ES2061319T3 - Utilizacion de derivados 4-(3-trifluorometifenil)-1,2,3,6-tetrahidropiridinicos como captadores de radicales libres. - Google Patents
Utilizacion de derivados 4-(3-trifluorometifenil)-1,2,3,6-tetrahidropiridinicos como captadores de radicales libres.Info
- Publication number
- ES2061319T3 ES2061319T3 ES92400289T ES92400289T ES2061319T3 ES 2061319 T3 ES2061319 T3 ES 2061319T3 ES 92400289 T ES92400289 T ES 92400289T ES 92400289 T ES92400289 T ES 92400289T ES 2061319 T3 ES2061319 T3 ES 2061319T3
- Authority
- ES
- Spain
- Prior art keywords
- free radicals
- compounds
- trifluorometifenil
- tetrahidropiridinicos
- collectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Liquid Crystal Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A LA UTILIZACION DE COMPUESTOS DE FORMULA (I): EN LA QUE R Y R SUB 1, CADA UNO INDEPENDIENTEMENTE, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO METILO, Y DE SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES COMO CAPTADORES DE RADICALES LIBRES. LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS SIRVEN DE MEDICAMENTOS EN TODOS LOS PROCESOS PATOLOGICOS QUE OCASIONAN DAÑOS CELULARES QUE ESTAN RELACIONADOS CON LA FORMACION DE RADICALES LIBRES. LA INVENCION SE REFIERE TAMBIEN A LOS COMPUESTOS DE FORMULA (I), EN LA QUE AL MENOS UNO DE LOS RADICALES R Y R SUB 1 ES UN GRUPO METILO, QUE SON PRODUCTOS NUEVOS, ASI COMO AL PROCESO PARA SU PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9101283A FR2672213B1 (fr) | 1991-02-05 | 1991-02-05 | Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061319T3 true ES2061319T3 (es) | 1994-12-01 |
Family
ID=9409370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92400289T Expired - Lifetime ES2061319T3 (es) | 1991-02-05 | 1992-02-05 | Utilizacion de derivados 4-(3-trifluorometifenil)-1,2,3,6-tetrahidropiridinicos como captadores de radicales libres. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5292745A (es) |
EP (1) | EP0498718B1 (es) |
JP (1) | JP3471820B2 (es) |
AT (1) | ATE109467T1 (es) |
AU (1) | AU649099B2 (es) |
CA (1) | CA2060616C (es) |
DE (1) | DE69200284T2 (es) |
DK (1) | DK0498718T3 (es) |
ES (1) | ES2061319T3 (es) |
FR (1) | FR2672213B1 (es) |
HU (2) | HU212945B (es) |
IE (1) | IE66593B1 (es) |
MX (1) | MX9200485A (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2662442A1 (fr) * | 1990-05-23 | 1991-11-29 | Midy Spa | Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant. |
FR2702656B1 (fr) * | 1993-03-18 | 1995-06-16 | Sanofi Elf | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments cardioprotecteurs. |
ES2159362T3 (es) * | 1995-10-26 | 2001-10-01 | Sanofi Synthelabo | Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica. |
FR2740343B1 (fr) * | 1995-10-26 | 1999-01-22 | Sanofi Sa | Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique |
FR2763847B1 (fr) | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
ATE419843T1 (de) * | 1998-12-01 | 2009-01-15 | Alexandre T Rotta | Methode zur in vitro reduzierung von durch freie radikale induzierte schäden |
CA2455896A1 (en) * | 2001-08-29 | 2003-03-13 | Alcon, Inc. | Use of compounds for treating conditions resulting from injury to the corneal nerve after lasik and other ocular surgeries or trauma |
US7064211B2 (en) * | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
EA200700118A1 (ru) * | 2004-06-24 | 2007-08-31 | Инсайт Корпорейшн | Амидосоединения и их применение в качестве лекарственных средств |
CA2584502A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | 2-methylpropanamides and their use as pharmaceuticals |
US20060009491A1 (en) * | 2004-06-24 | 2006-01-12 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
EP1758580A4 (en) | 2004-06-24 | 2008-01-16 | Incyte Corp | N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT |
US20060122197A1 (en) * | 2004-08-10 | 2006-06-08 | Wenqing Yao | Amido compounds and their use as pharmaceuticals |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2501682A1 (fr) * | 1981-03-11 | 1982-09-17 | Sanofi Sa | Trifluoromethylphenylpyridines a activite anorexigene, un procede de preparation et compositions pharmaceutiques en contenant |
US4691019A (en) * | 1981-03-11 | 1987-09-01 | Sanofi | Anorectic agent; 4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine |
FR2531707A1 (fr) * | 1982-08-16 | 1984-02-17 | Midy Spa | Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques |
FR2639226B1 (fr) * | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
GB2226269B (en) * | 1988-12-22 | 1992-11-25 | Zdzislaw Bieganski | Cable stripper |
FR2650505B1 (fr) * | 1989-08-07 | 1994-06-03 | Midy Spa | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale |
FR2662442A1 (fr) * | 1990-05-23 | 1991-11-29 | Midy Spa | Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant. |
-
1991
- 1991-02-05 FR FR9101283A patent/FR2672213B1/fr not_active Expired - Fee Related
-
1992
- 1992-02-03 AU AU10655/92A patent/AU649099B2/en not_active Ceased
- 1992-02-04 MX MX9200485A patent/MX9200485A/es not_active IP Right Cessation
- 1992-02-04 IE IE920354A patent/IE66593B1/en not_active IP Right Cessation
- 1992-02-04 CA CA002060616A patent/CA2060616C/en not_active Expired - Fee Related
- 1992-02-04 US US07/830,857 patent/US5292745A/en not_active Expired - Lifetime
- 1992-02-04 HU HU9200335A patent/HU212945B/hu not_active IP Right Cessation
- 1992-02-04 JP JP01895192A patent/JP3471820B2/ja not_active Expired - Fee Related
- 1992-02-05 AT AT92400289T patent/ATE109467T1/de not_active IP Right Cessation
- 1992-02-05 ES ES92400289T patent/ES2061319T3/es not_active Expired - Lifetime
- 1992-02-05 DK DK92400289.2T patent/DK0498718T3/da active
- 1992-02-05 DE DE69200284T patent/DE69200284T2/de not_active Expired - Fee Related
- 1992-02-05 EP EP92400289A patent/EP0498718B1/fr not_active Expired - Lifetime
-
1995
- 1995-06-28 HU HU95P/P00485P patent/HU211457A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
MX9200485A (es) | 1992-11-01 |
EP0498718B1 (fr) | 1994-08-03 |
EP0498718A1 (fr) | 1992-08-12 |
DK0498718T3 (da) | 1994-12-05 |
JPH04312528A (ja) | 1992-11-04 |
HUT62563A (en) | 1993-05-28 |
HU212945B (en) | 1996-12-30 |
DE69200284D1 (de) | 1994-09-08 |
AU1065592A (en) | 1992-08-13 |
FR2672213B1 (fr) | 1995-03-10 |
AU649099B2 (en) | 1994-05-12 |
CA2060616C (en) | 2004-04-06 |
US5292745A (en) | 1994-03-08 |
DE69200284T2 (de) | 1995-03-02 |
IE66593B1 (en) | 1996-01-24 |
JP3471820B2 (ja) | 2003-12-02 |
ATE109467T1 (de) | 1994-08-15 |
FR2672213A1 (fr) | 1992-08-07 |
CA2060616A1 (en) | 1992-08-06 |
IE920354A1 (en) | 1992-08-12 |
HU211457A9 (en) | 1995-11-28 |
HU9200335D0 (en) | 1992-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 498718 Country of ref document: ES |
|
FA2A | Application withdrawn |
Effective date: 19941215 |