DE68928934D1 - Verfahren zur herstellung von menschlicher dnase - Google Patents
Verfahren zur herstellung von menschlicher dnaseInfo
- Publication number
- DE68928934D1 DE68928934D1 DE68928934T DE68928934T DE68928934D1 DE 68928934 D1 DE68928934 D1 DE 68928934D1 DE 68928934 T DE68928934 T DE 68928934T DE 68928934 T DE68928934 T DE 68928934T DE 68928934 D1 DE68928934 D1 DE 68928934D1
- Authority
- DE
- Germany
- Prior art keywords
- human dnase
- producing human
- dna
- dnase
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28995888A | 1988-12-23 | 1988-12-23 | |
US44803889A | 1989-12-08 | 1989-12-08 | |
PCT/US1989/005744 WO1990007572A1 (en) | 1988-12-23 | 1989-12-20 | HUMAN DNase |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68928934D1 true DE68928934D1 (de) | 1999-04-01 |
DE68928934T2 DE68928934T2 (de) | 1999-08-05 |
Family
ID=26965935
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929551T Expired - Lifetime DE68929551T2 (de) | 1988-12-23 | 1989-12-20 | Menschliche DNase |
DE68928934T Revoked DE68928934T2 (de) | 1988-12-23 | 1989-12-20 | Verfahren zur herstellung von menschlicher dnase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929551T Expired - Lifetime DE68929551T2 (de) | 1988-12-23 | 1989-12-20 | Menschliche DNase |
Country Status (11)
Country | Link |
---|---|
US (3) | US20030044403A1 (de) |
EP (2) | EP0449968B1 (de) |
JP (2) | JP3162372B2 (de) |
AT (2) | ATE176924T1 (de) |
AU (1) | AU630658B2 (de) |
BG (1) | BG62870B2 (de) |
CA (1) | CA2006473C (de) |
DE (2) | DE68929551T2 (de) |
ES (1) | ES2130120T3 (de) |
HU (1) | HU211232A9 (de) |
WO (1) | WO1990007572A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE176924T1 (de) * | 1988-12-23 | 1999-03-15 | Genentech Inc | Verfahren zur herstellung von menschlicher dnase |
US5279823A (en) * | 1992-06-08 | 1994-01-18 | Genentech, Inc. | Purified forms of DNASE |
JP3009224B2 (ja) | 1994-03-04 | 2000-02-14 | ジェネンテック インコーポレイテッド | 改良されたdnアーゼ液体溶液 |
ATE268605T1 (de) * | 1994-03-04 | 2004-06-15 | Genentech Inc | Pharmazeutische akzeptabel dnase zusammensetzung |
US5830744A (en) * | 1995-06-06 | 1998-11-03 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
JPH09512715A (ja) * | 1994-05-05 | 1997-12-22 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | ヒトdnase |
US6251648B1 (en) | 1998-04-03 | 2001-06-26 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
WO1996007735A1 (fr) * | 1994-09-06 | 1996-03-14 | Seiichi Tanuma | Nouvelle desoxyribonuclease |
US6348343B2 (en) | 1995-02-24 | 2002-02-19 | Genentech, Inc. | Human DNase I variants |
ATE230027T1 (de) * | 1995-02-24 | 2003-01-15 | Genentech Inc | Menschliche dnase i varianten |
SK284191B6 (sk) * | 1995-02-24 | 2004-10-05 | Genentech, Inc. | Aktín-rezistentný variant humánnej DNázy I |
DE19521046C1 (de) * | 1995-06-09 | 1996-08-08 | Deutsches Krebsforsch | Protein mit DNase-Aktivität |
PT854927E (pt) * | 1995-10-10 | 2008-09-08 | Genentech Inc | Variantes da adnase i humana |
US6482626B2 (en) * | 1996-02-05 | 2002-11-19 | Genentech, Inc. | Human DNase |
NZ331063A (en) * | 1996-02-05 | 2000-03-27 | Inc Genentech | Isolated nucleotide sequences encoding for mature LS- DNase which is resistant to actin inhibition |
US6265195B1 (en) * | 1996-04-25 | 2001-07-24 | Genentech, Inc. | Human DNase II |
US6391607B1 (en) | 1996-06-14 | 2002-05-21 | Genentech, Inc. | Human DNase I hyperactive variants |
DE60035851D1 (de) | 1999-08-17 | 2007-09-20 | Tanuma | Deoxyribonuklease, dafür kodierendes gen und verfahren |
US7297511B2 (en) | 2001-10-10 | 2007-11-20 | Neose Technologies, Inc. | Interferon alpha: remodeling and glycoconjugation of interferon alpha |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
IL161251A0 (en) | 2001-10-10 | 2004-09-27 | Neose Technologies Inc | Remodeling and glycoconjugation of peptides |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
US7226903B2 (en) | 2001-10-10 | 2007-06-05 | Neose Technologies, Inc. | Interferon beta: remodeling and glycoconjugation of interferon beta |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7265085B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
US7179617B2 (en) | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7399613B2 (en) | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
US7473680B2 (en) | 2001-11-28 | 2009-01-06 | Neose Technologies, Inc. | Remodeling and glycoconjugation of peptides |
DE60335602D1 (de) | 2002-12-18 | 2011-02-17 | Roche Diagnostics Gmbh | Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität |
EP1433842B1 (de) | 2002-12-18 | 2011-01-05 | Roche Diagnostics GmbH | Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität |
BRPI0408358A (pt) | 2003-03-14 | 2006-03-21 | Neose Technologies Inc | polìmeros hidrossolúveis ramificados e seus conjugados |
DK1615689T3 (da) | 2003-04-09 | 2016-03-14 | Novartis Ag | Apparatur til dannelse af en aerosol og omfattende en opretningsføring til punktering af en kapsel |
WO2004091499A2 (en) | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
US8710012B2 (en) | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
US8431123B2 (en) * | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
EP1694347B1 (de) | 2003-11-24 | 2013-11-20 | BioGeneriX AG | Glycopegyliertes Erythropoetin |
CN101072789B (zh) | 2004-01-08 | 2013-05-15 | 生物种属学股份公司 | 肽的o-连接的糖基化 |
CA2565414A1 (en) | 2004-05-04 | 2005-11-24 | Novo Nordisk Health Care Ag | O-linked glycoforms of polypeptides and method to manufacture them |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化 |
EP1858543B1 (de) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylierten Granulocyten-Kolonie-stimulierender Faktor |
EP2386571B1 (de) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons |
US8916151B2 (en) * | 2005-04-25 | 2014-12-23 | Cls Therapeutics Limited | Method for treating a reduction of fertility |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
JP2010505874A (ja) | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー/エス | ポリペプチドコンジュゲートの精製方法 |
WO2008047364A2 (en) * | 2006-10-18 | 2008-04-24 | Periness Ltd. | Method and pharmacological composition for the diagnosis and treatment of male sub-fertility |
PL2095825T3 (pl) * | 2006-11-28 | 2011-12-30 | Cls Therapeutics Ltd | Sposób leczenia ludzkich chorób związanych ze zwiększoną zawartością kwasu deoksyrybonukleinowego w przestrzeniach pozakomórkowych i tkankach i preparat leczniczy do przeprowadzenia tego sposobu |
KR20150064246A (ko) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | 글리코페길화 g―csf를 이용하는 치료 방법 |
CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
US9198957B2 (en) * | 2011-01-31 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Treatment and prevention of bacterial vaginosis and Gardnerella vaginalis infections |
US20150010527A1 (en) | 2012-02-01 | 2015-01-08 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
WO2014160284A1 (en) * | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of stroke |
WO2014160243A1 (en) | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | Purification and purity assessment of rna molecules synthesized with modified nucleosides |
WO2015066557A1 (en) * | 2013-10-31 | 2015-05-07 | Resolve Therapeutics, Llc | Therapeutic nuclease molecules with altered glycosylation and methods |
US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
WO2016067944A1 (ja) * | 2014-10-31 | 2016-05-06 | Jcrファーマ株式会社 | 組換えヒトDNaseIの製造方法 |
RU2017125957A (ru) * | 2015-01-04 | 2019-02-04 | Проталикс Лтд. | Модифицированная днказа и ее применения |
CA2974369A1 (en) | 2015-01-20 | 2016-07-28 | The Children's Medical Center Corporation | Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing |
RU2726131C2 (ru) | 2015-05-22 | 2020-07-09 | Дмитрий Дмитриевич Генкин | Внеклеточная днк в качестве терапевтической мишени при нейродегенерации |
DE102015118011A1 (de) * | 2015-10-22 | 2017-04-27 | Human Med Ag | Vorrichtung zur Transplantation von Körperfett |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
JP7125392B2 (ja) | 2016-11-17 | 2022-08-24 | アイオバンス バイオセラピューティクス,インコーポレイテッド | レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法 |
EP3351263A1 (de) * | 2017-01-20 | 2018-07-25 | Universitätsklinikum Hamburg-Eppendorf | Pharmazeutische zusammensetzung zur behandlung oder prävention von gewebeadhäsion |
KR20200122320A (ko) * | 2018-01-16 | 2020-10-27 | 씨엘에스 테라퓨틱스 리미티드 | 데옥시리보뉴클레아제 (dnase) 활성을 갖는 효소의 간 발현에 의한 질환의 치료 |
WO2022074656A1 (en) | 2020-10-07 | 2022-04-14 | Protalix Ltd. | Long-acting dnase |
US11993792B2 (en) | 2021-05-27 | 2024-05-28 | New England Biolabs, Inc. | DNase I variants, compositions, methods, and kits |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2801956A (en) * | 1954-08-24 | 1957-08-06 | Merck & Co Inc | Process for preparing pancreatic desoxyribonuclease |
US2834710A (en) * | 1955-06-29 | 1958-05-13 | Merck & Co Inc | Pancreatic desoxyribonuclease penicillin composition and process of preparation |
US3208908A (en) * | 1961-11-16 | 1965-09-28 | Parke Davis & Co | Fibrinolysin-desoxyribonuclease for enzymatic debridement |
US3663690A (en) * | 1969-08-12 | 1972-05-16 | Hoechst Co American | Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith |
CA1059937A (en) * | 1975-03-25 | 1979-08-07 | Boen T. Khouw | Isolation and purification of deoxyribonuclease |
JPS55131389A (en) * | 1979-04-02 | 1980-10-13 | Amano Pharmaceut Co Ltd | Purification of deoxyribonuclease i |
ATE176924T1 (de) * | 1988-12-23 | 1999-03-15 | Genentech Inc | Verfahren zur herstellung von menschlicher dnase |
US5279823A (en) * | 1992-06-08 | 1994-01-18 | Genentech, Inc. | Purified forms of DNASE |
US6251648B1 (en) * | 1998-04-03 | 2001-06-26 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
US5830744A (en) * | 1995-06-06 | 1998-11-03 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
US6348343B2 (en) * | 1995-02-24 | 2002-02-19 | Genentech, Inc. | Human DNase I variants |
US6482626B2 (en) * | 1996-02-05 | 2002-11-19 | Genentech, Inc. | Human DNase |
-
1989
- 1989-12-20 AT AT90901443T patent/ATE176924T1/de not_active IP Right Cessation
- 1989-12-20 DE DE68929551T patent/DE68929551T2/de not_active Expired - Lifetime
- 1989-12-20 EP EP90901443A patent/EP0449968B1/de not_active Revoked
- 1989-12-20 AU AU48265/90A patent/AU630658B2/en not_active Expired
- 1989-12-20 WO PCT/US1989/005744 patent/WO1990007572A1/en not_active Application Discontinuation
- 1989-12-20 AT AT98105190T patent/ATE358176T1/de not_active IP Right Cessation
- 1989-12-20 ES ES90901443T patent/ES2130120T3/es not_active Expired - Lifetime
- 1989-12-20 DE DE68928934T patent/DE68928934T2/de not_active Revoked
- 1989-12-20 JP JP50190090A patent/JP3162372B2/ja not_active Expired - Lifetime
- 1989-12-20 EP EP98105190A patent/EP0853121B1/de not_active Expired - Lifetime
- 1989-12-21 CA CA002006473A patent/CA2006473C/en not_active Expired - Lifetime
-
1994
- 1994-02-28 BG BG098613A patent/BG62870B2/bg unknown
-
1995
- 1995-06-20 HU HU95P/P00277P patent/HU211232A9/hu unknown
-
2000
- 2000-10-11 JP JP2000310722A patent/JP2001157580A/ja active Pending
-
2001
- 2001-11-07 US US10/005,675 patent/US20030044403A1/en not_active Abandoned
-
2004
- 2004-05-04 US US10/839,046 patent/US7297526B2/en not_active Expired - Fee Related
-
2007
- 2007-09-27 US US11/862,934 patent/US20080026426A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HU211232A9 (en) | 1995-11-28 |
US20030044403A1 (en) | 2003-03-06 |
ATE176924T1 (de) | 1999-03-15 |
AU4826590A (en) | 1990-08-01 |
US20050009056A1 (en) | 2005-01-13 |
JP3162372B2 (ja) | 2001-04-25 |
CA2006473A1 (en) | 1990-06-23 |
AU630658B2 (en) | 1992-11-05 |
EP0853121A3 (de) | 1998-08-05 |
JPH04502406A (ja) | 1992-05-07 |
CA2006473C (en) | 2002-02-05 |
EP0853121A2 (de) | 1998-07-15 |
EP0853121B1 (de) | 2007-03-28 |
US20080026426A1 (en) | 2008-01-31 |
DE68929551T2 (de) | 2008-03-06 |
BG62870B2 (bg) | 2000-09-29 |
EP0449968A1 (de) | 1991-10-09 |
ATE358176T1 (de) | 2007-04-15 |
EP0449968B1 (de) | 1999-02-24 |
US7297526B2 (en) | 2007-11-20 |
WO1990007572A1 (en) | 1990-07-12 |
JP2001157580A (ja) | 2001-06-12 |
DE68929551D1 (de) | 2007-05-10 |
DE68928934T2 (de) | 1999-08-05 |
ES2130120T3 (es) | 1999-07-01 |
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8331 | Complete revocation |