DE60311584T2 - Verfahren zur lagenweisen beschichtung eines medizinischen gegenstandes - Google Patents
Verfahren zur lagenweisen beschichtung eines medizinischen gegenstandes Download PDFInfo
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- DE60311584T2 DE60311584T2 DE60311584T DE60311584T DE60311584T2 DE 60311584 T2 DE60311584 T2 DE 60311584T2 DE 60311584 T DE60311584 T DE 60311584T DE 60311584 T DE60311584 T DE 60311584T DE 60311584 T2 DE60311584 T2 DE 60311584T2
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- polyionic material
- coating
- polyionic
- medical device
- coating solution
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- 238000002604 ultrasonography Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/18—Processes for applying liquids or other fluent materials performed by dipping
- B05D1/185—Processes for applying liquids or other fluent materials performed by dipping applying monomolecular layers
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Materials For Medical Uses (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40994502P | 2002-09-11 | 2002-09-11 | |
| US409945P | 2002-09-11 | ||
| PCT/EP2003/010065 WO2004025332A1 (en) | 2002-09-11 | 2003-09-10 | Method for applying an lbl coating onto a medical device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60311584D1 DE60311584D1 (de) | 2007-03-22 |
| DE60311584T2 true DE60311584T2 (de) | 2007-10-31 |
Family
ID=31994035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60311584T Expired - Lifetime DE60311584T2 (de) | 2002-09-11 | 2003-09-10 | Verfahren zur lagenweisen beschichtung eines medizinischen gegenstandes |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6896926B2 (https=) |
| EP (1) | EP1540381B1 (https=) |
| JP (1) | JP4551219B2 (https=) |
| AT (1) | ATE353141T1 (https=) |
| AU (1) | AU2003273851A1 (https=) |
| DE (1) | DE60311584T2 (https=) |
| WO (1) | WO2004025332A1 (https=) |
Families Citing this family (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159232A (en) | 1997-12-16 | 2000-12-12 | Closys Corporation | Clotting cascade initiating apparatus and methods of use and methods of closing wounds |
| US6478808B2 (en) | 1997-12-17 | 2002-11-12 | Closys Corporation | Clotting cascade initiating apparatus and methods of use and methods of closing wounds |
| US6451871B1 (en) | 1998-11-25 | 2002-09-17 | Novartis Ag | Methods of modifying surface characteristics |
| US20030069601A1 (en) * | 1998-12-15 | 2003-04-10 | Closys Corporation | Clotting cascade initiating apparatus and methods of use |
| AR027348A1 (es) * | 2000-02-04 | 2003-03-26 | Novartis Ag | Proceso para recubrir una superficie |
| US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
| US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
| US7402318B2 (en) * | 2001-11-14 | 2008-07-22 | Novartis Ag | Medical devices having antimicrobial coatings thereon |
| US6926965B2 (en) * | 2002-09-11 | 2005-08-09 | Novartis Ag | LbL-coated medical device and method for making the same |
| US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
| EP1750780B1 (en) * | 2004-05-20 | 2007-10-03 | Boston Scientific Limited | Medical devices and methods of making the same |
| US8133274B2 (en) * | 2004-06-18 | 2012-03-13 | Medennium, Inc. | Photochromic intraocular lenses and methods of making the same |
