DE3768516D1 - Chinonamide, deren herstellung und anwendung. - Google Patents

Chinonamide, deren herstellung und anwendung.

Info

Publication number
DE3768516D1
DE3768516D1 DE8787300580T DE3768516T DE3768516D1 DE 3768516 D1 DE3768516 D1 DE 3768516D1 DE 8787300580 T DE8787300580 T DE 8787300580T DE 3768516 T DE3768516 T DE 3768516T DE 3768516 D1 DE3768516 D1 DE 3768516D1
Authority
DE
Germany
Prior art keywords
optionally substituted
inhibitory activity
production inhibitory
ameliorating
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787300580T
Other languages
English (en)
Inventor
Shinji Terao
Yoshitaka Maki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3768516D1 publication Critical patent/DE3768516D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE8787300580T 1986-01-28 1987-01-23 Chinonamide, deren herstellung und anwendung. Expired - Fee Related DE3768516D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1618286 1986-01-28

Publications (1)

Publication Number Publication Date
DE3768516D1 true DE3768516D1 (de) 1991-04-18

Family

ID=11909371

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787300580T Expired - Fee Related DE3768516D1 (de) 1986-01-28 1987-01-23 Chinonamide, deren herstellung und anwendung.

Country Status (7)

Country Link
EP (1) EP0232089B1 (de)
JP (1) JPH07116117B2 (de)
KR (1) KR870007102A (de)
AT (1) ATE61568T1 (de)
CA (1) CA1307259C (de)
DE (1) DE3768516D1 (de)
ES (1) ES2037077T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272180A (en) * 1987-07-29 1993-12-21 Takeda Chemical Industries, Ltd. Cell proliferation inhibitor
ATE74269T1 (de) * 1987-07-29 1992-04-15 Takeda Chemical Industries Ltd Zellproliferationsinhibitor.
US5189038A (en) * 1990-09-07 1993-02-23 G. D. Searle And Co. Method of stimulating superoxide generation
US5082854A (en) * 1990-09-07 1992-01-21 G. D. Searle & Co. Method of stimulating superoxide generation
EP0645137B1 (de) * 1993-09-21 1998-07-22 Takeda Chemical Industries, Ltd. Verwendung von Chinonen zur Herstellung eines Arzneimittels zur Vorbeugung und Behandlung von allergischer Rhinitis
CA2166017A1 (en) * 1994-12-26 1996-06-27 Yasuko Ashida Pharmaceutical composition for the dermatitis
CN100999452B (zh) * 2007-01-08 2010-06-02 重庆大学 一种合成赛曲司特的方法
ES2624446T3 (es) * 2013-04-18 2017-07-14 Nicox Science Ireland Compuestos donantes de óxido nítrico a base de quinona para uso oftalmológico
CN104497085B (zh) * 2015-01-16 2017-05-24 华东理工大学 腺苷衍生物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640651A (en) * 1979-09-12 1981-04-16 Takeda Chem Ind Ltd Quinone compound and its preparation
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
MX9203040A (es) * 1984-08-01 1992-07-31 Takeda Chemical Industries Ltd Derivados de quinona y composicion farmaceutica que los contiene.

Also Published As

Publication number Publication date
CA1307259C (en) 1992-09-08
ATE61568T1 (de) 1991-03-15
EP0232089B1 (de) 1991-03-13
JPH07116117B2 (ja) 1995-12-13
JPS62246545A (ja) 1987-10-27
EP0232089A3 (en) 1988-01-27
KR870007102A (ko) 1987-08-14
ES2037077T3 (es) 1993-06-16
EP0232089A2 (de) 1987-08-12

Similar Documents

Publication Publication Date Title
SE8804036L (sv) Ny anvaendning av 11,28-dioxa-4-azatricklo (22.3.1.04.9)-oktakos-18-en-derivat och farmaceutiska kompositioner innehaallande desamma
LU90949I2 (fr) Esters aminoalcohol d'acide thienylcarboxyliques leurs produits quaternaires leur préparation et l'utilisation de ces composés
NO178923C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 24-homo-vitamin-D-derivater
FR2354091A1 (fr) Utilisation d'esters aliphatiques d'acide 2-methyl-2-alkylalcanoiques comme matieres aromatiques et compositions de parfums en contenant
DE3777544D1 (de) Glutaminsaeure-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische formulierungen.
DE3768516D1 (de) Chinonamide, deren herstellung und anwendung.
TNSN87012A1 (fr) Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
DE3873578D1 (de) Verwendung von tetrahydrobenz(c,d)indol-6-carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
WO1994014833A3 (en) Substituted 6-azaandrostenones
ES2062406T3 (es) Nuevos compuestos de morfolinol, su preparacion y uso.
KR880007070A (ko) 백내장 치료용 약학 조성물
DE3786865D1 (de) Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate.
FR2378741A1 (fr) Acides garyl goxo isovaleriques doues de proprietes antiphlogistiques et antalgiques
HUT41025A (en) Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients
FR2416885A1 (fr) Nouveaux derives d'acides gras a longue chaine, leur preparation et leur application comme medicaments
IT1223395B (it) Composti ad attivita' cardiovascolare
ATE64921T1 (de) Benzochinonderivate, ihre herstellung und verwendung.
ATE173921T1 (de) Verwendung von deoxyspergualin zur herstellung eines arzneimittels zur behandlung von entzündlich-hyperreaktiven erkrankungen
DE3464330D1 (en) Medicaments containing valepotriathydrines
FR2386540A1 (fr) Derives d'acides furoyl- ou thenoyl- naphtyloxyalkylcarboxyliques, leur preparation et leur utilisation comme medicaments
ES2083961T3 (es) Acidos 3-anilino-2-hidroxicarbonil-4-tiofenoaceticos.
ATE144257T1 (de) Tetrahydro-4-phenylimino-3-thiophenessigsäuren
DE3784883D1 (de) Fluor enthaltende makrolid-verbindungen, pharmazeutische zusammensetzungen, welche diese enthalten und ihre verwendung fuer die herstellung von arzneimitteln.
ATE32514T1 (de) 3-(4'-aminobutylamino)-propylamino-bleomycinderivate, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3685744T2 (de) Fraktion von listeria monocytogenes mit therapeutischer wirkung, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee