DE60319848T2 - Medikament mit Mesenchymstammzellen - Google Patents
Medikament mit Mesenchymstammzellen Download PDFInfo
- Publication number
- DE60319848T2 DE60319848T2 DE60319848T DE60319848T DE60319848T2 DE 60319848 T2 DE60319848 T2 DE 60319848T2 DE 60319848 T DE60319848 T DE 60319848T DE 60319848 T DE60319848 T DE 60319848T DE 60319848 T2 DE60319848 T2 DE 60319848T2
- Authority
- DE
- Germany
- Prior art keywords
- mscs
- tendon
- cells
- injury
- bone marrow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims description 11
- 229940079593 drug Drugs 0.000 title claims description 6
- 210000002901 mesenchymal stem cell Anatomy 0.000 title description 81
- 210000004027 cell Anatomy 0.000 claims description 119
- 210000002435 tendon Anatomy 0.000 claims description 97
- 230000006378 damage Effects 0.000 claims description 78
- 208000014674 injury Diseases 0.000 claims description 74
- 208000027418 Wounds and injury Diseases 0.000 claims description 72
- 241000283073 Equus caballus Species 0.000 claims description 48
- 210000001185 bone marrow Anatomy 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 24
- 210000003041 ligament Anatomy 0.000 claims description 22
- 239000006194 liquid suspension Substances 0.000 claims description 12
- 210000001074 muscle attachment cell Anatomy 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 9
- 230000004069 differentiation Effects 0.000 claims description 7
- 239000003102 growth factor Substances 0.000 claims description 7
- 230000000735 allogeneic effect Effects 0.000 claims description 5
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 210000004700 fetal blood Anatomy 0.000 claims description 5
- 230000008929 regeneration Effects 0.000 claims description 5
- 238000011069 regeneration method Methods 0.000 claims description 5
- 241000282836 Camelus dromedarius Species 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000007920 subcutaneous administration Methods 0.000 claims description 3
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 12
- 239000003349 gelling agent Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 38
- 238000000034 method Methods 0.000 description 36
- 230000003902 lesion Effects 0.000 description 29
- 239000000523 sample Substances 0.000 description 25
- 238000002604 ultrasonography Methods 0.000 description 24
- 238000002513 implantation Methods 0.000 description 21
- 238000002347 injection Methods 0.000 description 21
- 239000007924 injection Substances 0.000 description 21
- 210000001364 upper extremity Anatomy 0.000 description 17
- 208000000491 Tendinopathy Diseases 0.000 description 14
- 238000011835 investigation Methods 0.000 description 11
- 229920001917 Ficoll Polymers 0.000 description 10
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 10
- 230000033558 biomineral tissue development Effects 0.000 description 10
- 229920000669 heparin Polymers 0.000 description 10
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 9
- 241000283086 Equidae Species 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 229960002897 heparin Drugs 0.000 description 9
- 206010043255 Tendonitis Diseases 0.000 description 8
- 239000008188 pellet Substances 0.000 description 8
- 210000002381 plasma Anatomy 0.000 description 8
- 201000004415 tendinitis Diseases 0.000 description 8
- 241000282414 Homo sapiens Species 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 230000035876 healing Effects 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 239000003550 marker Substances 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 210000004623 platelet-rich plasma Anatomy 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000000130 stem cell Anatomy 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 239000006285 cell suspension Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 231100000241 scar Toxicity 0.000 description 6
- 210000001562 sternum Anatomy 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 102000012422 Collagen Type I Human genes 0.000 description 5
- 108010022452 Collagen Type I Proteins 0.000 description 5
- 208000021945 Tendon injury Diseases 0.000 description 5
- 230000001332 colony forming effect Effects 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000012549 training Methods 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 101001138480 Homo sapiens Olfactory receptor 5AC2 Proteins 0.000 description 4
- 102100020806 Olfactory receptor 5AC2 Human genes 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 238000001266 bandaging Methods 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 208000030175 lameness Diseases 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 238000002559 palpation Methods 0.000 description 4
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 206010000362 Accessory carpal bone Diseases 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000002695 general anesthesia Methods 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000005499 meniscus Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 238000004393 prognosis Methods 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- OIWRDXKNDCJZSM-UHFFFAOYSA-N 5-[(2,3-dimethylphenyl)methyl]-1h-imidazole;hydron;chloride Chemical compound Cl.CC1=CC=CC(CC=2NC=NC=2)=C1C OIWRDXKNDCJZSM-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 206010061223 Ligament injury Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 241000283011 Rangifer Species 0.000 description 2
- 210000001361 achilles tendon Anatomy 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000000386 athletic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- AGSPXMVUFBBBMO-UHFFFAOYSA-N beta-aminopropionitrile Chemical compound NCCC#N AGSPXMVUFBBBMO-UHFFFAOYSA-N 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 2
- 229960001113 butorphanol Drugs 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000012997 ficoll-paque Substances 0.000 description 2
- 210000003194 forelimb Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 229940054269 sodium pyruvate Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
- 208000032984 Intraoperative Complications Diseases 0.000 description 1
- 229940121922 Lysyl oxidase inhibitor Drugs 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 102000003505 Myosin Human genes 0.000 description 1
- 108060008487 Myosin Proteins 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 238000005460 biophysical method Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- GMTYREVWZXJPLF-AFHUBHILSA-N butorphanol D-tartrate Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O.N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 GMTYREVWZXJPLF-AFHUBHILSA-N 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000001608 connective tissue cell Anatomy 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229960002273 detomidine hydrochloride Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 102000054766 genetic haplotypes Human genes 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 102000046949 human MSC Human genes 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 1
- 210000001037 metacarpus Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000000513 rotator cuff Anatomy 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000009168 stem cell therapy Methods 0.000 description 1
- 238000009580 stem-cell therapy Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940037546 torbugesic Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220841A GB0220841D0 (en) | 2002-09-07 | 2002-09-07 | Therapy |
| GB0220841 | 2002-09-07 | ||
| GB0226275A GB0226275D0 (en) | 2002-11-12 | 2002-11-12 | Method of treatment |
| GB0226275 | 2002-11-12 | ||
| PCT/GB2003/003894 WO2004022078A1 (en) | 2002-09-07 | 2003-09-08 | Pharmaceutical kits comprising mesenchymal stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60319848D1 DE60319848D1 (de) | 2008-04-30 |
| DE60319848T2 true DE60319848T2 (de) | 2009-04-30 |
Family
ID=31980022
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60319848T Expired - Lifetime DE60319848T2 (de) | 2002-09-07 | 2003-09-08 | Medikament mit Mesenchymstammzellen |
| DE60335752T Expired - Lifetime DE60335752D1 (enExample) | 2002-09-07 | 2003-09-08 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60335752T Expired - Lifetime DE60335752D1 (enExample) | 2002-09-07 | 2003-09-08 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8178084B2 (enExample) |
| EP (3) | EP2316462A1 (enExample) |
| AR (1) | AR047712A1 (enExample) |
| AT (2) | ATE494898T1 (enExample) |
| AU (1) | AU2003263340B2 (enExample) |
| CA (1) | CA2538187C (enExample) |
| DE (2) | DE60319848T2 (enExample) |
| ES (1) | ES2304541T3 (enExample) |
| NZ (1) | NZ539308A (enExample) |
| WO (1) | WO2004022078A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| US7608258B2 (en) | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
| AU2004291065B2 (en) * | 2003-05-13 | 2007-11-01 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US8361467B2 (en) | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| EP2450433A3 (en) | 2003-10-08 | 2012-08-08 | Vet-Stem Inc | Methods of preparing and using stem cell compositions and kits comprising the same |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| WO2005065242A2 (en) | 2003-12-29 | 2005-07-21 | Am Biosolutions | Method of treating cancer using platelet releasate |
| US7462268B2 (en) | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
| KR100593397B1 (ko) | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 ｐ 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
| NZ580786A (en) * | 2007-04-24 | 2012-05-25 | Univ Western Australia | Tenocyte containing bioscaffolds and treatment using the same |
| US8785191B2 (en) * | 2007-08-27 | 2014-07-22 | University Of Connecticut | Concentration of stem cells obtained during orthopaedic surgeries |
| WO2009074807A2 (en) | 2007-12-12 | 2009-06-18 | Imperial Innovations Limited | Methods |
| US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| IT1394262B1 (it) * | 2008-07-17 | 2012-06-01 | Università Degli Studi Di Milano | Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali |
| US20100112081A1 (en) | 2008-10-07 | 2010-05-06 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
| GB0820492D0 (en) | 2008-11-07 | 2008-12-17 | Sportcell | Cell compositions and uses thereof |
| WO2010140162A2 (en) * | 2009-05-17 | 2010-12-09 | Dravida Subhadra | A process for preparing stem cell based formulations |
| RU2423089C1 (ru) * | 2009-11-17 | 2011-07-10 | Александр Михайлович Савинцев | Способ лечения повреждений ахиллова сухожилия |
| RU2419442C1 (ru) * | 2010-01-22 | 2011-05-27 | Александр Михайлович Савинцев | Способ лечения повреждений сухожильно-связочных структур конечностей животных |
| DE102010046218A1 (de) | 2010-09-21 | 2012-03-22 | Livlmplant Gmbh | Zell-basiertes Injektionssystem zur Behandlung von Verletzungen |
| EP2686419B1 (en) * | 2011-03-18 | 2016-11-16 | MicroVascular Tissues, Inc. | Allogeneic microvascular tissue for soft tissue treatments |
| TW202537630A (zh) | 2011-11-30 | 2025-10-01 | 美商安斯泰來再生醫藥協會 | 利用血管母細胞產生間葉基質細胞之方法 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| ES2710921T3 (es) | 2012-09-19 | 2019-04-29 | Microvascular Tissues Inc | Composiciones para tratar y prevenir lesión y enfermedad tisular |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| WO2014167142A1 (es) | 2013-04-09 | 2014-10-16 | Equicord, S.L. | Procedimiento para el tratamiento de células madre mesenquimales equinas y sistema para llevar a cabo el procedimiento |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
| MX2016007926A (es) * | 2013-12-19 | 2016-12-15 | Université de Liège | Celulas madre derivadas de musculo de mamifero. |
| EP3209768A1 (en) | 2014-07-25 | 2017-08-30 | Recellerate Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
| WO2016073989A2 (en) * | 2014-11-07 | 2016-05-12 | The Trustees Of Columbia University In The City Of New York | Osteochondroreticular stem cells for bone and cartilage regeneration |
| RU2644650C2 (ru) | 2014-12-01 | 2018-02-13 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток и способ его получения |
| WO2016172004A1 (en) * | 2015-04-18 | 2016-10-27 | The Johns Hopkins University | Bone healing, angiogenesis-promoting and vasculogenesis-producing system |
| WO2017059089A1 (en) * | 2015-09-29 | 2017-04-06 | Anicell Biotech, Llc | Methods and articles of manufacture for the treatment of animals |
| US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| CN106308817B (zh) * | 2016-08-12 | 2023-07-28 | 玉溪九洲生物技术有限责任公司 | 一种马血浆采集系统 |
