GB1524318A - Polypeptide - Google Patents
PolypeptideInfo
- Publication number
- GB1524318A GB1524318A GB2564276A GB2564276A GB1524318A GB 1524318 A GB1524318 A GB 1524318A GB 2564276 A GB2564276 A GB 2564276A GB 2564276 A GB2564276 A GB 2564276A GB 1524318 A GB1524318 A GB 1524318A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lys
- leu
- ala
- thr
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/675—Beta-endorphins
- C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1524318 Polypeptide IMPERIAL CHEMICAL INDUSTRIES Ltd 12 May 1977 [21 June 1976 28 Oct 1976] 25642/76 and 44839/76 Heading C3H A polypeptide of the Formula (I) H-Tyr-AGly - Phe - B - Thr - Ser - Glu - Lys - Ser - Gln- Thr - Pro - Leu - Val - Thr - Leu - Phe - Lys- Asn - Ala - Ile - E - Lys - Asn - Ala - F - Lys- Lys-G-K, wherein D-Ala, D-Ser or D-Met; B is Leu or Met; E is Val or Ile; F is His or Tyr; G is Gly-Gln, Gly-Glu or a direct bond; K is OH, NH2 or O(C1-C5 alkyl); and the pharmaceutically-acceptable acid addition salts thereof, and, where the said polypeptide contains a carboxyl group, the pharmaceutically-acceptable base addition salts thereof. The polypeptide (I) exemplified is: H-Tyr- D - Ala - Gly - Phe - Leu - Thr - Ser - Glu - Lys- Ser - Gln - Thr - Pro - Leu - Val - Thr - Leu- Phe - Lys - Asn - Ala - Ile - Val - Lys - Asn - Ala- His - Lys - Lys - Gly - Gln - OH. Peptide intermediates isolated are: TRIACONTAPEPTIDE: Boc - Tyr(But) - D - Ala - Gly Phe - Leu - Thr(Bzl) - Ser(Bzl) - Glu(OBzl) - Lys(2,4 - DiClZ) - Ser(Bzl) - Gln- Thr(Bzl) - Pro - Leu - Val - Thr(Bzl) - Leu - Phe- Lys(2,4 - DiClZ) - Asn - Ala - Ile - Val - Lys- (2,4 - DiClZ) - Asn Ala - His(Tas) - Lys(2,4 - DiClZ) - Lys(2,4 - DiClZ) - Gly - Gln - polystyrene which is prepared by solid phase synthesis. PENTAPEPTIDES: Boc - Tyr(But) D - Ala- Gly - Phe - Leu - OMe and OH. TETRAPEPTIDES: Z and H-D-Ala-Gly-Phe- Leu-OMe. Pharmaceutical compositions, which may be in a form of parenteral administration, in association with a non-toxic, pharmaceuticallyacceptable carrier therefor.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2564276A GB1524318A (en) | 1976-06-21 | 1976-06-21 | Polypeptide |
US05/799,938 US4320117A (en) | 1976-06-21 | 1977-05-24 | Polypeptide |
FR7718847A FR2355803A1 (en) | 1976-06-21 | 1977-06-20 | NEW POLYPEPTIDE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING IT |
DE19772727846 DE2727846A1 (en) | 1976-06-21 | 1977-06-21 | POLYPEPTIDE |
JP7379377A JPS52156861A (en) | 1976-06-21 | 1977-06-21 | Polipeptde* its preparation and analgesic anodyne composition containing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2564276A GB1524318A (en) | 1976-06-21 | 1976-06-21 | Polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1524318A true GB1524318A (en) | 1978-09-13 |
Family
ID=10230992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2564276A Expired GB1524318A (en) | 1976-06-21 | 1976-06-21 | Polypeptide |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1524318A (en) |
-
1976
- 1976-06-21 GB GB2564276A patent/GB1524318A/en not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |