DE68901944T2 - Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. - Google Patents
Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.Info
- Publication number
- DE68901944T2 DE68901944T2 DE8989401076T DE68901944T DE68901944T2 DE 68901944 T2 DE68901944 T2 DE 68901944T2 DE 8989401076 T DE8989401076 T DE 8989401076T DE 68901944 T DE68901944 T DE 68901944T DE 68901944 T2 DE68901944 T2 DE 68901944T2
- Authority
- DE
- Germany
- Prior art keywords
- haemoglobin
- sites
- polymer
- hand
- carried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8805240A FR2630329B1 (fr) | 1988-04-20 | 1988-04-20 | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68901944D1 DE68901944D1 (de) | 1992-08-06 |
DE68901944T2 true DE68901944T2 (de) | 1992-12-10 |
Family
ID=9365495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8989401076T Expired - Fee Related DE68901944T2 (de) | 1988-04-20 | 1989-04-18 | Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5110909A (de) |
EP (1) | EP0338916B1 (de) |
JP (1) | JPH0242023A (de) |
AT (1) | ATE77753T1 (de) |
DE (1) | DE68901944T2 (de) |
ES (1) | ES2043054T3 (de) |
FR (1) | FR2630329B1 (de) |
GR (1) | GR3005220T3 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
FR2680369B1 (fr) * | 1991-08-14 | 1993-11-05 | Pasteur Merieux Serums Vaccins | Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits. |
JPH10501823A (ja) * | 1995-04-10 | 1998-02-17 | バクスター、インターナショナル、インコーポレイテッド | クモ膜下出血の治療における架橋ヘモグロビンの使用 |
US5928916A (en) * | 1996-04-25 | 1999-07-27 | Medtronic, Inc. | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces |
DE19628705A1 (de) * | 1996-07-08 | 1998-01-15 | Fresenius Ag | Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe |
US6018035A (en) * | 1997-07-21 | 2000-01-25 | Baxter International Inc. | Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate |
US5981710A (en) * | 1997-07-21 | 1999-11-09 | Baxter International, Inc. | Therapeutic hemoglobin composition having isotropically increased size |
AU9597198A (en) * | 1997-10-03 | 1999-04-27 | Galenica Pharmaceuticals, Inc. | Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants |
CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
AU760669B2 (en) | 1998-04-28 | 2003-05-22 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
EP1223942A2 (de) * | 1999-08-25 | 2002-07-24 | GMP Companies, Inc. | Mittel zur verstärkten sauerstoffzufuhr bei säugern |
CA2319966A1 (en) * | 2000-09-19 | 2002-03-19 | Dextro-Sang Corporation | Improved dextran-hemoglobin conjugate as potential blood substitute |
DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
JP2006516534A (ja) | 2002-09-11 | 2006-07-06 | フレセニウス・カビ・ドイッチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Has化ポリペプチド、特にhas化エリスロポエチン |
AU2003273413A1 (en) | 2002-10-08 | 2004-05-04 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US20080274948A1 (en) * | 2003-08-08 | 2008-11-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of Hydroxyalkyl Starch and G-Csf |
KR100580642B1 (ko) * | 2004-01-12 | 2006-05-16 | 삼성전자주식회사 | 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이 |
EP2336192A1 (de) | 2004-03-11 | 2011-06-22 | Fresenius Kabi Deutschland GmbH | Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt. |
EP2279752A3 (de) * | 2004-03-11 | 2011-08-24 | Fresenius Kabi Deutschland GmbH | Konjugate von hydroxyalkylstärke und einem protein hergestellt durch native chemische ligation |
US7678888B2 (en) * | 2004-04-21 | 2010-03-16 | Albert Einstein College Of Medicine Of Yeshiva University | Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof |
WO2006094810A2 (en) * | 2005-03-11 | 2006-09-14 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch |
EP1762250A1 (de) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen |
EP2070950A1 (de) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkylstärkederivate und deren Herstellungsverfahren |
EP2070951A1 (de) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1055932A (en) * | 1975-10-22 | 1979-06-05 | Hematech Inc. | Blood substitute based on hemoglobin |
FR2551660B1 (fr) * | 1983-09-13 | 1986-11-14 | Centre Nat Rech Scient | Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation |
GB8328917D0 (en) * | 1983-10-28 | 1983-11-30 | Fisons Plc | Blood substitute |
DE3501349A1 (de) * | 1985-01-17 | 1986-07-17 | Battelle-Institut E.V., 6000 Frankfurt | Blutersatz |
FR2600894B1 (fr) * | 1986-07-02 | 1989-01-13 | Centre Nat Rech Scient | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
-
1988
- 1988-04-20 FR FR8805240A patent/FR2630329B1/fr not_active Expired - Lifetime
-
1989
- 1989-04-18 ES ES89401076T patent/ES2043054T3/es not_active Expired - Lifetime
- 1989-04-18 EP EP89401076A patent/EP0338916B1/de not_active Expired - Lifetime
- 1989-04-18 DE DE8989401076T patent/DE68901944T2/de not_active Expired - Fee Related
- 1989-04-18 AT AT89401076T patent/ATE77753T1/de not_active IP Right Cessation
- 1989-04-20 US US07/340,826 patent/US5110909A/en not_active Expired - Fee Related
- 1989-04-20 JP JP1099007A patent/JPH0242023A/ja active Pending
-
1992
- 1992-07-16 GR GR920401548T patent/GR3005220T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE77753T1 (de) | 1992-07-15 |
DE68901944D1 (de) | 1992-08-06 |
ES2043054T3 (es) | 1993-12-16 |
FR2630329A1 (fr) | 1989-10-27 |
EP0338916A1 (de) | 1989-10-25 |
FR2630329B1 (fr) | 1991-07-05 |
GR3005220T3 (de) | 1993-05-24 |
JPH0242023A (ja) | 1990-02-13 |
US5110909A (en) | 1992-05-05 |
EP0338916B1 (de) | 1992-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |