IT1394262B1 - Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali - Google Patents

Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali

Info

Publication number
IT1394262B1
IT1394262B1 ITVR2008A000079A ITVR20080079A IT1394262B1 IT 1394262 B1 IT1394262 B1 IT 1394262B1 IT VR2008A000079 A ITVR2008A000079 A IT VR2008A000079A IT VR20080079 A ITVR20080079 A IT VR20080079A IT 1394262 B1 IT1394262 B1 IT 1394262B1
Authority
IT
Italy
Prior art keywords
tenocytes
stem cells
mesenchimal stem
characterization
starting
Prior art date
Application number
ITVR2008A000079A
Other languages
English (en)
Inventor
Fausto Cremonesi
Paola Mariani
Stefania Violini
Original Assignee
Università Degli Studi Di Milano
Fond Parco Tecnologico Padano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Università Degli Studi Di Milano, Fond Parco Tecnologico Padano filed Critical Università Degli Studi Di Milano
Priority to ITVR2008A000079A priority Critical patent/IT1394262B1/it
Priority to PCT/IB2009/052542 priority patent/WO2010007542A2/en
Priority to PCT/IB2009/052810 priority patent/WO2010007551A2/en
Publication of ITVR20080079A1 publication Critical patent/ITVR20080079A1/it
Application granted granted Critical
Publication of IT1394262B1 publication Critical patent/IT1394262B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/066—Tenocytes; Tendons, Ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
ITVR2008A000079A 2008-07-17 2008-07-17 Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali IT1394262B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITVR2008A000079A IT1394262B1 (it) 2008-07-17 2008-07-17 Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali
PCT/IB2009/052542 WO2010007542A2 (en) 2008-07-17 2009-06-15 Method for the in vitro production of tenocytes
PCT/IB2009/052810 WO2010007551A2 (en) 2008-07-17 2009-06-29 Method for the production of tenocytes in vitro from mesenchymal stem cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITVR2008A000079A IT1394262B1 (it) 2008-07-17 2008-07-17 Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali

Publications (2)

Publication Number Publication Date
ITVR20080079A1 ITVR20080079A1 (it) 2010-01-18
IT1394262B1 true IT1394262B1 (it) 2012-06-01

Family

ID=40750928

Family Applications (1)

Application Number Title Priority Date Filing Date
ITVR2008A000079A IT1394262B1 (it) 2008-07-17 2008-07-17 Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali

Country Status (2)

Country Link
IT (1) IT1394262B1 (it)
WO (2) WO2010007542A2 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10801014B2 (en) 2013-12-06 2020-10-13 Global Stem Cell Technology Method and composition for inducing chondrogenesis or tenogenesis in mesenchymal stem cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR047712A1 (es) * 2002-09-07 2006-02-15 Royal Veterinary College Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas

Also Published As

Publication number Publication date
WO2010007551A2 (en) 2010-01-21
ITVR20080079A1 (it) 2010-01-18
WO2010007551A3 (en) 2010-04-29
WO2010007542A2 (en) 2010-01-21

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