DE68921167T2 - Mutanten des transformierenden Affenwachstumsfaktors beta-1. - Google Patents

Mutanten des transformierenden Affenwachstumsfaktors beta-1.

Info

Publication number
DE68921167T2
DE68921167T2 DE68921167T DE68921167T DE68921167T2 DE 68921167 T2 DE68921167 T2 DE 68921167T2 DE 68921167 T DE68921167 T DE 68921167T DE 68921167 T DE68921167 T DE 68921167T DE 68921167 T2 DE68921167 T2 DE 68921167T2
Authority
DE
Germany
Prior art keywords
beta
tgf
cells
precursor
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68921167T
Other languages
English (en)
Other versions
DE68921167D1 (de
Inventor
Anthony F Purchio
Larry Gentry
Daniel Twardzik
Amy M Brunner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Application granted granted Critical
Publication of DE68921167D1 publication Critical patent/DE68921167D1/de
Publication of DE68921167T2 publication Critical patent/DE68921167T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
  • Control Of Eletrric Generators (AREA)
DE68921167T 1988-12-16 1989-11-28 Mutanten des transformierenden Affenwachstumsfaktors beta-1. Expired - Fee Related DE68921167T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28591788A 1988-12-16 1988-12-16
US35017189A 1989-04-17 1989-04-17
US35372889A 1989-05-17 1989-05-17

Publications (2)

Publication Number Publication Date
DE68921167D1 DE68921167D1 (de) 1995-03-23
DE68921167T2 true DE68921167T2 (de) 1995-06-01

Family

ID=27403570

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921167T Expired - Fee Related DE68921167T2 (de) 1988-12-16 1989-11-28 Mutanten des transformierenden Affenwachstumsfaktors beta-1.

Country Status (16)

Country Link
EP (1) EP0373994B1 (de)
JP (1) JPH03130089A (de)
KR (1) KR900009985A (de)
CN (1) CN1044125A (de)
AT (1) ATE118546T1 (de)
AU (1) AU638952B2 (de)
CA (1) CA2003886A1 (de)
DE (1) DE68921167T2 (de)
DK (1) DK638989A (de)
ES (1) ES2070924T3 (de)
FI (1) FI895730A0 (de)
IE (1) IE67811B1 (de)
IL (1) IL92489A0 (de)
NO (1) NO179676C (de)
NZ (1) NZ231581A (de)
PT (1) PT92454B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
US5304541A (en) * 1988-12-15 1994-04-19 Bristol-Myers Squibb Company Methods using novel chimeric transforming growth factor-β1/β2
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US7141392B2 (en) 2001-01-09 2006-11-28 Queen Mary And Westfield College Latent fusion protein
GB0100551D0 (en) * 2001-01-09 2001-02-21 Queen Mary & Westfield College Protein
EP1279740A1 (de) * 2001-07-26 2003-01-29 Vrije Universiteit Brussel Von Adeno-assoziertem Virus abstammender Vektor zur Gentherapy
WO2005068499A1 (en) * 2004-01-06 2005-07-28 The Government Of The United States As Representedby The Secretary, Department Of Health & Human Services Compositions and methods for the high efficiency expression of the transforming growth factor-beta supergene family
WO2012055541A1 (en) * 2010-10-25 2012-05-03 Bavarian Nordic A/S Tgf-beta in the development of conventional dendritic cells and uses thereof
CN104211778A (zh) * 2014-09-28 2014-12-17 苏州普罗达生物科技有限公司 一种转化生长因子β1激动剂多肽及其制备方法、应用
CN104311631A (zh) * 2014-09-28 2015-01-28 苏州普罗达生物科技有限公司 转化生长因子β1激动剂多肽及其制备方法、应用
RU2652312C2 (ru) * 2016-01-20 2018-04-25 Селл энд Джин Терапи Лтд Линейка биологически активных генно-терапевтических субстанций на основе гена tgfb1 для коррекции патологических состояний клеток органов и тканей и органов и тканей человека, способ получения и использования

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
CA2005120A1 (en) * 1988-12-15 1990-06-15 Anthony F. Purchio Tgf-beta 1/beta 2: a novel chimeric transforming growth factor-beta
FI901920A0 (fi) * 1989-04-20 1990-04-17 Lubrizol Corp Foerfaranden foer minskning av friktionen mellan i foerhaollande till varandra glidande komponenter genom anvaendning av metallkarboxylater.

Also Published As

Publication number Publication date
NO894759L (no) 1990-06-18
DK638989D0 (da) 1989-12-15
IL92489A0 (en) 1990-08-31
NO894759D0 (no) 1989-11-29
CN1044125A (zh) 1990-07-25
EP0373994B1 (de) 1995-02-15
IE67811B1 (en) 1996-05-01
NO179676B (no) 1996-08-19
CA2003886A1 (en) 1990-06-16
ES2070924T3 (es) 1995-06-16
KR900009985A (ko) 1990-07-06
DK638989A (da) 1990-06-17
AU638952B2 (en) 1993-07-15
PT92454A (pt) 1990-06-29
PT92454B (pt) 1995-07-18
IE893779L (en) 1990-06-16
EP0373994A1 (de) 1990-06-20
NO179676C (no) 1996-11-27
ATE118546T1 (de) 1995-03-15
JPH03130089A (ja) 1991-06-03
DE68921167D1 (de) 1995-03-23
FI895730A0 (fi) 1989-11-29
AU4588289A (en) 1990-06-21
NZ231581A (en) 1993-01-27

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee