DK0489032T3 - Hydroxaminsyre-baserede kollagenaseinhibitorer - Google Patents
Hydroxaminsyre-baserede kollagenaseinhibitorerInfo
- Publication number
- DK0489032T3 DK0489032T3 DK90911398.7T DK90911398T DK0489032T3 DK 0489032 T3 DK0489032 T3 DK 0489032T3 DK 90911398 T DK90911398 T DK 90911398T DK 0489032 T3 DK0489032 T3 DK 0489032T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxamic acid
- collagenase inhibitors
- based collagenase
- disease
- involving
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898919251A GB8919251D0 (en) | 1989-08-24 | 1989-08-24 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0489032T3 true DK0489032T3 (da) | 1995-01-30 |
Family
ID=10662057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90911398.7T DK0489032T3 (da) | 1989-08-24 | 1990-07-20 | Hydroxaminsyre-baserede kollagenaseinhibitorer |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5453438A (da) |
| EP (1) | EP0489032B1 (da) |
| JP (1) | JP2871849B2 (da) |
| KR (1) | KR927003624A (da) |
| AT (1) | ATE111443T1 (da) |
| AU (1) | AU639706B2 (da) |
| CA (1) | CA2064786A1 (da) |
| DE (1) | DE69012575T2 (da) |
| DK (1) | DK0489032T3 (da) |
| ES (1) | ES2063975T3 (da) |
| FI (1) | FI920771A0 (da) |
| GB (1) | GB8919251D0 (da) |
| NO (1) | NO920702L (da) |
| NZ (1) | NZ235050A (da) |
| TW (1) | TW202456B (da) |
| WO (1) | WO1991002716A2 (da) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
| US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
| EP0634998B1 (en) * | 1992-04-07 | 1997-03-19 | British Biotech Pharmaceuticals Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
| GB9211707D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211706D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| JPH08508027A (ja) * | 1993-03-16 | 1996-08-27 | ブリテッシュ バイオテック ファーマシューティカルズ リミテッド | 金属タンパク加水分解酵素阻害剤である天然アミノ酸誘導体 |
| GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| DE69419473T2 (de) * | 1993-04-27 | 2000-03-16 | Celltech Therapeutics Ltd. | Peptidylderivate als inhibitoren von metalloproteinase |
| ES2075798B1 (es) * | 1993-08-18 | 1996-03-01 | British Bio Technology | Derivados de aminoacidos naturales como inhibidores de metaloproteinasas, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina. |
| ES2075797B1 (es) * | 1993-08-18 | 1996-05-16 | British Bio Technology | Derivados de acidos hidroxamicos terapeuticamente activos, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina. |
| US6037472A (en) | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| DK0822186T3 (da) * | 1994-01-20 | 2000-06-26 | British Biotech Pharm | L-tert-leucin-2-pyridylamid |
| GB9501737D0 (en) * | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| US5831004A (en) | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| US5919940A (en) * | 1995-01-20 | 1999-07-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
| US5917090A (en) * | 1995-06-30 | 1999-06-29 | British Biotech Pharmaceuticals Ltd. | Matrix metalloproteinase inhibitors |
| NZ322553A (en) | 1995-11-23 | 1998-12-23 | British Biotech Pharm | Metalloproteinase inhibitors |
| PL331856A1 (en) * | 1996-08-28 | 1999-08-16 | Procter & Gamble | Heterocyclic inhibitors of metaloprotease |
| BR9713182A (pt) * | 1996-08-28 | 1999-11-03 | Procter & Gamble | Amidas de ácido fosfìnico como inibidores de metalo protease de matriz |
| DK0923561T3 (da) | 1996-08-28 | 2003-02-24 | Procter & Gamble | Heterocykliske metalloproteaseinhibitorer |
| AU736238B2 (en) * | 1996-08-28 | 2001-07-26 | Procter & Gamble Company, The | Spirocyclic metalloprotease inhibitors |
| DE69716934T2 (de) * | 1996-08-28 | 2003-07-31 | The Procter & Gamble Company, Cincinnati | 1,3-diheterozyklische metalloprotease inhibitoren |
| CZ298048B6 (cs) * | 1996-09-10 | 2007-06-06 | British Biotech Pharmaceuticals Limited | Farmaceutický prostredek a deriváty kyseliny hydroxamové |
| US6462023B1 (en) | 1996-09-10 | 2002-10-08 | British Biotech Pharmaceuticals, Ltd. | Cytostatic agents |
| US5840974A (en) * | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
| US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
| US5952320A (en) * | 1997-01-07 | 1999-09-14 | Abbott Laboratories | Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion |
| HUP0004595A3 (en) | 1997-07-31 | 2001-12-28 | Procter & Gamble | Acyclic metalloprotease inhibitors |
| GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
| US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| IL145089A0 (en) | 1999-03-03 | 2002-06-30 | Procter & Gamble | Alkenyl-and alkynyl-containing metalloprotease inhibitors |
| TR200200360T2 (tr) * | 1999-08-10 | 2002-06-21 | British Biotech Pharmaceuticals Limited | Antibakteriyel aktif maddeler. |
| GB9929527D0 (en) * | 1999-12-14 | 2000-02-09 | Smithkline Beecham Plc | Novel compounds |
| US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| CA2446931A1 (en) | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
| US4496540A (en) * | 1982-12-30 | 1985-01-29 | Biomeasure, Inc. | Therapeutic compounds |
| JPS6115840A (ja) * | 1984-07-03 | 1986-01-23 | Microbial Chem Res Found | 免疫賦活剤 |
| US4743587A (en) * | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
-
1989
- 1989-08-24 GB GB898919251A patent/GB8919251D0/en active Pending
-
1990
- 1990-07-20 JP JP2510523A patent/JP2871849B2/ja not_active Expired - Fee Related
- 1990-07-20 ES ES90911398T patent/ES2063975T3/es not_active Expired - Lifetime
- 1990-07-20 DK DK90911398.7T patent/DK0489032T3/da active
- 1990-07-20 KR KR1019920700412A patent/KR927003624A/ko not_active Application Discontinuation
- 1990-07-20 WO PCT/GB1990/001117 patent/WO1991002716A2/en active IP Right Grant
- 1990-07-20 CA CA002064786A patent/CA2064786A1/en not_active Abandoned
- 1990-07-20 AT AT90911398T patent/ATE111443T1/de not_active IP Right Cessation
- 1990-07-20 DE DE69012575T patent/DE69012575T2/de not_active Expired - Fee Related
- 1990-07-20 US US07/820,664 patent/US5453438A/en not_active Expired - Fee Related
- 1990-07-20 AU AU60454/90A patent/AU639706B2/en not_active Ceased
- 1990-07-20 EP EP90911398A patent/EP0489032B1/en not_active Expired - Lifetime
- 1990-08-01 TW TW079106338A patent/TW202456B/zh active
- 1990-08-24 NZ NZ235050A patent/NZ235050A/en unknown
-
1992
- 1992-02-21 NO NO92920702A patent/NO920702L/no unknown
- 1992-02-21 FI FI920771A patent/FI920771A0/fi not_active Application Discontinuation
-
1995
- 1995-04-05 US US08/417,095 patent/US5910609A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO920702D0 (no) | 1992-02-21 |
| KR927003624A (ko) | 1992-12-18 |
| NO920702L (no) | 1992-04-23 |
| TW202456B (da) | 1993-03-21 |
| US5453438A (en) | 1995-09-26 |
| GB8919251D0 (en) | 1989-10-04 |
| DE69012575T2 (de) | 1995-03-30 |
| US5910609A (en) | 1999-06-08 |
| FI920771A0 (fi) | 1992-02-21 |
| DE69012575D1 (de) | 1994-10-20 |
| WO1991002716A3 (en) | 1991-06-27 |
| NZ235050A (en) | 1991-12-23 |
| ES2063975T3 (es) | 1995-01-16 |
| CA2064786A1 (en) | 1991-02-25 |
| ATE111443T1 (de) | 1994-09-15 |
| AU6045490A (en) | 1991-04-03 |
| EP0489032A1 (en) | 1992-06-10 |
| AU639706B2 (en) | 1993-08-05 |
| EP0489032B1 (en) | 1994-09-14 |
| WO1991002716A2 (en) | 1991-03-07 |
| JPH05501864A (ja) | 1993-04-08 |
| JP2871849B2 (ja) | 1999-03-17 |
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