ATE61568T1 - Chinonamide, deren herstellung und anwendung. - Google Patents
Chinonamide, deren herstellung und anwendung.Info
- Publication number
- ATE61568T1 ATE61568T1 AT87300580T AT87300580T ATE61568T1 AT E61568 T1 ATE61568 T1 AT E61568T1 AT 87300580 T AT87300580 T AT 87300580T AT 87300580 T AT87300580 T AT 87300580T AT E61568 T1 ATE61568 T1 AT E61568T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- inhibitory activity
- production inhibitory
- ameliorating
- compounds
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 108010003541 Platelet Activating Factor Proteins 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 230000007885 bronchoconstriction Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 abstract 1
- -1 lipid peroxides Chemical class 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 150000002926 oxygen Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 230000002000 scavenging effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1618286 | 1986-01-28 | ||
| EP87300580A EP0232089B1 (de) | 1986-01-28 | 1987-01-23 | Chinonamide, deren Herstellung und Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE61568T1 true ATE61568T1 (de) | 1991-03-15 |
Family
ID=11909371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87300580T ATE61568T1 (de) | 1986-01-28 | 1987-01-23 | Chinonamide, deren herstellung und anwendung. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0232089B1 (de) |
| JP (1) | JPH07116117B2 (de) |
| KR (1) | KR870007102A (de) |
| AT (1) | ATE61568T1 (de) |
| CA (1) | CA1307259C (de) |
| DE (1) | DE3768516D1 (de) |
| ES (1) | ES2037077T3 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3869692D1 (de) * | 1987-07-29 | 1992-05-07 | Takeda Chemical Industries Ltd | Zellproliferationsinhibitor. |
| US5272180A (en) * | 1987-07-29 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Cell proliferation inhibitor |
| US5189038A (en) * | 1990-09-07 | 1993-02-23 | G. D. Searle And Co. | Method of stimulating superoxide generation |
| US5082854A (en) * | 1990-09-07 | 1992-01-21 | G. D. Searle & Co. | Method of stimulating superoxide generation |
| DK0645137T3 (da) * | 1993-09-21 | 1999-04-26 | Takeda Chemical Industries Ltd | Anvendelse af quinoner til fremstilling af et lægemiddel til behandling og forebyggelse af allergisk rhinitis |
| CA2166017A1 (en) * | 1994-12-26 | 1996-06-27 | Yasuko Ashida | Pharmaceutical composition for the dermatitis |
| CN100999452B (zh) * | 2007-01-08 | 2010-06-02 | 重庆大学 | 一种合成赛曲司特的方法 |
| WO2014170264A1 (en) * | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds for ophthalmic use |
| CN104497085B (zh) * | 2015-01-16 | 2017-05-24 | 华东理工大学 | 腺苷衍生物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5640651A (en) * | 1979-09-12 | 1981-04-16 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
| JPS58177934A (ja) * | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
| MX9203040A (es) * | 1984-08-01 | 1992-07-31 | Takeda Chemical Industries Ltd | Derivados de quinona y composicion farmaceutica que los contiene. |
-
1987
- 1987-01-23 DE DE8787300580T patent/DE3768516D1/de not_active Expired - Fee Related
- 1987-01-23 EP EP87300580A patent/EP0232089B1/de not_active Expired - Lifetime
- 1987-01-23 AT AT87300580T patent/ATE61568T1/de not_active IP Right Cessation
- 1987-01-23 ES ES198787300580T patent/ES2037077T3/es not_active Expired - Lifetime
- 1987-01-27 CA CA000528211A patent/CA1307259C/en not_active Expired - Lifetime
- 1987-01-28 KR KR870000701A patent/KR870007102A/ko not_active Withdrawn
- 1987-01-28 JP JP62019366A patent/JPH07116117B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3768516D1 (de) | 1991-04-18 |
| JPS62246545A (ja) | 1987-10-27 |
| KR870007102A (ko) | 1987-08-14 |
| EP0232089B1 (de) | 1991-03-13 |
| CA1307259C (en) | 1992-09-08 |
| ES2037077T3 (es) | 1993-06-16 |
| EP0232089A3 (en) | 1988-01-27 |
| JPH07116117B2 (ja) | 1995-12-13 |
| EP0232089A2 (de) | 1987-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |