DE69024652D1 - Expression von tetanustoxinfragment c - Google Patents

Expression von tetanustoxinfragment c

Info

Publication number
DE69024652D1
DE69024652D1 DE69024652T DE69024652T DE69024652D1 DE 69024652 D1 DE69024652 D1 DE 69024652D1 DE 69024652 T DE69024652 T DE 69024652T DE 69024652 T DE69024652 T DE 69024652T DE 69024652 D1 DE69024652 D1 DE 69024652D1
Authority
DE
Germany
Prior art keywords
expression
tetanustox
infragment
tetanus toxin
mature fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69024652T
Other languages
English (en)
Other versions
DE69024652T2 (de
Inventor
Neil Fairweather
Andrew Makoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma Ltd
Original Assignee
Evans Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evans Medical Ltd filed Critical Evans Medical Ltd
Application granted granted Critical
Publication of DE69024652D1 publication Critical patent/DE69024652D1/de
Publication of DE69024652T2 publication Critical patent/DE69024652T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69024652T 1989-06-20 1990-06-20 Expression von tetanustoxinfragment c Expired - Lifetime DE69024652T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898914122A GB8914122D0 (en) 1989-06-20 1989-06-20 Polypeptide expression
PCT/GB1990/000943 WO1990015871A1 (en) 1989-06-20 1990-06-20 Expression of tetanus toxin fragment c

Publications (2)

Publication Number Publication Date
DE69024652D1 true DE69024652D1 (de) 1996-02-15
DE69024652T2 DE69024652T2 (de) 1996-05-15

Family

ID=10658724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024652T Expired - Lifetime DE69024652T2 (de) 1989-06-20 1990-06-20 Expression von tetanustoxinfragment c

Country Status (9)

Country Link
US (1) US5443966A (de)
EP (1) EP0478602B1 (de)
JP (1) JP2981286B2 (de)
AT (1) ATE132532T1 (de)
DE (1) DE69024652T2 (de)
DK (1) DK0478602T3 (de)
ES (1) ES2084030T3 (de)
GB (1) GB8914122D0 (de)
WO (1) WO1990015871A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5601826A (en) * 1989-06-30 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Peptide which produces protective immunity against tetanus
GB9209118D0 (en) * 1992-04-28 1992-06-10 Sb 120 Amsterdam Bv Vaccine compositions
WO1994000487A1 (en) * 1992-06-30 1994-01-06 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Peptide which produces protective immunity against tetanus
ES2127829T3 (es) 1992-07-31 1999-05-01 Medeva Holdings Bv Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
AU725295B2 (en) * 1996-01-22 2000-10-12 Brandeis University Morphogen analogs and methods for producing them
DE69731357T2 (de) * 1996-03-23 2006-02-02 The Research Foundation For Microbial Diseases Of Osaka University, Suita Funktionelles antigenfragment von tetanustoxin und tetanusvakzine
US5958469A (en) * 1997-05-14 1999-09-28 Eastman Kodak Company Method for fabricating tools for molding diffractive surfaces on optical lenses
US20100081197A1 (en) * 1997-08-14 2010-04-01 Sylvie Roux In vivo modulation of neuronal transport
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
ES2281135T3 (es) * 1997-08-14 2007-09-16 Institut Pasteur Proteinas hibridas de un toxoide tetanico que migran de forma retrograda y transinaptica al snc.
GB0108364D0 (en) 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
PT1296715E (pt) 2000-06-29 2012-01-19 Smithkline Beecham Biolog Composição vacinal multivalente
EP1575505A4 (de) * 2002-09-10 2007-01-24 Vical Inc Codon-optimierte vakzine auf polynucleotid-basis gegen infektionen mit bacillus anthracis
DE602004017864D1 (de) * 2003-06-23 2009-01-02 Baxter Int Trägerproteine für impfstoffe
US20070092449A1 (en) * 2005-04-05 2007-04-26 Rafael Vazquez-Martinez Methods for direct visualization of active synapses
EP1790358A1 (de) * 2005-11-23 2007-05-30 Université de Reims Champagne-Ardennes Proteinkonstrukte designed zum Targeting und Lyse von Zellen
AU2007293673B2 (en) 2006-09-07 2013-06-27 Glaxosmithkline Biologicals S.A. Vaccine
EP2142211A1 (de) 2007-05-02 2010-01-13 GlaxoSmithKline Biologicals S.A. Impfstoff
NZ602958A (en) 2010-03-30 2014-07-25 Pfenex Inc High level expression of recombinant toxin proteins
WO2011143557A2 (en) 2010-05-14 2011-11-17 The Children's Hospital Of Philadelphia Humanized ttc and methods of use thereof
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
WO2013083254A1 (en) 2011-12-09 2013-06-13 Bavarian Nordic A/S Poxvirus vector for the expression of bacterial antigens linked to tetanus toxin fragment c
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
DK2863943T3 (en) 2013-03-08 2016-11-07 Janssen Vaccines & Prevention Bv acellular pertussis vaccines
JP2017521408A (ja) 2014-07-02 2017-08-03 スフェリウム バイオメッド エス．エル． 無毒性破傷風毒素ｃフラグメント（ｔｔｃ）を使用して筋量を増加させる方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2355094C3 (de) * 1973-11-03 1979-05-23 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines Tetanus-Impfstoffs
GB8516442D0 (en) * 1985-06-28 1985-07-31 Wellcome Found Cloned antigen

Also Published As

Publication number Publication date
JP2981286B2 (ja) 1999-11-22
EP0478602A1 (de) 1992-04-08
DE69024652T2 (de) 1996-05-15
US5443966A (en) 1995-08-22
WO1990015871A1 (en) 1990-12-27
EP0478602B1 (de) 1996-01-03
GB8914122D0 (en) 1989-08-09
JPH04506005A (ja) 1992-10-22
ES2084030T3 (es) 1996-05-01
ATE132532T1 (de) 1996-01-15
DK0478602T3 (da) 1996-02-05

Similar Documents

Publication Publication Date Title
ATE132532T1 (de) Expression von tetanustoxinfragment c
DK0423302T3 (da) Anvendelse af hidtil ukendte DNA-fragmenter som kodende sekvens for et signalpeptid til sekretion af modne proteiner i rekombinant gær, ekspressionskassetter, transformeret gær og tilsvarende fremgangsmåde til fremstilling af proteiner
DE69329202D1 (de) Methoden der erhöhung der sekretion von überexpremierten proteinen
ATE188508T1 (de) Impfstoffe gegen diphtherietoxin
DE69002817D1 (de) Vakzine.
FI961886A (fi) Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit
ES2103366T3 (es) Hidrolizado proteico de guisante, metodo para su produccion y su utilizacion.
FI952148A (fi) Geenitekninen menetelmä ja isäntä ksylitolin valmistamiseksi
JPS57134465A (en) Manufacture of 1,5-didesoxy-1,5-imino-d- glucitol or n-derivative thereof
ATE162311T1 (de) Immunoassay zum nachweis von kollagen oder kollagenfragmenten
TW362096B (en) Novel piperidine derivatives and the process for preparing the same
EP0146026A3 (en) Dna encoding rabbit tnf, vector having said dna inserted thereinto, host transformed with said vector, rabbit tnf polypeptide, and process for production thereof
ATE81136T1 (de) Immunogenes produkt, erhalten durch expression in einer rekombinanten hefe, und verfahren zu seiner reinigung.
ES8704975A1 (es) Un procedimiento para preparar un polipeptido que se puede utilizar en una vacuna para proteger seres humanos contra infeccion por plasmodium falciparum
DE69328992D1 (de) Mutanten von menschlichem Antithrombin III
NO913078L (no) Oekt proteinproduksjon i dyr.
ES2023560A6 (es) Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
ATE106744T1 (de) Neue methode zur induzierung der ovulation beim menschen.
SE8403929L (sv) Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas
ATE126794T1 (de) Verfahren zur herstellung von formyltetrahydropyranen.
MC1627A1 (fr) Procede de production d'un interferon immun
DK0592574T3 (da) Fremgangsmåde til fremstilling af rekombinante proteiner og værtsceller anvendt derved
ES2004438A6 (es) Un metodo para producir una proteina trombolitica
JPS52117611A (en) Production of magnetic head

Legal Events

Date Code Title Description
8364 No opposition during term of opposition