DE60327428D1 - Hif hydroxylase-inhibitoren zur anämiebehandlung - Google Patents

Hif hydroxylase-inhibitoren zur anämiebehandlung

Info

Publication number
DE60327428D1
DE60327428D1 DE60327428T DE60327428T DE60327428D1 DE 60327428 D1 DE60327428 D1 DE 60327428D1 DE 60327428 T DE60327428 T DE 60327428T DE 60327428 T DE60327428 T DE 60327428T DE 60327428 D1 DE60327428 D1 DE 60327428D1
Authority
DE
Germany
Prior art keywords
hydroxylase inhibitors
hif hydroxylase
anemia treatment
treatment
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327428T
Other languages
English (en)
Inventor
Christopher J Schofield
Patrick H Maxwell
Christopher W Pugh
Peter J Ratcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9933457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60327428(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Application granted granted Critical
Publication of DE60327428D1 publication Critical patent/DE60327428D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
DE60327428T 2002-03-21 2003-03-21 Hif hydroxylase-inhibitoren zur anämiebehandlung Expired - Lifetime DE60327428D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0206711.4A GB0206711D0 (en) 2002-03-21 2002-03-21 HIF Inhibitor
PCT/GB2003/001239 WO2003080566A2 (en) 2002-03-21 2003-03-21 Hif hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
DE60327428D1 true DE60327428D1 (de) 2009-06-10

Family

ID=9933457

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327428T Expired - Lifetime DE60327428D1 (de) 2002-03-21 2003-03-21 Hif hydroxylase-inhibitoren zur anämiebehandlung

Country Status (13)

Country Link
US (2) US20050227948A1 (de)
EP (2) EP2065366A3 (de)
JP (1) JP2005520859A (de)
CN (6) CN101199502A (de)
AT (1) ATE430127T1 (de)
AU (2) AU2003216857B2 (de)
CA (1) CA2479881A1 (de)
DE (1) DE60327428D1 (de)
ES (1) ES2322992T3 (de)
GB (1) GB0206711D0 (de)
MX (1) MXPA04009155A (de)
PL (1) PL205110B1 (de)
WO (1) WO2003080566A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US20050170019A1 (en) * 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
US20050136125A1 (en) * 2003-10-22 2005-06-23 Roth Mark B. Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
AU2004285477A1 (en) * 2003-10-22 2005-05-12 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in tissues and organs
JP2007530522A (ja) * 2004-03-26 2007-11-01 アイシス・イノベーション・リミテッド アッセイ
ES2686777T3 (es) * 2004-11-24 2018-10-19 Lifescan, Inc. Composiciones y métodos para crear un ambiente vascularizado para trasplante celular
CA2605631A1 (en) * 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
DE102005019712A1 (de) * 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
GB0519605D0 (en) 2005-09-26 2005-11-02 Isis Innovation Assay
BRPI0707302B8 (pt) 2006-01-27 2021-05-25 Fibrogen Inc compostos de cianoisoquinolina que atuam no dano tecidual associado com isquemia, hipóxia e anemia, bem como composição farmacêutica que os compreende
RU2461557C2 (ru) 2006-04-04 2012-09-20 Файброджен, Инк. Соединения пирроло- и тиазолопиридина (варианты) и фармацевтическая композиция на их основе
WO2008130527A1 (en) * 2007-04-18 2008-10-30 Merck & Co., Inc. Novel 1,8-naphthyridine compounds
US20110039878A1 (en) * 2007-11-02 2011-02-17 Volkmar Guenzler-Pukall Methods for reducing blood pressure
WO2009073669A1 (en) 2007-12-03 2009-06-11 Fibrogen, Inc. Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
WO2009134847A1 (en) * 2008-04-30 2009-11-05 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
GB0809262D0 (en) 2008-05-21 2008-06-25 Isis Innovation Assay
CN102264740B (zh) 2008-08-20 2014-10-15 菲布罗根有限公司 一种吡咯[1,2-b]哒嗪衍生物及其作为hif调节剂的用途
CN102272117B (zh) 2008-11-14 2015-06-17 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
EP3936608A1 (de) 2010-03-31 2022-01-12 The Scripps Research Institute Umprogrammierung von zellen
WO2012106472A1 (en) 2011-02-02 2012-08-09 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
US9446031B2 (en) 2012-01-18 2016-09-20 National University Of Singapore Compositions and methods for neovascularization
WO2013134632A2 (en) * 2012-03-09 2013-09-12 Fibrogen, Inc. Treatment for high cholesterol
ES2694297T3 (es) 2013-01-24 2018-12-19 Fibrogen, Inc. Formas cristalinas de ácido {[1-ciano-5-(4-clorofenoxi)-4-hidroxi-isoquinolina-3-carbonilo]-amino}-acético
CA3009350A1 (en) * 2016-01-05 2017-07-13 The Trustees Of Columbia University In The City Of New York Compositions and methods for regulating activity of inhibitor of dna binding-2 (id2) protein
EP3638217A4 (de) * 2017-06-15 2021-05-26 The Trustees of Columbia University in the City of New York Behandlung von neurodegeneration durch neuprogrammierung des stoffwechsels durch hemmung von phd
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
TW202313072A (zh) 2021-05-27 2023-04-01 美商凱立克斯生物製藥股份有限公司 檸檬酸鐵之兒科調配物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620359A1 (de) 1965-12-10 1969-12-18 Norddeutsche Affinerie Wachstumbeeinflussende Mittel
AT279048B (de) 1967-07-04 1970-02-25 Pharmazeutische Fabrik Montavit Gmbh Verfahren zur Herstellung neuer, löslicher und stabiler organischer Eisen(III)-Komplexverbindungen und Injektionslösungen davon
FR6969M (de) 1968-05-19 1969-05-19
US4273779A (en) * 1976-12-23 1981-06-16 Ciba-Geigy Corporation Treating hypertension with substituted-5-amino-2-pyridinecarboxylic acids
JPS5754151A (en) * 1980-09-18 1982-03-31 Takeda Chem Ind Ltd Physiologically active substance b-52653 and its preparation
JPS5899453A (ja) * 1981-12-10 1983-06-13 Mitsubishi Chem Ind Ltd オリゴペプチド
US4446038A (en) * 1982-09-27 1984-05-01 Texaco, Inc. Citric imide acid compositions and lubricants containing the same
US4551279A (en) * 1984-01-09 1985-11-05 G. D. Searle & Co. Protease inhibitors
JPS6197229A (ja) 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
EP0185225B1 (de) 1984-12-17 1990-01-03 American Cyanamid Company Platinkomplexe von aliphatischen Tricarbonsäuren
JPS61218522A (ja) 1985-03-22 1986-09-29 Sachimaru Senoo 中性乃至弱アルカリ性で安定な水酸化鉄コロイド溶液
JPS61249993A (ja) 1985-04-26 1986-11-07 Tanabe Seiyaku Co Ltd 新規有機白金錯体及びその製法
US4752602A (en) * 1985-09-09 1988-06-21 Board Of Regents, The University Of Texas System Dipeptide alkyl esters and their uses
DE3544338A1 (de) * 1985-12-14 1987-06-19 Hoechst Ag Peptid-derivate mit inhibitorischer wirkung auf hydroxylierende enzyme, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
FR2662359A1 (fr) 1986-04-18 1991-11-29 Flork Michel Nouveaux peptides diuretiques et natriuretiques.
CH673459A5 (de) 1987-05-15 1990-03-15 Eprova Ag
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
US5439930A (en) * 1992-04-14 1995-08-08 Russian-American Institute For New Drug Development Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects
RU2001588C1 (ru) 1992-05-07 1993-10-30 Феликс Семенович Ройтман Сок с м котью
JP3595352B2 (ja) 1993-02-01 2004-12-02 株式会社サンギ 抗腫瘍剤及び抗菌剤
DE4410453A1 (de) * 1994-03-25 1995-09-28 Hoechst Ag Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
WO1997024145A1 (fr) * 1995-12-28 1997-07-10 Daiichi Radioisotope Laboratories, Ltd. Medicaments d'aide au diagnostic
RU2079307C1 (ru) 1996-07-08 1997-05-20 Михаил Александрович Каплан Противоанемическое средство
RU2111746C1 (ru) 1996-07-31 1998-05-27 Всероссийский научный центр по безопасности биологически активных веществ Водный раствор, обладающий гепатопротекторным действием
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
US6200974B1 (en) * 1997-10-24 2001-03-13 Zeneca Limited Phenanthroline derivatives
RU2141943C1 (ru) 1998-11-27 1999-11-27 Научно-исследовательский институт фармакологии при Волгоградской медицинской академии Динатриевая соль n-ацетил-l-аспарагиновой кислоты, обладающая антидепрессантной и ноотропной активностью
US6583299B1 (en) 1999-05-20 2003-06-24 G.D. Searle & Co. α-amino-β-sulfonyl hydroxamic acid compounds
WO2000074725A1 (en) * 1999-06-04 2000-12-14 Dana-Farber Cancer Institute, Inc. Identification of compounds that modify transcriptional responses to hypoxia
GB0013655D0 (en) 2000-06-05 2000-07-26 Prolifix Ltd Therapeutic compounds
JP4590157B2 (ja) * 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段

Also Published As

Publication number Publication date
ATE430127T1 (de) 2009-05-15
CA2479881A1 (en) 2003-10-02
EP1485347B1 (de) 2009-04-29
CN101199537A (zh) 2008-06-18
PL371515A1 (en) 2005-06-27
CN1653040A (zh) 2005-08-10
JP2005520859A (ja) 2005-07-14
US7662854B2 (en) 2010-02-16
EP1485347A2 (de) 2004-12-15
AU2009202216A1 (en) 2009-06-25
WO2003080566A3 (en) 2003-12-11
AU2003216857A1 (en) 2003-10-08
US20070066576A1 (en) 2007-03-22
US20050227948A1 (en) 2005-10-13
EP2065366A2 (de) 2009-06-03
EP2065366A3 (de) 2009-09-02
CN101199512A (zh) 2008-06-18
CN101199502A (zh) 2008-06-18
CN101199503A (zh) 2008-06-18
PL205110B1 (pl) 2010-03-31
GB0206711D0 (en) 2002-05-01
CN100369891C (zh) 2008-02-20
CN101199501A (zh) 2008-06-18
ES2322992T3 (es) 2009-07-03
MXPA04009155A (es) 2004-11-26
WO2003080566A2 (en) 2003-10-02
AU2003216857B2 (en) 2009-06-11

Similar Documents

Publication Publication Date Title
DE60327428D1 (de) Hif hydroxylase-inhibitoren zur anämiebehandlung
ZA200706010B (en) 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-hetero-ayryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity
HK1113056A1 (en) Nicotinamide derivates useful as p38 inhibitors
IS7857A (is) Setnar pýrróló-pýrasól afleiður sem kínasa hindrar
ATE410430T1 (de) 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose
EP1596854A4 (de) Behandlung von erkrankungen im zusammenhang mit verringerter stickoxid-bioverfügbarkeit, einschliesslich erhöhte arginase
FR12C0008I2 (fr) Compositions et methodes permettant de stabiliser la transthyretine et d'inhiber un mauvais repliement de la transthyretine
EE05417B1 (et) Epotilooni analoogide ja kemoterapeutikumide kombinatsiooni kasutamine teraapias
CY1110742T1 (el) Αναστολεις ινδαζολης, βενζισοξαζολης, και βενζισοθειαζολης
IL174210A0 (en) 1,4 disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
DE60332163D1 (de) Zusammensetzung zur hautaufhellung
SE0203752D0 (sv) New compounds
MY140031A (en) Carbonyl compounds
DE60231804D1 (de) Verwendung von hepcidin zur herstellung eines arzneimittels zur behandlung von eisenhomöostase störungen
ATE550013T1 (de) Zink-konservierungszusammensetzung und anwendungsverfahren
ATE464396T1 (de) Mikrosatellitenmarker in form von mononukleotidwiederholungen zur detektion von mikrosatelliteninstabilität
WO2006034296A3 (en) Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof
EA200601699A1 (ru) Замещённые фенокси- и фенилтиопроизводные для лечения пролиферативных нарушений
ATE555674T1 (de) Zusammensetzung mit der reduzierten form von coenzym q10 und carotenoid-verbindung
MXPA05013251A (es) Composiciones para estado de oxigeno mejorado en animales de compania.
DE602006003094D1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
NO20053903D0 (no) Nukleotidlipidesterderivater.
ATE519380T1 (de) Unterstützung der kognitiven funktion
RS20060195A (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
DE602004022423D1 (de) Hemmung der s6-kinase-aktivität zur behandlung von insulinresistenz

Legal Events

Date Code Title Description
8363 Opposition against the patent