DE60331051D1 - Neue atorvastatinsalze und pharmazeutische zusammensetzungen, die diese enthalten - Google Patents
Neue atorvastatinsalze und pharmazeutische zusammensetzungen, die diese enthaltenInfo
- Publication number
- DE60331051D1 DE60331051D1 DE60331051T DE60331051T DE60331051D1 DE 60331051 D1 DE60331051 D1 DE 60331051D1 DE 60331051 T DE60331051 T DE 60331051T DE 60331051 T DE60331051 T DE 60331051T DE 60331051 D1 DE60331051 D1 DE 60331051D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- salts
- atorvastatin salts
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical class C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0201083A HUP0201083A2 (hu) | 2002-03-28 | 2002-03-28 | Új atorvastatinsók és az azokat tartalmazó gyógyszerkészítmények |
| PCT/HU2003/000024 WO2003082816A1 (en) | 2002-03-28 | 2003-03-27 | New atorvastatin salts and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60331051D1 true DE60331051D1 (de) | 2010-03-11 |
Family
ID=89980299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60331051T Expired - Lifetime DE60331051D1 (de) | 2002-03-28 | 2003-03-27 | Neue atorvastatinsalze und pharmazeutische zusammensetzungen, die diese enthalten |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1490333B1 (enExample) |
| AT (1) | ATE455761T1 (enExample) |
| AU (1) | AU2003241060A1 (enExample) |
| CY (1) | CY1109882T1 (enExample) |
| DE (1) | DE60331051D1 (enExample) |
| DK (1) | DK1490333T3 (enExample) |
| ES (1) | ES2339935T3 (enExample) |
| HU (1) | HUP0201083A2 (enExample) |
| PT (1) | PT1490333E (enExample) |
| SI (1) | SI1490333T1 (enExample) |
| WO (1) | WO2003082816A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227041B1 (en) * | 2003-03-24 | 2010-05-28 | Richter Gedeon Nyrt | Process for the synthesis of amorphous atorvastatin calcium |
| US20040242673A1 (en) | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| SI1711489T1 (sl) | 2003-12-29 | 2013-08-30 | Lek Pharmaceuticals D.D. | Postopek za pripravo amorfne (4R-cis)-6-(2-(3-fenil-4(fenilkarbamoil)-2 -(4-fluorofenil)-5-(1-metiletil)-pirol-1-il)-2,2-dimetil-(1,3)-dioksan- 4-il-ocetna kislina |
| FR2869539B1 (fr) * | 2004-04-29 | 2008-08-08 | Univ Paris Descartes | Compositions pharmaceutiques pour la prevention et le traitement de l'atherosclerose |
| EP1745020A2 (en) | 2004-05-05 | 2007-01-24 | Pfizer Products Incorporated | Salt forms of atorvastatin |
| CA2588216A1 (en) * | 2004-11-22 | 2006-05-26 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
| EP1898922A4 (en) * | 2005-07-04 | 2012-03-14 | Ramu Krishnan | MEDICINE OR IMPROVED PHARMACEUTICAL COMPOUNDS AND PREPARATION THEREOF |
| MX2007014329A (es) | 2005-12-13 | 2008-03-19 | Teva Pharma | Forma cristalina de hemi-calcio de atorvastatina y procesos para la preparacion de ella. |
| WO2011089559A1 (en) * | 2010-01-22 | 2011-07-28 | Orchid Chemicals And Pharmaceuticals Limited | A novel polymorphic form of atorvastatin salts |
| MX2010011006A (es) * | 2010-10-06 | 2012-04-18 | Senosiain S A De C V Lab | Nueva sal de un derivado de pirimidina. |
| CN103274985B (zh) * | 2010-12-03 | 2016-03-09 | 上海科州药物研发有限公司 | 一种阿托伐他汀氨基酸盐 |
| EP2787987B1 (de) * | 2011-12-08 | 2016-06-01 | Hexal AG | Neue pharmazeutische statin-zusammensetzung |
| CN103232398B (zh) * | 2012-04-28 | 2016-04-06 | 上海科州药物研发有限公司 | 一种瑞舒伐他汀氨基酸盐及其制备方法和应用 |
| WO2014139469A1 (en) * | 2013-03-15 | 2014-09-18 | Wuhan Qr Science And Technology Development Co. | Ornithine- or aspartate-containing compositions and the uses thereof |
| CN105246472B (zh) * | 2013-03-15 | 2018-10-12 | 武汉朗来科技发展有限公司 | 含有鸟氨酸和/或门冬氨酸的组合物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69634054T2 (de) * | 1995-07-17 | 2005-12-08 | Warner-Lambert Co. | Kristalline (R-(R*, R*))-2-(4-Fluorophenyl)-β, δ-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-1H-Pyrrol-1-Heptancarbonsäure Hemi Calcium Salz (Atorvastatin) |
| AU2001253287B2 (en) * | 2000-04-10 | 2005-04-28 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
-
2002
- 2002-03-28 HU HU0201083A patent/HUP0201083A2/hu unknown
-
2003
- 2003-03-27 SI SI200331777T patent/SI1490333T1/sl unknown
- 2003-03-27 AT AT03730380T patent/ATE455761T1/de active
- 2003-03-27 AU AU2003241060A patent/AU2003241060A1/en not_active Abandoned
- 2003-03-27 DK DK03730380.7T patent/DK1490333T3/da active
- 2003-03-27 WO PCT/HU2003/000024 patent/WO2003082816A1/en not_active Ceased
- 2003-03-27 EP EP03730380A patent/EP1490333B1/en not_active Expired - Lifetime
- 2003-03-27 DE DE60331051T patent/DE60331051D1/de not_active Expired - Lifetime
- 2003-03-27 ES ES03730380T patent/ES2339935T3/es not_active Expired - Lifetime
- 2003-03-27 PT PT03730380T patent/PT1490333E/pt unknown
-
2010
- 2010-03-11 CY CY20101100235T patent/CY1109882T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2339935T3 (es) | 2010-05-27 |
| WO2003082816A1 (en) | 2003-10-09 |
| PT1490333E (pt) | 2010-03-04 |
| EP1490333A1 (en) | 2004-12-29 |
| ATE455761T1 (de) | 2010-02-15 |
| DK1490333T3 (da) | 2010-05-25 |
| HUP0201083A2 (hu) | 2004-06-28 |
| CY1109882T1 (el) | 2014-09-10 |
| SI1490333T1 (sl) | 2010-04-30 |
| EP1490333B1 (en) | 2010-01-20 |
| AU2003241060A1 (en) | 2003-10-13 |
| HU0201083D0 (enExample) | 2002-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |