DE69231098D1 - Lyophilisierte zusammensetzung, die s(+)-4,4'-(1-methyl-1,2-ethandiyl)-bis(2,6-piperazindion)enthält - Google Patents

Lyophilisierte zusammensetzung, die s(+)-4,4'-(1-methyl-1,2-ethandiyl)-bis(2,6-piperazindion)enthält

Info

Publication number
DE69231098D1
DE69231098D1 DE69231098T DE69231098T DE69231098D1 DE 69231098 D1 DE69231098 D1 DE 69231098D1 DE 69231098 T DE69231098 T DE 69231098T DE 69231098 T DE69231098 T DE 69231098T DE 69231098 D1 DE69231098 D1 DE 69231098D1
Authority
DE
Germany
Prior art keywords
icrf
piperazindion
ethandiyl
bis
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231098T
Other languages
English (en)
Other versions
DE69231098T2 (de
Inventor
Josephus Johannes Mar Holthuis
Alwinus Antonius Voetman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10703550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69231098(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE69231098D1 publication Critical patent/DE69231098D1/de
Application granted granted Critical
Publication of DE69231098T2 publication Critical patent/DE69231098T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
DE69231098T 1991-10-25 1992-10-22 Lyophilisierte zusammensetzung, die s(+)-4,4'-(1-methyl-1,2-ethandiyl)-bis(2,6-piperazindion)enthält Expired - Lifetime DE69231098T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919122720A GB9122720D0 (en) 1991-10-25 1991-10-25 (s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)formulations and their preparation
PCT/EP1992/002400 WO1993007873A1 (en) 1991-10-25 1992-10-22 Lyophilized composition containing s(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)

Publications (2)

Publication Number Publication Date
DE69231098D1 true DE69231098D1 (de) 2000-06-29
DE69231098T2 DE69231098T2 (de) 2000-09-14

Family

ID=10703550

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231098T Expired - Lifetime DE69231098T2 (de) 1991-10-25 1992-10-22 Lyophilisierte zusammensetzung, die s(+)-4,4'-(1-methyl-1,2-ethandiyl)-bis(2,6-piperazindion)enthält

Country Status (11)

Country Link
EP (1) EP0619735B1 (de)
AT (1) ATE193205T1 (de)
AU (1) AU2791292A (de)
DE (1) DE69231098T2 (de)
DK (1) DK0619735T3 (de)
ES (1) ES2145748T3 (de)
GB (1) GB9122720D0 (de)
GR (1) GR3034135T3 (de)
MX (1) MX9206139A (de)
PT (1) PT101007B (de)
WO (1) WO1993007873A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265385B1 (en) * 1996-01-11 2001-07-24 Topo Target Aps Topoisomerase II poison and bis-dioxopiperazine derivative combination therapy
RU2252761C2 (ru) * 1999-03-12 2005-05-27 Топотаргет А/С Лечение случайной транссудации антрациклинов
WO2007062076A2 (en) * 2005-11-23 2007-05-31 Novartis Ag Dexrazoxane formulations and methods
CN114306251B (zh) * 2021-12-22 2023-08-11 乐普药业股份有限公司 一种含有右雷佐生的冻干制剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
US4963551A (en) * 1987-12-21 1990-10-16 Erbamont Inc. Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof

Also Published As

Publication number Publication date
MX9206139A (es) 1993-07-01
AU2791292A (en) 1993-05-21
PT101007A (pt) 1994-01-31
DK0619735T3 (da) 2000-12-04
WO1993007873A1 (en) 1993-04-29
GB9122720D0 (en) 1991-12-11
PT101007B (pt) 1999-07-30
GR3034135T3 (en) 2000-11-30
EP0619735B1 (de) 2000-05-24
ES2145748T3 (es) 2000-07-16
ATE193205T1 (de) 2000-06-15
EP0619735A1 (de) 1994-10-19
DE69231098T2 (de) 2000-09-14

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US

R071 Expiry of right

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