DE69121844D1 - Immunotest für Cyclosporin - Google Patents

Immunotest für Cyclosporin

Info

Publication number
DE69121844D1
DE69121844D1 DE69121844T DE69121844T DE69121844D1 DE 69121844 D1 DE69121844 D1 DE 69121844D1 DE 69121844 T DE69121844 T DE 69121844T DE 69121844 T DE69121844 T DE 69121844T DE 69121844 D1 DE69121844 D1 DE 69121844D1
Authority
DE
Germany
Prior art keywords
cyclosporin
conjugated
conjugates
label
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69121844T
Other languages
English (en)
Other versions
DE69121844T2 (de
Inventor
Dariush Davalian
Maureen H Beresini
Svetlana Alexander
Mae W Hu
Edwin F Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of DE69121844D1 publication Critical patent/DE69121844D1/de
Publication of DE69121844T2 publication Critical patent/DE69121844T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69121844T 1990-11-20 1991-11-19 Immunotest für Cyclosporin Expired - Lifetime DE69121844T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61611690A 1990-11-20 1990-11-20

Publications (2)

Publication Number Publication Date
DE69121844D1 true DE69121844D1 (de) 1996-10-10
DE69121844T2 DE69121844T2 (de) 1997-01-23

Family

ID=24468093

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69133095T Expired - Lifetime DE69133095T2 (de) 1990-11-20 1991-11-19 Cyclosporin-Immunoassay
DE69121844T Expired - Lifetime DE69121844T2 (de) 1990-11-20 1991-11-19 Immunotest für Cyclosporin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69133095T Expired - Lifetime DE69133095T2 (de) 1990-11-20 1991-11-19 Cyclosporin-Immunoassay

Country Status (7)

Country Link
US (3) US6190873B1 (de)
EP (2) EP0674178B1 (de)
JP (2) JP3433952B2 (de)
AT (1) ATE142344T1 (de)
CA (1) CA2055813A1 (de)
DE (2) DE69133095T2 (de)
ES (2) ES2091301T3 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279561B1 (en) 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
ES2176245T3 (es) 1993-04-23 2002-12-01 Wyeth Corp Anticuerpos de ramapicinas de ciclo abierto.
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
US5650288A (en) * 1995-07-14 1997-07-22 Macfarlane; Gordon D. Immunophilin-bound immunosuppressant assay
EP1719781A3 (de) * 1997-08-08 2006-11-15 Dade Behring Marburg GmbH Verfahren zum Einbringen einer aminreaktiven Gruppe in einem Dextran
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US5990274A (en) 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US6231982B1 (en) 1997-12-10 2001-05-15 Dade Behring Inc. Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
US6686454B1 (en) 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
BR9914092A (pt) 1998-10-09 2001-06-12 Isotechnika Inc Processos para a produção de anticorpos a regiões especìficas de ciclosporina e metabólitos de ciclosporina
KR20020039528A (ko) * 2000-11-22 2002-05-27 조명재 사이클로스포린 7- 티오아미드 유도체를 유효성분으로하는 모발성장촉진제
US7045098B2 (en) 2001-02-02 2006-05-16 James Matthew Stephens Apparatus and method for removing interfering substances from a urine sample using a chemical oxidant
PL210841B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247
US20030109067A1 (en) * 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US20030022390A1 (en) * 2002-05-30 2003-01-30 Stephens James Matthew Method and kit for making interfering substances in urine undetectable
EP1582870B1 (de) * 2002-12-26 2011-03-16 Nitto Boseki Co., Ltd. Immunoassay-verfahren
US20080188479A1 (en) * 2004-05-30 2008-08-07 Sloan-Kettering Institute For Cancer Research Methods to Treat Cancer with 10-propargyl-10-deazaaminopterin and Methods for Assessing Cancer for Increased Sensitivity to 10-propargyl-10-deazaaminopterin
US8263354B2 (en) * 2004-05-30 2012-09-11 Sloan-Kettering Institute For Cancer Research Methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin
DE602005009176D1 (de) * 2004-05-30 2008-10-02 Sloan Kettering Inst Cancer Behandlung von t-zellen-lymphom mittels 10-propargyl-10-deazaaminopterin
US7226906B2 (en) * 2004-08-16 2007-06-05 Array Biopharma, Inc. Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
US8021849B2 (en) * 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
US20060216762A1 (en) * 2005-03-24 2006-09-28 Bayer Healthcare Llc Extracting reagent for hydrophobic analyte in whole blood
US7189582B2 (en) * 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
WO2008121096A1 (en) * 2005-05-19 2008-10-09 The Board Of Governors For Higher Education Monitoring cyclosporine in saliva
BRPI0706575B8 (pt) * 2006-01-13 2021-05-25 Univ Indiana Res & Tech Corp uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado.
US20080081379A1 (en) * 2006-07-13 2008-04-03 Sigler Gerald F Homogeneous double receptor agglutination assay for immunosuppressant drugs
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
US7914999B2 (en) * 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
ES2393135T3 (es) * 2006-12-29 2012-12-18 Abbott Laboratories Ensayo mejorado para fármacos inmunosupresores
JP5450092B2 (ja) 2006-12-29 2014-03-26 アボット・ラボラトリーズ 全血中の分子または薬物の検出のための診断検査
EP2118657B1 (de) * 2006-12-29 2014-05-21 Abbott Laboratories Nichtdenaturierendes lysereagens zur verwendung mit einem capture-in-solution-immunoassay
CA2685830C (en) * 2007-05-24 2012-12-18 Abbott Laboratories Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites
US7790401B2 (en) * 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US20100248249A1 (en) * 2007-08-17 2010-09-30 Allos Therapeutics, Inc. Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels
US20090048262A1 (en) * 2007-08-17 2009-02-19 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
US9901578B2 (en) 2007-08-17 2018-02-27 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
US7910378B2 (en) * 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
US20090170218A1 (en) * 2008-01-02 2009-07-02 Dade Behring Inc. Methods for detection of cyclosporin a
EP2277040A4 (de) * 2008-04-21 2011-06-08 Univ Arkansas Vorrichtung und verfahren für paracetamol-proteinaddukttest
DK2531193T3 (en) 2010-02-02 2016-11-07 Allos Therapeutics Inc Diastereomers of the 10-propargyl-10-deazaaminopterin FOR USE IN THE TREATMENT OF CANCER
CN102368072B (zh) * 2011-06-30 2014-09-24 同昕生物技术（北京）有限公司 检测环孢霉素a药物浓度的化学发光酶联免疫检测试剂盒
CN104603146B (zh) 2012-09-29 2018-01-02 诺华股份有限公司 环肽类化合物及其作为药物的用途
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
EP3104849B1 (de) 2014-02-14 2019-08-28 BioVentures, LLC Acetaminophenproteinaddukte und verfahren zur verwendung davon
AU2015358373B2 (en) 2014-12-03 2021-05-27 Arkansas Children's Research Institute Anti-acetaminophen antibodies and acetaminophen protein adducts
CN108794621A (zh) * 2017-05-04 2018-11-13 南开大学 环孢霉素的偶联物及其制备方法与应用
CN110736835B (zh) * 2018-07-19 2023-05-23 上海云泽生物科技有限公司 一种高灵敏度胶乳增强免疫比浊法测定全血中免疫抑制剂环孢霉素a的试剂盒
CN110174363A (zh) * 2019-01-09 2019-08-27 北京九强生物技术股份有限公司 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IL62965A0 (en) 1980-07-17 1981-07-31 Scripps Miles Lab Inc Monoclonal antibodies to drugs and theri production
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US5169773A (en) * 1984-10-04 1992-12-08 Sandoz Ltd. Monoclonal antibodies to cyclosporins
WO1986002080A1 (en) * 1984-10-04 1986-04-10 Sandoz Ag Monoclonal antibodies to cyclosporings
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
EP0283801A3 (de) * 1987-03-27 1990-05-30 Abbott Laboratories Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper
EP0373260B1 (de) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen
US5089390A (en) 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
CA1340387C (en) * 1987-10-30 1999-02-09 Carol A. Schlesinger Heterobifunctional coupling agents
CA2004626A1 (en) * 1988-12-05 1990-06-05 Bernard F. Erlanger Derivatives of cyclosporine a, antibodies directed thereto and uses thereof
DE69116034T2 (de) * 1990-08-15 1996-06-20 Abbott Lab Immunotestreagenzien und Verfahren zur Bestimmung von Cyclosporin
DK0487301T3 (da) * 1990-11-20 2000-09-18 Dade Behring Marburg Gmbh Fremgangsmåde til stabilisering af enzymkonjugater

Also Published As

Publication number Publication date
EP0674178A3 (de) 1996-07-10
DE69133095D1 (de) 2002-10-02
ATE142344T1 (de) 1996-09-15
JP3433952B2 (ja) 2003-08-04
ES2091301T3 (es) 1996-11-01
US6054303A (en) 2000-04-25
JP2003201298A (ja) 2003-07-18
JPH04316599A (ja) 1992-11-06
DE69121844T2 (de) 1997-01-23
JP3936285B2 (ja) 2007-06-27
DE69133095T2 (de) 2003-03-27
ES2181734T3 (es) 2003-03-01
EP0487289B1 (de) 1996-09-04
CA2055813A1 (en) 1992-05-21
US6410696B1 (en) 2002-06-25
EP0487289A2 (de) 1992-05-27
EP0674178B1 (de) 2002-08-28
EP0674178A2 (de) 1995-09-27
EP0487289A3 (de) 1994-02-23
US6190873B1 (en) 2001-02-20

Similar Documents

Publication Publication Date Title
DE69121844T2 (de) Immunotest für Cyclosporin
KR960702003A (ko) 라파마이신 분석법(rapamycin assay)
DK261386A (da) Monoklonale antistoffer
FI914298A0 (fi) Monoklonala motkroppar foer metall- katjoner och smao molekyler.
FI913560A0 (fi) Syntetiska peptider, speciellt foer observation av hcv-anti-kroppar, hcv-infektionsdiagnos och dess foerhindrande sm vaccin.
ES2063098T3 (es) Nuevos derivados de digoxigenina y su utilizacion.
DE3886265T2 (de) Anti-FR-900506-Stoffe-Antikörper und höchstempfindliches Enzym-Immunoassay-Verfahren.
EP0375422A3 (de) Zusammensetzung und Methoden zur Bestimmung der Anwesenheit von Amphetaminen in einer Probe, die in Verdacht steht, Amphetamine und/oder Metamphetamine zu enthalten
EP0231914A3 (en) Htlv-iii envelope peptides
DE69022578D1 (de) Test für Hepatitis-C.
DE69610716T2 (de) Topiramate-immunoassay, sowie analoge und antikörper
DE69609108D1 (de) Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden
DK304087A (da) Humant monoklonalt antistof mod lumfadenopati-associeret virus
ES2176347T3 (es) Modulacion de la respuesta inmune.
ATE74662T1 (de) Immunoanalysetestverfahren fuer cholesterolepoxide.
SE8103198L (sv) Forfarande for framstellning av antikroppar
KR930703290A (ko) 코티닌 면역검정용 합텐, 트레이서, 면역원 및 항체
ATE88901T1 (de) Fluorkohlenstoffkette enthaltende antigene konjugate.
ATE52251T1 (de) Histamin-derivate, immunogen-konjugate und dadurch induzierte antikoerper.
AU6873487A (en) Monoclonal antibodies useful in the identification of microorganisms causing peridontal disease
KR910021586A (ko) 리간드의 면역학적 검출방법
KR910006712A (ko) 형광편광기술에 사용하기 위한 모노클로날 항체의 안정화
SE8705137D0 (sv) Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in certain versions of the method
ES8405155A1 (es) Procedimiento de inmunoanalisis para determinar etosuximida en una muestra de analisis.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DADE BEHRING MARBURG GMBH, 35041 MARBURG, DE

8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH, , DE