DE69109631D1 - 2-Substituierte Adenosinderivate und pharmazeutische Zusammensetzungen zur Verwendung gegen Infektionskrankheiten. - Google Patents
2-Substituierte Adenosinderivate und pharmazeutische Zusammensetzungen zur Verwendung gegen Infektionskrankheiten.Info
- Publication number
- DE69109631D1 DE69109631D1 DE69109631T DE69109631T DE69109631D1 DE 69109631 D1 DE69109631 D1 DE 69109631D1 DE 69109631 T DE69109631 T DE 69109631T DE 69109631 T DE69109631 T DE 69109631T DE 69109631 D1 DE69109631 D1 DE 69109631D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- substituted adenosine
- infectious diseases
- use against
- against infectious
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33727390 | 1990-11-30 | ||
JP3-34249A JP3025541B2 (ja) | 1990-11-30 | 1991-02-28 | 2−置換アデノシン誘導体および循環器疾患用薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69109631D1 true DE69109631D1 (de) | 1995-06-14 |
DE69109631T2 DE69109631T2 (de) | 1995-09-07 |
Family
ID=26373034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69109631T Expired - Lifetime DE69109631T2 (de) | 1990-11-30 | 1991-11-29 | 2-Substituierte Adenosinderivate und pharmazeutische Zusammensetzungen zur Verwendung gegen Infektionskrankheiten. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5189027A (de) |
EP (1) | EP0488336B1 (de) |
AT (1) | ATE122355T1 (de) |
CA (1) | CA2056596C (de) |
DE (1) | DE69109631T2 (de) |
ES (1) | ES2073653T3 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852000A (en) * | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
US6448235B1 (en) | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
US5817641A (en) * | 1994-07-21 | 1998-10-06 | Thomas Jefferson University | Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives |
WO1998057651A1 (en) | 1997-06-18 | 1998-12-23 | Discovery Therapeutics, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6322771B1 (en) | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
US6180615B1 (en) * | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
GB0003960D0 (en) * | 2000-02-18 | 2000-04-12 | Pfizer Ltd | Purine derivatives |
CA2671940A1 (en) * | 2000-02-23 | 2001-08-30 | Cv Therapeutics, Inc. | Identification of partial agonists of the a2a adenosine receptor |
CA2421067A1 (en) * | 2000-09-08 | 2003-02-28 | Toa Eiyo Ltd. | Adenosine derivatives and use thereof |
WO2002020539A1 (fr) | 2000-09-08 | 2002-03-14 | Toa Eiyo Ltd. | Derives d'adenosine et leur utilisation |
US6670334B2 (en) | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
GB2372741A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,8-Disubstituted adenosine derivatives and their different uses |
GB2372742A (en) * | 2001-03-03 | 2002-09-04 | Univ Leiden | C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses |
CA2460911C (en) * | 2001-10-01 | 2011-08-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
WO2003051881A1 (en) * | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
JP2004018453A (ja) * | 2002-06-14 | 2004-01-22 | Sumika Fine Chemicals Co Ltd | アルキニルプリン化合物およびその製造方法 |
JP2005538190A (ja) * | 2002-07-29 | 2005-12-15 | シーブイ・セラピューティクス・インコーポレイテッド | 心筋潅流イメージング |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
CN1972945A (zh) * | 2004-04-02 | 2007-05-30 | 腺苷治疗有限责任公司 | A2a腺苷受体的选择性拮抗剂 |
WO2006028618A1 (en) * | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
US7605143B2 (en) * | 2004-08-02 | 2009-10-20 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity |
US7442687B2 (en) * | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
CA2583185A1 (en) * | 2004-10-20 | 2006-04-27 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists |
KR101494125B1 (ko) | 2006-02-03 | 2015-02-16 | 길리애드 사이언시즈, 인코포레이티드 | A2a-아데노신 수용체 효능제 및 이의 다형체의 제조 방법 |
WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
WO2007120972A2 (en) | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
US20070299089A1 (en) * | 2006-06-22 | 2007-12-27 | Cv Therapeutics, Inc. | Use of A2A Adenosine Receptor Agonists in the Treatment of Ischemia |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
RU2459626C2 (ru) * | 2006-09-01 | 2012-08-27 | Гайлид Сайэнсиз, Инк. | Способы и композиции, повышающие переносимость пациентом методов визуализации миокарда |
EP2066232A1 (de) * | 2006-09-29 | 2009-06-10 | Cv Therapeutics, Inc. | Verfahren zur myokardialen abbildung für patienten mit einer lungenerkrankungs-vorgeschichte |
WO2008086096A2 (en) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Myocardial perfusion imaging |
US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
MX2011003168A (es) * | 2008-09-29 | 2011-05-19 | Gilead Sciences Inc | Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples. |
US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
IN2015DN00538A (de) | 2012-08-01 | 2015-06-26 | Lewis And Clark Pharmaceuticals Inc |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
EP0277917A3 (de) | 1987-02-04 | 1990-03-28 | Ciba-Geigy Ag | Bestimmte Derivate von Adenosin-5'-carboxamid |
US4992427A (en) * | 1987-06-29 | 1991-02-12 | University Of Iowa Research Foundation | 2-substituted inosines and their use as antiviral agents |
JPS6433477A (en) | 1987-07-29 | 1989-02-03 | Sanyo Electric Co | Absorption heat pump device |
US5034381A (en) | 1988-01-07 | 1991-07-23 | Ciba-Geigy Corporation | 2-(substituted amino) adenosines as antihypertensives |
JPH0217526A (ja) | 1988-07-06 | 1990-01-22 | Canon Inc | 印刷装置 |
EP0429681B1 (de) | 1989-06-20 | 1995-09-06 | Yamasa Shoyu Kabushiki Kaisha (Yamasa Corporation) | Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat |
-
1991
- 1991-11-27 US US07/799,071 patent/US5189027A/en not_active Expired - Lifetime
- 1991-11-28 CA CA002056596A patent/CA2056596C/en not_active Expired - Lifetime
- 1991-11-29 AT AT91120461T patent/ATE122355T1/de not_active IP Right Cessation
- 1991-11-29 DE DE69109631T patent/DE69109631T2/de not_active Expired - Lifetime
- 1991-11-29 EP EP91120461A patent/EP0488336B1/de not_active Expired - Lifetime
- 1991-11-29 ES ES91120461T patent/ES2073653T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0488336B1 (de) | 1995-05-10 |
ES2073653T3 (es) | 1995-08-16 |
ATE122355T1 (de) | 1995-05-15 |
CA2056596A1 (en) | 1992-05-31 |
CA2056596C (en) | 2001-08-21 |
US5189027A (en) | 1993-02-23 |
DE69109631T2 (de) | 1995-09-07 |
EP0488336A1 (de) | 1992-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: JUNG, SCHIRDEWAHN, GRUENBERG, SCHNEIDER PATENTANWAELTE |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE |