DE60233142D1 - Verfahren und reagentien zum nachweis von endotoxin - Google Patents

Verfahren und reagentien zum nachweis von endotoxin

Info

Publication number
DE60233142D1
DE60233142D1 DE60233142T DE60233142T DE60233142D1 DE 60233142 D1 DE60233142 D1 DE 60233142D1 DE 60233142 T DE60233142 T DE 60233142T DE 60233142 T DE60233142 T DE 60233142T DE 60233142 D1 DE60233142 D1 DE 60233142D1
Authority
DE
Germany
Prior art keywords
reagent
detecting endotoxin
endotoxin
factor
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60233142T
Other languages
English (en)
Inventor
Lin Chen
Michael Pepe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza Walkersville Inc
Original Assignee
Lonza Walkersville Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23162060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60233142(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Walkersville Inc filed Critical Lonza Walkersville Inc
Application granted granted Critical
Publication of DE60233142D1 publication Critical patent/DE60233142D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60233142T 2001-06-28 2002-06-28 Verfahren und reagentien zum nachweis von endotoxin Expired - Lifetime DE60233142D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30112501P 2001-06-28 2001-06-28
PCT/US2002/020395 WO2003002976A2 (en) 2001-06-28 2002-06-28 Methods and reagents for detecting endotoxin

Publications (1)

Publication Number Publication Date
DE60233142D1 true DE60233142D1 (de) 2009-09-10

Family

ID=23162060

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60233142T Expired - Lifetime DE60233142D1 (de) 2001-06-28 2002-06-28 Verfahren und reagentien zum nachweis von endotoxin

Country Status (14)

Country Link
US (2) US20040235080A1 (de)
EP (1) EP1409984B2 (de)
JP (2) JP2005500520A (de)
CN (1) CN100390193C (de)
AT (1) ATE437886T1 (de)
AU (1) AU2002330860C1 (de)
BR (1) BRPI0210681B8 (de)
CY (1) CY1109554T1 (de)
DE (1) DE60233142D1 (de)
DK (1) DK1409984T4 (de)
ES (1) ES2329664T5 (de)
MX (1) MXPA03012032A (de)
PT (1) PT1409984E (de)
WO (1) WO2003002976A2 (de)

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CN1318848C (zh) * 2003-11-26 2007-05-30 中国科学院大连化学物理研究所 一种用于细菌内毒素鲎试验检测法的缓冲液及其制备方法
ES2560448T3 (es) * 2004-05-07 2016-02-19 Ares Trading S.A. Procedimientos de tratamiento de enfermedades con copolímeros aleatorios
JP2008518625A (ja) * 2004-11-05 2008-06-05 ダウ・アグロサイエンス・エル・エル・シー 細胞の低温保存
US20060223074A1 (en) * 2005-04-05 2006-10-05 Bunch Thomas A Spotting compositions and methods of use thereof
US8038885B2 (en) * 2005-10-14 2011-10-18 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
CN101454448A (zh) 2006-07-07 2009-06-10 生化学工业株式会社 凝固酶原以及使用所述酶检测内毒素或(1→3)-β-D-葡聚糖的方法
ATE539102T1 (de) 2006-10-31 2012-01-15 Surmodics Pharmaceuticals Inc Kugelförmige polymer-partikel
WO2009064442A1 (en) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
EP2293921A4 (de) * 2008-05-22 2013-05-22 Univ California Membranvorläufer und daraus hergestellte membrane
US7846678B2 (en) * 2008-08-18 2010-12-07 BioDtech, Inc. Enhancing endotoxin detection
JP5926958B2 (ja) 2008-10-29 2016-05-25 ティー２ バイオシステムズ，インコーポレーテッド 凝固時間のｎｍｒ検出
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
AU2010265985B2 (en) 2009-06-26 2016-04-21 Charles River Laboratories, Inc. Heat-treated Limulus amebocyte lysates
WO2011085047A1 (en) 2010-01-05 2011-07-14 The Regents Of The University Of California Droplet bilayer formation using throughput liquid handling techniques
WO2011146463A2 (en) * 2010-05-17 2011-11-24 BioDtech, Inc. Enhancing endotoxin detection
WO2012030822A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Process for reducing moisture in a biodegradable implant device
WO2012118226A1 (en) * 2011-02-28 2012-09-07 Seikagaku Corporation An agent for measuring endotoxin
EP2681328A4 (de) 2011-02-28 2014-10-29 Biodtech Inc Verstärkte endotoxinerkennung
CN103917658B (zh) 2011-07-13 2016-09-21 T2生物系统公司 用于监测血块形成的nmr方法
WO2013043858A1 (en) 2011-09-21 2013-03-28 T2 Biosystems, Inc. Nmr methods for endotoxin analysis
US9150598B2 (en) 2011-10-05 2015-10-06 The Regents Of The University Of California Masking apertures enabling automation and solution exchange in sessile bilayers
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
CN103290042A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 内毒素检测及去除关键分子中国鲎c因子克隆和序列分析
CN103290054A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 应用昆虫细胞表达重组的中国鲎c因子
CN103290041A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 中国鲎c因子原核及昆虫杆状病毒重组表达载体的构建
EP2740791A1 (de) 2012-12-05 2014-06-11 MicroCoat Biotechnologie GmbH Verfahren für die rekombinante Herstellung von Pfeilschwanzkrebs-Faktor-C-Protein in Protozoen
US9739733B2 (en) 2012-12-07 2017-08-22 T2 Biosystems, Inc. Methods for monitoring tight clot formation
EP3441466B1 (de) * 2012-12-10 2020-02-05 Seikagaku Corporation Verfahren zur herstellung eines neuartigen rekombinanten faktors c, verfahren zur verminderung der reaktionshemmung in endotoxin-assays und verfahren zur messung von endotoxin
CN104356211B (zh) * 2014-09-22 2017-08-29 山东信得科技股份有限公司 一种应用Triton X‑114和尿囊素去除重组蛋白质溶液中内毒素的方法
CN111077307B (zh) * 2018-10-21 2022-08-23 厦门鲎试剂生物科技股份有限公司 一种用革兰氏阴性细菌感染快速检测脓毒病的新方法
JP7349104B2 (ja) * 2019-11-13 2023-09-22 株式会社島津製作所 ベロ毒素の検出方法
JPWO2021210669A1 (de) 2020-04-16 2021-10-21

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322217A (en) * 1980-06-27 1982-03-30 Mallinckrodt, Inc. Process for preparing Limulus lysate
BE889407A (fr) * 1980-06-27 1981-10-16 Mallinckrodt Inc Amelioration du procede de preparation d'un lysat de limule
JPH03187378A (ja) * 1989-12-16 1991-08-15 Taiyo Fishery Co Ltd 酵素前駆体ファクターｃの調整方法及びその調整試薬
JP3524120B2 (ja) * 1992-05-08 2004-05-10 生化学工業株式会社 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法
JP3402476B2 (ja) 1992-08-24 2003-05-06 生化学工業株式会社 リポ多糖結合性タンパク質及びその製造法
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
DE69734046T2 (de) 1996-10-21 2006-06-14 Seikagaku Kogyo Co Ltd Verfahren zur Bestimmung von Endotoxin
JP3869094B2 (ja) * 1996-10-21 2007-01-17 生化学工業株式会社 エンドトキシンの測定方法
DE69826013T2 (de) * 1997-09-19 2005-09-15 National University Of Singapore Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin
JP3957386B2 (ja) * 1998-01-08 2007-08-15 生化学工業株式会社 昆虫体液反応性物質の特異的測定剤及び測定方法
EP1224299B2 (de) * 1999-10-15 2019-10-16 National University Of Singapore Rekombinante proteine zur verwendung als endotoxinbiosensor, als antimikrobielle und antiendotoxin therapeutika und für die entfernung von endotoxin

Also Published As

Publication number Publication date
EP1409984B2 (de) 2013-04-10
CN100390193C (zh) 2008-05-28
WO2003002976A3 (en) 2003-05-15
US6849426B2 (en) 2005-02-01
ES2329664T5 (es) 2013-08-28
BR0210681A (pt) 2004-09-21
US20040235080A1 (en) 2004-11-25
EP1409984A2 (de) 2004-04-21
WO2003002976A2 (en) 2003-01-09
JP5039729B2 (ja) 2012-10-03
ATE437886T1 (de) 2009-08-15
CY1109554T1 (el) 2014-08-13
PT1409984E (pt) 2009-10-29
JP2005500520A (ja) 2005-01-06
CN1529711A (zh) 2004-09-15
DK1409984T3 (da) 2009-11-16
AU2002330860C1 (en) 2009-05-14
JP2009150903A (ja) 2009-07-09
ES2329664T3 (es) 2009-11-30
BRPI0210681B8 (pt) 2021-07-27
AU2002330860B2 (en) 2008-12-04
DK1409984T4 (da) 2013-07-08
EP1409984B1 (de) 2009-07-29
BRPI0210681B1 (pt) 2016-03-29
US20030054432A1 (en) 2003-03-20
EP1409984A4 (de) 2006-07-19
MXPA03012032A (es) 2005-07-01

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Legal Events

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8363 Opposition against the patent