DE69105501D1 - (+)-alpha-(2,3 dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinmethanol. - Google Patents
(+)-alpha-(2,3 dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinmethanol.Info
- Publication number
- DE69105501D1 DE69105501D1 DE69105501T DE69105501T DE69105501D1 DE 69105501 D1 DE69105501 D1 DE 69105501D1 DE 69105501 T DE69105501 T DE 69105501T DE 69105501 T DE69105501 T DE 69105501T DE 69105501 D1 DE69105501 D1 DE 69105501D1
- Authority
- DE
- Germany
- Prior art keywords
- dimethoxyphenyl
- fluorophenyl
- alpha
- ethyl
- piperidine methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53195490A | 1990-06-01 | 1990-06-01 | |
PCT/US1991/003036 WO1991018602A1 (en) | 1990-06-01 | 1991-04-30 | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69105501D1 true DE69105501D1 (de) | 1995-01-12 |
DE69105501T2 DE69105501T2 (de) | 1995-04-13 |
Family
ID=24119769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69105501T Expired - Lifetime DE69105501T2 (de) | 1990-06-01 | 1991-04-30 | (+)-alpha-(2,3 dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinmethanol. |
Country Status (15)
Country | Link |
---|---|
US (6) | US5134149A (de) |
EP (1) | EP0531410B1 (de) |
JP (1) | JP2869512B2 (de) |
KR (1) | KR100211713B1 (de) |
AT (1) | ATE114467T1 (de) |
AU (1) | AU652759B2 (de) |
CA (1) | CA2083698C (de) |
DE (1) | DE69105501T2 (de) |
DK (1) | DK0531410T3 (de) |
ES (1) | ES2067937T3 (de) |
FI (1) | FI95370C (de) |
GR (1) | GR3015087T3 (de) |
HU (1) | HU213271B (de) |
NO (1) | NO179250C (de) |
WO (1) | WO1991018602A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
AU652759B2 (en) * | 1990-06-01 | 1994-09-08 | Aventisub Ii Inc. | (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)- 4-piperidinemethanol |
EP0796619A1 (de) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Verwendung von (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-Fluorophenyl)ethyl)-4-Piperidinmethanol zur Behandlung von Depressionen und bipolaren Erkrankungen |
US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
GB9718712D0 (en) | 1997-09-03 | 1997-11-12 | Merck Sharp & Dohme | Theraputic Agents |
GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
KR100258018B1 (ko) * | 1997-12-23 | 2000-07-01 | 유승필 | 티클로피딘과 은행잎 추출물을 함유한 약제조성물 |
US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
US20050261341A1 (en) * | 1998-03-13 | 2005-11-24 | Aventis Pharmaceuticals Inc. | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
TWI249526B (en) * | 1998-03-13 | 2006-02-21 | Aventis Pharma Inc | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
SE9801516D0 (sv) * | 1998-04-30 | 1998-04-30 | Maria Carlsson | M100907/4-Piperidinemethanol derivatives for autism |
GB9816263D0 (en) | 1998-07-24 | 1998-09-23 | Merck Sharp & Dohme | Therapeutic agents |
US6939879B2 (en) * | 1998-08-28 | 2005-09-06 | Aventis Pharmaceuticals Inc. | Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia |
US6277864B1 (en) | 1998-08-28 | 2001-08-21 | Aventis Pharmaceuticals Inc. | Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
NZ510083A (en) * | 1998-08-28 | 2003-08-29 | Aventis Pharma Inc | The use of R(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
CN1160333C (zh) * | 1998-10-14 | 2004-08-04 | 阿温蒂斯药物公司 | 哌啶甲醇的酯和它们作为5ht2a受体拮抗剂mdl110907药物前体的用途 |
US6455526B1 (en) * | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
EE200100314A (et) * | 1998-12-16 | 2002-08-15 | Aventis Pharmaceuticals Inc. | Meetod farmatseutilise kompositsiooni valmistamiseks, farmatseutiline kompositsioon ja selle kasutamine |
FR2787328A1 (fr) | 1998-12-22 | 2000-06-23 | Sanofi Sa | Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures |
GB9901147D0 (en) | 1999-01-19 | 1999-03-10 | Merck Sharp & Dohme | Therapeutic agents |
JP2003505374A (ja) * | 1999-07-16 | 2003-02-12 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 硫酸モノ−[3−({1−[2−(4−フルオロ−フェニル)−エチル]−ピペリジン−4−イル}−ヒドロキシ−メチル)−2−メトキシ−フェニル]エステル |
US6465490B1 (en) | 1999-07-16 | 2002-10-15 | Aventis Pharmaceuticals Inc. | Sulfuric acid mono-[3({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester |
DE19939756A1 (de) | 1999-08-21 | 2001-02-22 | Merck Patent Gmbh | Piperidinalkohole |
ES2225031T3 (es) * | 1999-12-29 | 2005-03-16 | Pfizer Products Inc. | Compuestos de 3-((2-piperazinil-fenil)metil)-1-(4-(trifluorometil)fenil)-2-pirrolidinona opticamente activos como antagonistas selectivos del receptor de 5-ht1d. |
RU2257384C2 (ru) * | 2000-02-29 | 2005-07-27 | Мицубиси Фарма Корпорейшн | Новые производные циклического амида |
GB0007907D0 (en) * | 2000-03-31 | 2000-05-17 | Merck Sharp & Dohme | Therapeutic agents |
US20020099076A1 (en) * | 2000-05-25 | 2002-07-25 | Richard Scheyer D. | Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis |
US20030177248A1 (en) * | 2001-09-05 | 2003-09-18 | International Business Machines Corporation | Apparatus and method for providing access rights information on computer accessible content |
CA2492924C (en) * | 2002-07-19 | 2011-12-20 | Biovitrum Ab | Novel piperazinone derivates for the treatment of 5-ht2a receptor-related disorders |
CN101099734A (zh) * | 2002-08-15 | 2008-01-09 | 惠氏公司 | 用于治疗体温调节机能障碍的5HT2a受体的激动作用 |
US7345096B2 (en) | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7419980B2 (en) | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7531543B2 (en) | 2003-10-14 | 2009-05-12 | Wyeth | Phenylpiperazine cycloalkanol derivatives and methods of their use |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
US7402698B2 (en) | 2003-10-14 | 2008-07-22 | Wyeth | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use |
US7524846B2 (en) | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
DK1691811T3 (da) | 2003-12-11 | 2014-10-20 | Sunovion Pharmaceuticals Inc | Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
WO2006029182A2 (en) * | 2004-09-07 | 2006-03-16 | The La Jolla Institute For Molecular Medicine | Use of mdl-100,907 for treatment of allergic and eosinophil mediated diseases |
CN102114244A (zh) | 2004-09-30 | 2011-07-06 | 弗·哈夫曼-拉罗切有限公司 | 治疗认知障碍的组合物和方法 |
WO2009152647A1 (zh) * | 2008-06-20 | 2009-12-23 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
JP5925301B2 (ja) | 2011-05-23 | 2016-05-25 | サノフイ | N−アルキル基を含有するジュウテリウム化化合物の製造方法 |
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AU629535B2 (en) * | 1988-02-10 | 1992-10-08 | A.H. Robins Company, Incorporated | N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents |
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US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
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-
1991
- 1991-04-30 AU AU79509/91A patent/AU652759B2/en not_active Expired
- 1991-04-30 DE DE69105501T patent/DE69105501T2/de not_active Expired - Lifetime
- 1991-04-30 CA CA002083698A patent/CA2083698C/en not_active Expired - Lifetime
- 1991-04-30 KR KR1019920703050A patent/KR100211713B1/ko not_active IP Right Cessation
- 1991-04-30 EP EP91910548A patent/EP0531410B1/de not_active Expired - Lifetime
- 1991-04-30 WO PCT/US1991/003036 patent/WO1991018602A1/en active IP Right Grant
- 1991-04-30 DK DK91910548.6T patent/DK0531410T3/da active
- 1991-04-30 HU HU9203779A patent/HU213271B/hu unknown
- 1991-04-30 AT AT91910548T patent/ATE114467T1/de not_active IP Right Cessation
- 1991-04-30 ES ES91910548T patent/ES2067937T3/es not_active Expired - Lifetime
- 1991-04-30 JP JP3510161A patent/JP2869512B2/ja not_active Expired - Lifetime
- 1991-07-26 US US07/736,194 patent/US5134149A/en not_active Expired - Lifetime
-
1992
- 1992-11-25 FI FI925342A patent/FI95370C/fi active
- 1992-11-30 NO NO924619A patent/NO179250C/no not_active IP Right Cessation
-
1995
- 1995-01-13 US US08/372,694 patent/US5561144A/en not_active Expired - Lifetime
- 1995-02-16 GR GR950400305T patent/GR3015087T3/el unknown
- 1995-06-07 US US08/485,701 patent/US5700812A/en not_active Expired - Lifetime
- 1995-06-07 US US08/485,700 patent/US5700813A/en not_active Expired - Lifetime
- 1995-06-07 US US08/476,538 patent/US5721249A/en not_active Expired - Lifetime
-
1997
- 1997-10-02 US US08/942,629 patent/US5874445A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU652759B2 (en) | 1994-09-08 |
KR930700103A (ko) | 1993-03-13 |
EP0531410B1 (de) | 1994-11-30 |
NO179250C (no) | 1996-09-04 |
KR100211713B1 (ko) | 1999-08-02 |
ES2067937T3 (es) | 1995-04-01 |
HU9203779D0 (en) | 1993-03-29 |
US5561144A (en) | 1996-10-01 |
ATE114467T1 (de) | 1994-12-15 |
DE69105501T2 (de) | 1995-04-13 |
FI95370C (fi) | 1996-01-25 |
FI95370B (fi) | 1995-10-13 |
JP2869512B2 (ja) | 1999-03-10 |
US5700812A (en) | 1997-12-23 |
NO924619L (no) | 1992-11-30 |
CA2083698A1 (en) | 1991-12-02 |
WO1991018602A1 (en) | 1991-12-12 |
NO179250B (no) | 1996-05-28 |
DK0531410T3 (da) | 1995-01-30 |
US5874445A (en) | 1999-02-23 |
US5721249A (en) | 1998-02-24 |
EP0531410A1 (de) | 1993-03-17 |
NO924619D0 (no) | 1992-11-30 |
GR3015087T3 (en) | 1995-05-31 |
US5700813A (en) | 1997-12-23 |
HU213271B (en) | 1997-04-28 |
HUT64745A (en) | 1994-02-28 |
AU7950991A (en) | 1991-12-31 |
FI925342A (fi) | 1992-11-25 |
CA2083698C (en) | 1997-11-04 |
US5134149A (en) | 1992-07-28 |
JPH05507482A (ja) | 1993-10-28 |
FI925342A0 (fi) | 1992-11-25 |
EP0531410A4 (en) | 1993-05-26 |
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8327 | Change in the person/name/address of the patent owner |
Owner name: MERRELL PHARMACEUTICALS INC. (N.D.GES.D. STAATES D |
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8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR |
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8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTISUB II INC., GREENVILLE, DEL., US |