DE69002448T2 - Zyklische Pentapeptide als Endothelin-Antagonisten. - Google Patents

Zyklische Pentapeptide als Endothelin-Antagonisten.

Info

Publication number
DE69002448T2
DE69002448T2 DE90124947T DE69002448T DE69002448T2 DE 69002448 T2 DE69002448 T2 DE 69002448T2 DE 90124947 T DE90124947 T DE 90124947T DE 69002448 T DE69002448 T DE 69002448T DE 69002448 T2 DE69002448 T2 DE 69002448T2
Authority
DE
Germany
Prior art keywords
group
alpha
dtrp
met
cho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE90124947T
Other languages
English (en)
Other versions
DE69002448D1 (de
Inventor
Ishikawa Kiyofumi
Fukami Takehiro
Hayama Takashi
Niiyama Kenji
Nagase Toshio
Mase Toshiaki
Fujita Kagari
Nishikibe Masaru
Ihara C O Banyu Pharm C Masaki
Yano C O Banyu Pharm Co Mitsuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of DE69002448D1 publication Critical patent/DE69002448D1/de
Application granted granted Critical
Publication of DE69002448T2 publication Critical patent/DE69002448T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE90124947T 1989-12-28 1990-12-20 Zyklische Pentapeptide als Endothelin-Antagonisten. Expired - Lifetime DE69002448T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34269589 1989-12-28
JP18586790 1990-07-13

Publications (2)

Publication Number Publication Date
DE69002448D1 DE69002448D1 (de) 1993-09-02
DE69002448T2 true DE69002448T2 (de) 1994-03-17

Family

ID=26503375

Family Applications (2)

Application Number Title Priority Date Filing Date
DE199090124947T Pending DE436189T1 (de) 1989-12-28 1990-12-20 Zyklische pentapeptide als endothelin-antagonisten.
DE90124947T Expired - Lifetime DE69002448T2 (de) 1989-12-28 1990-12-20 Zyklische Pentapeptide als Endothelin-Antagonisten.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE199090124947T Pending DE436189T1 (de) 1989-12-28 1990-12-20 Zyklische pentapeptide als endothelin-antagonisten.

Country Status (8)

Country Link
US (1) US5114918A (de)
EP (1) EP0436189B1 (de)
KR (1) KR0145317B1 (de)
AT (1) ATE92079T1 (de)
AU (1) AU632193B2 (de)
CA (1) CA2032559C (de)
DE (2) DE436189T1 (de)
ES (1) ES2041611T3 (de)

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US5514691A (en) * 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) * 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) * 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) * 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5496928A (en) * 1990-06-07 1996-03-05 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic substance
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
ES2089256T3 (es) * 1991-02-15 1996-10-01 Takeda Chemical Industries Ltd Antagonista de la endotelina.
CA2104860A1 (en) * 1991-03-08 1992-09-09 Thomas T. Andersen Endothelin antagonists
US5382569A (en) * 1991-05-16 1995-01-17 Warner-Lambert Company Endotherlin antagonists
US5260276A (en) * 1991-06-14 1993-11-09 Warner-Lambert Company Linear and monocyclic endothelin antagonists
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
ES2103857T3 (es) * 1991-08-13 1997-10-01 Takeda Chemical Industries Ltd Peptidos ciclicos y su uso.
EP0552417B1 (de) * 1991-11-19 1999-07-07 Takeda Chemical Industries, Ltd. Zyklische Peptide und ihre Verwendung
WO1993013218A1 (en) * 1991-12-27 1993-07-08 Kyowa Hakko Kogyo Co., Ltd. Endothelin-antagonizing peptide
WO1993017701A1 (en) * 1992-03-12 1993-09-16 The Administrators Of The Tulane Educational Fund Endothelin receptor-binding peptides
AU4376893A (en) * 1992-05-19 1993-12-13 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
WO1993025580A1 (en) * 1992-06-18 1993-12-23 Immunopharmaceutics, Inc. Cyclic peptides that modulate endothelin activity
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
US5922681A (en) * 1992-09-14 1999-07-13 Warner-Lambert Company Endothelin antagonists
DE69418353T2 (de) * 1993-01-13 1999-10-28 Takeda Chemical Industries Ltd Cyclische Pentapeptide mit Beta-Turn und Gamma-Turn
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
CA2121724A1 (en) * 1993-04-21 1994-10-22 Toshifumi Watanabe Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
AU673731B2 (en) * 1993-06-03 1996-11-21 Banyu Pharmaceutical Co., Ltd. Novel endothelin antagonistic peptide
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
JPH09500625A (ja) * 1993-07-09 1997-01-21 スミスクライン・ビーチャム・コーポレイション 環状セミランダムペプチドライブラリー
US5391566A (en) * 1993-07-20 1995-02-21 Merck & Co., Inc. Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
EP0714391A1 (de) * 1993-08-19 1996-06-05 Warner-Lambert Company Substituierte 2(5h) furanon, 2(5h) thiophenon und 2(5h) pyrrolon derivate, deren herstellung und deren verwendung als endothelin antagonisten
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
AU691201B2 (en) * 1993-11-01 1998-05-14 Japat Ltd. Endothelin receptor antagonists
CA2135151A1 (en) * 1993-11-08 1995-05-09 Mitsuhiro Wakimasu Cyclic hexapeptides, their production and use
US6346604B1 (en) 1995-10-31 2002-02-12 Takeda Chemical Industries, Inc. Method for controlling conformation of cyclopentapeptide
US5620953A (en) * 1994-07-27 1997-04-15 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
US5610177A (en) * 1994-08-08 1997-03-11 Warner-Lambert Company Acylated amino acids as endothelin antagonists
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5482960A (en) * 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5658902A (en) * 1994-12-22 1997-08-19 Warner-Lambert Company Quinazolines as inhibitors of endothelin converting enzyme
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
US5573762A (en) * 1995-04-24 1996-11-12 Genentech, Inc. Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy
EP0822939A1 (de) * 1995-04-28 1998-02-11 Takeda Chemical Industries, Ltd. Zyklische pentapeptid-lh-rh-rezeptor-antagonisten
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5922759A (en) * 1996-06-21 1999-07-13 Warner-Lambert Company Butenolide endothelin antagonists
US5998468A (en) * 1995-08-24 1999-12-07 Warner-Lambert Company Furanone endothelin antagonists
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
WO1997037986A1 (en) * 1996-04-10 1997-10-16 Warner-Lambert Company Endothelin antagonists with ether-linked groups
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US5891892A (en) * 1996-10-29 1999-04-06 Warner-Lambert Company Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
EE04156B1 (et) 1997-04-28 2003-10-15 Texas Biotechnology Corporation Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks
US6608027B1 (en) 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
AU2464301A (en) 1999-12-31 2001-07-16 Encysive Pharmaceuticals Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin
CA2430934C (en) 2000-12-01 2011-06-21 Takeda Chemical Industries, Ltd. A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
EP1562895A1 (de) 2002-11-19 2005-08-17 Achillion Pharmaceuticals, Inc. Subsitiuierte arylacylthioharstoffe und ähnliche verbindungen; inhibitoren der viralen replikation
MXPA06003141A (es) * 2003-09-22 2006-06-05 Boehringer Ingelheim Int Peptidos macrociclicos activos contra el virus de la hepatitis c.
GB0326632D0 (en) 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
ES2358333T3 (es) * 2004-01-21 2011-05-09 Boehringer Ingelheim International Gmbh Péptidos macrocíclicos con acción contra el virus de la hepatitis c.
JP2009530284A (ja) * 2006-03-13 2009-08-27 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド 拡張期心不全を治療するための方法と組成物
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
EP2010203A2 (de) * 2006-03-17 2009-01-07 San Diego State University Foundation Makrocyclische peptide sowie verfahren zu ihrer herstellung und verwendung
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
CA2699101A1 (en) * 2007-09-11 2009-04-02 Dorian Bevec Use of a peptide as a therapeutic agent
EP2611416B1 (de) 2010-09-03 2015-08-19 Pharmaterials Ltd. Pharmazeutische zubereitung zur verwendung in pulverinhalatoren
EP2873422A4 (de) 2012-07-10 2015-12-30 Takeda Pharmaceutical Pharmazeutische zubereitung zur injektion
ES2930730T3 (es) * 2019-01-04 2022-12-21 Avon Prod Inc Derivados oxidados de fragmentos de gdf-11

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505897A (en) * 1983-04-18 1985-03-19 The Administrators Of The Tulane Educational Fund Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
DE3401545A1 (de) * 1983-08-03 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue peptide mit immunstimulierender wirkung, verfahren zu deren herstellung und deren verwendung
EP0310887B1 (de) * 1987-10-09 1993-06-02 Takeda Chemical Industries, Ltd. Vasokonstriktor-Peptid

Also Published As

Publication number Publication date
EP0436189B1 (de) 1993-07-28
ATE92079T1 (de) 1993-08-15
US5114918A (en) 1992-05-19
DE69002448D1 (de) 1993-09-02
EP0436189A1 (de) 1991-07-10
AU6828590A (en) 1991-07-11
CA2032559A1 (en) 1991-06-29
KR910011899A (ko) 1991-07-30
ES2041611T3 (es) 1994-11-16
AU632193B2 (en) 1992-12-17
ES2041611T1 (es) 1993-12-01
KR0145317B1 (ko) 1998-07-01
CA2032559C (en) 2001-11-06
DE436189T1 (de) 1992-09-24

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Legal Events

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8380 Miscellaneous part iii

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8364 No opposition during term of opposition