DE69009746T2 - Derivate von n-phenylbenzamid mit antiulcerativer sowie antiallergischer aktivität und verfahren zu ihrer herstellung. - Google Patents

Derivate von n-phenylbenzamid mit antiulcerativer sowie antiallergischer aktivität und verfahren zu ihrer herstellung.

Info

Publication number
DE69009746T2
DE69009746T2 DE69009746T DE69009746T DE69009746T2 DE 69009746 T2 DE69009746 T2 DE 69009746T2 DE 69009746 T DE69009746 T DE 69009746T DE 69009746 T DE69009746 T DE 69009746T DE 69009746 T2 DE69009746 T2 DE 69009746T2
Authority
DE
Germany
Prior art keywords
hydrogen
derivatives
pct
phenylbenzamide
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69009746T
Other languages
English (en)
Other versions
DE69009746D1 (de
Inventor
Francesco Makovec
Walter Peris
Angelo Luigi Rovati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm SpA
Original Assignee
Rotta Research Laboratorium SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Laboratorium SpA filed Critical Rotta Research Laboratorium SpA
Application granted granted Critical
Publication of DE69009746D1 publication Critical patent/DE69009746D1/de
Publication of DE69009746T2 publication Critical patent/DE69009746T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69009746T 1989-02-22 1990-02-19 Derivate von n-phenylbenzamid mit antiulcerativer sowie antiallergischer aktivität und verfahren zu ihrer herstellung. Expired - Fee Related DE69009746T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8967119A IT1232252B (it) 1989-02-22 1989-02-22 Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
PCT/EP1990/000270 WO1990009989A1 (en) 1989-02-22 1990-02-19 Derivatives of n-phenylbenzamide with anti-ulcer and anti-allergy activity and a method for their preparation

Publications (2)

Publication Number Publication Date
DE69009746D1 DE69009746D1 (de) 1994-07-14
DE69009746T2 true DE69009746T2 (de) 1994-11-17

Family

ID=11299739

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69009746T Expired - Fee Related DE69009746T2 (de) 1989-02-22 1990-02-19 Derivate von n-phenylbenzamid mit antiulcerativer sowie antiallergischer aktivität und verfahren zu ihrer herstellung.

Country Status (16)

Country Link
US (1) US5232937A (de)
EP (1) EP0460083B1 (de)
JP (1) JP2716259B2 (de)
AT (1) ATE106863T1 (de)
AU (1) AU627285B2 (de)
CA (1) CA2046874C (de)
DD (1) DD294477A5 (de)
DE (1) DE69009746T2 (de)
ES (1) ES2055424T3 (de)
GR (1) GR1002183B (de)
HU (1) HU207986B (de)
IE (1) IE64437B1 (de)
IT (1) IT1232252B (de)
PT (1) PT93213B (de)
WO (1) WO1990009989A1 (de)
ZA (1) ZA901316B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JPH0597706A (ja) * 1991-04-09 1993-04-20 Chemex Block Drug Jv アフタ性潰瘍および他の粘膜皮膚障害の処置方法
IT1256870B (it) * 1992-02-13 1995-12-27 Rotta Research Lab Derivati bis-tetrazolici ad attivita' antiallergica e citoprotettiva
ES2199336T3 (es) * 1997-08-08 2004-02-16 Rotta Research Laboratorium S.P.A. Una composicion farmaceutica novedosa para inhalacion que contiene cr 2039 (andolast).
AU754943B2 (en) 1998-05-22 2002-11-28 Avanir Pharmaceuticals Benzimidazole analogs as down-regulators of IgE
US6303645B1 (en) 1998-05-22 2001-10-16 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6369091B1 (en) 1998-05-22 2002-04-09 Avanir Pharmaceuticals Benzimidazole analogs as down-regulators of IgE
US6919366B2 (en) 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6759425B2 (en) 1999-10-21 2004-07-06 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
HUP0303460A3 (en) 2001-03-12 2004-07-28 Avanir Pharmaceuticals San Die Benzimidazole compounds for modulating ige and inhibiting cellular proliferation and pharmaceutical compositions containing them
TWI319387B (en) * 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
US7078423B2 (en) 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US7037927B2 (en) * 2003-10-16 2006-05-02 Abbott Laboratories Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
DE602004015788D1 (de) * 2004-08-19 2008-09-25 Rottapharm Spa Verwendung von Phenylbenzamide-derivaten zur Behandlung von chronisch-obstruktiver Lungenerkrankung (COPD)
GB0521244D0 (en) * 2005-10-19 2005-11-30 Astrazeneca Ab Benzamide compounds
ES2327265T3 (es) 2006-04-10 2009-10-27 Rottapharm S.P.A. Una nueva forma cristalina estable de andolast.
US8809306B2 (en) 2006-07-31 2014-08-19 Rottapharm S.P.A. Combination andolast/glucocorticoids
US8380355B2 (en) * 2007-03-19 2013-02-19 Wayne/Scott Fetzer Company Capacitive sensor and method and apparatus for controlling a pump using same
AU2013207510A1 (en) 2012-01-06 2014-07-31 The Regents Of The University Of California Compositions, methods of use, and methods of treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3580134D1 (de) * 1984-07-07 1990-11-22 Shudo Koichi Prof Dr Chem Benzoesaeurederivate.
LU86258A1 (fr) * 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
DE3616721A1 (de) * 1986-05-17 1987-11-19 Basf Lacke & Farben Zink- und/oder bleisalze von carbonsaeuren und deren verwendung als korrosionsschutzmittel
US4835181A (en) * 1987-02-18 1989-05-30 Eli Lilly And Company Anticonvulsant agents using cyano dimethylphenyl benzamides
IL85896A (en) * 1987-04-06 1993-01-14 Riker Laboratories Inc Substituted di-tert.- butylphenols and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DD294477A5 (de) 1991-10-02
AU627285B2 (en) 1992-08-20
PT93213B (pt) 1996-01-31
IE900645L (en) 1990-08-22
GR1002183B (en) 1996-03-12
US5232937A (en) 1993-08-03
AU5175690A (en) 1990-09-26
IE64437B1 (en) 1995-08-09
WO1990009989A1 (en) 1990-09-07
HUT60464A (en) 1992-09-28
CA2046874C (en) 1999-03-23
HU207986B (en) 1993-07-28
EP0460083A1 (de) 1991-12-11
PT93213A (pt) 1990-08-31
GR900100136A (el) 1991-06-28
JP2716259B2 (ja) 1998-02-18
CA2046874A1 (en) 1990-08-23
ES2055424T3 (es) 1994-08-16
IT1232252B (it) 1992-01-28
ZA901316B (en) 1990-11-28
ATE106863T1 (de) 1994-06-15
EP0460083B1 (de) 1994-06-08
DE69009746D1 (de) 1994-07-14
IT8967119A0 (it) 1989-02-22

Similar Documents

Publication Publication Date Title
DE69009746T2 (de) Derivate von n-phenylbenzamid mit antiulcerativer sowie antiallergischer aktivität und verfahren zu ihrer herstellung.
ATE187724T1 (de) Azachinoxaline, verfahren zu ihrer herstellung und ihre verwendung
DE3784401D1 (de) Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
ATE242769T1 (de) Verfahren zur herstellung von 2-(3-pyrazolyl- oxymethylen)nitrobenzolen
DE3481120D1 (de) 3,6-disubstituierte-1,8-naphthalimide, verfahren zu ihrer herstellung und ihre verwendung.
TR199700206A2 (xx) Floralkil- ve floralkoksi ikame edilmi� heterosiklik bradikinin-antagonistleri, bunlar�n imal edilmesine mahsus usul ve bunlar�n kullan�lmalar�.
DE3684445D1 (de) Neue harnstoffderivate, verfahren zu ihrer herstellung und herbizide.
DE3873524D1 (de) Iodierte polymere, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel.
DE3764027D1 (de) Substituierte 6-hydroxymethylcarbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung.
DE3586324D1 (de) Tetrahydrophthalimidderivate, verfahren zu ihrer herstellung und ihre verwendung.
DE3765853D1 (de) Hydroxipyrazol-derivate- verfahren zu ihrer herstellung und ihre verwendung gegen mikroorganismen.
DE59309756D1 (de) 4-Iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3889637D1 (de) Monoazopigmente, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE3770287D1 (de) Neue n-glycosylamidderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
DE59607683D1 (de) Neue borneolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE3889043T2 (de) N-(substituiertes Alkyliden)-1,2,3,4-tetrahydro-9-acridinamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
ATE113598T1 (de) Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE59507531D1 (de) Cyclohexanon-derivate, verfahren zu deren herstellung und zwischenprodukte des verfahrens
DE59206026D1 (de) In 4-Stellung substituierte Derivate von 2,2-Dihalogenbenzo(1,3)dioxolen, Verfahren zu ihrer Herstellung und ihre Verwendung
TR199801683A2 (xx) Yeni �re t�revleri.
DE69112987D1 (de) Polyhalogenphthalocyanine, Verfahren zu ihrer Herstellung und ihre Verwendung.
ATE42284T1 (de) Unsymmetrische dihydro-dithiazine, verfahren zu ihrer herstellung und ihre verwendung als riech- und geschmacksstoffe.
NZ330138A (en) Phenanthridine derivatives, methods of producing them and medicaments containing phenanthridine derivatives
DE68907857T2 (de) Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
ATE36855T1 (de) 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ROTTAPHARM S.P.A., MILANO, IT

8339 Ceased/non-payment of the annual fee