DE60236864D1 - Chimere alphavirus-replikon-partikel - Google Patents
Chimere alphavirus-replikon-partikelInfo
- Publication number
- DE60236864D1 DE60236864D1 DE60236864T DE60236864T DE60236864D1 DE 60236864 D1 DE60236864 D1 DE 60236864D1 DE 60236864 T DE60236864 T DE 60236864T DE 60236864 T DE60236864 T DE 60236864T DE 60236864 D1 DE60236864 D1 DE 60236864D1
- Authority
- DE
- Germany
- Prior art keywords
- particles
- alphavirus
- replicant
- alphaviruses
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000710929 Alphavirus Species 0.000 title abstract 7
- 239000002245 particle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 101710172711 Structural protein Proteins 0.000 abstract 1
- 210000000234 capsid Anatomy 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/10—Vectors comprising a non-peptidic targeting moiety
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29545101P | 2001-05-31 | 2001-05-31 | |
PCT/US2002/011585 WO2002099035A2 (en) | 2001-05-31 | 2002-04-11 | Chimeric alphavirus replicon particles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60236864D1 true DE60236864D1 (de) | 2010-08-12 |
Family
ID=23137786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60236864T Expired - Lifetime DE60236864D1 (de) | 2001-05-31 | 2002-04-11 | Chimere alphavirus-replikon-partikel |
Country Status (9)
Country | Link |
---|---|
US (2) | US7531180B2 (de) |
EP (3) | EP1399183B1 (de) |
JP (2) | JP4608210B2 (de) |
AT (1) | ATE472335T1 (de) |
AU (1) | AU2002303330B2 (de) |
CA (1) | CA2448066A1 (de) |
DE (1) | DE60236864D1 (de) |
ES (2) | ES2624854T3 (de) |
WO (1) | WO2002099035A2 (de) |
Families Citing this family (70)
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US7078218B2 (en) * | 2002-12-13 | 2006-07-18 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
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WO2005026316A2 (en) * | 2003-09-15 | 2005-03-24 | Bioption Ab | Alphavirus vaccines |
US7622125B2 (en) | 2004-05-05 | 2009-11-24 | Novartis Vaccines And Diagnostics, Inc. | Polycistronic HIV vector constructs |
ATE420965T1 (de) | 2004-05-18 | 2009-01-15 | Alphavax Inc | Von tc-83 abgeleitete alphavirus-vektoren, partikel und verfahren |
EP1766034B1 (de) | 2004-05-21 | 2014-03-19 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus-vektoren für impfstoffe gegen das influenza virus |
EP1773403B1 (de) | 2004-07-09 | 2018-04-25 | The University of North Carolina At Chapel Hill | Auf alphavirus basierende adjuvanzien |
EP2266602A3 (de) | 2004-11-01 | 2011-08-10 | Novartis Vaccines and Diagnostics, Inc. | Kombinationswege zur Erzeugung von Immunantworten |
US8486420B2 (en) | 2005-02-15 | 2013-07-16 | The University Of North Carolina At Chapel Hill | Live virus vaccines |
WO2007047749A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
CA2630220C (en) | 2005-11-22 | 2020-10-13 | Doris Coit | Norovirus and sapovirus antigens |
CA2636032C (en) * | 2006-01-04 | 2016-04-12 | Novartis Vaccines And Diagnostics, Inc. | Activation of hcv-specific t cells |
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CN101802199B (zh) * | 2007-06-21 | 2012-08-22 | 阿尔法瓦克斯公司 | 用于α病毒结构蛋白表达的无启动子盒 |
WO2009048633A2 (en) * | 2007-10-11 | 2009-04-16 | The Board Of Regents Of The University Of Texas System | Chimeric chikungunya virus and uses thereof |
AU2008314485B9 (en) | 2007-10-15 | 2015-02-26 | Jingang Medicine (Australia) Pty Ltd | Expression system for modulating an immune response |
US20110229969A1 (en) * | 2008-06-25 | 2011-09-22 | Volker Sandig | Cell Line for Propagation of Highly Attenuated AlphaViruses |
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US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
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EP2971188A1 (de) * | 2013-03-15 | 2016-01-20 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Selektiver nachweis von hepatitis a-, b-, c-, d- oder e-viren oder kombinationen davon |
US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
EP3189138A4 (de) | 2014-09-07 | 2018-04-18 | Selecta Biosciences, Inc. | Verfahren und zusammensetzungen zur abschwächung der immunantworten auf antivirale geneditierende transfervektoren |
EP3313863B1 (de) | 2015-06-29 | 2020-12-23 | The Board of Trustees of the Leland Stanford Junior University | Degronfusionskonstrukte und verfahren zur steuerung der proteinproduktion |
EP3331554B1 (de) | 2015-08-03 | 2022-05-11 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury-deletionsmutanten, nichthefevektoren zur codierung von brachyury-deletionsmutanten und verwendung davon |
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-
2002
- 2002-04-11 EP EP02731350A patent/EP1399183B1/de not_active Expired - Lifetime
- 2002-04-11 ES ES10006727.1T patent/ES2624854T3/es not_active Expired - Lifetime
- 2002-04-11 JP JP2003502145A patent/JP4608210B2/ja not_active Expired - Fee Related
- 2002-04-11 AU AU2002303330A patent/AU2002303330B2/en not_active Ceased
- 2002-04-11 EP EP10006727.1A patent/EP2305299B1/de not_active Expired - Lifetime
- 2002-04-11 CA CA002448066A patent/CA2448066A1/en not_active Abandoned
- 2002-04-11 WO PCT/US2002/011585 patent/WO2002099035A2/en active Application Filing
- 2002-04-11 AT AT02731350T patent/ATE472335T1/de active
- 2002-04-11 US US10/123,101 patent/US7531180B2/en not_active Expired - Fee Related
- 2002-04-11 DE DE60236864T patent/DE60236864D1/de not_active Expired - Lifetime
- 2002-04-11 EP EP20100179805 patent/EP2332573A1/de not_active Withdrawn
- 2002-04-11 ES ES02731350T patent/ES2345876T3/es not_active Expired - Lifetime
-
2009
- 2009-02-17 US US12/372,295 patent/US8158418B2/en not_active Expired - Fee Related
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2010
- 2010-08-02 JP JP2010174039A patent/JP5268196B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1399183A2 (de) | 2004-03-24 |
JP4608210B2 (ja) | 2011-01-12 |
US8158418B2 (en) | 2012-04-17 |
WO2002099035A3 (en) | 2003-12-18 |
JP2005515755A (ja) | 2005-06-02 |
JP2010254711A (ja) | 2010-11-11 |
CA2448066A1 (en) | 2002-12-12 |
EP2332573A1 (de) | 2011-06-15 |
EP2305299B1 (de) | 2017-03-01 |
US20090305344A1 (en) | 2009-12-10 |
EP1399183A4 (de) | 2005-01-26 |
ATE472335T1 (de) | 2010-07-15 |
AU2002303330B2 (en) | 2008-07-24 |
US7531180B2 (en) | 2009-05-12 |
ES2345876T3 (es) | 2010-10-05 |
US20030148262A1 (en) | 2003-08-07 |
ES2624854T3 (es) | 2017-07-17 |
JP5268196B2 (ja) | 2013-08-21 |
WO2002099035A2 (en) | 2002-12-12 |
EP2305299A1 (de) | 2011-04-06 |
EP1399183B1 (de) | 2010-06-30 |
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