GB1524319A - Polypeptide - Google Patents

Polypeptide

Info

Publication number
GB1524319A
GB1524319A GB2564376A GB2564376A GB1524319A GB 1524319 A GB1524319 A GB 1524319A GB 2564376 A GB2564376 A GB 2564376A GB 2564376 A GB2564376 A GB 2564376A GB 1524319 A GB1524319 A GB 1524319A
Authority
GB
United Kingdom
Prior art keywords
lys
ala
tyr
leu
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2564376A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2564376A priority Critical patent/GB1524319A/en
Priority to US05/803,233 priority patent/US4123523A/en
Priority to FR7718848A priority patent/FR2355804A1/en
Priority to DE19772727847 priority patent/DE2727847A1/en
Priority to JP7379477A priority patent/JPS52156832A/en
Publication of GB1524319A publication Critical patent/GB1524319A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/67—Lipotropins, e.g. beta, gamma lipotropin
    • C07K14/672—Lipotropins, e.g. beta, gamma lipotropin with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1524319 Polypeptides IMPERIAL CHEMICAL INDUSTRIES Ltd 27 May 1977 [21 June 1976 28 Oct 1976] 25643/76 and 44840/76 Heading C3H A polypeptide of the Formula (I) H-Tyr-AGly-Phe-B-P-E wherein A is D-Ala, D-Ser, D-Met or Gly; B is Leu or Met; E is OH, NH2 or O(C1-C6 alkyl); P is a peptide residue selected from Lys-Lys, Asn-Ala-Y-Lys-Lys, Thr- Leu - Phe - Lys - Asn - Ala - Ile - X - Lys - Asn- Ala - Y - Lys - Lys, Ala - Ile - X - Lys - Asn- Ala - Y - Lys - Lys, Ser - Gln - Thr - Pro - Leu- Val - Thr - Leu - Phe - Lys - Asn - Ala - Ile - X - Lys - Asn - Ala - Y - Lys - Lys, wherein X is Val or Ile, Y is Tyr or His; and the pharmaceutically-acceptable acid addition salts thereof, and, if the polypeptide of Formula (I) contains a carboxy group, the pharmaceutically-acceptable base addition salts thereof. Polypeptides (I) prepared in the examples are: H - Tyr - D - Ala - Gly - Phe - Leu - Lys - Lys- OH; H - Tyr - D - Ala - Gly-Phe Leu - Asn- Ala - Tyr - Lys - Lys - OH; H - Tyr - D - Ala- Gly - Phe - Leu - Ala - Ile - Ile - Lys - Asn - Ala- Tyr - Lys - Lys OH; H - Tyr - D - Ala - Gly- Phe - Leu - Thr - Leu - Phe - Lys - Asn - Ala- Ile-Ile-Ly-Asn-Aly-Tyr-Ls-Lys-OH; Peptide intermediates, prepared by solid phase synthesis, isolated are: PENTACOSAPEPTIDE: Boc - Tyr(But) D - Ala - Gly - Phe - Leu - Ser(Bzl) - Gln - Thr(Bzl)- Pro - Leu - Val - Thr(Bzl) Leu - Phe - Lys- (2,4 - DiClZ) - Asn Ala - Ile - Ile - Lys(2,4 - DiClZ) - Asn Ala - Tyr(mBrBzl) - Lys(2,4 - DiClZ)-Lys(2,4-DiClZ)-polystyrene resin. NONADECAPEPTIDE: Boc - Tyr(But) D - Ala - Gly - Phe Leu - Thr(Bzl) - Leu - Phe - Lys- (2,4 - - DiClZ) - Asn - Ala - Ile - Ile - Lys(2,4 - DiClZ) - Asn Ala - Tyr(mBrBzl) - Lys(2,4 DiClZ)-Lys(2,4 - DiClZ)-polystyrene resin. TETRADECAPEPTIDE: Boc - Tyr(But) - D - Ala - Gly - Phe - Leu Ala - Ile - Ile - Lys(2,4- DiClZ) - Asn - Ala - Tyr(mBrBzl) - Lys(2,4 - DiClZ) - Lys(2,4 - DiClz) - polystyrene resin. DECAPEPTIDE: Boc Byr(But) D - Ala- Gly - Phe Leu - Asn - Ala - Tyr(mBrBzl) Lys- (2,4 - DiClZ) - Lys(2,4 - DiClZ) - polystyrene resin. HEPTAPEPTIDE: Boc - Tyr(But) - D - Ala- Gly - Phe - Leu - Lys(2,4 - DiClZ) - Lys(2,4- DiClZ)-polystyrene resin. Pharmaceutical compositions, which may be in a form of parenteral administration, comprise polypeptide (I) in association with a pharmaceutically acceptable carrier.
GB2564376A 1976-06-21 1976-06-21 Polypeptide Expired GB1524319A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2564376A GB1524319A (en) 1976-06-21 1976-06-21 Polypeptide
US05/803,233 US4123523A (en) 1976-06-21 1977-06-03 Analgesic and sedative polypeptides
FR7718848A FR2355804A1 (en) 1976-06-21 1977-06-20 NEW POLYPEPTIDE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING IT
DE19772727847 DE2727847A1 (en) 1976-06-21 1977-06-21 POLYPEPTIDES, THE PROCESS FOR THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
JP7379477A JPS52156832A (en) 1976-06-21 1977-06-21 Production of polypeptide and pharmaceutical composition containing same with lenitive and tranquilizing activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2564376A GB1524319A (en) 1976-06-21 1976-06-21 Polypeptide

Publications (1)

Publication Number Publication Date
GB1524319A true GB1524319A (en) 1978-09-13

Family

ID=10231006

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2564376A Expired GB1524319A (en) 1976-06-21 1976-06-21 Polypeptide

Country Status (1)

Country Link
GB (1) GB1524319A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee