DE69126301T2 - Hiv-induzierte synzytien blockierender anti-cd-4-antikörper - Google Patents
Hiv-induzierte synzytien blockierender anti-cd-4-antikörperInfo
- Publication number
- DE69126301T2 DE69126301T2 DE69126301T DE69126301T DE69126301T2 DE 69126301 T2 DE69126301 T2 DE 69126301T2 DE 69126301 T DE69126301 T DE 69126301T DE 69126301 T DE69126301 T DE 69126301T DE 69126301 T2 DE69126301 T2 DE 69126301T2
- Authority
- DE
- Germany
- Prior art keywords
- antibody
- seq
- cells
- hiv
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61854290A | 1990-11-27 | 1990-11-27 | |
| PCT/US1991/008843 WO1992009305A1 (en) | 1990-11-27 | 1991-11-27 | Anti cd-4 antibodies blocking hiv-induced syncytia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69126301D1 DE69126301D1 (de) | 1997-07-03 |
| DE69126301T2 true DE69126301T2 (de) | 1998-01-02 |
Family
ID=24478147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69126301T Expired - Lifetime DE69126301T2 (de) | 1990-11-27 | 1991-11-27 | Hiv-induzierte synzytien blockierender anti-cd-4-antikörper |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5871732A (enExample) |
| EP (1) | EP0512112B1 (enExample) |
| JP (5) | JPH05505112A (enExample) |
| AT (1) | ATE153536T1 (enExample) |
| AU (1) | AU662891B2 (enExample) |
| CA (1) | CA2073031C (enExample) |
| DE (1) | DE69126301T2 (enExample) |
| DK (1) | DK0512112T3 (enExample) |
| ES (1) | ES2101834T3 (enExample) |
| GR (1) | GR3024274T3 (enExample) |
| OA (1) | OA10079A (enExample) |
| WO (1) | WO1992009305A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5651970A (en) * | 1993-03-19 | 1997-07-29 | Allen; Allen D. | Method for inhibiting disease associated with the human immunodeficiency virus through the use of monoclonal antibodies directed against anti-self cytotoxic T-lymphocytes or their lytics |
| DE4435950A1 (de) * | 1994-10-07 | 1996-04-11 | Hoechst Ag | Copolymerisate mit cyclischen oder polycyclischen Monomeren mit einer speziellen Isomerenverteilung und deren Einsatz in Beschichtungsmitteln |
| US5961976A (en) * | 1996-06-03 | 1999-10-05 | United Biomedical, Inc. | Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV |
| AU3044697A (en) * | 1997-06-24 | 1999-01-04 | Norman Godin | A composition for specific immunoprotection and method for obtaining said comp osition |
| US6420545B1 (en) * | 1999-05-24 | 2002-07-16 | The Trustees Of The University Of Pennsylvania | CD4-independent HIV envelope proteins as vaccines and therapeutics |
| CA2382161A1 (en) * | 1999-09-03 | 2001-03-15 | Human Genome Sciences, Inc. | Immunoglobulin superfamily polynucleotides, polypeptides, and antibodies |
| WO2001043779A2 (en) * | 1999-12-16 | 2001-06-21 | Tanox, Inc. | Anti-hiv-1 conjugates for treatment of hiv disease |
| AU2003299085B2 (en) * | 2002-09-27 | 2008-04-10 | Tanox, Inc. | Synergistic compositions for the prevention and treatment of acquired immunodeficiency syndrome |
| EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| WO2007094983A2 (en) * | 2006-02-03 | 2007-08-23 | Tanox, Inc. | Methods and compositions for the inhibition of hiv infection of t cells |
| TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| WO2008019817A1 (en) * | 2006-08-17 | 2008-02-21 | F. Hoffmann-La Roche Ag | A conjugate of an antibody against ccr5 and an antifusogenic peptide |
| TW200902544A (en) * | 2007-03-13 | 2009-01-16 | Hoffmann La Roche | Peptide-complement conjugates |
| US20130195881A1 (en) | 2007-04-27 | 2013-08-01 | Sanjaya Singh | Potent, stable and non-immunosuppressive anti-cd4 antibodies |
| US20090022720A1 (en) | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
| SG190598A1 (en) * | 2008-03-13 | 2013-06-28 | Biotest Ag | Agent for treating disease |
| KR20100135808A (ko) * | 2008-03-13 | 2010-12-27 | 바이오테스트 아게 | 질병 치료제 |
| EP2262838B1 (en) * | 2008-03-13 | 2016-04-13 | Biotest AG | Agent for treating disease |
| MX2011001583A (es) | 2008-08-11 | 2011-04-04 | Nektar Therapeutics | Conjugados de alcanoato polimericos de multiples brazos. |
| DK2341937T3 (en) * | 2008-09-29 | 2015-02-09 | Biotest Ag | Composition for the treatment of a disease |
| EP2246364A1 (en) * | 2009-04-29 | 2010-11-03 | Pierre Fabre Médicament | Anti CXCR4 antibodies for the treatment of HIV |
| GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012166555A1 (en) | 2011-05-27 | 2012-12-06 | Nektar Therapeutics | Water - soluble polymer - linked binding moiety and drug compounds |
| RS57397B8 (sr) | 2011-06-10 | 2020-01-31 | Univ Oregon Health & Science | Cmv glikoproteini i rekombinantni vektori |
| CN102321653B (zh) * | 2011-07-18 | 2013-11-20 | 清华大学 | 人鼠嵌合型cd4质粒及其多抗在抑制hiv感染中的应用 |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| JP6408487B2 (ja) | 2012-12-18 | 2018-10-24 | ザ ロックフェラー ユニバーシティ | Ｈｉｖの防止および療法のためのグリカン修飾された抗ｃｄ４抗体 |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3194442A4 (en) | 2014-09-16 | 2018-05-23 | UBI IP Holdings | Treatment and functional cure of hiv infection by monoclonal antibodies to cd4 mediating competitive hiv entry inhibition |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US10858760B2 (en) | 2015-06-01 | 2020-12-08 | Medigene Immunotherapies Gmbh | T cell receptor library |
| JP2018517711A (ja) * | 2015-06-01 | 2018-07-05 | メディジーン イミュノテラピーズ ゲーエムベーハー | 細胞表面タンパク質に対する抗体を作製する方法 |
| US9925258B2 (en) | 2015-10-02 | 2018-03-27 | International Aids Vaccine Initiative | Replication-competent VSV-HIV Env vaccines |
| BR112018012826A2 (pt) | 2015-12-23 | 2018-12-04 | Medigene Immunotherapies Gmbh | método para gerar linfócitos, para gerar um tcr e tcr específico para gage-1 |
| KR20190071677A (ko) | 2016-08-13 | 2019-06-24 | 유나이티드 바이오파마, 인크. | Haart 안정화된 환자에서 cd4에 대한 항체에 의한 hiv 감염의 치료 및 지속적 바이러스 완화 |
| CN112175087B (zh) * | 2019-07-02 | 2022-05-13 | 深圳市迈加瑞生物技术有限公司 | 一种抗CD4和TGFβ的双特异性抗体、其药物组合及其用途 |
| WO2021034913A1 (en) * | 2019-08-19 | 2021-02-25 | The Rockefeller University | Engineering ph-dependent antigen binding activity into anti-hiv antibodies with improved pharmacokinetics |
| WO2021062546A1 (en) * | 2019-10-01 | 2021-04-08 | Taimed Biologics Inc. | Use of ibalizumab for the treatment of hiv-2 infection |
| CN112500491B (zh) | 2020-12-18 | 2022-04-08 | 深圳市迈加瑞生物技术有限公司 | 一种特异性中和辅助性T细胞TGF-β信号的双特异性抗体、其药物组合及其用途 |
| TW202321457A (zh) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | 靶向ｃｄ４之病毒載體之用途 |
| US20250059560A1 (en) | 2021-12-16 | 2025-02-20 | Sana Biotechnology, Inc. | Methods and systems of particle production |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| US20250144235A1 (en) | 2022-02-02 | 2025-05-08 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
| WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
| WO2024064838A1 (en) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
| EP4622631A1 (en) | 2022-11-23 | 2025-10-01 | University of Georgia Research Foundation, Inc. | Compositions and methods of use thereof for increasing immune responses |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024220597A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Digital droplet based assay for detecting replication competent lentiviral vector |
