DE69224520T2 - Anti-proliferative -und anti-inflammatorische Verbindungen: 5- oder6-deoxyhexose Monosaccharide die, in 5- oder 6-Stellung einen, über das Stickstoffatom gebundenen gesättigten stickstoffhaltigen Heterozyklen, haben - Google Patents

Anti-proliferative -und anti-inflammatorische Verbindungen: 5- oder6-deoxyhexose Monosaccharide die, in 5- oder 6-Stellung einen, über das Stickstoffatom gebundenen gesättigten stickstoffhaltigen Heterozyklen, haben

Info

Publication number
DE69224520T2
DE69224520T2 DE69224520T DE69224520T DE69224520T2 DE 69224520 T2 DE69224520 T2 DE 69224520T2 DE 69224520 T DE69224520 T DE 69224520T DE 69224520 T DE69224520 T DE 69224520T DE 69224520 T2 DE69224520 T2 DE 69224520T2
Authority
DE
Germany
Prior art keywords
monosaccharide
hexofuranose
isopropylidene
pyrrolidinyl
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224520T
Other languages
German (de)
English (en)
Other versions
DE69224520D1 (de
Inventor
M Akhtar
Sudershan Arora
David Thomson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alseres Pharmaceuticals Inc
Original Assignee
Boston Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Life Sciences Inc filed Critical Boston Life Sciences Inc
Publication of DE69224520D1 publication Critical patent/DE69224520D1/de
Application granted granted Critical
Publication of DE69224520T2 publication Critical patent/DE69224520T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69224520T 1991-12-20 1992-12-18 Anti-proliferative -und anti-inflammatorische Verbindungen: 5- oder6-deoxyhexose Monosaccharide die, in 5- oder 6-Stellung einen, über das Stickstoffatom gebundenen gesättigten stickstoffhaltigen Heterozyklen, haben Expired - Fee Related DE69224520T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81090691A 1991-12-20 1991-12-20
US07/905,320 US5360792A (en) 1991-12-20 1992-06-29 Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
PCT/US1992/010775 WO1993013117A2 (en) 1991-12-20 1992-12-18 5- or 6-aminodeoxyfuranoside derivatives with antiinflammatory and antiproliferative activity

Publications (2)

Publication Number Publication Date
DE69224520D1 DE69224520D1 (de) 1998-04-02
DE69224520T2 true DE69224520T2 (de) 1998-07-23

Family

ID=27123396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224520T Expired - Fee Related DE69224520T2 (de) 1991-12-20 1992-12-18 Anti-proliferative -und anti-inflammatorische Verbindungen: 5- oder6-deoxyhexose Monosaccharide die, in 5- oder 6-Stellung einen, über das Stickstoffatom gebundenen gesättigten stickstoffhaltigen Heterozyklen, haben

Country Status (12)

Country Link
US (1) US5360792A (enExample)
EP (1) EP0581916B1 (enExample)
JP (1) JPH06508152A (enExample)
CN (1) CN1077198A (enExample)
AT (1) ATE163422T1 (enExample)
CA (1) CA2104477A1 (enExample)
DE (1) DE69224520T2 (enExample)
FI (1) FI106863B (enExample)
IL (1) IL104112A (enExample)
NZ (1) NZ246305A (enExample)
TW (1) TW293013B (enExample)
WO (1) WO1993013117A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432163A (en) * 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
DE69432593T2 (de) * 1993-06-11 2003-11-27 Boston Life Sciences, Inc. Immunomodulierende, entzündungshemmende und antiproliferative verbindungen:5,6-dideoxy, 5-aminoderivate von idose und 6-deoxy, 6-aminoderivate von glukose
US6329344B1 (en) 1998-10-22 2001-12-11 Ranbaxy Laboratories Limited Derivatives of monosaccharides as cell adhesion inhibitors
CN1338947B (zh) 1999-02-05 2012-11-14 爱尔开-阿贝优公司 粘膜递送系统
WO2005092907A2 (en) * 2004-03-26 2005-10-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
WO2005100373A2 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
EP2583678A3 (en) * 2004-06-24 2013-11-13 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
EP1789428A1 (en) * 2004-09-02 2007-05-30 Ranbaxy Laboratories Limited Monosaccharide derivatives
JP2008525421A (ja) * 2004-12-22 2008-07-17 ランバクシー ラボラトリーズ リミテッド モノサッカリド誘導体
US20080114031A1 (en) * 2006-03-29 2008-05-15 Sattigeri Viswajanani J Monosaccharide derivatives
US7790689B2 (en) * 2006-05-30 2010-09-07 Ranbaxy Laboratories Limited Monosaccharide derivatives
US20080300196A1 (en) * 2006-10-03 2008-12-04 Ashwani Kumar Verma Monosaccharide derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715121A (en) * 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
US3939146A (en) * 1973-03-01 1976-02-17 Strategic Medical Research Corporation Novel ethereal monosubstitutions of monosaccharide derivatives
US3965262A (en) * 1973-03-01 1976-06-22 Strategic Medical Research Corporation Method of enhancing learning and/or memory in warm blooded animals
USRE30379E (en) * 1973-03-01 1980-08-19 Strategic Medical Research Corp. Ethereal monosubstitutions of monosaccharide derivatives
USRE32268E (en) * 1973-03-01 1986-10-21 Strategic Medical Research Corp. Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US4016261A (en) * 1973-03-01 1977-04-05 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US3939145A (en) * 1973-03-01 1976-02-17 Strategic Medical Research Corporation Novel ethereally monosubstituted monosaccharides
US4017608A (en) * 1973-12-14 1977-04-12 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US4056322A (en) * 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
GB1589916A (en) * 1976-11-16 1981-05-20 Prodotti Antibiotici Spa Glucofuranose derivatives
USRE30354E (en) * 1978-02-17 1980-07-29 Strategic Medical Research Corp. Novel ethereally monosubstituted monosaccharides
USRE33000E (en) * 1981-01-12 1989-07-25 Greenwich Pharmaceuticals, Incorporated Therapeutic composition and method of treating viruses
US4738953A (en) * 1981-02-17 1988-04-19 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease and a synergistic composition therefor
US4735934A (en) * 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) * 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) * 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
CA2091587A1 (en) * 1990-09-12 1992-03-13 Sudershan K. Arora Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
IL100833A0 (en) * 1991-02-20 1992-09-06 Greenwich Pharma Method for synthesis of ethereally substituted blocked monosaccharides

Also Published As

Publication number Publication date
AU3249593A (en) 1993-07-28
TW293013B (enExample) 1996-12-11
EP0581916B1 (en) 1998-02-25
DE69224520D1 (de) 1998-04-02
EP0581916A1 (en) 1994-02-09
CN1077198A (zh) 1993-10-13
US5360792A (en) 1994-11-01
WO1993013117A3 (en) 1993-09-30
AU665977B2 (en) 1996-01-25
ATE163422T1 (de) 1998-03-15
FI933654A0 (fi) 1993-08-19
FI933654L (fi) 1993-08-19
FI106863B (fi) 2001-04-30
CA2104477A1 (en) 1993-06-21
IL104112A (en) 1997-09-30
JPH06508152A (ja) 1994-09-14
IL104112A0 (en) 1993-05-13
WO1993013117A2 (en) 1993-07-08
NZ246305A (en) 1996-10-28

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8339 Ceased/non-payment of the annual fee