DE68901944D1 - Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. - Google Patents

Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.

Info

Publication number
DE68901944D1
DE68901944D1 DE8989401076T DE68901944T DE68901944D1 DE 68901944 D1 DE68901944 D1 DE 68901944D1 DE 8989401076 T DE8989401076 T DE 8989401076T DE 68901944 T DE68901944 T DE 68901944T DE 68901944 D1 DE68901944 D1 DE 68901944D1
Authority
DE
Germany
Prior art keywords
haemoglobin
sites
polymer
hand
carried
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989401076T
Other languages
English (en)
Other versions
DE68901944T2 (de
Inventor
Edith Dellacherie
Michele Leonard
Daniel Sacco
Claude Vigneron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Publication of DE68901944D1 publication Critical patent/DE68901944D1/de
Application granted granted Critical
Publication of DE68901944T2 publication Critical patent/DE68901944T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6445—Haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)
DE8989401076T 1988-04-20 1989-04-18 Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen. Expired - Lifetime DE68901944T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8805240A FR2630329B1 (fr) 1988-04-20 1988-04-20 Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications

Publications (2)

Publication Number Publication Date
DE68901944D1 true DE68901944D1 (de) 1992-08-06
DE68901944T2 DE68901944T2 (de) 1992-12-10

Family

ID=9365495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989401076T Expired - Lifetime DE68901944T2 (de) 1988-04-20 1989-04-18 Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.

Country Status (8)

Country Link
US (1) US5110909A (de)
EP (1) EP0338916B1 (de)
JP (1) JPH0242023A (de)
AT (1) ATE77753T1 (de)
DE (1) DE68901944T2 (de)
ES (1) ES2043054T3 (de)
FR (1) FR2630329B1 (de)
GR (1) GR3005220T3 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
FR2680369B1 (fr) * 1991-08-14 1993-11-05 Pasteur Merieux Serums Vaccins Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
JPH10501823A (ja) * 1995-04-10 1998-02-17 バクスター、インターナショナル、インコーポレイテッド クモ膜下出血の治療における架橋ヘモグロビンの使用
US5928916A (en) * 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
DE19628705A1 (de) * 1996-07-08 1998-01-15 Fresenius Ag Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe
US5981710A (en) * 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
US6018035A (en) * 1997-07-21 2000-01-25 Baxter International Inc. Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
IL135148A0 (en) * 1997-10-03 2001-05-20 Galenica Pharmaceuticals Inc A polysaccharide conjugate and pharmaceutical compositions containing the same
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
JP2002513028A (ja) 1998-04-28 2002-05-08 ガレニカ ファーマシューティカルズ， インコーポレイテッド ポリサッカリド抗原結合体
WO2001013933A2 (en) * 1999-08-25 2001-03-01 Gmp Companies, Inc. Agents for the enhanced oxygen delivery in mammals
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
KR101045422B1 (ko) 2002-09-11 2011-06-30 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬 전분 유도체의 제조 방법
ATE409048T1 (de) 2002-10-08 2008-10-15 Fresenius Kabi De Gmbh Pharmazeutisch aktive oligosaccharid-conjugate
BRPI0413450A (pt) * 2003-08-08 2006-10-17 Fresenius Kabi De Gmbh conjugados de hidroxialquil amido e g-csf
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
KR100580642B1 (ko) * 2004-01-12 2006-05-16 삼성전자주식회사 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
WO2005092928A1 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
WO2005103080A2 (en) * 2004-04-21 2005-11-03 Albert Einstein College Of Medicine Of Yeshiva University Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
EP1861124A2 (de) * 2005-03-11 2007-12-05 Fresenius Kabi Deutschland GmbH Herstellung von bioaktiven glykoproteinen aus inaktiven ausgangsmaterialien durch konjugation mit hydroxyalkylstärke
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
FR2551660B1 (fr) * 1983-09-13 1986-11-14 Centre Nat Rech Scient Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
DE3501349A1 (de) * 1985-01-17 1986-07-17 Battelle-Institut E.V., 6000 Frankfurt Blutersatz
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications

Also Published As

Publication number Publication date
EP0338916A1 (de) 1989-10-25
GR3005220T3 (de) 1993-05-24
EP0338916B1 (de) 1992-07-01
ATE77753T1 (de) 1992-07-15
DE68901944T2 (de) 1992-12-10
FR2630329B1 (fr) 1991-07-05
ES2043054T3 (es) 1993-12-16
US5110909A (en) 1992-05-05
JPH0242023A (ja) 1990-02-13
FR2630329A1 (fr) 1989-10-27

Similar Documents

Publication Publication Date Title
DE68901944D1 (de) Makromolekulare haemoglobinkomplexe, verfahren zu ihrer herstellung und ihre verwendungen.
DE3773309D1 (de) Makromolekulare haemoglobinkonjugate, verfahren zu ihrer herstellung und ihre verwendungen.
EP0080614B1 (de) Ein Latex, biologisch aktive Latexkonjugate und Verfahren zu ihrer Herstellung
KR850007982A (ko) 폴리삭카라이드-단백질 결합체의 제조방법
ES2001756A6 (es) Procedimiento para la preparacion de un polimero termoplastico
DE68915737D1 (de) Wässriges gel von hyaluronsäure und desoxynibonukleinsäure, verwendbar für kosmetik und verfahren zu seiner herstellung.
NZ227869A (en) Ultrasonic contrast agents containing amylose microparticles
BR9812381A (pt) Peptopiranosilnucleosìdeo, seu preparo e uso
DE69636289D1 (de) Vernetzten polymerisatmassen und verfahren für ihre verwendung
NO20002547L (no) Poly(vinylamin)-baserte superabsorberende geler og fremgangsmÕte for fremstilling derav
DE69128732T2 (de) Affinitätstrennung mit mikroporösen aktivierten Polyamidmembranen
ATE51629T1 (de) Blutersatz.
ES8501788A1 (es) Procedimiento para la obtencion de materiales de recubrimiento termoendurecibles
PL322251A1 (en) Polymer-modified asphalt compositions of acidic reactivity and their production
CA2273078A1 (en) Use of nucleic acids bound to carrier macromolecules
FI843265A (fi) Haerdande sammansaettningar.
ATE277624T1 (de) Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen
ATE67511T1 (de) Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung.
DE58900338D1 (de) Wasserverduennbare bindemittel, ein verfahren zu ihrer herstellung und ihre verwendung.
EP0315009A3 (de) Chromanderivate, Verfahren zu ihrer Herstelllung und ihre Verwendung in Arzneimitteln
EP0378203A3 (de) Neue Cobalamin-Säurehydrazide und davon abgeleitete Cobalamin-Konjugate
ATE22899T1 (de) Antithrombin-heparin komplex.
ATE90790T1 (de) Verfahren zur herstellung einer festphasenmatrix.
EP0251072A3 (de) Ionenbindungen enthaltende Polymere
IE40645B1 (en) Visual method for the detection of syphilis and other treponemal diseases, and an antigen preparation useful therein

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee