DE69012575D1 - Auf hydroxaminsäure basierte kollagenaseinhibitoren. - Google Patents
Auf hydroxaminsäure basierte kollagenaseinhibitoren.Info
- Publication number
- DE69012575D1 DE69012575D1 DE69012575T DE69012575T DE69012575D1 DE 69012575 D1 DE69012575 D1 DE 69012575D1 DE 69012575 T DE69012575 T DE 69012575T DE 69012575 T DE69012575 T DE 69012575T DE 69012575 D1 DE69012575 D1 DE 69012575D1
- Authority
- DE
- Germany
- Prior art keywords
- collagenas
- hydroxamic acid
- inhibitors based
- disease
- involving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898919251A GB8919251D0 (en) | 1989-08-24 | 1989-08-24 | Compounds |
PCT/GB1990/001117 WO1991002716A2 (en) | 1989-08-24 | 1990-07-20 | Hydroxamic acid based collagenase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69012575D1 true DE69012575D1 (de) | 1994-10-20 |
DE69012575T2 DE69012575T2 (de) | 1995-03-30 |
Family
ID=10662057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69012575T Expired - Fee Related DE69012575T2 (de) | 1989-08-24 | 1990-07-20 | Auf hydroxaminsäure basierte kollagenaseinhibitoren. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5453438A (de) |
EP (1) | EP0489032B1 (de) |
JP (1) | JP2871849B2 (de) |
KR (1) | KR927003624A (de) |
AT (1) | ATE111443T1 (de) |
AU (1) | AU639706B2 (de) |
CA (1) | CA2064786A1 (de) |
DE (1) | DE69012575T2 (de) |
DK (1) | DK0489032T3 (de) |
ES (1) | ES2063975T3 (de) |
FI (1) | FI920771A0 (de) |
GB (1) | GB8919251D0 (de) |
NO (1) | NO920702L (de) |
NZ (1) | NZ235050A (de) |
TW (1) | TW202456B (de) |
WO (1) | WO1991002716A2 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
EP0520573A1 (de) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Derivate von cyclischen Imiden |
JP3348725B2 (ja) * | 1992-04-07 | 2002-11-20 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | ヒドロキサム酸ベースのコラゲナーゼとサイトカイン阻害剤 |
GB9211706D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
GB9211707D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
CA2158352A1 (en) * | 1993-03-16 | 1994-09-29 | Michael John Crimmin | Hydroxamic acid derivatives as metalloproteinase inhibitors |
ATE182137T1 (de) * | 1993-04-27 | 1999-07-15 | Celltech Therapeutics Ltd | Peptidylderivate als inhibitoren von metalloproteinase |
GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
ES2075797B1 (es) * | 1993-08-18 | 1996-05-16 | British Bio Technology | Derivados de acidos hidroxamicos terapeuticamente activos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina. |
ES2075798B1 (es) * | 1993-08-18 | 1996-03-01 | British Bio Technology | Derivados de aminoacidos naturales como inhibidores de metaloproteinasas, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina. |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
DE69502378T2 (de) * | 1994-01-20 | 1998-10-01 | British Biotech Pharm | Metalloproteinaseinhibitoren |
GB9501737D0 (en) * | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
US5919940A (en) * | 1995-01-20 | 1999-07-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
US5917090A (en) * | 1995-06-30 | 1999-06-29 | British Biotech Pharmaceuticals Ltd. | Matrix metalloproteinase inhibitors |
DE69615058T2 (de) | 1995-11-23 | 2002-06-27 | British Biotech Pharm | Metalloproteinase inhibitoren |
TR199900429T2 (xx) * | 1996-08-28 | 1999-05-21 | The Procter & Gamble Company | Spirosiklik metaloproteaz inhibit�rleri. |
EP0925287B1 (de) * | 1996-08-28 | 2003-01-15 | The Procter & Gamble Company | Heterocyclische metalloprotease inhibitoren |
PL331838A1 (en) * | 1996-08-28 | 1999-08-02 | Procter & Gamble | 1,3-diheterocyclic inhibitors of metaloproteases |
NZ334258A (en) * | 1996-08-28 | 2000-11-24 | Procter & Gamble | Phosphinic acid amides as matrix metalloprotease inhibitors |
WO1998008823A1 (en) * | 1996-08-28 | 1998-03-05 | The Procter & Gamble Company | Heterocyclic metalloprotease inhibitors |
ATE220660T1 (de) | 1996-09-10 | 2002-08-15 | British Biotech Pharm | Cytostatische hydroxamsäurederivate |
US6462023B1 (en) | 1996-09-10 | 2002-10-08 | British Biotech Pharmaceuticals, Ltd. | Cytostatic agents |
US5840974A (en) * | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
US5952320A (en) * | 1997-01-07 | 1999-09-14 | Abbott Laboratories | Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
KR100352316B1 (ko) | 1997-07-31 | 2002-09-12 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제억제제로서사용되는술포닐아미노치환히드록삼산유도체 |
GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
IL145089A0 (en) | 1999-03-03 | 2002-06-30 | Procter & Gamble | Alkenyl-and alkynyl-containing metalloprotease inhibitors |
TR200200360T2 (tr) | 1999-08-10 | 2002-06-21 | British Biotech Pharmaceuticals Limited | Antibakteriyel aktif maddeler. |
GB9929527D0 (en) * | 1999-12-14 | 2000-02-09 | Smithkline Beecham Plc | Novel compounds |
US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
PT1406893E (pt) | 2001-06-15 | 2007-07-12 | Vicuron Pharm Inc | Compostos bicíclicos de pirrolidina |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4496540A (en) * | 1982-12-30 | 1985-01-29 | Biomeasure, Inc. | Therapeutic compounds |
JPS6115840A (ja) * | 1984-07-03 | 1986-01-23 | Microbial Chem Res Found | 免疫賦活剤 |
US4743587A (en) * | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
-
1989
- 1989-08-24 GB GB898919251A patent/GB8919251D0/en active Pending
-
1990
- 1990-07-20 DE DE69012575T patent/DE69012575T2/de not_active Expired - Fee Related
- 1990-07-20 JP JP2510523A patent/JP2871849B2/ja not_active Expired - Fee Related
- 1990-07-20 DK DK90911398.7T patent/DK0489032T3/da active
- 1990-07-20 WO PCT/GB1990/001117 patent/WO1991002716A2/en active IP Right Grant
- 1990-07-20 KR KR1019920700412A patent/KR927003624A/ko not_active Application Discontinuation
- 1990-07-20 AU AU60454/90A patent/AU639706B2/en not_active Ceased
- 1990-07-20 EP EP90911398A patent/EP0489032B1/de not_active Expired - Lifetime
- 1990-07-20 CA CA002064786A patent/CA2064786A1/en not_active Abandoned
- 1990-07-20 AT AT90911398T patent/ATE111443T1/de not_active IP Right Cessation
- 1990-07-20 US US07/820,664 patent/US5453438A/en not_active Expired - Fee Related
- 1990-07-20 ES ES90911398T patent/ES2063975T3/es not_active Expired - Lifetime
- 1990-08-01 TW TW079106338A patent/TW202456B/zh active
- 1990-08-24 NZ NZ235050A patent/NZ235050A/en unknown
-
1992
- 1992-02-21 FI FI920771A patent/FI920771A0/fi not_active Application Discontinuation
- 1992-02-21 NO NO92920702A patent/NO920702L/no unknown
-
1995
- 1995-04-05 US US08/417,095 patent/US5910609A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH05501864A (ja) | 1993-04-08 |
EP0489032B1 (de) | 1994-09-14 |
CA2064786A1 (en) | 1991-02-25 |
EP0489032A1 (de) | 1992-06-10 |
ES2063975T3 (es) | 1995-01-16 |
AU639706B2 (en) | 1993-08-05 |
WO1991002716A2 (en) | 1991-03-07 |
GB8919251D0 (en) | 1989-10-04 |
US5453438A (en) | 1995-09-26 |
JP2871849B2 (ja) | 1999-03-17 |
WO1991002716A3 (en) | 1991-06-27 |
NO920702D0 (no) | 1992-02-21 |
NO920702L (no) | 1992-04-23 |
NZ235050A (en) | 1991-12-23 |
KR927003624A (ko) | 1992-12-18 |
FI920771A0 (fi) | 1992-02-21 |
DK0489032T3 (da) | 1995-01-30 |
US5910609A (en) | 1999-06-08 |
DE69012575T2 (de) | 1995-03-30 |
ATE111443T1 (de) | 1994-09-15 |
TW202456B (de) | 1993-03-21 |
AU6045490A (en) | 1991-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |