MX9206139A - Formulaciones de (s) (+) -4-4'-(1 metil-1,2-etanodiil)-bis (2,6-piperazindiona). - Google Patents

Formulaciones de (s) (+) -4-4'-(1 metil-1,2-etanodiil)-bis (2,6-piperazindiona).

Info

Publication number
MX9206139A
MX9206139A MX9206139A MX9206139A MX9206139A MX 9206139 A MX9206139 A MX 9206139A MX 9206139 A MX9206139 A MX 9206139A MX 9206139 A MX9206139 A MX 9206139A MX 9206139 A MX9206139 A MX 9206139A
Authority
MX
Mexico
Prior art keywords
icrf
piperazindiona
ethanodiyl
formulations
bis
Prior art date
Application number
MX9206139A
Other languages
English (en)
Inventor
Josephus Johannes Mari Voetman
Original Assignee
Josephus Johannes Maria Holtui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10703550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9206139(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Josephus Johannes Maria Holtui filed Critical Josephus Johannes Maria Holtui
Publication of MX9206139A publication Critical patent/MX9206139A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se refiere a una preparación liofilizada estable de ICRF-187 caracterizada por la torta de ICRF-187 se encuentra protegida contra los efectos deteriorantes de la luz, tiene un contenido de humedad de no más de aproximadamente 3 por ciento y es obtenible por un proceso de liofilización usando una solución inicial de una sal ácida de ICRF-187 aceptable para uso terapéutico con una concentración de hasta aproximadamente 25 mg/ml y en la cual la etapa de secado primaria tiene una duración mínima de 30 horas preferentemente de 40 horas y/o, se utiliza una temperatura de secado primario de desde aproximadamente 30°C a aproximadamente 40°C.
MX9206139A 1991-10-25 1992-10-23 Formulaciones de (s) (+) -4-4'-(1 metil-1,2-etanodiil)-bis (2,6-piperazindiona). MX9206139A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919122720A GB9122720D0 (en) 1991-10-25 1991-10-25 (s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)formulations and their preparation

Publications (1)

Publication Number Publication Date
MX9206139A true MX9206139A (es) 1993-07-01

Family

ID=10703550

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9206139A MX9206139A (es) 1991-10-25 1992-10-23 Formulaciones de (s) (+) -4-4'-(1 metil-1,2-etanodiil)-bis (2,6-piperazindiona).

Country Status (11)

Country Link
EP (1) EP0619735B1 (es)
AT (1) ATE193205T1 (es)
AU (1) AU2791292A (es)
DE (1) DE69231098T2 (es)
DK (1) DK0619735T3 (es)
ES (1) ES2145748T3 (es)
GB (1) GB9122720D0 (es)
GR (1) GR3034135T3 (es)
MX (1) MX9206139A (es)
PT (1) PT101007B (es)
WO (1) WO1993007873A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265385B1 (en) * 1996-01-11 2001-07-24 Topo Target Aps Topoisomerase II poison and bis-dioxopiperazine derivative combination therapy
DE60010241T2 (de) 1999-03-12 2005-01-13 Topotarget A/S Dexrazoxan zur behandlung von unerwünschter extravasation von anthrazyklinen
WO2007062076A2 (en) * 2005-11-23 2007-05-31 Novartis Ag Dexrazoxane formulations and methods
CN114306251B (zh) * 2021-12-22 2023-08-11 乐普药业股份有限公司 一种含有右雷佐生的冻干制剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
US4963551A (en) * 1987-12-21 1990-10-16 Erbamont Inc. Stable lyophilized form of (S)-(+)-bis-4,4'-(1-methyl-1,2-ethanediyl)2,6-piperazinedione and solutions thereof

Also Published As

Publication number Publication date
AU2791292A (en) 1993-05-21
ATE193205T1 (de) 2000-06-15
GR3034135T3 (en) 2000-11-30
DK0619735T3 (da) 2000-12-04
DE69231098D1 (de) 2000-06-29
WO1993007873A1 (en) 1993-04-29
PT101007A (pt) 1994-01-31
DE69231098T2 (de) 2000-09-14
EP0619735B1 (en) 2000-05-24
EP0619735A1 (en) 1994-10-19
ES2145748T3 (es) 2000-07-16
PT101007B (pt) 1999-07-30
GB9122720D0 (en) 1991-12-11

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