| FR3058065B1 (fr) * | 2016-10-27 | 2019-02-01 | Scarcell Therapeutics | Composition pour le traitement d’une affection de l’appareil locomoteur |
| EP3388511A1 (en) * | 2017-04-12 | 2018-10-17 | Revatis SA | New uses of mammalian muscle derived stel cells |
| WO2021041858A1 (en) * | 2019-08-29 | 2021-03-04 | Icahn School Of Medicine At Mount Sinai | Differentiated tendon cells derived from pluripotent progenitor cells and methods of use thereof |
| RU2722162C1 (ru) * | 2019-10-14 | 2020-05-27 | Федеральное государственное бюджетное учреждение науки Сибирский федеральный научный центр агробиотехнологий Российской академии наук (СФНЦА РАН) | Способ лечения травм сухожильно-связочного аппарата у лошадей |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| WO1996003160A1 (en) * | 1994-07-26 | 1996-02-08 | Children's Medical Center Corporation | Fibrin-cell suspension for construction of new tissue |
| US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| DK2111876T3 (da) | 1995-12-18 | 2011-12-12 | Angiodevice Internat Gmbh | Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf |
| US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US6280473B1 (en) * | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
| WO1998051317A1 (en) * | 1997-05-13 | 1998-11-19 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration using human mesenchymal stem cells |
| ATE307195T1 (de) * | 1997-07-14 | 2005-11-15 | Osiris Therapeutics Inc | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US20020123143A1 (en) * | 1997-08-22 | 2002-09-05 | Jean Toma | Multipotent stem cells from peripheral tissues and uses thereof |
| PT1062321E (pt) * | 1998-03-13 | 2005-05-31 | Osiris Therapeutics Inc | Utilizacoes para celulas estaminais mesenquimais humanas nao autologas |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| BR9912662A (pt) * | 1998-07-31 | 2001-06-05 | Genzyme Corp | Melhoria de função cardìaca por transplante de célula de ramo mesenquimal |
| WO2000049136A1 (en) | 1999-02-17 | 2000-08-24 | United States Surgical | Genetically altered mesenchymal stem cells and methods of use thereof |
| FR2799371A1 (fr) * | 1999-10-12 | 2001-04-13 | Univ Paris Curie | Compositions de tenocytes preparation et utilisations |
| EP1099754A1 (en) | 1999-11-10 | 2001-05-16 | Universiteit Leiden | Mesenchymal stem cells and/or progenitor cells, their isolation and use |
| ATE327783T1 (de) | 2000-03-20 | 2006-06-15 | Biosphere Medical Inc | Injizierbare mikrokügelchen für den gewebeaufbau |
| DE60143517D1 (de) * | 2000-04-25 | 2011-01-05 | Osiris Therapeutics Inc | Wiederherstellung der gelenken mit mesenchymalen stammzellen |
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| WO2002034889A2 (en) | 2000-10-24 | 2002-05-02 | Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| EP1416944B1 (en) | 2001-08-14 | 2005-12-14 | Medipost, Co., Ltd. | Composition for treatment of articular cartilage damage |
| US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
-
2003
- 2003-09-05 AR ARP030103236A patent/AR047712A1/es not_active Application Discontinuation
- 2003-09-08 DE DE60319848T patent/DE60319848T2/de not_active Expired - Lifetime
- 2003-09-08 CA CA2538187A patent/CA2538187C/en not_active Expired - Fee Related
- 2003-09-08 AT AT07014066T patent/ATE494898T1/de not_active IP Right Cessation
- 2003-09-08 US US10/526,753 patent/US8178084B2/en active Active - Reinstated
- 2003-09-08 EP EP10186184A patent/EP2316462A1/en not_active Withdrawn
- 2003-09-08 DE DE60335752T patent/DE60335752D1/de not_active Expired - Lifetime
- 2003-09-08 EP EP07014066A patent/EP1872789B1/en not_active Expired - Lifetime
- 2003-09-08 WO PCT/GB2003/003894 patent/WO2004022078A1/en not_active Ceased
- 2003-09-08 AU AU2003263340A patent/AU2003263340B2/en not_active Ceased
- 2003-09-08 EP EP03793917A patent/EP1545567B1/en not_active Expired - Lifetime
- 2003-09-08 AT AT03793917T patent/ATE389412T1/de active
- 2003-09-08 ES ES03793917T patent/ES2304541T3/es not_active Expired - Lifetime
- 2003-09-08 NZ NZ539308A patent/NZ539308A/en not_active IP Right Cessation
-
2012
- 2012-05-15 US US13/471,517 patent/US20120230960A1/en not_active Abandoned
- 2012-07-17 US US13/551,051 patent/US20130039896A1/en not_active Abandoned
-
2014
- 2014-09-16 US US14/487,660 patent/US20150017145A1/en not_active Abandoned
-
2017
- 2017-02-24 US US15/442,590 patent/US20170258848A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60335752D1 (enExample) | 2011-02-24 |
| US20060130852A1 (en) | 2006-06-22 |
| EP1545567B1 (en) | 2008-03-19 |
| US20170258848A1 (en) | 2017-09-14 |
| ES2304541T3 (es) | 2008-10-16 |
| CA2538187A1 (en) | 2004-03-18 |
| US20150017145A1 (en) | 2015-01-15 |
| AR047712A1 (es) | 2006-02-15 |
| CA2538187C (en) | 2019-01-08 |
| AU2003263340A1 (en) | 2004-03-29 |
| EP1545567A1 (en) | 2005-06-29 |
| AU2003263340B2 (en) | 2008-12-18 |
| NZ539308A (en) | 2008-03-28 |
| US20120230960A1 (en) | 2012-09-13 |
| ATE494898T1 (de) | 2011-01-15 |
| WO2004022078A1 (en) | 2004-03-18 |
| DE60319848D1 (de) | 2008-04-30 |
| EP1872789B1 (en) | 2011-01-12 |
| US20130039896A1 (en) | 2013-02-14 |
| EP1872789A1 (en) | 2008-01-02 |
| US8178084B2 (en) | 2012-05-15 |
| ATE389412T1 (de) | 2008-04-15 |
| EP2316462A1 (en) | 2011-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60319848T2 (de) | Medikament mit Mesenchymstammzellen | |
| Waselau et al. | Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses | |
| Fortier et al. | Regenerative medicine for tendinous and ligamentous injuries of sport horses | |
| Romagnoli et al. | Clinical evaluation of intralesional injection of platelet-rich plasma for the treatment of proximal suspensory ligament desmitis in horses | |
| Garrett et al. | Injection of platelet-and leukocyte-rich plasma at the junction of the proximal sesamoid bone and the suspensory ligament branch for treatment of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated suspensory ligament branch desmitis | |
| Maleas et al. | Effectiveness of platelet-rich plasma and bone marrow aspirate concentrate as treatments for chronic hindlimb proximal suspensory desmopathy | |
| Zuffova et al. | Platelet rich plasma treatment of superficial digital flexor tendon lesions in racing Thoroughbreds. | |
| US20080197048A1 (en) | Use of bone marrow stromal cells for the treatment of tendons and/or ligaments damages | |
| EP3666298A1 (en) | A collagen formulation suitable for injection | |
| Shokry et al. | Autologous mesenchymal stem cells for treatment of acute superficial digital flexor tendonitis in athletic horses-A clinical study of 1 5 cases | |
| Park et al. | Therapeutic effect of equine musculoskeletal disease using autogenous platelet rich plasma. | |
| Roshini et al. | Autologous platelet rich plasma for regeneration of tendon injuries in horses. | |
| Moran | Clinical and ultrasonographic evaluation of the treatment of naturally occurring front limb suspensory branch injuries in sport horses with a standardized leukocyte poor platelet-rich plasma | |
| Smith | Stem cell therapy for tendon and ligament injuries in the horse-technique and outcome | |
| Viktorova et al. | The treatment of tibia fracture by mesenchymal stem cells (Clinical case) | |
| Rosenbrock et al. | Autologous bone marrow transplantation to stimulate suspensory ligament regeneration in 24 horses-a clinical case control study. | |
| US11020436B2 (en) | Multipotent and immunocompatible stem cell concentrate | |
| Pepke | A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions | |
| Malyuk et al. | Influence of autological growth factors on activation of regenerative processes of the superficial digital flexor tendon of horses | |
| Hopper | Treatment Options for Hindlimb Proximal Suspensory Desmitis | |
| Patil et al. | HEMATO-BIOCHEMICAL STUDIES ON LUMBAR VERTEBRAL STABILIZATION BY MID VENTRAL APPROACH USING POLYMETHYL METHACRYLATE AND PINS IN DOGS. | |
| TW201822775A (zh) | 用於治療坐骨神經損傷之醫藥組合物 | |
| Tyrnenopoulou et al. | Clinical application of adipose-derived stromal vascular fraction in 3 thoroughbred horses with superficial digital flexor tendonitis: case report | |
| MANSING | Krantisinh Nana Patil College of Veterinary Science, Shirwal, Dist. Satara 412801 | |
| LA CABALINE et al. | TENDON INJURIES IN HORSES: A COMPARISON OF MODERN THERAPIES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: QUY BIOSCIENCES LTD., NORWICH NORFOLK, GB |