| AU2024274792A1 (en) | 2023-05-23 | 2025-10-23 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| CN117659192A (zh) * | 2023-10-19 | 2024-03-08 | 深圳市福元生物科技有限公司 | Cd4纳米抗体的制备及其应用 |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515895A (en) * | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to human helper T cells |
| US4381295A (en) * | 1979-04-26 | 1983-04-26 | Ortho Pharmaceutical Corporation | Monoclonal antibody to human helper T cells and methods of preparing same |
| US4652447A (en) * | 1979-04-26 | 1987-03-24 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human helper T cells |
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4653020A (en) * | 1983-10-17 | 1987-03-24 | International Business Machines Corporation | Display of multiple data windows in a multi-tasking system |
| NZ215865A (en) * | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| WO1989001940A1 (en) * | 1987-09-04 | 1989-03-09 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins |
| US4908203A (en) * | 1987-09-09 | 1990-03-13 | Johnson & Johnson | Method for inducing HIV neutralizing antibodies using an internal image idiotope |
| AU631357B2 (en) * | 1987-10-14 | 1992-11-26 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | New anti-receptor peptides and therapeutic agents |
| WO1990004978A1 (en) * | 1988-11-01 | 1990-05-17 | Becton Dickinson And Company | Method of directing immune response to a viral binding site |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
-
1991
- 1991-11-27 CA CA002073031A patent/CA2073031C/en not_active Expired - Lifetime
- 1991-11-27 WO PCT/US1991/008843 patent/WO1992009305A1/en not_active Ceased
- 1991-11-27 JP JP92503666A patent/JPH05505112A/ja not_active Withdrawn
- 1991-11-27 EP EP92903295A patent/EP0512112B1/en not_active Expired - Lifetime
- 1991-11-27 US US07/916,098 patent/US5871732A/en not_active Expired - Lifetime
- 1991-11-27 ES ES92903295T patent/ES2101834T3/es not_active Expired - Lifetime
- 1991-11-27 AU AU91543/91A patent/AU662891B2/en not_active Expired
- 1991-11-27 AT AT92903295T patent/ATE153536T1/de not_active IP Right Cessation
- 1991-11-27 DK DK92903295.1T patent/DK0512112T3/da active
- 1991-11-27 DE DE69126301T patent/DE69126301T2/de not_active Expired - Lifetime
-
1992
- 1992-07-27 OA OA60249A patent/OA10079A/en unknown
-
1997
- 1997-07-30 GR GR970401923T patent/GR3024274T3/el unknown
-
2002
- 2002-03-08 JP JP2002064584A patent/JP2002356499A/ja not_active Withdrawn
-
2004
- 2004-03-04 JP JP2004061381A patent/JP2005041859A/ja not_active Withdrawn
-
2007
- 2007-01-22 JP JP2007012058A patent/JP2007151556A/ja not_active Withdrawn
- 2007-01-22 JP JP2007012057A patent/JP4642035B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007175055A (ja) | 2007-07-12 |
| ATE153536T1 (de) | 1997-06-15 |
| US5871732A (en) | 1999-02-16 |
| CA2073031C (en) | 2002-10-01 |
| AU9154391A (en) | 1992-06-25 |
| JP2002356499A (ja) | 2002-12-13 |
| ES2101834T3 (es) | 1997-07-16 |
| AU662891B2 (en) | 1995-09-21 |
| DE69126301D1 (de) | 1997-07-03 |
| EP0512112B1 (en) | 1997-05-28 |
| CA2073031A1 (en) | 1992-05-28 |
| WO1992009305A1 (en) | 1992-06-11 |
| HK1007686A1 (en) | 1999-04-23 |
| DK0512112T3 (da) | 1997-09-29 |
| JP2007151556A (ja) | 2007-06-21 |
| JPH05505112A (ja) | 1993-08-05 |
| EP0512112A1 (en) | 1992-11-11 |
| JP2005041859A (ja) | 2005-02-17 |
| JP4642035B2 (ja) | 2011-03-02 |
| OA10079A (en) | 1996-12-18 |
| GR3024274T3 (en) | 1997-10-31 |
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Owner name: BIOGEN IDEC MA INC., CAMBRIDGE, MASS., US |