DE69130345D1 - Verfahren und Vorrichtung zur Vorbereitung von Zellen für die Untersuchung - Google Patents
Verfahren und Vorrichtung zur Vorbereitung von Zellen für die UntersuchungInfo
- Publication number
- DE69130345D1 DE69130345D1 DE69130345T DE69130345T DE69130345D1 DE 69130345 D1 DE69130345 D1 DE 69130345D1 DE 69130345 T DE69130345 T DE 69130345T DE 69130345 T DE69130345 T DE 69130345T DE 69130345 D1 DE69130345 D1 DE 69130345D1
- Authority
- DE
- Germany
- Prior art keywords
- filter element
- particles
- transfer
- cells
- spatial distribution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002245 particle Substances 0.000 abstract 6
- 239000011521 glass Substances 0.000 abstract 2
- 239000006194 liquid suspension Substances 0.000 abstract 2
- 230000000007 visual effect Effects 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2846—Cytocentrifuge method
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/550,142 US5143627A (en) | 1990-07-09 | 1990-07-09 | Method and apparatus for preparing cells for examination |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69130345D1 true DE69130345D1 (de) | 1998-11-19 |
DE69130345T2 DE69130345T2 (de) | 1999-06-17 |
Family
ID=24195922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69130345T Expired - Lifetime DE69130345T2 (de) | 1990-07-09 | 1991-06-06 | Verfahren und Vorrichtung zur Vorbereitung von Zellen für die Untersuchung |
Country Status (5)
Country | Link |
---|---|
US (1) | US5143627A (de) |
EP (1) | EP0465832B1 (de) |
JP (1) | JP3106254B2 (de) |
AT (1) | ATE172244T1 (de) |
DE (1) | DE69130345T2 (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5301685A (en) * | 1989-01-10 | 1994-04-12 | Guirguis Raouf A | Method and apparatus for obtaining a cytology monolayer |
US6106483A (en) * | 1989-01-10 | 2000-08-22 | Lamina, Inc. | Apparatus for obtaining a cytology monolayer |
US5282978A (en) * | 1990-07-09 | 1994-02-01 | Cytyc Corporation | Specimen processor method and apparatus |
US5269918A (en) * | 1990-07-09 | 1993-12-14 | Cytyc Corporation | Clinical cartridge apparatus |
US5240606A (en) * | 1990-07-09 | 1993-08-31 | Cytyc Corporation | Apparatus for preparing cells for examination |
US5364597A (en) * | 1991-03-13 | 1994-11-15 | Cytyc Corporation | Apparatus for collection and transfer of particles |
US6309362B1 (en) * | 1992-07-28 | 2001-10-30 | Lamina, Inc. | Method and apparatus for automatically separating particulate matter from a fluid |
DE69305947T2 (de) * | 1992-09-18 | 1997-03-13 | Amersham Int Plc | Vorrichtung und Methode zur Affinitätstrennung |
DE4331596A1 (de) * | 1993-09-17 | 1995-03-23 | Boehringer Mannheim Gmbh | Verfahren zur quantitativen Analyse von Probenflüssigkeiten |
US5602042A (en) * | 1994-04-14 | 1997-02-11 | Cytyc Corporation | Method and apparatus for magnetically separating biological particles from a mixture |
US5470758A (en) * | 1994-12-14 | 1995-11-28 | Shandon, Inc. | Large cytology sample chamber for distributing material onto a microscope slide |
US6091483A (en) * | 1995-11-03 | 2000-07-18 | Lamina, Inc. | Method and apparatus for preparing substances for optical analysis |
US5641229A (en) * | 1995-12-22 | 1997-06-24 | Universal Healthwatch, Inc. | Sample rotator with manually energized spring motor |
US6149871A (en) * | 1997-08-25 | 2000-11-21 | Lamina, Inc. | System for processing multiple specimens of biological fluid |
JP4074058B2 (ja) | 1997-11-04 | 2008-04-09 | モノジェン,インコーポレイテッド | 流体試料と粒子物質を混合および流体試料から粒子物質を分離をする方法、およびその装置 |
US6830935B1 (en) * | 1998-07-07 | 2004-12-14 | Lamina, Inc. | Method for mixing and processing specimen samples |
US6562299B1 (en) * | 1998-09-18 | 2003-05-13 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
US20030059347A1 (en) | 1998-09-18 | 2003-03-27 | Roy A. Ostgaard | Sample vial for use in preparing cytological specimen |
US6572824B1 (en) | 1998-09-18 | 2003-06-03 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
US6828157B1 (en) * | 1999-05-04 | 2004-12-07 | Dan A. Pankowsky | Products and methods for single parameter and multiparameter phenotyping of cells |
AU4350501A (en) * | 2000-03-08 | 2001-09-17 | Cytyc Corp | Method and apparatus for preparing cytological specimens |
US6936443B2 (en) * | 2000-04-03 | 2005-08-30 | Cytyc Corporation | Detection and typing of human papillomavirus using PNA probes |
DE60141205D1 (de) | 2000-04-03 | 2010-03-18 | Cytyc Corp | Nachweis und typisierung des papillomavirus mittels pna-sonden |
US6284543B1 (en) * | 2000-08-08 | 2001-09-04 | Iliana I. Alvarez | Rapid papanicolaou staining method for cervico-vaginal specimens |
US20020086431A1 (en) * | 2000-08-21 | 2002-07-04 | Markham Walter Bruce | Sample preparation and slide plating apparatus and method |
US6881543B2 (en) | 2000-11-15 | 2005-04-19 | Whatman, Inc. | Sampling and storage system for genetic material from tissue |
SG93921A1 (en) * | 2001-06-05 | 2003-01-21 | Leng Hwee Ong | A device for use in preserving a specimen for microscopic examination |
US7771662B2 (en) * | 2001-10-19 | 2010-08-10 | Hologic, Inc | Vial system and method for processing liquid-based specimens |
CA2462447A1 (en) | 2001-10-19 | 2003-04-24 | Monogen, Inc. | Article handling system and method |
AU2003234730A1 (en) | 2002-04-13 | 2003-12-22 | Newport Instruments | Centrifugal cytology system, chamber block and method for the preparation of treated monolayers of sample material |
ES2263948T3 (es) * | 2002-04-24 | 2006-12-16 | Jlc Consultants Sarl | Dispositivo para la realizacion de una preparacion citologica sobre un portaobjetos. |
US7198902B2 (en) | 2003-09-25 | 2007-04-03 | Cytyc Corporation | Apparatus and method for separating viral particles from cells |
ZA200609269B (en) | 2004-04-09 | 2008-06-25 | Res Think Tank Inc | Devices and methods for collection, storage and transportation of biological specimens |
US20050237607A1 (en) * | 2004-04-27 | 2005-10-27 | Cytyc Corporation | Microscope slide mask and method |
US7687032B2 (en) * | 2004-05-06 | 2010-03-30 | Cytyc Corporation | Filter assembly for molecular testing |
US7507578B2 (en) * | 2004-10-21 | 2009-03-24 | Cytyc Corporation | Reduced aperture biological specimen collection and transfer device |
WO2006052247A1 (en) * | 2004-11-09 | 2006-05-18 | Monogen, Inc. | Vial assembly, sampling apparatus and method for processing liquid-based specimens |
US7556777B2 (en) * | 2005-03-08 | 2009-07-07 | Cytyc Corporation | Specimen vial cap handler and slide labeler |
US20070099291A1 (en) * | 2005-11-03 | 2007-05-03 | Cytyc Corporation | Ambient pressure monitor and method of preparing biological specimens |
US7735068B2 (en) | 2005-12-01 | 2010-06-08 | Infosys Technologies Ltd. | Automated relationship traceability between software design artifacts |
US7472593B2 (en) * | 2005-12-01 | 2009-01-06 | Cytyc Corporation | Fluid level regulator |
US7357042B2 (en) * | 2005-12-01 | 2008-04-15 | Cytyc Corporation | Filter contamination control device |
US20070134130A1 (en) * | 2005-12-09 | 2007-06-14 | Cytyc Corporation | Biological specimen collection and transfer device and method of use |
US20070292315A1 (en) * | 2006-06-16 | 2007-12-20 | Cytyc Corporation | Mini-tray for slide processing |
US20080009072A1 (en) * | 2006-07-07 | 2008-01-10 | Cytyc Corporation | Ultrasonic mixing of a biological sample |
US7449153B2 (en) * | 2006-07-21 | 2008-11-11 | Cytyc Corporation | Tray for slide processing |
US8034307B2 (en) * | 2006-10-18 | 2011-10-11 | Cytyc Corporation | Filter for automated slide preparation system |
US20080101666A1 (en) * | 2006-10-30 | 2008-05-01 | Cytyc Corporation | Automated imaging system with slide marking |
GB2479842B (en) * | 2007-05-18 | 2012-03-14 | Malvern Instr Ltd | Method and apparatus for dispersing a sample of particulate material |
US7981054B2 (en) * | 2007-07-16 | 2011-07-19 | Phuong Nguyen | All-in-one biological specimen collecting, transporting and analyzing device |
WO2009085745A1 (en) | 2007-12-20 | 2009-07-09 | Cytyc Corporation | Method for magnetic separation of red blood cells from a patient sample |
US8137958B2 (en) * | 2007-12-20 | 2012-03-20 | Cytyc Corporation | Active grip filter plug for sample collection devices |
JP5206610B2 (ja) | 2008-08-25 | 2013-06-12 | セイコーエプソン株式会社 | アクチュエータ、光スキャナおよび画像形成装置 |
CN102203581B (zh) * | 2008-10-10 | 2013-10-23 | 西泰克公司 | 用于制备细胞试样的微流体装置及方法 |
JP2010172251A (ja) * | 2009-01-29 | 2010-08-12 | Sysmex Corp | 細胞分散装置及び試料前処理装置 |
US8669118B2 (en) | 2009-09-11 | 2014-03-11 | Hologic, Inc. | Methods and systems for collecting cells of a biological specimen |
US20110151505A1 (en) * | 2009-12-16 | 2011-06-23 | Girees Sherif K | Substance for Specimen Preparations and Related Methods |
JP5738552B2 (ja) * | 2010-07-28 | 2015-06-24 | シスメックス株式会社 | 細胞分散装置および試料調製装置 |
US8329121B2 (en) * | 2011-02-22 | 2012-12-11 | Hologic, Inc. | Apparatus for preparing cytological specimens |
US20140193848A1 (en) | 2013-01-09 | 2014-07-10 | Hologic, Inc. | Sample vial cap and sample vial for use in preparing cytological specimen and method of preparing cytological specimen |
KR101317311B1 (ko) | 2013-02-26 | 2013-10-10 | 임욱빈 | 블로윙 방식을 이용한 검진 대상물 착상 장치 |
US10641689B2 (en) | 2016-07-25 | 2020-05-05 | Optnics Precision Co., Ltd. | Method of preparing glass slide specimen of cells |
US10508977B2 (en) | 2016-11-21 | 2019-12-17 | Hologic, Inc. | Wash solution and method to remediate lubricant contamination |
CA3053184C (en) | 2017-03-09 | 2022-04-12 | Hologic, Inc. | Systems and methods for automated preparation of biological specimens |
US10845275B2 (en) | 2017-07-17 | 2020-11-24 | Hologic, Inc. | Fine tank pressure control using thermal energy for preparing cytological specimens from patient samples |
US11768135B2 (en) | 2017-09-05 | 2023-09-26 | Hologic, Inc. | Waste evacuation apparatus for an automated specimen preparation system |
KR101985008B1 (ko) * | 2018-09-08 | 2019-05-31 | (주)바이오다인 | 탈락세포 처리 장치 |
US11977215B2 (en) | 2018-11-02 | 2024-05-07 | Hologic, Inc. | Digital imaging system and method |
CA3157382A1 (en) | 2019-11-25 | 2021-06-03 | Hologic, Inc. | Digital imaging system and method |
JP2022071963A (ja) * | 2020-10-29 | 2022-05-17 | シスメックス株式会社 | 試料調製方法、細胞分析方法、試料調製装置および細胞分析装置 |
US20230139871A1 (en) * | 2021-11-02 | 2023-05-04 | Terumo Bct, Inc. | Systems and Methods For Using Microfluidic Devices With Apheresis Systems |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3647632A (en) * | 1968-04-11 | 1972-03-07 | Little Inc A | Apparatus for cell culture |
NL7303522A (de) * | 1973-03-13 | 1974-09-17 | ||
US4166768A (en) * | 1977-11-14 | 1979-09-04 | Monsanto Company | Continuous cell culture system |
US4184916A (en) * | 1977-11-14 | 1980-01-22 | Monsanto Company | Continuous cell culture system |
SE445676B (sv) * | 1980-07-08 | 1986-07-07 | Stenkvist Bjoern G | Forfarande och anordning for beredning av cellprover |
DE3169176D1 (de) * | 1980-09-15 | 1985-04-11 | Shandon Southern Prod | Cytocentrifuge |
CA1178183A (en) * | 1981-05-14 | 1984-11-20 | David J. Zahniser | Disaggregation device for cell suspensions |
US4395493A (en) * | 1981-05-14 | 1983-07-26 | Coulter Electronics, Inc. | Monolayer device using filter techniques |
WO1984000816A1 (en) * | 1982-08-13 | 1984-03-01 | Secretary Trade Ind Brit | Contamination level indicator |
US4468410A (en) * | 1982-08-18 | 1984-08-28 | Immunomed Corp. | Method and apparatus for producing a microscopic specimen slide |
DE3338782C2 (de) * | 1983-10-26 | 1985-09-12 | Sartorius GmbH, 3400 Göttingen | Vorrichtung zur aseptischen Probeentnahme von Flüssigkeiten aus einer Leitung, insbesondere in der Getränke-, Pharma- und Kosmetikindustrie |
US4790942A (en) * | 1983-12-20 | 1988-12-13 | Membrex Incorporated | Filtration method and apparatus |
FR2567767B1 (fr) * | 1984-07-17 | 1986-11-07 | Comp Generale Electricite | Dispositif pour prelever la phase liquide d'une suspension |
US4660462A (en) * | 1985-08-12 | 1987-04-28 | Deere & Company | Ventilation system and filter |
EP0224962A1 (de) * | 1985-11-25 | 1987-06-10 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Vorrichtung zur kontinuierlichen Züchtung von Mikroorganismen in einem flüssigen Kulturmedium |
US4755300A (en) * | 1985-12-23 | 1988-07-05 | Haemonetics Corporation | Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear |
US4830753A (en) * | 1986-04-28 | 1989-05-16 | Rohm And Haas Company | Membrane filtration of cell culture media with charged particles |
JPS63202372A (ja) * | 1987-02-17 | 1988-08-22 | N K Eng Kk | 被検査体の瀘過装置 |
NZ228374A (en) * | 1988-03-21 | 1990-12-21 | Du Pont | Method for separating and detecting microorganisms from a difficult-to-separate fluid sample, and apparatus therefor |
JPH0716393B2 (ja) * | 1988-11-10 | 1995-03-01 | 株式会社日立製作所 | 生物細胞用遠心分離装置及び細胞の分離方法 |
US5019512A (en) * | 1989-03-17 | 1991-05-28 | Baxter International Inc. | Spin filter for removing substantially cell-free culture medium from suspension cell culture system |
DE69032577T2 (de) * | 1990-03-02 | 1999-04-29 | Cytyc Corp | Verfahren und Vorrichtung für kontrollierte Instrumentation von Teilchen mittels einer Filtervorrichtung |
-
1990
- 1990-07-09 US US07/550,142 patent/US5143627A/en not_active Expired - Lifetime
-
1991
- 1991-06-06 AT AT91109286T patent/ATE172244T1/de not_active IP Right Cessation
- 1991-06-06 EP EP91109286A patent/EP0465832B1/de not_active Expired - Lifetime
- 1991-06-06 DE DE69130345T patent/DE69130345T2/de not_active Expired - Lifetime
- 1991-06-07 JP JP03163824A patent/JP3106254B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69130345T2 (de) | 1999-06-17 |
EP0465832A2 (de) | 1992-01-15 |
JPH04232834A (ja) | 1992-08-21 |
EP0465832B1 (de) | 1998-10-14 |
JP3106254B2 (ja) | 2000-11-06 |
EP0465832A3 (en) | 1992-02-26 |
ATE172244T1 (de) | 1998-10-15 |
US5143627A (en) | 1992-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KRAMER - BARSKE - SCHMIDTCHEN, 81245 MUENCHEN |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |