DE69022163T2 - Steriles erzeugnis und verfahren zur sterilisierung und zusammenbau dieses erzeugnisses. - Google Patents
Steriles erzeugnis und verfahren zur sterilisierung und zusammenbau dieses erzeugnisses.Info
- Publication number
- DE69022163T2 DE69022163T2 DE69022163T DE69022163T DE69022163T2 DE 69022163 T2 DE69022163 T2 DE 69022163T2 DE 69022163 T DE69022163 T DE 69022163T DE 69022163 T DE69022163 T DE 69022163T DE 69022163 T2 DE69022163 T2 DE 69022163T2
- Authority
- DE
- Germany
- Prior art keywords
- flow path
- sterilization
- terminal end
- product
- sterilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001954 sterilising effect Effects 0.000 title claims description 58
- 238000000034 method Methods 0.000 title claims description 38
- 238000004659 sterilization and disinfection Methods 0.000 claims description 50
- 238000010894 electron beam technology Methods 0.000 claims description 32
- 239000012530 fluid Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 22
- 230000002411 adverse Effects 0.000 claims description 14
- 229920003023 plastic Polymers 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 230000035515 penetration Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 1
- 239000000047 product Substances 0.000 description 69
- 230000005855 radiation Effects 0.000 description 39
- 239000000243 solution Substances 0.000 description 22
- 238000012545 processing Methods 0.000 description 15
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000002617 apheresis Methods 0.000 description 9
- 239000000090 biomarker Substances 0.000 description 9
- 229920002457 flexible plastic Polymers 0.000 description 9
- 239000000306 component Substances 0.000 description 8
- 230000008878 coupling Effects 0.000 description 7
- 238000010168 coupling process Methods 0.000 description 7
- 238000005859 coupling reaction Methods 0.000 description 7
- 238000005304 joining Methods 0.000 description 7
- 241000194103 Bacillus pumilus Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000036512 infertility Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000000191 radiation effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000006150 trypticase soy agar Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/321,698 US5009654A (en) | 1989-03-10 | 1989-03-10 | Sterile product and method for sterilizing and assembling such product |
| PCT/US1990/001182 WO1990011095A2 (en) | 1989-03-10 | 1990-03-05 | Sterile product and method for sterilizing and assembling such product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69022163D1 DE69022163D1 (de) | 1995-10-12 |
| DE69022163T2 true DE69022163T2 (de) | 1996-05-09 |
Family
ID=23251657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69022163T Expired - Lifetime DE69022163T2 (de) | 1989-03-10 | 1990-03-05 | Steriles erzeugnis und verfahren zur sterilisierung und zusammenbau dieses erzeugnisses. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5009654A (OSRAM) |
| EP (1) | EP0425602B1 (OSRAM) |
| JP (1) | JP2932316B2 (OSRAM) |
| CA (1) | CA2027595C (OSRAM) |
| DE (1) | DE69022163T2 (OSRAM) |
| IE (1) | IE69127B1 (OSRAM) |
| WO (1) | WO1990011095A2 (OSRAM) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064429A (en) * | 1990-11-19 | 1991-11-12 | Diacor, Inc. | Skin gathering and holding device |
| US5672481A (en) * | 1991-10-23 | 1997-09-30 | Cellpro, Incorporated | Apparatus and method for particle separation in a closed field |
| DE69432167T2 (de) * | 1993-10-28 | 2003-07-24 | Medrad, Inc. | System zur Kontrastmittelabgabe |
| DE69432582T2 (de) * | 1993-10-28 | 2003-11-27 | Medrad, Inc. | System zur Administration von Flüssigkeiten bei mehreren Patienten |
| US5569181A (en) * | 1993-10-28 | 1996-10-29 | Medrad, Inc. | Sterility assurance for contrast delivery system |
| US5827219A (en) * | 1993-10-28 | 1998-10-27 | Medrad, Inc. | Injection system and pumping system for use therein |
| DE69526613T2 (de) * | 1994-07-12 | 2002-08-29 | Medrad, Inc. | Informationswegregelkreis für ein System, das medizinische Flüssigkeiten ausliefert |
| US5840026A (en) * | 1994-09-21 | 1998-11-24 | Medrad, Inc. | Patient specific dosing contrast delivery systems and methods |
| US5910138A (en) | 1996-05-13 | 1999-06-08 | B. Braun Medical, Inc. | Flexible medical container with selectively enlargeable compartments and method for making same |
| US5928213A (en) | 1996-05-13 | 1999-07-27 | B. Braun Medical, Inc. | Flexible multiple compartment medical container with preferentially rupturable seals |
| JP2000510728A (ja) * | 1996-05-13 | 2000-08-22 | ビー．ブラウン メディカル，インコーポレイティド | 柔軟な、多隔室の薬剤容器およびその製造および使用方法 |
| US5944709A (en) | 1996-05-13 | 1999-08-31 | B. Braun Medical, Inc. | Flexible, multiple-compartment drug container and method of making and using same |
| USD385027S (en) * | 1996-07-30 | 1997-10-14 | Bracco Diagnostics, Inc. | Flexible medical fluid container |
| USD385035S (en) * | 1996-07-30 | 1997-10-14 | Bracco Diagnostics, Inc. | Flexible medical fluid container |
| US7264771B2 (en) | 1999-04-20 | 2007-09-04 | Baxter International Inc. | Method and apparatus for manipulating pre-sterilized components in an active sterile field |
| US7358505B2 (en) * | 1998-09-15 | 2008-04-15 | Baxter International Inc. | Apparatus for fabricating a reconstitution assembly |
| GB9820457D0 (en) | 1998-09-18 | 1998-11-11 | Medlogic Global Corp | Methods for sterilizing cyanoacrylate compositions |
| US6191424B1 (en) | 1998-12-03 | 2001-02-20 | I-Ax Technologies | Irradiation apparatus for production line use |
| JP2002533839A (ja) * | 1998-12-16 | 2002-10-08 | アイシーユー メディカル インコーポレイテッド | 製品のブラウズおよび比較を行うためのシステムおよび方法 |
| US6594156B1 (en) | 2000-04-24 | 2003-07-15 | Minimed Inc. | Device and method for circuit protection during radiation sterilization |
| CA2372739C (en) * | 1999-05-21 | 2005-10-18 | Minimed, Inc. | Device and method for circuit protection during radiation sterilization |
| US6632164B1 (en) | 1999-09-27 | 2003-10-14 | Stephen Warburton-Pitt | Silicone bag assembly manufacturing apparatus |
| US7686779B1 (en) * | 1999-10-01 | 2010-03-30 | Caridian BCT, Inc | Extracorporeal blood processing methods and apparatus |
| US7651474B2 (en) * | 1999-10-01 | 2010-01-26 | Caridianbct, Inc. | Method and apparatus for leukoreduction of red blood cells |
| DE60032024T2 (de) * | 1999-12-14 | 2007-06-21 | ICU Medical, Inc., San Clemente | Verfahren zur herstellung eines produktes mit mehreren komponenten |
| US7243689B2 (en) * | 2000-02-11 | 2007-07-17 | Medical Instill Technologies, Inc. | Device with needle penetrable and laser resealable portion and related method |
| US6416489B1 (en) * | 2000-03-02 | 2002-07-09 | William H Booth | Process for effecting sterile connections of medical tubing by way of terminally sterilizing an isolated fluid filled connected area |
| US6698162B2 (en) * | 2000-03-23 | 2004-03-02 | Teikoku Pharma Usa, Inc. | Methods of producing a terminally sterilized topical patch preparation |
| EP1166818A1 (en) * | 2000-06-29 | 2002-01-02 | Societe Des Produits Nestle S.A. | Medium cracking pressure valve |
| WO2002040122A2 (en) | 2000-10-23 | 2002-05-23 | Py Patent, Inc. | Fluid dispenser with bladder inside rigid vial |
| US7331944B2 (en) | 2000-10-23 | 2008-02-19 | Medical Instill Technologies, Inc. | Ophthalmic dispenser and associated method |
| FR2816924B1 (fr) * | 2000-11-20 | 2003-02-14 | Becton Dickinson France | Emballage pour produits steriles |
| FR2816926B1 (fr) * | 2000-11-20 | 2003-02-14 | Becton Dickinson France | Emballage multifonctionnels, et plus particulierement emballages destines a transporter des produits sterilises ou destines a etre sterilises |
| US6579916B1 (en) | 2000-11-21 | 2003-06-17 | Medlogic Global Corporation | Methods for sterilizing cyanoacrylate compositions |
| AU2002243215A1 (en) * | 2000-11-21 | 2002-07-24 | Medlogic Global Corporation | Method for sterilizing cyanoacrylate compositions |
| US20020172615A1 (en) * | 2001-03-08 | 2002-11-21 | Archie Woodworth | Apparatus for and method of manufacturing a prefilled sterile container |
| EP1450881A4 (en) * | 2001-10-03 | 2008-06-18 | Medical Instill Tech Inc | SYRINGE AND SYRINGE OF RECONSTITUTION |
| EP1446328B1 (en) * | 2001-10-16 | 2017-05-31 | Medical Instill Technologies, Inc. | DISPENSER WITH SEALED CHAMBER AND ONE−WAY VALVE FOR PROVIDING METERED AMOUNTS OF SUBSTANCES |
| US7798185B2 (en) * | 2005-08-01 | 2010-09-21 | Medical Instill Technologies, Inc. | Dispenser and method for storing and dispensing sterile food product |
| US7052606B2 (en) * | 2001-12-10 | 2006-05-30 | Gambro, Inc. | Methods and apparatus for leukoreduction of red blood cells |
| US7109974B2 (en) * | 2002-03-05 | 2006-09-19 | Matsushita Electric Industrial Co., Ltd. | Remote control system including an on-screen display (OSD) |
| US20030174810A1 (en) * | 2002-03-12 | 2003-09-18 | Steris Inc. | Method and apparatus for destroying microbial contamination of mail |
| EP1517834B1 (en) * | 2002-06-19 | 2012-05-23 | Medical Instill Technologies, Inc. | Sterile filling machine having needle filling station within e-beam chamber |
| US20040028555A1 (en) * | 2002-08-09 | 2004-02-12 | Truseal Usa, Inc. | Sterile connection |
| MXPA05001662A (es) * | 2002-08-13 | 2005-10-19 | Medical Instill Tech Inc | Ensamble de contenedor y valvula para almacenar y surtir substancias, y metodo relacionado. |
| JP4425140B2 (ja) * | 2002-09-03 | 2010-03-03 | メディカル・インスティル・テクノロジーズ・インコーポレイテッド | 水薬瓶アセンブリ |
| US20040062694A1 (en) * | 2002-10-01 | 2004-04-01 | Vandlik Mark R. | One-piece connector for assembling a sterile medical product |
| US6883222B2 (en) * | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| RU2504357C2 (ru) * | 2003-01-28 | 2014-01-20 | Медикал Инстилл Текнолоджис, Инк. | Устройство, содержащее камеру, для заполнения его веществом, и способ изготовления и заполнения веществом устройства, содержащего камеру |
| WO2004096113A2 (en) * | 2003-04-28 | 2004-11-11 | Medical Instill Technologies, Inc. | Container with valve assembly for filling and dispensing substances, and apparatus and method for filling |
| WO2004101027A2 (en) | 2003-05-12 | 2004-11-25 | Medical Instill Technologies, Inc. | Dispenser and apparatus for fillling a dispenser |
| WO2005032619A1 (ja) * | 2003-10-02 | 2005-04-14 | Terumo Kabushiki Kaisha | 血液処理回路の製造方法およびフィルターユニット |
| US7641851B2 (en) | 2003-12-23 | 2010-01-05 | Baxter International Inc. | Method and apparatus for validation of sterilization process |
| US7264142B2 (en) | 2004-01-27 | 2007-09-04 | Medical Instill Technologies, Inc. | Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances |
| US20050288808A1 (en) * | 2004-06-14 | 2005-12-29 | Lopez George A | Computer system for efficient design and manufacture of multiple-component devices |
| DE102004033219A1 (de) * | 2004-07-09 | 2006-02-02 | Roche Diagnostics Gmbh | Verfahren zur selektiven Sterilisation von diagnostischen Testelementen |
| WO2006055813A2 (en) * | 2004-11-16 | 2006-05-26 | Medrad, Inc. | Modeling of pharmaceutical propagation |
| HUE034171T2 (en) | 2004-11-24 | 2018-02-28 | Bayer Healthcare Llc | Tools, systems and procedures for fluid transfer |
| US7931859B2 (en) * | 2005-12-22 | 2011-04-26 | Intelligent Hospital Systems Ltd. | Ultraviolet sanitization in pharmacy environments |
| US8747738B2 (en) | 2006-08-15 | 2014-06-10 | Abbott Cardiovascular Systems Inc. | Sterilization methods for medical devices |
| HUE040477T2 (hu) | 2006-12-29 | 2019-03-28 | Bayer Healthcare Llc | Betegalapú paramétergeneráló rendszerek gyógyászati injekciós eljárásokhoz |
| FR2911072B1 (fr) * | 2007-01-09 | 2010-10-22 | Becton Dickinson France | Emballage pour produits qui doit etre decontamine par rayonnement |
| FR2911071A1 (fr) * | 2007-01-09 | 2008-07-11 | Becton Dickinson France Soc Pa | Procede et equipement pour la decontamination par rayonnement d'un produit tel qu'un emballage contenant des dispositifs medicaux. |
| EP2125043A4 (en) * | 2007-02-23 | 2011-04-13 | Intelligent Hospital Systems Ltd | ULTRAVIOLET SPIRIT FREEZE IN A PHARMACY ENVIRONMENT |
| US8729121B2 (en) | 2007-06-25 | 2014-05-20 | Adhezion Biomedical, Llc | Curing accelerator and method of making |
| US7832185B2 (en) | 2007-07-11 | 2010-11-16 | Stokely-Van Camp, Inc. | Active sterilization zone for container filling |
| JP5437240B2 (ja) | 2007-07-17 | 2014-03-12 | メドラッド インコーポレーテッド | 心肺機能の評価、及び流体搬送の手順のパラメータを決定する装置、システム及び方法 |
| WO2009064291A1 (en) * | 2007-11-14 | 2009-05-22 | Spartan Medical Products, Llc | Cyanoacrylate tissue adhesives |
| US8608484B2 (en) * | 2008-03-04 | 2013-12-17 | Medrad, Inc. | Dynamic anthropomorphic cardiovascular phantom |
| US8198344B2 (en) * | 2008-06-20 | 2012-06-12 | Adhezion Biomedical, Llc | Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator |
| US8293838B2 (en) * | 2008-06-20 | 2012-10-23 | Adhezion Biomedical, Llc | Stable and sterile tissue adhesive composition with a controlled high viscosity |
| US20110117047A1 (en) | 2008-06-23 | 2011-05-19 | Adhezion Biomedical, Llc | Cyanoacrylate tissue adhesives with desirable permeability and tensile strength |
| US8315449B2 (en) | 2008-06-24 | 2012-11-20 | Medrad, Inc. | Identification of regions of interest and extraction of time value curves in imaging procedures |
| DE102008053131A1 (de) * | 2008-10-24 | 2010-04-29 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Anordnung zum Sterilisieren, insbesondere zum Sterilisieren eines Adsorbers |
| US8652510B2 (en) | 2008-10-31 | 2014-02-18 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
| US8609128B2 (en) * | 2008-10-31 | 2013-12-17 | Adhezion Biomedical, Llc | Cyanoacrylate-based liquid microbial sealant drape |
| US9254133B2 (en) | 2008-10-31 | 2016-02-09 | Adhezion Biomedical, Llc | Sterilized liquid compositions of cyanoacrylate monomer mixtures |
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| EP2758096A4 (en) | 2011-09-21 | 2015-07-01 | Bayer Medical Care Inc | SYSTEM AND METHOD FOR CONTINUOUS MULTI-FLUID DISTRIBUTION |
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| CA2973257C (en) | 2015-01-09 | 2023-09-19 | Bayer Healthcare Llc | Multiple fluid delivery system with multi-use disposable set and features thereof |
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| US12263326B2 (en) | 2016-11-14 | 2025-04-01 | Bayer Healthcare Llc | Methods and systems for verifying the contents of a syringe used for medical fluid delivery |
| CN110869071B (zh) | 2017-08-31 | 2023-05-02 | 拜耳医药保健有限公司 | 流体注入器系统中的动态压力控制的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3968195A (en) * | 1974-06-17 | 1976-07-06 | Marilyn Bishop | Method for making sterile connections |
| US4157723A (en) * | 1977-10-19 | 1979-06-12 | Baxter Travenol Laboratories, Inc. | Method of forming a connection between two sealed conduits using radiant energy |
| US4223675A (en) * | 1978-07-24 | 1980-09-23 | Baxter Travenol Laboratories, Inc. | Solution containers such as blood bags and system for preparing same |
| US4332122A (en) * | 1978-07-24 | 1982-06-01 | Baxter Travenol Laboratories, Inc. | Method of making and filling liquid-containing sterile packages such as blood bags |
| US4340049A (en) * | 1979-10-18 | 1982-07-20 | Baxter Travenol Laboratories, Inc. | Breakaway valve |
| US4410026A (en) * | 1981-07-13 | 1983-10-18 | Baxter Travenol Laboratories, Inc. | Port block assembly for interconnecting a fluid container with a fluid conduit |
| US4610670A (en) * | 1983-06-13 | 1986-09-09 | E. I. Du Pont De Nemours And Company | Sterile connection process, apparatus and system |
| US4828557A (en) * | 1984-04-06 | 1989-05-09 | Persidsky Maxim D | Sterile connector and method |
| US4652763A (en) * | 1985-03-29 | 1987-03-24 | Energy Sciences, Inc. | Electron-beam irradiation sterilization process |
-
1989
- 1989-03-10 US US07/321,698 patent/US5009654A/en not_active Expired - Lifetime
-
1990
- 1990-03-05 CA CA002027595A patent/CA2027595C/en not_active Expired - Lifetime
- 1990-03-05 JP JP2504479A patent/JP2932316B2/ja not_active Expired - Lifetime
- 1990-03-05 WO PCT/US1990/001182 patent/WO1990011095A2/en not_active Ceased
- 1990-03-05 DE DE69022163T patent/DE69022163T2/de not_active Expired - Lifetime
- 1990-03-05 EP EP90904574A patent/EP0425602B1/en not_active Expired - Lifetime
- 1990-03-08 IE IE83490A patent/IE69127B1/en not_active IP Right Cessation
-
1992
- 1992-04-29 US US07/876,125 patent/US5496302A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5009654A (en) | 1991-04-23 |
| US5009654B1 (OSRAM) | 1993-07-13 |
| IE900834L (en) | 1990-09-10 |
| IE69127B1 (en) | 1996-08-07 |
| US5496302A (en) | 1996-03-05 |
| JP2932316B2 (ja) | 1999-08-09 |
| CA2027595C (en) | 1998-09-01 |
| WO1990011095A2 (en) | 1990-10-04 |
| CA2027595A1 (en) | 1990-09-11 |
| JPH04500472A (ja) | 1992-01-30 |
| EP0425602A4 (en) | 1993-02-10 |
| EP0425602B1 (en) | 1995-09-06 |
| DE69022163D1 (de) | 1995-10-12 |
| WO1990011095A3 (en) | 1991-08-08 |
| EP0425602A1 (en) | 1991-05-08 |
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