DE68928492T2 - Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels - Google Patents

Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels

Info

Publication number
DE68928492T2
DE68928492T2 DE68928492T DE68928492T DE68928492T2 DE 68928492 T2 DE68928492 T2 DE 68928492T2 DE 68928492 T DE68928492 T DE 68928492T DE 68928492 T DE68928492 T DE 68928492T DE 68928492 T2 DE68928492 T2 DE 68928492T2
Authority
DE
Germany
Prior art keywords
amine
exposure
moiety
reducing agent
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68928492T
Other languages
English (en)
Other versions
DE68928492D1 (de
Inventor
Jonathan Leland
Michael Powell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
IGEN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN Inc filed Critical IGEN Inc
Application granted granted Critical
Publication of DE68928492D1 publication Critical patent/DE68928492D1/de
Publication of DE68928492T2 publication Critical patent/DE68928492T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Control Of El Displays (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE68928492T 1988-11-03 1989-10-31 Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels Expired - Lifetime DE68928492T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26691488A 1988-11-03 1988-11-03
PCT/US1989/004859 WO1990005296A1 (en) 1988-11-03 1989-10-31 Electrochemiluminescent reaction utilizing amine-derived reductant

Publications (2)

Publication Number Publication Date
DE68928492D1 DE68928492D1 (de) 1998-01-22
DE68928492T2 true DE68928492T2 (de) 1998-08-20

Family

ID=23016522

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928492T Expired - Lifetime DE68928492T2 (de) 1988-11-03 1989-10-31 Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels

Country Status (8)

Country Link
EP (1) EP0441894B1 (de)
JP (1) JPH076913B2 (de)
AT (1) ATE161096T1 (de)
AU (2) AU641374B2 (de)
CA (1) CA2002099C (de)
DE (1) DE68928492T2 (de)
HK (1) HK1006353A1 (de)
WO (1) WO1990005296A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702986B1 (en) * 1988-04-29 2004-03-09 Igen International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
CA2161666C (en) * 1993-05-03 1999-08-10 Ursula Giesen Electrochemiluminescence assay
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
CA2205050A1 (en) * 1995-09-12 1997-03-20 Yuzaburo Namba Method and apparatus for measuring electrochemiluminescent emission
US6146838A (en) * 1997-03-18 2000-11-14 Igen International, Inc. Detecting water-borne parasites using electrochemiluminescence
DE19811582A1 (de) 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
DE19828441A1 (de) 1998-06-25 1999-12-30 Roche Diagnostics Gmbh Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US7695919B2 (en) 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
CA2460114C (en) * 2001-09-10 2012-11-06 Meso Scale Technologies, Llc Assay buffer, compositions containing the same, and methods of using the same
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7749772B1 (en) 2006-06-29 2010-07-06 Varian, Inc. Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
EP2035831B1 (de) * 2006-06-30 2013-08-14 Applied Biosystems, LLC Verfahren zur analyse von verbindungsinteraktionen
US20080300796A1 (en) 2007-05-31 2008-12-04 Lassahn Gordon D Biological analysis methods, biological analysis devices, and articles of manufacture
US9410965B2 (en) 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
CN117491623A (zh) 2015-08-20 2024-02-02 豪夫迈·罗氏有限公司 使用聚乙二醇化分析物特异性结合剂的基于颗粒的免疫测定法
BR112018017336A2 (pt) 2016-03-07 2018-12-26 Hoffmann La Roche método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
CN110234995A (zh) 2017-02-02 2019-09-13 豪夫迈·罗氏有限公司 使用至少两种聚乙二醇化的分析物特异性结合试剂的免疫测定
WO2019201901A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Novel anti-thymidine kinase antibodies
WO2020043868A1 (en) 2018-08-31 2020-03-05 F. Hoffmann-La Roche Ag Thymidine kinase (tk-1) in prognostic indices for dlbcl
SG11202106924VA (en) 2019-01-03 2021-07-29 Meso Scale Technologies Llc Compositions and methods for carrying out assay measurements
KR20220024699A (ko) 2019-07-22 2022-03-03 에프. 호프만-라 로슈 아게 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a12
EP4004555A1 (de) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a6 als blutbiomarker zur nichtinvasiven diagnose von endometriose
JP7315780B2 (ja) 2019-07-22 2023-07-26 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスｐ
JP7291288B2 (ja) 2019-07-22 2023-06-14 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ９
WO2021013784A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021019732A1 (ja) 2019-07-31 2021-02-04 株式会社日立ハイテク 生体分子分析方法および生体分子分析装置
EP4058459A1 (de) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Derivatisierung von beta-lactam-antibiotika für massspec-messungen in patientenproben
US20230406909A1 (en) 2020-11-02 2023-12-21 Roche Diagnostics Operations, Inc. Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
EP4314838A1 (de) 2021-04-01 2024-02-07 F. Hoffmann-La Roche AG Psp94 als blutbiomarker zur nichtinvasiven diagnose von endometriose
EP4341700A1 (de) 2021-05-17 2024-03-27 F. Hoffmann-La Roche AG Sfrp4 als blutbiomarker zur nichtinvasiven diagnose von adenomyose
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
WO2024017982A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017983A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
WO2024017985A1 (en) 2022-07-22 2024-01-25 F. Hoffmann-La Roche Ag Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4853327A (en) * 1985-07-10 1989-08-01 Molecular Diagnostics, Inc. Enhanced phthalazinedione chemiluminescence
KR960016340B1 (ko) * 1986-04-30 1996-12-09 이겐 인코오포레이팃드 전기화학발광 분석법

Also Published As

Publication number Publication date
WO1990005296A1 (en) 1990-05-17
HK1006353A1 (en) 1999-02-19
AU4657289A (en) 1990-05-28
ATE161096T1 (de) 1997-12-15
EP0441894A4 (en) 1992-09-16
EP0441894B1 (de) 1997-12-10
JPH076913B2 (ja) 1995-01-30
CA2002099A1 (en) 1990-05-03
JPH04502964A (ja) 1992-05-28
DE68928492D1 (de) 1998-01-22
EP0441894A1 (de) 1991-08-21
CA2002099C (en) 2001-01-09
AU667594B2 (en) 1996-03-28
AU641374B2 (en) 1993-09-23
AU5269793A (en) 1994-03-10

Similar Documents

Publication Publication Date Title
ATE161096T1 (de) Elektrochemilumineszente reaktion unter verwendung eines von einem amin abgeleiteten reduktionsmittels
DE68928171D1 (de) Gesteigerte elektrochemilumineszenz
EP0064484A3 (en) Method for fluorescence spectroscopic determination of a biologically active substance
ATE274601T1 (de) Elektroerzeugte chemilumineszierende markierungsmittel zur analyse und/oder zur referenzbildung
ES2113547T3 (es) Matrices quimioluminiscentes fotoactivables.
MY103023A (en) Composition and method for rapid detection of microorganisms in clinical samples.
ES453442A1 (es) Procedimiento para preparar una tira de ensayo para sangre oculta en excreta o fluidos del cuerpo.
ES2086326T3 (es) Metodo para intensificar la quimiluminiscencia.
ATE22698T1 (de) Grundierungsmittel und seine verwendung.
TW354388B (en) Novel sulfonium salt and chemically amplified positive resist composition
GB1491560A (en) Reagent composition and method for determination of glycerol concentrations
ES2117132T3 (es) Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral.
SE8801011D0 (sv) Time-resolved electroluminescence in solution
ES2032380T3 (es) Un metodo para producir un material desodorizante.
PT83826B (pt) Processo para a preparacao dum reagente para a determinacao da actividade de peroxidase
CA2122707A1 (en) Light emitting method of acridinium derivative and method of detecting substance to be examined, using same
DE3868544D1 (de) Verwendung einer waessrigen zusammensetzung als rostinhibitor.
ATE46325T1 (de) Zink- und/oder bleisalze von carbonsaeuren und deren verwendung als korrosionsschutzmittel.
JPS6463954A (en) Photosensitive composition
ES8202011A1 (es) Un procedimiento para la preparacion de derivados de campto-tecina
KR890011818A (ko) 벤조산 유도체의 제조방법
KR870007913A (ko) 치환된 피리미딘 유도체의 제조방법
ATE136060T1 (de) Verwendung von superoxiddismutase in untersuchungsverfahren unter einbeziehung von einer oxidase
GB1501746A (en) Enzymatic ethanol assay
JPS57131061A (en) Test piece for detecting peroxiding substance

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: IGEN INTERNATIONAL,INC.(N.D.GES.D.STAATES DELAWARE

8327 Change in the person/name/address of the patent owner

Owner name: BIOVERIS CORP.(N.D.GES.D.STAATES DELAWARE), GAITHE