DE69006682D1 - Neue Morpholinol-Verbindungen, deren Herstellung und Anwendung. - Google Patents

Neue Morpholinol-Verbindungen, deren Herstellung und Anwendung.

Info

Publication number
DE69006682D1
DE69006682D1 DE90311851T DE69006682T DE69006682D1 DE 69006682 D1 DE69006682 D1 DE 69006682D1 DE 90311851 T DE90311851 T DE 90311851T DE 69006682 T DE69006682 T DE 69006682T DE 69006682 D1 DE69006682 D1 DE 69006682D1
Authority
DE
Germany
Prior art keywords
compounds
morpholinol
new
production
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90311851T
Other languages
English (en)
Other versions
DE69006682T2 (de
Inventor
James Leroy Kelley
David Lee Musso
Grady Evan Boswell
Barrett Randolph Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE69006682D1 publication Critical patent/DE69006682D1/de
Publication of DE69006682T2 publication Critical patent/DE69006682T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69006682T 1989-10-31 1990-10-30 Neue Morpholinol-Verbindungen, deren Herstellung und Anwendung. Expired - Fee Related DE69006682T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898924528A GB8924528D0 (en) 1989-10-31 1989-10-31 Heterocyclic pharmaceutical compounds,preparation and use

Publications (2)

Publication Number Publication Date
DE69006682D1 true DE69006682D1 (de) 1994-03-24
DE69006682T2 DE69006682T2 (de) 1994-08-04

Family

ID=10665482

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69006682T Expired - Fee Related DE69006682T2 (de) 1989-10-31 1990-10-30 Neue Morpholinol-Verbindungen, deren Herstellung und Anwendung.

Country Status (19)

Country Link
US (1) US5104870A (de)
EP (1) EP0426416B1 (de)
JP (1) JP2873076B2 (de)
AT (1) ATE101604T1 (de)
AU (1) AU645763B2 (de)
CA (1) CA2028893C (de)
DE (1) DE69006682T2 (de)
DK (1) DK0426416T3 (de)
ES (1) ES2062406T3 (de)
FI (1) FI94753C (de)
GB (1) GB8924528D0 (de)
HU (2) HU207304B (de)
IE (1) IE66115B1 (de)
LV (1) LV11030B (de)
MX (1) MX9203219A (de)
NZ (1) NZ235882A (de)
PT (1) PT95735B (de)
SG (1) SG28347G (de)
ZA (1) ZA908696B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
WO1999025355A1 (en) * 1997-11-14 1999-05-27 Glaxo Group Ltd. Method of treating addiction to nicotine products
MA26693A1 (fr) * 1998-09-28 2004-12-20 Glaxo Group Ltd Compositions pour administration par voie buccale
EP1220673A2 (de) * 1999-10-13 2002-07-10 Glaxo Group Limited Morpholinol-verbindungen zur behandlung von fettleibigkeit
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
EP1968603A4 (de) * 2006-01-03 2013-01-16 Algebra Inc Therapeutische aminarylsulfonamidkonjugatverbindungen
EP2419400A1 (de) 2009-04-15 2012-02-22 Research Triangle Institute Monoaminwiederaufnahmehemmer
WO2011146821A2 (en) * 2010-05-21 2011-11-24 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
ES2687095T3 (es) 2010-05-21 2018-10-23 Research Triangle Institute Fenilimorfolinas y análogos de las mismas
CN105949142B (zh) * 2016-05-21 2018-03-27 南华大学 具有抗抑郁活性的单一手性化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117967A (en) * 1962-04-02 1964-01-14 Smith Kline French Lab 2-biphenylyl-2-hydroxy-morpholinium halides
FR2553413B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8417170D0 (en) * 1984-07-05 1984-08-08 Wellcome Found Heterocyclic pharmaceutical compounds

Also Published As

Publication number Publication date
ES2062406T3 (es) 1994-12-16
IE903888A1 (en) 1991-05-08
IE66115B1 (en) 1995-12-13
JPH03206084A (ja) 1991-09-09
HUT57748A (en) 1991-12-30
PT95735A (pt) 1991-09-13
AU6563990A (en) 1991-05-09
HU207304B (en) 1993-03-29
DK0426416T3 (da) 1994-03-14
FI905356A0 (fi) 1990-10-30
CA2028893A1 (en) 1991-05-01
HU906935D0 (en) 1991-05-28
DE69006682T2 (de) 1994-08-04
LV11030B (en) 1996-08-20
PT95735B (pt) 1998-01-30
MX9203219A (es) 1992-07-01
NZ235882A (en) 1993-05-26
AU645763B2 (en) 1994-01-27
ATE101604T1 (de) 1994-03-15
FI94753B (fi) 1995-07-14
EP0426416B1 (de) 1994-02-16
US5104870A (en) 1992-04-14
EP0426416A1 (de) 1991-05-08
JP2873076B2 (ja) 1999-03-24
HU211304A9 (en) 1995-11-28
ZA908696B (en) 1992-07-29
FI94753C (fi) 1995-10-25
CA2028893C (en) 2000-10-10
SG28347G (en) 1995-09-18
GB8924528D0 (en) 1989-12-20
LV11030A (lv) 1996-02-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee