DE69132797D1 - Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems - Google Patents

Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems

Info

Publication number
DE69132797D1
DE69132797D1 DE69132797T DE69132797T DE69132797D1 DE 69132797 D1 DE69132797 D1 DE 69132797D1 DE 69132797 T DE69132797 T DE 69132797T DE 69132797 T DE69132797 T DE 69132797T DE 69132797 D1 DE69132797 D1 DE 69132797D1
Authority
DE
Germany
Prior art keywords
vincristine
nervous system
central nervous
active substances
evaluate active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132797T
Other languages
English (en)
Other versions
DE69132797T2 (de
Inventor
Francois-Xavier Coude
Jacqueline Fournier
Umberto Guzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of DE69132797D1 publication Critical patent/DE69132797D1/de
Application granted granted Critical
Publication of DE69132797T2 publication Critical patent/DE69132797T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69132797T 1990-05-22 1991-05-21 Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems Expired - Fee Related DE69132797T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9006399A FR2662355B1 (fr) 1990-05-22 1990-05-22 Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.

Publications (2)

Publication Number Publication Date
DE69132797D1 true DE69132797D1 (de) 2001-12-06
DE69132797T2 DE69132797T2 (de) 2002-05-29

Family

ID=9396855

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69132797T Expired - Fee Related DE69132797T2 (de) 1990-05-22 1991-05-21 Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems
DE69115989T Expired - Lifetime DE69115989T2 (de) 1990-05-22 1991-05-21 Verwendung von 1-(2-Naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur Herstellung eines Medikaments zur Behandlung von zerebralen und neuronalen Krankheiten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69115989T Expired - Lifetime DE69115989T2 (de) 1990-05-22 1991-05-21 Verwendung von 1-(2-Naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur Herstellung eines Medikaments zur Behandlung von zerebralen und neuronalen Krankheiten

Country Status (17)

Country Link
US (3) US5229389A (de)
EP (2) EP0655247B1 (de)
JP (2) JP2618115B2 (de)
KR (1) KR0181330B1 (de)
AT (2) ATE207747T1 (de)
BR (1) BR9105015A (de)
CA (2) CA2365832C (de)
CY (1) CY2283B1 (de)
DE (2) DE69132797T2 (de)
DK (2) DK0458696T3 (de)
FR (1) FR2662355B1 (de)
HK (1) HK1001471A1 (de)
HU (1) HU208922B (de)
IE (1) IE911707A1 (de)
IL (3) IL112167A (de)
TW (1) TW216771B (de)
ZA (1) ZA913865B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0192386A (ja) * 1987-10-05 1989-04-11 Hitachi Ltd 密閉循環型吸収式冷凍機及び吸収式冷凍機用吸収液
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
US5618822A (en) * 1990-05-23 1997-04-08 Sanofi N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them
FR2662442A1 (fr) * 1990-05-23 1991-11-29 Midy Spa Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
US5557209A (en) * 1990-12-20 1996-09-17 Hewlett-Packard Company Identification of pin-open faults by capacitive coupling through the integrated circuit package
FR2690158B1 (fr) * 1992-04-17 1994-07-22 Sanofi Elf Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant.
FR2702656B1 (fr) * 1993-03-18 1995-06-16 Sanofi Elf Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments cardioprotecteurs.
US5698565A (en) * 1995-06-09 1997-12-16 Hoffmann-La Roche Inc. Use of phenoxy-pyridine derivatives
FR2736053B1 (fr) * 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
JP3468526B2 (ja) * 1995-10-26 2003-11-17 サノフィーサンテラボ 筋萎縮性側索硬化症治療薬調製のための１−（２−ナフタ−２−イルエチル）−４−（３−トリフルオロメチルフェニル）−１，２，３，６−テトラヒドロピリジンの使用
FR2740343B1 (fr) * 1995-10-26 1999-01-22 Sanofi Sa Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique
DE69736976T2 (de) * 1996-03-29 2007-10-18 Trustees Of Boston University, Boston Mit Alzheimer Krankheit verknüpften Verfahren zur Diagnose, zur Herstellung von Medikamenten und zum Screenen von Substanzen sowie aus Beta-Amyloid abgeleiteten Peptiden
US5891465A (en) * 1996-05-14 1999-04-06 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth
FR2757160B1 (fr) * 1996-12-13 1999-03-12 Sanofi Sa 1-phenylalkyl-1,2,3,6-tetrahydropyridines
FR2757161B1 (fr) * 1996-12-13 1999-03-12 Sanofi Sa Diphenylalkyl-tetrahydropyridines
FR2757510B1 (fr) * 1996-12-23 2000-01-07 Sanofi Sa Forme microparticulaire d'un derive de tetrahydropyridine
FR2757512B1 (fr) * 1996-12-24 1999-03-12 Sanofi Sa Utilisation de benzoylalkyl-1-1,2,3,6-tetrahydropyridines
EP0954311A1 (de) * 1997-02-03 1999-11-10 Sanofi-Synthelabo Verwendung von 1-(6,7-dimethoxynaphthyl-2-ethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur herstellung eines medikaments zur behandlung von zerebralen und neuronalen krankheiten
FR2762514B1 (fr) 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
TWI237035B (en) * 1998-07-24 2005-08-01 Polyplastics Co Polyacetal copolymer
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531707A1 (fr) * 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.

Also Published As

Publication number Publication date
CY2283B1 (en) 2003-07-04
ATE132369T1 (de) 1996-01-15
EP0458696A2 (de) 1991-11-27
FR2662355B1 (fr) 1994-11-10
IE911707A1 (en) 1991-12-04
FR2662355A1 (fr) 1991-11-29
EP0655247B1 (de) 2001-10-31
HU911729D0 (en) 1991-12-30
BR9105015A (pt) 1993-05-25
EP0655247A1 (de) 1995-05-31
KR0181330B1 (ko) 1999-03-20
JPH09132535A (ja) 1997-05-20
IL112167A0 (en) 1995-03-15
DK0655247T3 (da) 2002-02-18
CA2042974C (en) 2002-09-17
KR910019617A (ko) 1991-12-19
DK0458696T3 (da) 1996-05-20
US5270320A (en) 1993-12-14
JP2954029B2 (ja) 1999-09-27
JP2618115B2 (ja) 1997-06-11
EP0458696A3 (en) 1992-03-18
HUT59824A (en) 1992-07-28
CA2365832C (en) 2007-08-07
JPH04226917A (ja) 1992-08-17
ZA913865B (en) 1992-02-26
IL112167A (en) 1996-01-31
DE69132797T2 (de) 2002-05-29
IL98175A (en) 1996-01-19
AU7713391A (en) 1991-11-28
ATE207747T1 (de) 2001-11-15
CA2042974A1 (en) 1991-11-22
US5229389A (en) 1993-07-20
HK1001471A1 (en) 1998-06-19
TW216771B (de) 1993-12-01
AU636488B2 (en) 1993-04-29
IL98175A0 (en) 1992-06-21
DE69115989T2 (de) 1996-08-22
US5468753A (en) 1995-11-21
CA2365832A1 (en) 1991-11-23
IE20011078A1 (en) 2002-03-20
HU208922B (en) 1994-02-28
EP0458696B1 (de) 1996-01-03
DE69115989D1 (de) 1996-02-15

Similar Documents

Publication Publication Date Title
DE69132797D1 (de) Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems
DE69100547T2 (de) Methode und Vorrichtung zum elektrochemischen Bearbeiten der Spritzöffnungen von Brennstoff-Einspritzdüsen.
DE3177156D1 (de) Guanin-verbindungen und ihre verwendung zur herstellung eines antivirusmittels.
AT368656B (de) Optisch auslesbarer scheibenfoermiger aufzeichnungstraeger, verfahren zu dessen herstellung und vorrichtung zur durchfuehrung dieses verfahrens
DE3882058D1 (de) Immunoreaktives reagens, verfahren zu seiner herstellung und seine verwendung zur bestimmung einer immunoreaktiven spezies.
DE3763289D1 (de) Ultrafiltrations-, hyperfiltrations- oder entmineralisierungselement, verfahren zu seiner herstellung und seine verwendung zur aufbereitung von fluessigen, radioaktiven abfaellen.
DE3680632D1 (de) Verfahren zur herstellung von kohlenstoffasern und diese kohlenstoffasern.
DE3687064T2 (de) Verfahren zur identifizierung von mit gesteigerter diabetesgefahr assoziierten allelen.
DE3783773T2 (de) Vorrichtung zur feststellung der lebensfaehigkeit von nematoden und verfahren zu ihrer verwendung.
DE68909997T2 (de) Vorrichtung zur Kultur von tierischen Zellen, Kulturmethode und Mittel zum Nachweis der Kultur.
DE59000468D1 (de) Verfahren zur schnellen pruefung der wirksamkeit von agenzien auf mikroorganismen.
DE68910163T2 (de) Verfahren zur Bekämpfung von biologischen Verschmutzungen bei der Erdölförderung.
DE69000266D1 (de) Verfahren und vorrichtung zur verbesserung des langelier-index von staedtischem wasser.
DE3864229D1 (de) Verfahren und vorrichtung zur bestimmung der mittleren feinheit von losen fasern.
DE3865794D1 (de) Hydroraffinationskatalysator, ausgehend von hydrogelen, verfahren zur herstellung und verwendung.
DE58905617D1 (de) Verfahren zur Überwachung und/oder Regelung eines Spritzgiessprozesses.
Nevin et al. Ratio reinforcement of signal detection.
DE69103425D1 (de) Verfahren zur verhinderung der zerstörung von meerwasserzellen durch biologische verschmutzung.
ATE9343T1 (de) 2,6-diethyl-3,5-dimethyl-2,3-dihydro-4h-pyran, verfahren zu seiner herstellung und seine verwendung zur frueherkennung, lokalisierung und bekaempfung von lasioderma serricorne f.
AT367821B (de) Verfahren zur erhoehung der standfestigkeit von plastischem, tonig-schluffigem gebirge und vorrichtung zur durchfuehrung des verfahrens
DE3580344D1 (de) Vorrichtung zur entfernung von tierhoernern.
DE3773331D1 (de) Optisch aktives propanon-derivat, verfahren zu seiner herstellung und seine verwendung.
ATA77785A (de) Pruefmodell zur verwendung in sterilisiergeraeten, insbesondere beim sterilisieren von biologische stoffe enthaltendem sterilisiergut
DE69028173D1 (de) Methode zur Wiedergabe von einem optischen Aufzeichnungsträger und Vorrichtung, die stimulierte Photonenechos verwenden
Manning River Recreation Use and Analysis of Carrying Capacity

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

8339 Ceased/non-payment of the annual fee