DE60302765D1 - Vorrichtung und verfahren zum herstellen von kristallinen teilchen - Google Patents

Vorrichtung und verfahren zum herstellen von kristallinen teilchen

Info

Publication number
DE60302765D1
DE60302765D1 DE60302765T DE60302765T DE60302765D1 DE 60302765 D1 DE60302765 D1 DE 60302765D1 DE 60302765 T DE60302765 T DE 60302765T DE 60302765 T DE60302765 T DE 60302765T DE 60302765 D1 DE60302765 D1 DE 60302765D1
Authority
DE
Germany
Prior art keywords
crystalline particles
producing crystalline
producing
particles
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60302765T
Other languages
English (en)
Other versions
DE60302765T2 (de
Inventor
Hardev Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE60302765D1 publication Critical patent/DE60302765D1/de
Application granted granted Critical
Publication of DE60302765T2 publication Critical patent/DE60302765T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/25—Mixing by jets impinging against collision plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B01F35/717611—Peristaltic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
DE60302765T 2002-01-22 2003-01-21 Vorrichtung und verfahren zum herstellen von kristallinen teilchen Expired - Lifetime DE60302765T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0201400 2002-01-22
GBGB0201400.9A GB0201400D0 (en) 2002-01-22 2002-01-22 Novel apparatus and process
PCT/EP2003/000558 WO2003061816A1 (en) 2002-01-22 2003-01-21 Apparatus and process for preparing crystalline particles

Publications (2)

Publication Number Publication Date
DE60302765D1 true DE60302765D1 (de) 2006-01-19
DE60302765T2 DE60302765T2 (de) 2006-07-06

Family

ID=9929515

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60302765T Expired - Lifetime DE60302765T2 (de) 2002-01-22 2003-01-21 Vorrichtung und verfahren zum herstellen von kristallinen teilchen

Country Status (22)

Country Link
US (1) US7384478B2 (de)
EP (1) EP1469938B1 (de)
JP (1) JP4408700B2 (de)
KR (1) KR20040082395A (de)
CN (1) CN1620333A (de)
AR (1) AR038200A1 (de)
AT (1) ATE312661T1 (de)
BR (1) BR0306738A (de)
CA (1) CA2473059A1 (de)
CO (1) CO5611178A2 (de)
DE (1) DE60302765T2 (de)
ES (1) ES2253656T3 (de)
GB (1) GB0201400D0 (de)
IL (1) IL162751A0 (de)
IS (1) IS7335A (de)
MX (1) MXPA04007073A (de)
NO (1) NO20043444L (de)
PL (1) PL372897A1 (de)
RU (1) RU2004120549A (de)
TW (1) TW200302129A (de)
WO (1) WO2003061816A1 (de)
ZA (1) ZA200405143B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
WO2005051511A1 (ja) * 2003-11-28 2005-06-09 Mitsubishi Chemical Corporation 有機化合物微粒子の製造方法
GB0406069D0 (en) * 2004-03-17 2004-04-21 Thompson James Process
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
JP4597107B2 (ja) * 2006-03-02 2010-12-15 三井金属鉱業株式会社 砒素含有体からの砒素除去方法及び砒素除去装置
RU2008142388A (ru) * 2006-04-03 2010-05-10 Тева Фармасьютикл Индастриес Лтд. (Il) Микрочастицы лекарственного вещества
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
GB0900080D0 (en) 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
GB0918149D0 (en) 2009-10-16 2009-12-02 Jagotec Ag Improved medicinal aerosol formulation
GB0918150D0 (en) * 2009-10-16 2009-12-02 Jagotec Ag Improved formulations
EP2500072A1 (de) * 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. Neuartiges Verfahren zum Entfernen von Restlösemittel
WO2013009591A1 (en) * 2011-07-08 2013-01-17 Pfizer Limited Process for the preparation of fluticasone propionate form 1
EP2732078B1 (de) * 2011-07-14 2017-03-15 Covaris, Inc. Verfahren zur herstellung nanokristalliner zusammensetzungen mittels fokussierter akustik
JP5848621B2 (ja) * 2012-01-25 2016-01-27 浜松ホトニクス株式会社 薬物評価方法及び薬物評価装置
EP2847207B1 (de) 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Nanokristalle von Fluticasonpropionat
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
MX2015009891A (es) 2013-01-31 2016-03-08 Prosonix Ltd Composiciones farmaceuticas que comprenden particulas cristalinas de multicomponentes adecuadas para usar en terapia de inhalacion.
WO2014137982A1 (en) 2013-03-08 2014-09-12 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
CN103977593B (zh) * 2014-05-19 2017-01-04 中国工程物理研究院化工材料研究所 制备纳米共晶含能材料的方法及装置
DE102021121631A1 (de) 2021-08-20 2023-02-23 Dionex Softron Gmbh Mischanordnung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4930820B1 (de) * 1966-02-10 1974-08-16
US3749318A (en) * 1971-03-01 1973-07-31 E Cottell Combustion method and apparatus burning an intimate emulsion of fuel and water
JPS5756031A (en) * 1980-09-19 1982-04-03 Toshiba Corp Ultrasonic emulsifier
JPS58163425A (ja) * 1982-03-25 1983-09-28 Toshiba Corp 超音波乳化装置
US5032027A (en) * 1989-10-19 1991-07-16 Heat Systems Incorporated Ultrasonic fluid processing method
HUT59692A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars
JP3178873B2 (ja) * 1991-12-20 2001-06-25 第一高周波工業株式会社 超音波を利用した液体混合方法
US5471001A (en) * 1994-12-15 1995-11-28 E. I. Du Pont De Nemours And Company Crystallization of adipic acid
JP3630834B2 (ja) * 1995-04-24 2005-03-23 株式会社リコー 二種以上の樹脂原料液体の混合法及びその混合装置
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US20010023252A1 (en) * 1998-07-02 2001-09-20 Smithkline Beecham Plc Novel compound
GB9828721D0 (en) 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
EP1173265B1 (de) 1999-01-29 2005-12-21 Bristol-Myers Squibb Company Vorrichtung und verfahren zur mit ultraschall beaufschlagten strahlkristallisation

Also Published As

Publication number Publication date
ES2253656T3 (es) 2006-06-01
CO5611178A2 (es) 2006-02-28
EP1469938B1 (de) 2005-12-14
GB0201400D0 (en) 2002-03-13
NO20043444L (no) 2004-08-18
CA2473059A1 (en) 2003-07-31
EP1469938A1 (de) 2004-10-27
JP2005525216A (ja) 2005-08-25
IS7335A (is) 2004-06-28
JP4408700B2 (ja) 2010-02-03
RU2004120549A (ru) 2005-05-10
CN1620333A (zh) 2005-05-25
AR038200A1 (es) 2005-01-05
WO2003061816A1 (en) 2003-07-31
BR0306738A (pt) 2004-12-28
TW200302129A (en) 2003-08-01
ATE312661T1 (de) 2005-12-15
US20060096522A1 (en) 2006-05-11
ZA200405143B (en) 2005-12-28
DE60302765T2 (de) 2006-07-06
IL162751A0 (en) 2005-11-20
MXPA04007073A (es) 2004-10-29
US7384478B2 (en) 2008-06-10
KR20040082395A (ko) 2004-09-24
PL372897A1 (en) 2005-08-08

Similar Documents

Publication Publication Date Title
DE60302765D1 (de) Vorrichtung und verfahren zum herstellen von kristallinen teilchen
DE60238085D1 (de) Vorrichtung und Verfahren zum herstellen von Mikrokapseln
DE60331902D1 (de) Verfahren und vorrichtung zum rührreibschweissen
DE50211121D1 (de) Verfahren und vorrichtung zum herstellen von beutelpackungen
DE60301642D1 (de) Verfahren und Vorrichtung zum Selektieren und Zuführen von Artikeln
DE50311679D1 (de) Vorrichtung und Verfahren zum schichtweisen Herstellen von dreidimensionalen Objekten
DE60130217D1 (de) Verfahren und vorrichtung zum herstellen von fluorwasserstoff
DE602004009411D1 (de) Verfahren und vorrichtung zum zurückfalten von reifensturkturgliedern
DE50209553D1 (de) Verfahren und vorrichtung zum herstellen von filterzigaretten
DE50205725D1 (de) Verfahren und vorrichtung zum herstellen von hartpackungen für zigaretten
DE60311286D1 (de) Vorrichtung und verfahren zum herstellen von hüllenlosen würsten
DE60306247D1 (de) Vorrichtung und Verfahren zum Sterilisieren
DE602004003420D1 (de) Verfahren und Vorrichtung zum Einstellen und Aufrechterhaltung des Abstands zwischen Trommel und Gegenschneide
DE60329344D1 (de) Verfahren und Vorrichtung zum Herstellen von Metall-Schichten
DE502004004940D1 (de) Verfahren und vorrichtung zum fräsen von freiformflächen
DE60315540D1 (de) Vorrichtung und Verfahren zum Dispergieren
DE60306215D1 (de) Verfahren und Vorrichtung zum superplastischen Verformen
DE60127319D1 (de) Verfahren und vorrichtung zum integrieren mehrerer prozesssteuerungen
DE60228442D1 (de) Verfahren und vorrichtung zum sammeln von produkten
DE60232487D1 (de) Verfahren und vorrichtung zum herstellen von geflanschten gegenständen
DE60325804D1 (de) Verfahren und Vorrichtung zum Drucken
DE50311732D1 (de) Verfahren und vorrichtung zum herstellen von hohlkörpern
DE50313537D1 (de) Verfahren zum Herstellen von konischen Filterelementen
DE602005017003D1 (de) Verfahren und Vorrichtung zum Herstellen von Klebeband
DE502004009251D1 (de) Verfahren und Vorrichtung zum Herstellen von Zigarettenpackungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition