ATE464396T1 - Mikrosatellitenmarker in form von mononukleotidwiederholungen zur detektion von mikrosatelliteninstabilität - Google Patents
Mikrosatellitenmarker in form von mononukleotidwiederholungen zur detektion von mikrosatelliteninstabilitätInfo
- Publication number
- ATE464396T1 ATE464396T1 AT03724916T AT03724916T ATE464396T1 AT E464396 T1 ATE464396 T1 AT E464396T1 AT 03724916 T AT03724916 T AT 03724916T AT 03724916 T AT03724916 T AT 03724916T AT E464396 T1 ATE464396 T1 AT E464396T1
- Authority
- AT
- Austria
- Prior art keywords
- microsatellite
- detecting
- instability
- marker
- mononucleotide repeats
- Prior art date
Links
- 108091092878 Microsatellite Proteins 0.000 title abstract 2
- 208000032818 Microsatellite Instability Diseases 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290483A EP1340819A1 (de) | 2002-02-28 | 2002-02-28 | Mikrosatellitenmarker |
| PCT/EP2003/002654 WO2003072822A2 (en) | 2002-02-28 | 2003-02-26 | Mononucleotide repeats microsatellite markers for detecting microsatellite instability. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464396T1 true ATE464396T1 (de) | 2010-04-15 |
Family
ID=27675769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03724916T ATE464396T1 (de) | 2002-02-28 | 2003-02-26 | Mikrosatellitenmarker in form von mononukleotidwiederholungen zur detektion von mikrosatelliteninstabilität |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7521180B2 (de) |
| EP (2) | EP1340819A1 (de) |
| JP (1) | JP4436685B2 (de) |
| AT (1) | ATE464396T1 (de) |
| AU (1) | AU2003227532A1 (de) |
| CA (1) | CA2476892C (de) |
| DE (1) | DE60332096D1 (de) |
| ES (1) | ES2344636T3 (de) |
| WO (1) | WO2003072822A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1340819A1 (de) | 2002-02-28 | 2003-09-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mikrosatellitenmarker |
| ES2337573T3 (es) * | 2004-10-19 | 2010-04-27 | Mtm Laboratories Ag | Compuestos y procedimientos para la estimacion del estado de inestabilidad de microsatelites (msi). |
| US8012976B2 (en) | 2008-08-06 | 2011-09-06 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) |
| EP2218794A1 (de) * | 2009-02-13 | 2010-08-18 | Alphagenics International SA | Instabilitätserkennung in Regionen mit genomischem DNA mit einfacher Tandemwiederholung |
| US8541403B2 (en) | 2010-02-03 | 2013-09-24 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency |
| DK2533640T3 (en) | 2010-02-08 | 2017-01-23 | Medivation Technologies Inc | METHODS OF SYNTHESIS OF DIHYDROPYRIDOPHTHALAZINE DERIVATIVES |
| PL2630146T3 (pl) | 2010-10-21 | 2020-11-02 | Medivation Technologies Llc | Krystaliczna sól tosylanowa (8S,9R)-5-fluoro-8-(4-fluorofenylo)-9-(1-metylo-1H-1,2,4-triazol-5-ilo)-8,9-dihydro-2H-pirydo[4,3,2-de]ftalazyno-3(7H)-onu |
| WO2012166151A1 (en) * | 2011-06-03 | 2012-12-06 | Biomarin Pharmaceutical Inc. | Use of dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) in the treatment of myelodysplastic syndrome (mds) and acute myeloid leukaemia (aml) |
| AU2013263076B2 (en) | 2012-05-15 | 2017-08-31 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| US20150337388A1 (en) * | 2012-12-17 | 2015-11-26 | Virginia Tech Intellectual Properties, Inc. | Methods and compositions for identifying global microsatellite instability and for characterizing informative microsatellite loci |
| CN104087683B (zh) * | 2014-08-01 | 2016-06-15 | 上海赛安生物医药科技有限公司 | 微卫星不稳定性多重检测体系及试剂盒 |
| EP4098278A1 (de) * | 2014-11-13 | 2022-12-07 | The Johns Hopkins University | Checkpoint-blockade und mikrosatelliteninstabilität |
| CN105256057A (zh) * | 2015-11-19 | 2016-01-20 | 湖南宏雅基因技术有限公司 | 基于二代测序平台的结肠癌微卫星不稳定性检测试剂盒 |
| KR102702675B1 (ko) * | 2016-06-03 | 2024-09-05 | 브리스톨-마이어스 스큅 컴퍼니 | 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 |
| CN106755501B (zh) * | 2017-01-25 | 2020-11-17 | 广州燃石医学检验所有限公司 | 一种基于二代测序的同时检测微卫星位点稳定性和基因组变化的方法 |
| CA3056896A1 (en) * | 2017-03-20 | 2018-09-27 | Caris Mpi, Inc. | Genomic stability profiling |
| EP3642354B1 (de) | 2017-06-20 | 2022-08-03 | Bio-Rad Laboratories, Inc. | Digitale amplifikationsassays für genetische instabilität |
| CN109593847B (zh) * | 2017-09-29 | 2023-04-11 | 中山大学附属第六医院 | 检测微卫星nr24位点稳定性的引物对、试剂盒及方法 |
| WO2019074963A1 (en) * | 2017-10-09 | 2019-04-18 | Strata Oncology, Inc. | CHARACTERIZATION OF THE INSTABILITY OF MICROSATELLITES |
| EP3739064A1 (de) | 2019-05-15 | 2020-11-18 | Biotype GmbH | Vergleichende analyse von mikrosatelliten mittels kapillarelektrophorese (ce) -dna-profile |
| KR102506176B1 (ko) * | 2020-10-28 | 2023-03-03 | 사회복지법인 삼성생명공익재단 | 현미부수체 불안정성 진단용 마커 조성물 및 프라이머 세트 |
| AU2022341107A1 (en) | 2021-09-08 | 2024-02-29 | Amgen Inc. | Sotorasib and an egfr antibody for treating cancer comprising a kras g12c mutation |
| WO2024015360A1 (en) | 2022-07-11 | 2024-01-18 | Amgen Inc. | Methods of treating cancer |
| DE102023124346A1 (de) | 2023-09-09 | 2025-03-13 | Biotype Gmbh | Verfahren zur Detektion des Endometriumkarzinoms Subtyp CN hoch |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE19712332A1 (de) * | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik |
| EP1340819A1 (de) * | 2002-02-28 | 2003-09-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mikrosatellitenmarker |
-
2002
- 2002-02-28 EP EP02290483A patent/EP1340819A1/de not_active Withdrawn
-
2003
- 2003-02-26 AU AU2003227532A patent/AU2003227532A1/en not_active Abandoned
- 2003-02-26 CA CA2476892A patent/CA2476892C/en not_active Expired - Lifetime
- 2003-02-26 AT AT03724916T patent/ATE464396T1/de not_active IP Right Cessation
- 2003-02-26 US US10/505,725 patent/US7521180B2/en not_active Expired - Lifetime
- 2003-02-26 DE DE60332096T patent/DE60332096D1/de not_active Expired - Lifetime
- 2003-02-26 JP JP2003571502A patent/JP4436685B2/ja not_active Expired - Lifetime
- 2003-02-26 EP EP03724916A patent/EP1478781B1/de not_active Expired - Lifetime
- 2003-02-26 WO PCT/EP2003/002654 patent/WO2003072822A2/en not_active Ceased
- 2003-02-26 ES ES03724916T patent/ES2344636T3/es not_active Expired - Lifetime
-
2009
- 2009-03-30 US US12/385,086 patent/US7951564B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060068385A1 (en) | 2006-03-30 |
| EP1340819A1 (de) | 2003-09-03 |
| EP1478781B1 (de) | 2010-04-14 |
| JP4436685B2 (ja) | 2010-03-24 |
| EP1478781A2 (de) | 2004-11-24 |
| US20090317815A1 (en) | 2009-12-24 |
| WO2003072822A9 (en) | 2003-11-06 |
| ES2344636T3 (es) | 2010-09-02 |
| US7521180B2 (en) | 2009-04-21 |
| CA2476892A1 (en) | 2003-09-04 |
| JP2005518798A (ja) | 2005-06-30 |
| WO2003072822A2 (en) | 2003-09-04 |
| AU2003227532A1 (en) | 2003-09-09 |
| CA2476892C (en) | 2012-05-29 |
| US7951564B2 (en) | 2011-05-31 |
| WO2003072822A3 (en) | 2004-03-18 |
| DE60332096D1 (de) | 2010-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |