) * 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
GB9123967D0 (en) * 1991-11-12 1992-01-02 Fujisawa Pharmaceutical Co New compound and its preparation

Also Published As

Publication number Publication date
EP0555537A3 (en) 1994-11-02
CA2084163C (en) 2004-06-29
EP0555537B1 (en) 2000-11-02
TW217417B (enExample) 1993-12-11
AU2983892A (en) 1993-06-10
ATE197305T1 (de) 2000-11-15
CA2084163A1 (en) 1993-06-05
DE69231546D1 (de) 2000-12-07
AU657585B2 (en) 1995-03-16
EP0555537A2 (en) 1993-08-18

Similar Documents

Publication Publication Date Title
DE69231546T2 (de) Endothelin Antagonisten
DE69130408T2 (de) Endothelinantagonistische Peptidderivate
DE69002448T2 (de) Zyklische Pentapeptide als Endothelin-Antagonisten.
DE69517196T2 (de) Inhibitoren der menschlichen neutrophilenelastase
EP0871653B1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
EP1523493B1 (de) Neue tubulysinanaloga
DE69413606T2 (de) Endothelinantagonistische Peptide
DE69432573T2 (de) Inhibitoren des Endothelin konvertierenden Enzyms
DE60133817T2 (de) Verfahren zur herstellung von aplidin und neue antitumoralen derivate, verfahren zu deren herstellung und zu deren verwendung
WO1996024609A1 (de) Thrombininhibitoren
DE3783280T2 (de) Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
EP0374097A2 (de) Verwendung von Peptidisosteren als retrovirale Proteasehemmer
EP3440051A1 (en) Neuropeptide s receptor (npsr) agonists
DE69610145T2 (de) Benzo-kondensierte Azepinon-und Piperidinonverbindungen, nützlich als ACE-und NEP-Inhibitoren
EP0374098A2 (de) Retrovirale Proteasehemmer
WO1999037668A1 (de) Thrombininhibitoren
US5496928A (en) Endothelin antagonistic substance
US5614498A (en) Endothelin antagonistic substance
DE69913996T2 (de) Depsipeptide, die nicht-natürliche Aminosäuren enthalten
DE3850818T2 (de) Fluor enthaltende Renin-Inhibitoren.
US6753410B2 (en) Investigational compounds
DE3788888T2 (de) Perhydrothiazepin- und Perhydroazepinderivate, ihre Herstellung und ihre therapeutische Verwendung.
JP3398992B2 (ja) エンドセリン拮抗物質
KR0121861B1 (ko) 신규의 펩타이드 유도체
KR100230630B1 (ko) 엔도텔린(endothelin) 길항 작용을 갖는 물질

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R071 Expiry of right

Ref document number: 555537

Country of ref document: EP