ES2304541T3 - Medicamento que comprende celulas madre mesenquimales. - Google Patents
Medicamento que comprende celulas madre mesenquimales. Download PDFInfo
- Publication number
- ES2304541T3 ES2304541T3 ES03793917T ES03793917T ES2304541T3 ES 2304541 T3 ES2304541 T3 ES 2304541T3 ES 03793917 T ES03793917 T ES 03793917T ES 03793917 T ES03793917 T ES 03793917T ES 2304541 T3 ES2304541 T3 ES 2304541T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- tendon
- msc
- bone marrow
- lesion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 229940079593 drug Drugs 0.000 title claims abstract description 7
- 210000000130 stem cell Anatomy 0.000 title description 15
- 210000002435 tendon Anatomy 0.000 claims abstract description 97
- 230000003902 lesion Effects 0.000 claims abstract description 56
- 210000001185 bone marrow Anatomy 0.000 claims abstract description 51
- 241000283073 Equus caballus Species 0.000 claims abstract description 42
- 210000003041 ligament Anatomy 0.000 claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 239000006194 liquid suspension Substances 0.000 claims abstract description 14
- 239000006228 supernatant Substances 0.000 claims abstract description 10
- 241000282414 Homo sapiens Species 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 241000282836 Camelus dromedarius Species 0.000 claims abstract description 4
- 238000007920 subcutaneous administration Methods 0.000 claims abstract description 4
- 230000000717 retained effect Effects 0.000 claims abstract description 3
- 210000004027 cell Anatomy 0.000 claims description 125
- 230000006378 damage Effects 0.000 claims description 48
- 208000014674 injury Diseases 0.000 claims description 44
- 208000027418 Wounds and injury Diseases 0.000 claims description 43
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims description 37
- 210000001074 muscle attachment cell Anatomy 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 239000003102 growth factor Substances 0.000 claims description 7
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 230000004069 differentiation Effects 0.000 claims description 5
- 230000008929 regeneration Effects 0.000 claims description 4
- 238000011069 regeneration method Methods 0.000 claims description 4
- 210000003954 umbilical cord Anatomy 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 47
- 210000001519 tissue Anatomy 0.000 description 39
- 238000000034 method Methods 0.000 description 35
- 238000011282 treatment Methods 0.000 description 22
- 210000003414 extremity Anatomy 0.000 description 20
- 238000002347 injection Methods 0.000 description 20
- 239000007924 injection Substances 0.000 description 20
- 208000000491 Tendinopathy Diseases 0.000 description 16
- 238000002604 ultrasonography Methods 0.000 description 15
- 241001465754 Metazoa Species 0.000 description 14
- 238000002513 implantation Methods 0.000 description 13
- 241000283086 Equidae Species 0.000 description 11
- 229920001917 Ficoll Polymers 0.000 description 10
- 230000033558 biomineral tissue development Effects 0.000 description 10
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 9
- 229920000669 heparin Polymers 0.000 description 9
- 206010043255 Tendonitis Diseases 0.000 description 8
- 229960002897 heparin Drugs 0.000 description 8
- 210000004623 platelet-rich plasma Anatomy 0.000 description 8
- 201000004415 tendinitis Diseases 0.000 description 8
- 230000035876 healing Effects 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 210000002381 plasma Anatomy 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 206010042674 Swelling Diseases 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 239000003550 marker Substances 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 239000006285 cell suspension Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 231100000241 scar Toxicity 0.000 description 5
- 210000001562 sternum Anatomy 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 206010039897 Sedation Diseases 0.000 description 4
- 208000021945 Tendon injury Diseases 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 230000001332 colony forming effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000004700 fetal blood Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000005499 meniscus Effects 0.000 description 4
- 238000002559 palpation Methods 0.000 description 4
- 238000004393 prognosis Methods 0.000 description 4
- 230000036280 sedation Effects 0.000 description 4
- 239000013049 sediment Substances 0.000 description 4
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 102000012422 Collagen Type I Human genes 0.000 description 3
- 108010022452 Collagen Type I Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 206010061223 Ligament injury Diseases 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000003194 forelimb Anatomy 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 210000001364 upper extremity Anatomy 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- OIWRDXKNDCJZSM-UHFFFAOYSA-N 5-[(2,3-dimethylphenyl)methyl]-1h-imidazole;hydron;chloride Chemical compound Cl.CC1=CC=CC(CC=2NC=NC=2)=C1C OIWRDXKNDCJZSM-UHFFFAOYSA-N 0.000 description 2
- 206010000362 Accessory carpal bone Diseases 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 208000034693 Laceration Diseases 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 210000001361 achilles tendon Anatomy 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 238000009583 bone marrow aspiration Methods 0.000 description 2
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 2
- 229960001113 butorphanol Drugs 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 239000012997 ficoll-paque Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000002695 general anesthesia Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 210000001126 granulation tissue Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005201 scrubbing Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229940054269 sodium pyruvate Drugs 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000037816 tissue injury Diseases 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- 101150088952 IGF1 gene Proteins 0.000 description 1
- 101150002416 Igf2 gene Proteins 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 description 1
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 description 1
- 208000020339 Spinal injury Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- AGSPXMVUFBBBMO-UHFFFAOYSA-N beta-aminopropionitrile Chemical compound NCCC#N AGSPXMVUFBBBMO-UHFFFAOYSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 238000005460 biophysical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- GMTYREVWZXJPLF-AFHUBHILSA-N butorphanol D-tartrate Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O.N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 GMTYREVWZXJPLF-AFHUBHILSA-N 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 239000002771 cell marker Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229960002273 detomidine hydrochloride Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000003090 exacerbative effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 102000054766 genetic haplotypes Human genes 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 102000046949 human MSC Human genes 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 208000030175 lameness Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
- 210000001037 metacarpus Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 210000000513 rotator cuff Anatomy 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000002660 stem cell treatment Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 229940037546 torbugesic Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220841A GB0220841D0 (en) | 2002-09-07 | 2002-09-07 | Therapy |
| GB0220841 | 2002-09-07 | ||
| GB0226275A GB0226275D0 (en) | 2002-11-12 | 2002-11-12 | Method of treatment |
| GB0226275 | 2002-11-12 | ||
| PCT/GB2003/003894 WO2004022078A1 (en) | 2002-09-07 | 2003-09-08 | Pharmaceutical kits comprising mesenchymal stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2304541T3 true ES2304541T3 (es) | 2008-10-16 |
Family
ID=31980022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03793917T Expired - Lifetime ES2304541T3 (es) | 2002-09-07 | 2003-09-08 | Medicamento que comprende celulas madre mesenquimales. |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8178084B2 (enExample) |
| EP (3) | EP1872789B1 (enExample) |
| AR (1) | AR047712A1 (enExample) |
| AT (2) | ATE494898T1 (enExample) |
| AU (1) | AU2003263340B2 (enExample) |
| CA (1) | CA2538187C (enExample) |
| DE (2) | DE60335752D1 (enExample) |
| ES (1) | ES2304541T3 (enExample) |
| NZ (1) | NZ539308A (enExample) |
| WO (1) | WO2004022078A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| US7608258B2 (en) | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
| AU2004291065B2 (en) * | 2003-05-13 | 2007-11-01 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US8361467B2 (en) | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| US9453202B2 (en) | 2003-10-08 | 2016-09-27 | Vet-Stem, Inc. | Methods of preparing and using novel stem cell compositions and kits comprising the same |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| US7678780B2 (en) | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
| US7462268B2 (en) | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
| KR100593397B1 (ko) * | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 ｐ 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
| CA2685146C (en) * | 2007-04-24 | 2016-03-29 | The University Of Western Australia | Tenocyte containing bioscaffolds and treatment using the same |
| US8785191B2 (en) * | 2007-08-27 | 2014-07-22 | University Of Connecticut | Concentration of stem cells obtained during orthopaedic surgeries |
| EP2237798A2 (en) | 2007-12-12 | 2010-10-13 | Imperial Innovations Limited | Methods |
| US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| IT1394262B1 (it) * | 2008-07-17 | 2012-06-01 | Università Degli Studi Di Milano | Metodo per la produzione in vitro di tenociti a partire da cellule staminali mesenchimali, nonché rispettivi metodi per la caratterizzazione di detti tenociti e di dette cellule staminali mesenchimali |
| WO2010042658A1 (en) | 2008-10-07 | 2010-04-15 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
| GB0820492D0 (en) * | 2008-11-07 | 2008-12-17 | Sportcell | Cell compositions and uses thereof |
| WO2010140162A2 (en) * | 2009-05-17 | 2010-12-09 | Dravida Subhadra | A process for preparing stem cell based formulations |
| RU2423089C1 (ru) * | 2009-11-17 | 2011-07-10 | Александр Михайлович Савинцев | Способ лечения повреждений ахиллова сухожилия |
| RU2419442C1 (ru) * | 2010-01-22 | 2011-05-27 | Александр Михайлович Савинцев | Способ лечения повреждений сухожильно-связочных структур конечностей животных |
| DE102010046218A1 (de) | 2010-09-21 | 2012-03-22 | Livlmplant Gmbh | Zell-basiertes Injektionssystem zur Behandlung von Verletzungen |
| US9044430B2 (en) | 2011-03-18 | 2015-06-02 | Microvascular Tissues, Inc. | Allogeneic microvascular tissue for soft tissue treatments |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| TW202344258A (zh) | 2011-11-30 | 2023-11-16 | 安斯泰來再生醫藥協會 | 利用血管母細胞產生間葉基質細胞之方法 |
| HK1208054A1 (en) | 2012-07-12 | 2016-02-19 | 爱姆斯坦生物技术公司 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CA2885419A1 (en) | 2012-09-19 | 2014-03-27 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| WO2014167142A1 (es) | 2013-04-09 | 2014-10-16 | Equicord, S.L. | Procedimiento para el tratamiento de células madre mesenquimales equinas y sistema para llevar a cabo el procedimiento |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
| BR112016014116B1 (pt) * | 2013-12-19 | 2022-12-13 | Universite De Liege | Método para preparar células-tronco mesenquimais (mscs) de mamíferos |
| EP3209768A1 (en) | 2014-07-25 | 2017-08-30 | Recellerate Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
| US10479977B2 (en) | 2014-11-07 | 2019-11-19 | The Trustees Of Columbia University In The City Of New York | Osteochondroreticular stem cells for bone and cartilage regeneration |
| RU2644650C2 (ru) | 2014-12-01 | 2018-02-13 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток и способ его получения |
| WO2016172004A1 (en) * | 2015-04-18 | 2016-10-27 | The Johns Hopkins University | Bone healing, angiogenesis-promoting and vasculogenesis-producing system |
| WO2017059089A1 (en) * | 2015-09-29 | 2017-04-06 | Anicell Biotech, Llc | Methods and articles of manufacture for the treatment of animals |
| US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| CN106308817B (zh) * | 2016-08-12 | 2023-07-28 | 玉溪九洲生物技术有限责任公司 | 一种马血浆采集系统 |
| FR3058065B1 (fr) * | 2016-10-27 | 2019-02-01 | Scarcell Therapeutics | Composition pour le traitement d’une affection de l’appareil locomoteur |
| EP3388511A1 (en) * | 2017-04-12 | 2018-10-17 | Revatis SA | New uses of mammalian muscle derived stel cells |
| WO2021041858A1 (en) * | 2019-08-29 | 2021-03-04 | Icahn School Of Medicine At Mount Sinai | Differentiated tendon cells derived from pluripotent progenitor cells and methods of use thereof |
| RU2722162C1 (ru) * | 2019-10-14 | 2020-05-27 | Федеральное государственное бюджетное учреждение науки Сибирский федеральный научный центр агробиотехнологий Российской академии наук (СФНЦА РАН) | Способ лечения травм сухожильно-связочного аппарата у лошадей |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| AU3145795A (en) * | 1994-07-26 | 1996-02-22 | Children's Medical Center Corporation | Fibrin-cell suspension for construction of new tissue |
| US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| PT1704878E (pt) * | 1995-12-18 | 2013-07-17 | Angiodevice Internat Gmbh | Composições de polímeros reticulados e métodos para a sua utilização |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US6280473B1 (en) * | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
| EP0989855A4 (en) * | 1997-05-13 | 2002-06-12 | Osiris Therapeutics Inc | REGENERATION OF CARTILAGE IN OSTEOARTHRITIS BY MEANS OF HUMAN MESENCHYMAL STEM CELLS |
| DE69831957T3 (de) * | 1997-07-14 | 2009-07-23 | Osiris Therapeutics, Inc. | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US20020123143A1 (en) * | 1997-08-22 | 2002-09-05 | Jean Toma | Multipotent stem cells from peripheral tissues and uses thereof |
| ES2237089T3 (es) | 1998-03-13 | 2005-07-16 | Osiris Therapeutics, Inc. | Usos para celulas madre mesenquimatosas humanas no autologas. |
| US6835377B2 (en) * | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| BR9912662A (pt) | 1998-07-31 | 2001-06-05 | Genzyme Corp | Melhoria de função cardìaca por transplante de célula de ramo mesenquimal |
| WO2000049136A1 (en) * | 1999-02-17 | 2000-08-24 | United States Surgical | Genetically altered mesenchymal stem cells and methods of use thereof |
| FR2799371A1 (fr) * | 1999-10-12 | 2001-04-13 | Univ Paris Curie | Compositions de tenocytes preparation et utilisations |
| EP1099754A1 (en) | 1999-11-10 | 2001-05-16 | Universiteit Leiden | Mesenchymal stem cells and/or progenitor cells, their isolation and use |
| WO2001070290A2 (en) * | 2000-03-20 | 2001-09-27 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
| US20020005205A1 (en) * | 2000-04-25 | 2002-01-17 | Barry Francis P. | Joint repair using mesenchymal stem cells |
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| AU2002224444A1 (en) * | 2000-10-24 | 2002-05-06 | Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| KR100494265B1 (ko) * | 2001-08-14 | 2005-06-13 | 메디포스트(주) | 관절연골손상 치료용 조성물 |
| US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
-
2003
- 2003-09-05 AR ARP030103236A patent/AR047712A1/es not_active Application Discontinuation
- 2003-09-08 AU AU2003263340A patent/AU2003263340B2/en not_active Ceased
- 2003-09-08 US US10/526,753 patent/US8178084B2/en active Active - Reinstated
- 2003-09-08 AT AT07014066T patent/ATE494898T1/de not_active IP Right Cessation
- 2003-09-08 EP EP07014066A patent/EP1872789B1/en not_active Expired - Lifetime
- 2003-09-08 EP EP03793917A patent/EP1545567B1/en not_active Expired - Lifetime
- 2003-09-08 DE DE60335752T patent/DE60335752D1/de not_active Expired - Lifetime
- 2003-09-08 WO PCT/GB2003/003894 patent/WO2004022078A1/en not_active Ceased
- 2003-09-08 NZ NZ539308A patent/NZ539308A/en not_active IP Right Cessation
- 2003-09-08 CA CA2538187A patent/CA2538187C/en not_active Expired - Fee Related
- 2003-09-08 ES ES03793917T patent/ES2304541T3/es not_active Expired - Lifetime
- 2003-09-08 DE DE60319848T patent/DE60319848T2/de not_active Expired - Lifetime
- 2003-09-08 EP EP10186184A patent/EP2316462A1/en not_active Withdrawn
- 2003-09-08 AT AT03793917T patent/ATE389412T1/de active
-
2012
- 2012-05-15 US US13/471,517 patent/US20120230960A1/en not_active Abandoned
- 2012-07-17 US US13/551,051 patent/US20130039896A1/en not_active Abandoned
-
2014
- 2014-09-16 US US14/487,660 patent/US20150017145A1/en not_active Abandoned
-
2017
- 2017-02-24 US US15/442,590 patent/US20170258848A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2316462A1 (en) | 2011-05-04 |
| EP1872789A1 (en) | 2008-01-02 |
| AU2003263340A1 (en) | 2004-03-29 |
| AR047712A1 (es) | 2006-02-15 |
| CA2538187A1 (en) | 2004-03-18 |
| ATE494898T1 (de) | 2011-01-15 |
| US20170258848A1 (en) | 2017-09-14 |
| WO2004022078A1 (en) | 2004-03-18 |
| EP1545567A1 (en) | 2005-06-29 |
| ATE389412T1 (de) | 2008-04-15 |
| US20120230960A1 (en) | 2012-09-13 |
| DE60319848D1 (de) | 2008-04-30 |
| DE60319848T2 (de) | 2009-04-30 |
| US20130039896A1 (en) | 2013-02-14 |
| DE60335752D1 (enExample) | 2011-02-24 |
| NZ539308A (en) | 2008-03-28 |
| US8178084B2 (en) | 2012-05-15 |
| AU2003263340B2 (en) | 2008-12-18 |
| US20060130852A1 (en) | 2006-06-22 |
| CA2538187C (en) | 2019-01-08 |
| EP1872789B1 (en) | 2011-01-12 |
| US20150017145A1 (en) | 2015-01-15 |
| EP1545567B1 (en) | 2008-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2304541T3 (es) | Medicamento que comprende celulas madre mesenquimales. | |
| ES2870776T3 (es) | Prevención y tratamiento de daños o enfermedades de los huesos y cartílagos | |
| CN109666629A (zh) | 人多能干细胞来源的外泌体、基于该外泌体的制剂及用途 | |
| ES2676318T3 (es) | FGF-18 en procedimientos de trasplante de injertos y de ingeniería tisular | |
| US8182806B2 (en) | Synovial villi for use with tissue engineering | |
| Shu et al. | Efficacy of administered mesenchymal stem cells in the initiation and co‐ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration | |
| EA019305B1 (ru) | Способ получения плюрипотентных стволовых клеток взрослого организма из крови, в частности периферической, и применение полученных клеток в области медицины | |
| Beerts et al. | Desmitis of the accessory ligament of the equine deep digital flexor tendon: a regenerative approach | |
| US10434135B2 (en) | Pharmaceutical composition for preventing or treating arthritis | |
| Grist | Ovine meat inspection | |
| ES2359890T3 (es) | Composiciones que comprenden células madre mesenquimales. | |
| US20150290248A1 (en) | Fibrous component for health, performance, and aesthetic treatment | |
| Franklin et al. | Biological therapies in canine sports medicine | |
| Golonka et al. | Subchondral bone cyst surgical treatment using the application of stem progenitor cells combined with alginate hydrogel in small joints in horses | |
| Al Hussein et al. | Minimally invasive surgical protocol for adipose derived stem cells collection and isolation-ovine model | |
| Moran | Clinical and ultrasonographic evaluation of the treatment of naturally occurring front limb suspensory branch injuries in sport horses with a standardized leukocyte poor platelet-rich plasma | |
| AU2016244319B2 (en) | Cell free preparation and uses thereof | |
| Filardo et al. | Microfracture and microfracture plus techniques in the knee | |
| Birdwhistell et al. | Biological Therapies in Canine Sports Medicine | |
| Makhkamov et al. | Microscopic Structure of the Cartilage Disc in Human Spine. | |
| Tyrnenopoulou et al. | Clinical application of adipose-derived stromal vascular fraction in 3 thoroughbred horses with superficial digital flexor tendonitis: case report | |
| Bogers et al. | 4 Veterinary Medicine’s | |
| Bogers et al. | Veterinary Medicine’s Advances in Regenerative Orthopedics | |
| BR102013033827A2 (pt) | concentrado multipotente e imunocompatível de células tronco, uso do concentrado, biofármaco, forma de dosagem, método de tratamento e processo de obtenção de concentrado de células tronco | |
| Haas | The Transplantation of Bone into Joints |