DE69115989D1 - Verwendung von 1-(2-Naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur Herstellung eines Medikaments zur Behandlung von zerebralen und neuronalen Krankheiten - Google Patents
Verwendung von 1-(2-Naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur Herstellung eines Medikaments zur Behandlung von zerebralen und neuronalen KrankheitenInfo
- Publication number
- DE69115989D1 DE69115989D1 DE69115989T DE69115989T DE69115989D1 DE 69115989 D1 DE69115989 D1 DE 69115989D1 DE 69115989 T DE69115989 T DE 69115989T DE 69115989 T DE69115989 T DE 69115989T DE 69115989 D1 DE69115989 D1 DE 69115989D1
- Authority
- DE
- Germany
- Prior art keywords
- naphthylethyl
- tetrahydropyridine
- trifluoromethylphenyl
- cerebral
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9006399A FR2662355B1 (fr) | 1990-05-22 | 1990-05-22 | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69115989D1 true DE69115989D1 (de) | 1996-02-15 |
DE69115989T2 DE69115989T2 (de) | 1996-08-22 |
Family
ID=9396855
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69115989T Expired - Lifetime DE69115989T2 (de) | 1990-05-22 | 1991-05-21 | Verwendung von 1-(2-Naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridin zur Herstellung eines Medikaments zur Behandlung von zerebralen und neuronalen Krankheiten |
DE69132797T Expired - Fee Related DE69132797T2 (de) | 1990-05-22 | 1991-05-21 | Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132797T Expired - Fee Related DE69132797T2 (de) | 1990-05-22 | 1991-05-21 | Verwendung von Vincristin zur Auswertung von Wirkstoffen in Zentralnervensystems |
Country Status (17)
Country | Link |
---|---|
US (3) | US5229389A (de) |
EP (2) | EP0458696B1 (de) |
JP (2) | JP2618115B2 (de) |
KR (1) | KR0181330B1 (de) |
AT (2) | ATE207747T1 (de) |
BR (1) | BR9105015A (de) |
CA (2) | CA2365832C (de) |
CY (1) | CY2283B1 (de) |
DE (2) | DE69115989T2 (de) |
DK (2) | DK0458696T3 (de) |
FR (1) | FR2662355B1 (de) |
HK (1) | HK1001471A1 (de) |
HU (1) | HU208922B (de) |
IE (1) | IE911707A1 (de) |
IL (3) | IL98175A (de) |
TW (1) | TW216771B (de) |
ZA (1) | ZA913865B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0192386A (ja) * | 1987-10-05 | 1989-04-11 | Hitachi Ltd | 密閉循環型吸収式冷凍機及び吸収式冷凍機用吸収液 |
FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
US5618822A (en) * | 1990-05-23 | 1997-04-08 | Sanofi | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them |
FR2662442A1 (fr) * | 1990-05-23 | 1991-11-29 | Midy Spa | Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant. |
US5557209A (en) * | 1990-12-20 | 1996-09-17 | Hewlett-Packard Company | Identification of pin-open faults by capacitive coupling through the integrated circuit package |
FR2690158B1 (fr) * | 1992-04-17 | 1994-07-22 | Sanofi Elf | Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant. |
FR2702656B1 (fr) * | 1993-03-18 | 1995-06-16 | Sanofi Elf | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments cardioprotecteurs. |
US5698565A (en) * | 1995-06-09 | 1997-12-16 | Hoffmann-La Roche Inc. | Use of phenoxy-pyridine derivatives |
FR2736053B1 (fr) * | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
FR2740343B1 (fr) * | 1995-10-26 | 1999-01-22 | Sanofi Sa | Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique |
KR100472793B1 (ko) * | 1995-10-26 | 2005-06-16 | 사노피-신델라보 | 근위축성측삭경화증치료용약제를제조하기위한1-(2-나프트-2-일에틸)-4-(3-트리플루오로메틸페닐)-1,2,3,6-테트라히드로피리딘의용도 |
ATE346303T1 (de) * | 1996-03-29 | 2006-12-15 | Univ Boston | Mit alzheimer krankheit verknüpften verfahren zur diagnose, zur herstellung von medikamenten und zum screenen von substanzen sowie aus beta- amyloid abgeleiteten peptiden |
US5891465A (en) * | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
FR2757160B1 (fr) * | 1996-12-13 | 1999-03-12 | Sanofi Sa | 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
FR2757161B1 (fr) * | 1996-12-13 | 1999-03-12 | Sanofi Sa | Diphenylalkyl-tetrahydropyridines |
FR2757510B1 (fr) * | 1996-12-23 | 2000-01-07 | Sanofi Sa | Forme microparticulaire d'un derive de tetrahydropyridine |
FR2757512B1 (fr) * | 1996-12-24 | 1999-03-12 | Sanofi Sa | Utilisation de benzoylalkyl-1-1,2,3,6-tetrahydropyridines |
JP2001511141A (ja) * | 1997-02-03 | 2001-08-07 | サノフィ−サンテラボ | 1−[4−(3−トリフルオロメチルフェニル)−1,2,3,6−テトラヒドロピリド−1−イル]−2−(6,7−ジメトキシナフト−2−イル)エタンの、脳障害および神経障害を治療する目的の薬剤を調製するための使用 |
FR2762514B1 (fr) | 1997-04-29 | 1999-10-22 | Sanofi Sa | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation |
FR2763847B1 (fr) | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
FR2771007B1 (fr) * | 1997-11-14 | 2000-12-01 | Sanofi Sa | Association de principes actifs pour le traitement de la demence senile du type alzheimer |
CO4980891A1 (es) * | 1997-11-14 | 2000-11-27 | Sanofi Sa | Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer |
DE19751949A1 (de) | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
TWI237035B (en) * | 1998-07-24 | 2005-08-01 | Polyplastics Co | Polyacetal copolymer |
KR101130212B1 (ko) * | 2002-03-27 | 2012-04-13 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 사용법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2531707A1 (fr) * | 1982-08-16 | 1984-02-17 | Midy Spa | Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques |
FR2639226B1 (fr) * | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
-
1990
- 1990-05-22 FR FR9006399A patent/FR2662355B1/fr not_active Expired - Lifetime
-
1991
- 1991-05-17 IL IL9817591A patent/IL98175A/en not_active IP Right Cessation
- 1991-05-17 IL IL11216791A patent/IL112167A/en not_active IP Right Cessation
- 1991-05-20 TW TW080103889A patent/TW216771B/zh not_active IP Right Cessation
- 1991-05-20 IE IE170791A patent/IE911707A1/en not_active IP Right Cessation
- 1991-05-21 AT AT94403014T patent/ATE207747T1/de not_active IP Right Cessation
- 1991-05-21 DE DE69115989T patent/DE69115989T2/de not_active Expired - Lifetime
- 1991-05-21 EP EP91401311A patent/EP0458696B1/de not_active Expired - Lifetime
- 1991-05-21 CA CA002365832A patent/CA2365832C/en not_active Expired - Fee Related
- 1991-05-21 AT AT91401311T patent/ATE132369T1/de not_active IP Right Cessation
- 1991-05-21 DK DK91401311.5T patent/DK0458696T3/da active
- 1991-05-21 EP EP94403014A patent/EP0655247B1/de not_active Expired - Lifetime
- 1991-05-21 CA CA002042974A patent/CA2042974C/en not_active Expired - Lifetime
- 1991-05-21 DE DE69132797T patent/DE69132797T2/de not_active Expired - Fee Related
- 1991-05-21 DK DK94403014T patent/DK0655247T3/da active
- 1991-05-21 US US07/703,835 patent/US5229389A/en not_active Expired - Lifetime
- 1991-05-22 JP JP3146949A patent/JP2618115B2/ja not_active Expired - Lifetime
- 1991-05-22 HU HU911729A patent/HU208922B/hu unknown
- 1991-05-22 ZA ZA913865A patent/ZA913865B/xx unknown
- 1991-05-22 KR KR1019910008272A patent/KR0181330B1/ko not_active IP Right Cessation
- 1991-11-07 US US07/789,044 patent/US5270320A/en not_active Expired - Lifetime
- 1991-11-19 BR BR919105015A patent/BR9105015A/pt not_active Application Discontinuation
-
1993
- 1993-10-20 US US08/142,069 patent/US5468753A/en not_active Expired - Lifetime
-
1994
- 1994-12-27 IL IL11216794A patent/IL112167A0/xx unknown
-
1996
- 1996-08-20 JP JP8218926A patent/JP2954029B2/ja not_active Expired - Fee Related
-
1998
- 1998-01-20 HK HK98100449A patent/HK1001471A1/xx not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200037A patent/CY2283B1/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-SYNTHELABO, PARIS, FR |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-AVENTIS, PARIS, FR |