DE3889043T2 - N-(substituiertes Alkyliden)-1,2,3,4-tetrahydro-9-acridinamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. - Google Patents

N-(substituiertes Alkyliden)-1,2,3,4-tetrahydro-9-acridinamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.

Info

Publication number
DE3889043T2
DE3889043T2 DE3889043T DE3889043T DE3889043T2 DE 3889043 T2 DE3889043 T2 DE 3889043T2 DE 3889043 T DE3889043 T DE 3889043T DE 3889043 T DE3889043 T DE 3889043T DE 3889043 T2 DE3889043 T2 DE 3889043T2
Authority
DE
Germany
Prior art keywords
acridinamines
medicaments
tetrahydro
preparation
substituted alkylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3889043T
Other languages
English (en)
Other versions
DE3889043D1 (de
Inventor
Gregory Michael Shutske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3889043D1 publication Critical patent/DE3889043D1/de
Publication of DE3889043T2 publication Critical patent/DE3889043T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3889043T 1987-09-08 1988-09-01 N-(substituiertes Alkyliden)-1,2,3,4-tetrahydro-9-acridinamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. Expired - Fee Related DE3889043T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9393587A 1987-09-08 1987-09-08
US07/223,846 US5013741A (en) 1987-09-08 1988-07-25 N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal

Publications (2)

Publication Number Publication Date
DE3889043D1 DE3889043D1 (de) 1994-05-19
DE3889043T2 true DE3889043T2 (de) 1994-10-06

Family

ID=26788073

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3889043T Expired - Fee Related DE3889043T2 (de) 1987-09-08 1988-09-01 N-(substituiertes Alkyliden)-1,2,3,4-tetrahydro-9-acridinamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.

Country Status (16)

Country Link
US (1) US5013741A (de)
EP (1) EP0306825B1 (de)
JP (1) JP2641915B2 (de)
KR (1) KR890005058A (de)
AU (1) AU620043B2 (de)
CA (1) CA1334669C (de)
DE (1) DE3889043T2 (de)
DK (1) DK167251B1 (de)
ES (1) ES2053652T3 (de)
FI (1) FI89478C (de)
HU (1) HU201017B (de)
IE (1) IE63027B1 (de)
IL (1) IL87679A0 (de)
NO (1) NO883986L (de)
NZ (1) NZ226054A (de)
PT (1) PT88444B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
AU621416B2 (en) * 1988-11-16 1992-03-12 Hoechst Marion Roussel, Inc. Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments
US5175172A (en) * 1988-12-19 1992-12-29 Francois Dietlin Method of alleviating AIDS symptoms and compositions therefor
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
US5149813A (en) * 1989-06-26 1992-09-22 Hoechst-Roussel Pharmaceuticals Incorporated Process for (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds
JPH09500645A (ja) * 1993-07-22 1997-01-21 ワーナー−ランバート・コンパニー 制御放出タクリン薬物送達システムおよびその製造方法
CN108047202B (zh) * 2017-12-20 2021-06-11 东南大学 一种铝离子响应型化合物及其制备方法与应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318895A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
BE658695A (de) * 1964-02-03 1965-07-22
US3541066A (en) * 1968-09-16 1970-11-17 American Home Prod 2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives
US3580915A (en) * 1968-09-16 1971-05-25 American Home Prod 1,2,3,4-tetrahydrobenzol(b)(1,6)naphthyridine derivatives
US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3637706A (en) * 1970-04-30 1972-01-25 American Home Prod 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants
US3647800A (en) * 1970-04-30 1972-03-07 American Home Prod 10-substituted - 1 2 3 4 - tetrahydrobenzo(b)(1 6)naphthyridines useful as cns depressants
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
US4108998A (en) * 1976-11-08 1978-08-22 American Home Products Corp. Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them
US4575553A (en) * 1984-06-18 1986-03-11 Bristol-Myers Company Antitumor m-AMSA analog
EP0179383B1 (de) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-Amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
DK569087A (da) * 1986-10-31 1988-05-01 Sumitomo Pharma Quinolin-derivater, deres fremstilling og anvendelse
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
US4851536A (en) * 1987-05-07 1989-07-25 American Home Products Corporation Cyclohexylquinolines as inhibitors of interleukin 1
WO1989002739A1 (en) * 1987-10-05 1989-04-06 Pfizer Inc. 4-aminopyridine derivatives
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US4985430A (en) * 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient

Also Published As

Publication number Publication date
CA1334669C (en) 1995-03-07
JP2641915B2 (ja) 1997-08-20
IL87679A0 (en) 1989-02-28
IE63027B1 (en) 1995-03-22
NZ226054A (en) 1991-08-27
FI884104A0 (fi) 1988-09-06
JPH01131160A (ja) 1989-05-24
DK497888D0 (da) 1988-09-07
US5013741A (en) 1991-05-07
ES2053652T3 (es) 1994-08-01
DK167251B1 (da) 1993-09-27
EP0306825A1 (de) 1989-03-15
AU2193688A (en) 1989-03-09
FI89478C (fi) 1993-10-11
DK497888A (da) 1989-03-09
IE882703L (en) 1989-03-08
FI884104A (fi) 1989-03-09
NO883986D0 (no) 1988-09-07
HUT49332A (en) 1989-09-28
PT88444B (pt) 1992-10-30
HU201017B (en) 1990-09-28
EP0306825B1 (de) 1994-04-13
NO883986L (no) 1989-03-09
KR890005058A (ko) 1989-05-11
FI89478B (fi) 1993-06-30
AU620043B2 (en) 1992-02-13
DE3889043D1 (de) 1994-05-19
PT88444A (pt) 1989-07-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee