JP2005500520A - エンドトキシンを検出するための方法および試薬 - Google Patents

エンドトキシンを検出するための方法および試薬 Download PDF

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Publication number
JP2005500520A
JP2005500520A JP2003508913A JP2003508913A JP2005500520A JP 2005500520 A JP2005500520 A JP 2005500520A JP 2003508913 A JP2003508913 A JP 2003508913A JP 2003508913 A JP2003508913 A JP 2003508913A JP 2005500520 A JP2005500520 A JP 2005500520A
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factor
test sample
protein
reagent
endotoxin
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JP2003508913A
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English (en)
Japanese (ja)
Inventor
リン チェン
マイケル ペペ
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ケンブレックス バイオ サイエンス ウォカーズビル インコーポレーティッド
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Application filed by ケンブレックス バイオ サイエンス ウォカーズビル インコーポレーティッド filed Critical ケンブレックス バイオ サイエンス ウォカーズビル インコーポレーティッド
Publication of JP2005500520A publication Critical patent/JP2005500520A/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2003508913A 2001-06-28 2002-06-28 エンドトキシンを検出するための方法および試薬 Withdrawn JP2005500520A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30112501P 2001-06-28 2001-06-28
PCT/US2002/020395 WO2003002976A2 (en) 2001-06-28 2002-06-28 Methods and reagents for detecting endotoxin

Related Child Applications (1)

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JP2009041698A Division JP5039729B2 (ja) 2001-06-28 2009-02-25 エンドトキシンを検出するための方法および試薬

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JP2005500520A true JP2005500520A (ja) 2005-01-06

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JP2003508913A Withdrawn JP2005500520A (ja) 2001-06-28 2002-06-28 エンドトキシンを検出するための方法および試薬
JP2009041698A Expired - Lifetime JP5039729B2 (ja) 2001-06-28 2009-02-25 エンドトキシンを検出するための方法および試薬

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Country Link
US (2) US20040235080A1 (de)
EP (1) EP1409984B2 (de)
JP (2) JP2005500520A (de)
CN (1) CN100390193C (de)
AT (1) ATE437886T1 (de)
AU (1) AU2002330860C1 (de)
BR (1) BRPI0210681B8 (de)
CY (1) CY1109554T1 (de)
DE (1) DE60233142D1 (de)
DK (1) DK1409984T4 (de)
ES (1) ES2329664T5 (de)
MX (1) MXPA03012032A (de)
PT (1) PT1409984E (de)
WO (1) WO2003002976A2 (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008004674A1 (fr) * 2006-07-07 2008-01-10 Seikagaku Corporation ENZYME DE PRO-COAGULATION, ET PROCÉDÉ DE DÉTECTION D'ENDOTOXINE OU DE (1→3)-β-D-GLUCANE À L'AIDE DE LADITE ENZYME
JP2012500024A (ja) * 2008-08-18 2012-01-05 バイオディテック， インコーポレイテッド 内毒素検出を強化すること
JP2014510898A (ja) * 2011-02-28 2014-05-01 生化学工業株式会社 エンドトキシン測定剤
WO2014092079A1 (ja) * 2012-12-10 2014-06-19 生化学工業株式会社 新規組換えファクターｃ、その製造法、およびエンドトキシンの測定法

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CN1318848C (zh) * 2003-11-26 2007-05-30 中国科学院大连化学物理研究所 一种用于细菌内毒素鲎试验检测法的缓冲液及其制备方法
EP1750742A2 (de) * 2004-05-07 2007-02-14 Peptimmune, Inc. Verfahren zur behandlung von krankheiten mit statistischen coplymeren
AR051477A1 (es) * 2004-11-05 2007-01-17 Dow Agrosciences Llc Crioconservacion de celulas
US20060223074A1 (en) * 2005-04-05 2006-10-05 Bunch Thomas A Spotting compositions and methods of use thereof
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
WO2007047498A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US10669383B2 (en) 2006-10-31 2020-06-02 Evonik Corporation Spheronized polymer particles
WO2009064442A1 (en) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
US8772041B2 (en) * 2008-05-22 2014-07-08 The Regents Of The University Of California Membrane precursors and membranes formed therefrom
AU2009308841B2 (en) 2008-10-29 2014-07-17 T2 Biosystems, Inc. NMR detection of coagulation time
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
CA2766288C (en) 2009-06-26 2020-05-05 Charles River Laboratories, Inc. Heat-treated limulus amebocyte lysates
US9068280B2 (en) 2010-01-05 2015-06-30 The Regents Of The University Of California Droplet bilayer formation using throughput liquid handling techniques
WO2011146463A2 (en) * 2010-05-17 2011-11-24 BioDtech, Inc. Enhancing endotoxin detection
EP2611868B1 (de) 2010-08-30 2020-01-08 Surmodics Pharmaceuticals, Inc. Biologisch abbaubare terpolymere und terpolymermischungen als haftkleber
WO2012118800A2 (en) * 2011-02-28 2012-09-07 BioDtech, Inc. Enhancing endotoxin detection
EP2732046B1 (de) 2011-07-13 2017-09-06 T2 Biosystems, Inc. Kernspinresonanzverfahren zur überwachung der bildung von blutgerinnseln
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
US9150598B2 (en) 2011-10-05 2015-10-06 The Regents Of The University Of California Masking apertures enabling automation and solution exchange in sessile bilayers
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
CN103290042A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 内毒素检测及去除关键分子中国鲎c因子克隆和序列分析
CN103290041A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 中国鲎c因子原核及昆虫杆状病毒重组表达载体的构建
CN103290054A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 应用昆虫细胞表达重组的中国鲎c因子
EP2740791A1 (de) * 2012-12-05 2014-06-11 MicroCoat Biotechnologie GmbH Verfahren für die rekombinante Herstellung von Pfeilschwanzkrebs-Faktor-C-Protein in Protozoen
CA2893591A1 (en) 2012-12-07 2014-06-12 T2 Biosystems, Inc. Methods for monitoring tight clot formation
CN104356211B (zh) * 2014-09-22 2017-08-29 山东信得科技股份有限公司 一种应用Triton X‑114和尿囊素去除重组蛋白质溶液中内毒素的方法
CN111077307B (zh) * 2018-10-21 2022-08-23 厦门鲎试剂生物科技股份有限公司 一种用革兰氏阴性细菌感染快速检测脓毒病的新方法
JP7349104B2 (ja) * 2019-11-13 2023-09-22 株式会社島津製作所 ベロ毒素の検出方法
JPWO2021210669A1 (de) 2020-04-16 2021-10-21

Family Cites Families (12)

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BE889407A (fr) * 1980-06-27 1981-10-16 Mallinckrodt Inc Amelioration du procede de preparation d'un lysat de limule
US4322217A (en) * 1980-06-27 1982-03-30 Mallinckrodt, Inc. Process for preparing Limulus lysate
JPH03187378A (ja) * 1989-12-16 1991-08-15 Taiyo Fishery Co Ltd 酵素前駆体ファクターｃの調整方法及びその調整試薬
JP3524120B2 (ja) * 1992-05-08 2004-05-10 生化学工業株式会社 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法
JP3402476B2 (ja) * 1992-08-24 2003-05-06 生化学工業株式会社 リポ多糖結合性タンパク質及びその製造法
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US6168924B1 (en) * 1996-10-21 2001-01-02 Seikagaku Kogyo Kabushiki Kaisha Limulus reaction-activating substance, method for inactivating the substance and measuring its amount, and method for measuring limulus reaction
JP3869094B2 (ja) * 1996-10-21 2007-01-17 生化学工業株式会社 エンドトキシンの測定方法
WO1999015676A1 (en) * 1997-09-19 1999-04-01 National University Of Singapore A novel generation of cloned horseshoe crab recombinant factor c for detection and removal of endotoxin
JP3957386B2 (ja) * 1998-01-08 2007-08-15 生化学工業株式会社 昆虫体液反応性物質の特異的測定剤及び測定方法
AU7980300A (en) * 1999-10-15 2001-04-23 National University Of Singapore, The Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008004674A1 (fr) * 2006-07-07 2008-01-10 Seikagaku Corporation ENZYME DE PRO-COAGULATION, ET PROCÉDÉ DE DÉTECTION D'ENDOTOXINE OU DE (1→3)-β-D-GLUCANE À L'AIDE DE LADITE ENZYME
US9040254B2 (en) 2006-07-07 2015-05-26 Seikagaku Corporation Methods for detecting an endotoxin using a horseshoe crab clotting enzyme
JP2012500024A (ja) * 2008-08-18 2012-01-05 バイオディテック， インコーポレイテッド 内毒素検出を強化すること
JP2014510898A (ja) * 2011-02-28 2014-05-01 生化学工業株式会社 エンドトキシン測定剤
WO2014092079A1 (ja) * 2012-12-10 2014-06-19 生化学工業株式会社 新規組換えファクターｃ、その製造法、およびエンドトキシンの測定法
JPWO2014092079A1 (ja) * 2012-12-10 2017-01-12 生化学工業株式会社 新規組換えファクターｃ、その製造法、およびエンドトキシンの測定法
US10144923B2 (en) 2012-12-10 2018-12-04 Seikagaku Corporation Recombinant Factor C and method for producing the same, and method for measuring endotoxin
US10982202B2 (en) 2012-12-10 2021-04-20 Seikagaku Corporation Recombinant factor C and method for producing the same, and method for measuring endotoxin
US11236318B2 (en) 2012-12-10 2022-02-01 Seikagaku Corporation Recombinant Factor C and method for producing the same, and method for measuring endotoxin

Also Published As

Publication number Publication date
BR0210681A (pt) 2004-09-21
US20030054432A1 (en) 2003-03-20
ES2329664T5 (es) 2013-08-28
MXPA03012032A (es) 2005-07-01
JP5039729B2 (ja) 2012-10-03
DK1409984T3 (da) 2009-11-16
EP1409984A2 (de) 2004-04-21
BRPI0210681B8 (pt) 2021-07-27
CN1529711A (zh) 2004-09-15
US6849426B2 (en) 2005-02-01
EP1409984B1 (de) 2009-07-29
CY1109554T1 (el) 2014-08-13
CN100390193C (zh) 2008-05-28
AU2002330860C1 (en) 2009-05-14
EP1409984A4 (de) 2006-07-19
WO2003002976A3 (en) 2003-05-15
WO2003002976A2 (en) 2003-01-09
AU2002330860B2 (en) 2008-12-04
US20040235080A1 (en) 2004-11-25
JP2009150903A (ja) 2009-07-09
PT1409984E (pt) 2009-10-29
EP1409984B2 (de) 2013-04-10
ATE437886T1 (de) 2009-08-15
BRPI0210681B1 (pt) 2016-03-29
DK1409984T4 (da) 2013-07-08
DE60233142D1 (de) 2009-09-10
ES2329664T3 (es) 2009-11-30

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