| AU2005294316A1 (en) * | 2004-10-06 | 2006-04-20 | Cook Incorporated | Medical device with bioactive agent |
| US7767251B2 (en) * | 2005-03-16 | 2010-08-03 | Shiping Wang | Repellent elastomeric article |
| AU2006241145B2 (en) * | 2005-04-27 | 2011-04-28 | Baxter Healthcare S. A. | Surface-modified microparticles and methods of forming and using the same |
| US20070067882A1 (en) * | 2005-09-21 | 2007-03-22 | Liliana Atanasoska | Internal medical devices having polyelectrolyte-containing extruded regions |
| EP1931397B1 (en) * | 2005-10-05 | 2009-04-08 | SCA Hygiene Products AB | Absorbent article comprising hydrophilic and hydrophobic regions |
| AU2005337071B2 (en) * | 2005-10-05 | 2011-11-24 | Sca Hygiene Products Ab | Absorbent article comprising a thin film including an active agent |
| EP1971374A1 (en) * | 2005-11-30 | 2008-09-24 | SCA Hygiene Products AB | Absorbent article |
| US20080300558A1 (en) * | 2005-12-20 | 2008-12-04 | Sca Hygiene Products Ab | Article |
| US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
| US8044112B2 (en) | 2006-03-30 | 2011-10-25 | Novartis Ag | Method for applying a coating onto a silicone hydrogel lens |
| US20080094573A1 (en) * | 2006-04-04 | 2008-04-24 | Vermette Patrick | Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof |
| US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
| US7858000B2 (en) * | 2006-06-08 | 2010-12-28 | Novartis Ag | Method of making silicone hydrogel contact lenses |
| DK2038310T3 (da) | 2006-07-12 | 2010-09-27 | Novartis Ag | Aktinisk tværbindelige copolymerer til fremstilling af kontaktlinser |
| JP5118139B2 (ja) * | 2006-08-04 | 2013-01-16 | バクスター・インターナショナル・インコーポレイテッド | 新規発症自己免疫性糖尿病を予防および／または逆転させるためのマイクロスフィアに基づく組成物 |
| WO2008034048A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprosthesis with biostable inorganic layers |
| EP2068845A2 (en) * | 2006-10-06 | 2009-06-17 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
| US9052442B2 (en) * | 2006-10-30 | 2015-06-09 | Novartis Ag | Method for applying a coating onto a silicone hydrogel lens |
| AR064286A1 (es) * | 2006-12-13 | 2009-03-25 | Quiceno Gomez Alexandra Lorena | Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida |
| US8158192B2 (en) * | 2006-12-21 | 2012-04-17 | Novartis Ag | Process for the coating of biomedical articles |
| WO2008083190A2 (en) | 2006-12-28 | 2008-07-10 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making same |
| KR101375460B1 (ko) * | 2007-02-09 | 2014-03-18 | 노파르티스 아게 | 콘택트 렌즈용 가교형 다이온성 코팅재 |
| HUE027476T2 (en) * | 2007-02-26 | 2016-09-28 | Novartis Ag | A method for producing hydrogel contact lenses with desired properties |
| TW200840554A (en) * | 2007-02-28 | 2008-10-16 | Alcon Inc | Coated medical implants and lenses |
| WO2008116131A2 (en) | 2007-03-22 | 2008-09-25 | Novartis Ag | Prepolymers with dangling polysiloxane-containing polymer chains |
| US8071703B2 (en) | 2007-03-22 | 2011-12-06 | Novartis Ag | Silicone-containing prepolymers with dangling hydrophilic polymer chains |
| DE102007024642A1 (de) | 2007-05-24 | 2008-11-27 | Eyesense Ag | Hydrogel-Implantat für Sensorik von Metaboliten am Auge |
| WO2008157372A2 (en) | 2007-06-14 | 2008-12-24 | Massachusetts Institute Of Technology | Self assembled films for protein and drug delivery applications |
| US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
| US8044111B2 (en) | 2007-11-30 | 2011-10-25 | Novartis Ag | Actinically-crosslinkable silicone-containing block copolymers |
| US20090155519A1 (en) * | 2007-12-12 | 2009-06-18 | Emembrane Inc. | Hydrophilic Coating Of polymeric Substrates |
| US20090155595A1 (en) * | 2007-12-12 | 2009-06-18 | Emembrane Inc. | Polymeric Composites with a Hydrophilic Coating |
| EP2219865A4 (en) * | 2007-12-12 | 2013-01-23 | Emembrane Inc | HYDROPHILIC COATING OF POLYMER SUBSTRATES |
| EP2238480B1 (en) | 2007-12-20 | 2012-02-01 | Novartis AG | Method for making contact lenses |
| ATE551177T1 (de) * | 2008-01-23 | 2012-04-15 | Novartis Ag | Verfahren zur beschichtung von silikon-hydrogelen |
| US8460743B2 (en) * | 2008-03-18 | 2013-06-11 | Novartis Ag | Coating process for ophthalmic lenses |
| EP2258416B1 (en) * | 2008-03-26 | 2014-11-26 | Kaneka Corporation | Antithrombotic surface |
| US20090244479A1 (en) * | 2008-03-31 | 2009-10-01 | Diana Zanini | Tinted silicone ophthalmic devices, processes and polymers used in the preparation of same |
| US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
| WO2010011493A1 (en) | 2008-07-21 | 2010-01-28 | Novartis Ag | Silicone-containing polymeric materals with hydrolyzable groups |
| US8357760B2 (en) | 2008-07-21 | 2013-01-22 | Novartis Ag | Silicone hydrogel contact lenses with convertible comfort agents |
| US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
| US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
| CA2739102C (en) * | 2008-11-13 | 2016-06-21 | Novartis Ag | Silicone hydrogel materials with chemically bound wetting agents |
| BRPI0921894A2 (pt) * | 2008-11-13 | 2015-12-29 | Novartis Ag | copolímeros de polissiloxano com cadeias de polímero hidrofílicas terminais |
| TWI506333B (zh) * | 2008-12-05 | 2015-11-01 | Novartis Ag | 用以傳遞疏水性舒適劑之眼用裝置及其製造方法 |
| NZ592674A (en) | 2008-12-18 | 2012-08-31 | Novartis Ag | Method for making silicone hydrogel contact lenses |
| US8163358B2 (en) * | 2009-02-18 | 2012-04-24 | Synergeyes, Inc. | Surface modification of contact lenses |
| WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
| US8431624B2 (en) | 2009-09-15 | 2013-04-30 | Novartis Ag | Prepolymers suitable for making ultra-violet absorbing contact lenses |
| US20110064936A1 (en) * | 2009-09-17 | 2011-03-17 | Massachusetts Institute Of Technology | Method of Asymmetrically Functionalizing Porous Materials |
| WO2011045380A1 (en) | 2009-10-16 | 2011-04-21 | Novartis Ag | Apparatus and method for transporting contact lenses through dipping baths |
| TWI483996B (zh) * | 2009-12-08 | 2015-05-11 | Novartis Ag | 具有共價貼合塗層之聚矽氧水凝膠鏡片 |
| ES2693499T3 (es) | 2010-02-16 | 2018-12-12 | Toray Industries, Inc. | Lentilla ocular blanda que tiene contenido bajo de humedad y procedimiento para producir la misma |
| US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
| US20130273137A1 (en) * | 2010-05-03 | 2013-10-17 | Massachusetts Eye & Ear Infirmary | Drug delivery coating and devices |
| US9522980B2 (en) | 2010-05-06 | 2016-12-20 | Johnson & Johnson Vision Care, Inc. | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same |
| US10231721B2 (en) | 2010-06-24 | 2019-03-19 | St. Croix Surgical Systems, Llc | Failsafe percutaneous wound barrier |
| AU2011282603B2 (en) | 2010-07-30 | 2014-01-30 | Novartis Ag | Amphiphilic polysiloxane prepolymers and uses thereof |
| ES2423914T3 (es) | 2010-07-30 | 2013-09-25 | Novartis Ag | Lentes de hidrogel de silicona con superficies ricas en agua |
| CN103168067B (zh) | 2010-10-06 | 2015-08-05 | 诺华股份有限公司 | 可水处理的含硅氧烷预聚物及其用途 |
| US8835525B2 (en) | 2010-10-06 | 2014-09-16 | Novartis Ag | Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains |
| EP2625216B1 (en) | 2010-10-06 | 2019-06-05 | Novartis AG | Polymerisable chain-extended polysiloxanes with pendant hydrophilic groups |
| US9170349B2 (en) | 2011-05-04 | 2015-10-27 | Johnson & Johnson Vision Care, Inc. | Medical devices having homogeneous charge density and methods for making same |
| CN103517806A (zh) * | 2011-05-12 | 2014-01-15 | 日立化成株式会社 | 带有基材的薄膜及其制造方法 |
| WO2013024880A1 (ja) | 2011-08-17 | 2013-02-21 | 東レ株式会社 | 低含水性軟質眼用レンズおよびその製造方法 |
| EP2745854B1 (en) * | 2011-08-17 | 2018-02-07 | Toray Industries, Inc. | Medical device, and method for producing same |
| EP2745855B1 (en) | 2011-08-17 | 2023-06-21 | Toray Industries, Inc. | Medical device, and method for producing same |
| CN103733121B (zh) | 2011-08-17 | 2016-06-01 | 东丽株式会社 | 医疗设备、涂布溶液的组合和医疗设备的制造方法 |
| EP2745853B1 (en) | 2011-08-17 | 2023-03-15 | Toray Industries, Inc. | Medical device, and method for producing same |
| SG11201400228WA (en) | 2011-10-12 | 2014-05-29 | Novartis Ag | Method for making uv-absorbing ophthalmic lenses by coating |
| US9644140B2 (en) | 2011-10-27 | 2017-05-09 | Baker Hughes Incorporated | Method of reducing dust with particulates coated with a polycationic polymer |
| US9624377B2 (en) | 2011-10-27 | 2017-04-18 | Baker Hughes Incorporated | Methods of using sand composites to control dust |
| US9637671B2 (en) | 2011-10-27 | 2017-05-02 | Baker Hughes Incorporated | Method of suppressing the generation of dust from sand |
| US9168565B2 (en) | 2011-10-27 | 2015-10-27 | Baker Hughes Incorporated | Method of reducing dust with self-assembly composites |
| US9328590B2 (en) | 2011-10-27 | 2016-05-03 | Baker Hughes Incorporated | Well treatment operations using a treatment agent coated with alternating layers of polyionic material |
| HUE027313T2 (en) | 2011-11-15 | 2016-10-28 | Novartis Ag | Silicone hydrogel lens with cross-linked hydrophilic coating |
| WO2013096173A1 (en) | 2011-12-21 | 2013-06-27 | Novartis Ag | Contact lenses containing carotenoid and method for making same |
| WO2013163234A1 (en) | 2012-04-23 | 2013-10-31 | Massachusetts Institute Of Technology | Stable layer-by-layer coated particles |
| US9244196B2 (en) | 2012-05-25 | 2016-01-26 | Johnson & Johnson Vision Care, Inc. | Polymers and nanogel materials and methods for making and using the same |
| IN2014DN09503A (https=) | 2012-05-25 | 2015-07-17 | Johnson & Johnson Vision Care | |
| US10073192B2 (en) | 2012-05-25 | 2018-09-11 | Johnson & Johnson Vision Care, Inc. | Polymers and nanogel materials and methods for making and using the same |
| NZ700848A (en) | 2012-06-14 | 2016-08-26 | Novartis Ag | Azetidinium-containing copolymers and uses thereof |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| CN104837612B (zh) * | 2012-12-11 | 2017-08-25 | 诺华股份有限公司 | 将涂层施加于硅酮水凝胶透镜上的方法 |
| CN104871036B (zh) | 2012-12-17 | 2019-12-10 | 诺华股份有限公司 | 制备改进的uv吸收性眼用透镜的方法 |
| WO2014134029A1 (en) | 2013-02-26 | 2014-09-04 | Massachusetts Institute Of Technology | Nucleic acid particles, methods and use thereof |
| WO2014150074A1 (en) | 2013-03-15 | 2014-09-25 | Massachusetts Institute Of Technology | Compositions and methods for nucleic acid delivery |
| US9950483B2 (en) | 2013-05-29 | 2018-04-24 | Novartis Ag | Method for determining the surface concentration of carboxyl groups on a lens |
| SG11201601187VA (en) | 2013-09-30 | 2016-04-28 | Novartis Ag | Method for making uv-absorbing ophthalmic lenses |
| US9568645B2 (en) | 2013-09-30 | 2017-02-14 | Novartis Ag | Silicone hydrogel lenses with relatively-long thermal stability |
| HUE040618T2 (hu) | 2013-10-31 | 2019-03-28 | Novartis Ag | Eljárás szemészeti lencsék elõállítására |
| CN105917270A (zh) | 2013-11-15 | 2016-08-31 | 视觉力学有限责任公司 | 具有亲水层的接触透镜 |
| HUE036795T2 (hu) | 2013-12-13 | 2018-07-30 | Novartis Ag | Eljárás kontaktlencse elõállítására |
| HUE038809T2 (hu) | 2013-12-17 | 2018-11-28 | Novartis Ag | Térhálósított hidrofíl bevonattal ellátott szilikon hidrogél lencse |
| WO2015183716A1 (en) * | 2014-05-27 | 2015-12-03 | Artificial Cell Technologies, Inc. | Automated layer by layer construction of multilayer coated cores by tff |
| BR112017003447B1 (pt) | 2014-08-26 | 2021-10-26 | Alcon Inc | Copolímero de poli(oxazolina-co-etilenoimina)-epicloridrina, material polimérico hidrofílico reticulável termicamente e solúvel em água, e métodos para produzir lentes de contato revestidas |
| EP3186070B1 (en) | 2014-08-26 | 2019-09-25 | Novartis AG | Method for applying stable coating on silicone hydrogel contact lenses |
| JP6774947B2 (ja) | 2014-12-09 | 2020-10-28 | タンジブル サイエンス インコーポレイテッド | 生体適合性層を有する医療デバイスコーティング |
| US9453949B2 (en) * | 2014-12-15 | 2016-09-27 | Eastman Chemical Company | Electromagnetic energy-absorbing optical product and method for making |
| EP3268804B1 (en) | 2015-03-11 | 2020-11-04 | University of Florida Research Foundation, Inc. | Mesh size control of lubrication in gemini hydrogels |
| CA2992823C (en) | 2015-09-04 | 2019-10-29 | Novartis Ag | Method for producing contact lenses with durable lubricious coatings thereon |
| WO2017095469A1 (en) * | 2015-12-01 | 2017-06-08 | Eastman Chemical Company | Electromagnetic energy-absorbing optical product and method for making |
| WO2017093834A1 (en) | 2015-12-03 | 2017-06-08 | Novartis Ag | Contact lens packaging solutions |
| KR102604468B1 (ko) | 2015-12-15 | 2023-11-22 | 알콘 인코포레이티드 | 실리콘 하이드로겔 콘택트 렌즈 상에 안정한 코팅을 적용하기 위한 방법 |
| MY192377A (en) | 2015-12-15 | 2022-08-17 | Novartis Ag | Method for producing contact lenses with a lubricious surface |
| TWI606850B (zh) * | 2015-12-22 | 2017-12-01 | 美樺興業股份有限公司 | 人工水晶體以及其製作方法 |
| JP6718608B2 (ja) * | 2016-05-25 | 2020-07-08 | 国立大学法人愛媛大学 | 眼表面・眼瞼摩擦係数測定装置および眼表面・眼瞼摩擦係数評価方法 |
| JP7172037B2 (ja) * | 2016-07-28 | 2022-11-16 | 東レ株式会社 | 医療デバイス、医療デバイスの製造方法 |
| MY189895A (en) | 2016-09-20 | 2022-03-18 | Novartis Ag | Process for producing contact lenses with durable lubricious coatings thereon |
| HUE053839T2 (hu) | 2016-10-31 | 2021-07-28 | Alcon Inc | Eljárás felületi bevonattal ellátott, viselési kényelemmel rendelkezõ kontaktlencsék elõállítására |
| TW201823501A (zh) | 2016-11-16 | 2018-07-01 | 美商陶氏全球科技有限責任公司 | 用於製造膜上之薄塗層之方法 |
| WO2018224975A1 (en) | 2017-06-07 | 2018-12-13 | Novartis Ag | Silicone hydrogel contact lenses |
| KR102595791B1 (ko) | 2017-06-07 | 2023-10-31 | 알콘 인코포레이티드 | 실리콘 하이드로겔 콘택트 렌즈 |
| US10809181B2 (en) * | 2017-08-24 | 2020-10-20 | Alcon Inc. | Method and apparatus for determining a coefficient of friction at a test site on a surface of a contact lens |
| US10338287B2 (en) | 2017-08-29 | 2019-07-02 | Southwall Technologies Inc. | Infrared-rejecting optical products having pigmented coatings |
| US11747532B2 (en) | 2017-09-15 | 2023-09-05 | Southwall Technologies Inc. | Laminated optical products and methods of making them |
| WO2019089567A1 (en) | 2017-10-30 | 2019-05-09 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
| US10830923B2 (en) | 2017-12-13 | 2020-11-10 | Alcon Inc. | Method for producing MPS-compatible water gradient contact lenses |
| CN108451931B (zh) * | 2018-04-04 | 2021-04-30 | 华侨大学 | 一种pah/f聚电解质复合物纳米载体及其制备方法 |
| US10627555B2 (en) | 2018-04-09 | 2020-04-21 | Southwall Technologies Inc. | Selective light-blocking optical products having a neutral reflection |
| US10613261B2 (en) | 2018-04-09 | 2020-04-07 | Southwall Technologies Inc. | Selective light-blocking optical products having a neutral reflection |
| DE102018211526A1 (de) * | 2018-07-11 | 2020-01-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Beschichtung für implantierbare medizinische Geräte, Verfahren zu deren Herstellung sowie implantierbares medizinisches Gerät |
| EP3934623A4 (en) * | 2019-03-08 | 2022-11-23 | University of Pittsburgh - Of the Commonwealth System of Higher Education | MULTI-LAYER DRUG DELIVERY COATING FOR CONTACT LENSES |
| WO2021002984A1 (en) | 2019-05-30 | 2021-01-07 | Massachusetts Institute Of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
| EP4017346B1 (en) | 2019-11-04 | 2024-12-04 | Alcon Inc. | Method of producing contact lenses with surfaces of different softness |
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| US20230350100A1 (en) | 2022-04-29 | 2023-11-02 | Alcon Inc. | Method for making silicone hydrogel contact lenses |
| WO2024038390A1 (en) | 2022-08-17 | 2024-02-22 | Alcon Inc. | A contact lens with a hydrogel coating thereon |
| WO2025243221A1 (en) | 2024-05-22 | 2025-11-27 | Alcon Inc. | Reactive hevl-absorbing dyes |
| US20250362530A1 (en) | 2024-05-22 | 2025-11-27 | Alcon Inc. | Method for making centrally colored contact lenses |
| WO2025243219A1 (en) | 2024-05-22 | 2025-11-27 | Alcon Inc. | Reactive dyes and their use in contact lenses |
| US12225906B1 (en) * | 2024-09-26 | 2025-02-18 | Terry Earl Brady | Pathogenic affinity pathway of infectious or parasitic organisms for nanogram and picogram dosimetry prophylaxis or cure |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4168112A (en) | 1978-01-05 | 1979-09-18 | Polymer Technology Corporation | Contact lens with a hydrophilic, polyelectrolyte complex coating and method for forming same |
| EP0032443B1 (en) | 1980-01-10 | 1985-06-05 | CooperVision Inc. | Cross-linked polymers for contact lenses |
| GB2102070A (en) | 1981-07-14 | 1983-01-26 | Anglo Netherland Engineering C | Assisted gas flow device |
| US4570629A (en) | 1982-03-17 | 1986-02-18 | University Of Illinois Foundation | Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same |
| JPH01158412A (ja) * | 1986-12-26 | 1989-06-21 | Daicel Chem Ind Ltd | コンタクトレンズ用洗浄保存液 |
| US4941997A (en) | 1987-07-13 | 1990-07-17 | Ciba-Geigy Corporation | Amphiphilic azo dyes and molecular aggregates thereof |
| EP0329613A3 (de) | 1988-02-17 | 1991-06-05 | Ciba-Geigy Ag | Organische Materialien mit nichtlinearen optischen Eigenschaften |
| DE4026978A1 (de) | 1990-08-25 | 1992-02-27 | Bayer Ag | Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung |
| JP3166298B2 (ja) * | 1991-10-04 | 2001-05-14 | 株式会社ダイヘン | Ｇｍａ溶接のアーク長制御方法 |
| WO1995000618A1 (en) | 1993-06-18 | 1995-01-05 | Polymer Technology Corporation | Contact lens solution containing peo and cationic cellulose |
| US5518767A (en) | 1993-07-01 | 1996-05-21 | Massachusetts Institute Of Technology | Molecular self-assembly of electrically conductive polymers |
| GB9415926D0 (en) | 1994-08-04 | 1994-09-28 | Biocompatibles Ltd | New materials |
| US5529727A (en) | 1994-07-20 | 1996-06-25 | Bausch & Lomb Incorporated | Method of treating contact lenses |
| US5760100B1 (en) | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
| US5700559A (en) | 1994-12-16 | 1997-12-23 | Advanced Surface Technology | Durable hydrophilic surface coatings |
| WO1996037241A1 (en) | 1995-05-25 | 1996-11-28 | Minnesota Mining And Manufacturing Company | Process for producing biocompatible surfaces |
| US6011082A (en) | 1997-06-02 | 2000-01-04 | Pharmacia & Upjohn Ab | Process for the modification of elastomers with surface interpreting polymer networks and elastomers formed therefrom |
| US6451871B1 (en) | 1998-11-25 | 2002-09-17 | Novartis Ag | Methods of modifying surface characteristics |
| TW403841B (en) * | 1998-01-09 | 2000-09-01 | Novartis Ag | Coating of polymers |
| AR027348A1 (es) | 2000-02-04 | 2003-03-26 | Novartis Ag | Proceso para recubrir una superficie |
| US6719929B2 (en) | 2000-02-04 | 2004-04-13 | Novartis Ag | Method for modifying a surface |
| US6589665B2 (en) | 2000-05-30 | 2003-07-08 | Novartis Ag | Coated articles |
| AU2001267488A1 (en) | 2000-05-30 | 2001-12-11 | Novartis Ag | Coated articles |
| SK2152003A3 (en) | 2000-08-24 | 2003-08-05 | Novartis Ag | Process for surface modifying substrates and modified substrates resulting therefrom |
| US6811805B2 (en) | 2001-05-30 | 2004-11-02 | Novatis Ag | Method for applying a coating |
| US6858248B2 (en) | 2001-05-30 | 2005-02-22 | Novartis Ag | Method for applying a coating to a medical device |
| US6827966B2 (en) | 2001-05-30 | 2004-12-07 | Novartis Ag | Diffusion-controllable coatings on medical device |
| US6815074B2 (en) | 2001-05-30 | 2004-11-09 | Novartis Ag | Polymeric materials for making contact lenses |
| US7402318B2 (en) | 2001-11-14 | 2008-07-22 | Novartis Ag | Medical devices having antimicrobial coatings thereon |
| AR038269A1 (es) | 2002-01-09 | 2005-01-12 | Novartis Ag | Articulos polimericos que tienen un recubrimiento lubrico, y metodo para fabricarlos |
-
2003
- 2003-09-03 US US10/654,340 patent/US6896926B2/en not_active Expired - Lifetime
- 2003-09-10 JP JP2004535481A patent/JP4551219B2/ja not_active Expired - Lifetime
- 2003-09-10 DE DE60311584T patent/DE60311584T2/de not_active Expired - Lifetime
- 2003-09-10 AU AU2003273851A patent/AU2003273851A1/en not_active Abandoned
- 2003-09-10 EP EP03757817A patent/EP1540381B1/en not_active Expired - Lifetime
- 2003-09-10 WO PCT/EP2003/010065 patent/WO2004025332A1/en not_active Ceased
- 2003-09-10 AT AT03757817T patent/ATE353141T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040047979A1 (en) | 2004-03-11 |
| JP4551219B2 (ja) | 2010-09-22 |
| WO2004025332A1 (en) | 2004-03-25 |
| EP1540381A1 (en) | 2005-06-15 |
| DE60311584D1 (de) | 2007-03-22 |
| AU2003273851A1 (en) | 2004-04-30 |
| US6896926B2 (en) | 2005-05-24 |
| EP1540381B1 (en) | 2007-01-31 |
| JP2005538418A (ja) | 2005-12-15 |
| ATE353141T1 (de) | 2007-02-15 |
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