DE60228875D1 - Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus - Google Patents

Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus

Info

Publication number
DE60228875D1
DE60228875D1 DE60228875T DE60228875T DE60228875D1 DE 60228875 D1 DE60228875 D1 DE 60228875D1 DE 60228875 T DE60228875 T DE 60228875T DE 60228875 T DE60228875 T DE 60228875T DE 60228875 D1 DE60228875 D1 DE 60228875D1
Authority
DE
Germany
Prior art keywords
block copolymers
polyorthoesters
biodegradable amino
hydrophobic
biodegradable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60228875T
Other languages
German (de)
English (en)
Inventor
Steven Y Ng
Jorge Heller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heron Therapeutics LLC
Original Assignee
AP Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AP Pharma Inc filed Critical AP Pharma Inc
Application granted granted Critical
Publication of DE60228875D1 publication Critical patent/DE60228875D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
    • C08G63/42—Cyclic ethers; Cyclic carbonates; Cyclic sulfites; Cyclic orthoesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
DE60228875T 2001-11-16 2002-11-15 Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus Expired - Fee Related DE60228875D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/991,537 US6524606B1 (en) 2001-11-16 2001-11-16 Bioerodible polyorthoesters containing amine groups
PCT/US2002/036775 WO2003044076A1 (en) 2001-11-16 2002-11-15 Bioerodible poly(ortho esters) containing amine groups, and block copolymers containing them

Publications (1)

Publication Number Publication Date
DE60228875D1 true DE60228875D1 (de) 2008-10-23

Family

ID=25537313

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228875T Expired - Fee Related DE60228875D1 (de) 2001-11-16 2002-11-15 Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus

Country Status (10)

Country Link
US (3) US6524606B1 (https=)
EP (1) EP1448666B1 (https=)
JP (1) JP2005509709A (https=)
KR (1) KR20040066818A (https=)
AT (1) ATE407963T1 (https=)
AU (1) AU2002352743B2 (https=)
CA (1) CA2463179A1 (https=)
DE (1) DE60228875D1 (https=)
ES (1) ES2314118T3 (https=)
WO (1) WO2003044076A1 (https=)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2336703A1 (en) * 1998-07-10 2000-01-20 The University Of Sydney Prophylactic treatments of neovascularisation in macular degeneration
AUPQ496500A0 (en) * 2000-01-06 2000-02-03 University Of Sydney, The Kit
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
EP1315777B1 (en) * 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US8403954B2 (en) 2001-05-22 2013-03-26 Sanostec Corp. Nasal congestion, obstruction relief, and drug delivery
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7329413B1 (en) 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
WO2005070333A1 (en) * 2004-01-13 2005-08-04 Orthobiologica, Inc. Drug delivery to a joint
US20050192264A1 (en) * 2004-02-04 2005-09-01 Penfold Philip L. Slow release steroid composition
US20050192257A1 (en) * 2004-02-26 2005-09-01 Peyman Gholam A. Predictors for patients at risk for glaucoma from steroid therapy
JP2007523912A (ja) * 2004-02-26 2007-08-23 アドバンスト アキュラー システムズ リミテッド 眼病変治療用へパリン
SI1755616T1 (sl) * 2004-04-08 2014-04-30 Eye Co Pty Ltd. Zdravljenje eksudativne retinopatije z mineralkortikoidi
WO2005102303A2 (en) * 2004-04-21 2005-11-03 Advanced Ocular Systems Limited Antiprostaglandins for the treatment of ocular pathologies
EP1781343A1 (en) * 2004-08-19 2007-05-09 Coloplast A/S Absorbent fiber material and use thereof in wound dressings
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US20060122152A1 (en) * 2004-12-03 2006-06-08 Peyman Gholam A Heparin for the treatment of ocular pathologies
KR100732013B1 (ko) * 2005-03-18 2007-06-25 성균관대학교산학협력단 ｐＨ 민감성 블록 공중합체 및 이를 이용한 고분자 마이셀
EP1865988A2 (en) * 2005-03-31 2007-12-19 AP Pharma, Inc. Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
AU2006270041B2 (en) 2005-07-18 2011-08-18 Minu, Llc Enhanced ocular neuroprotection/neurostimulation
US7713916B2 (en) * 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
WO2007061896A1 (en) 2005-11-17 2007-05-31 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
EP2374472B9 (en) 2006-03-16 2019-06-12 Dyax Corp. Compositions and methods for treating ophthalmic disorders
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US7875697B2 (en) * 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
JP2009542232A (ja) 2006-07-10 2009-12-03 エスバテック・アーゲー 上皮および／または内皮層を通過するｓｃＦｖ抗体
WO2009091790A1 (en) 2008-01-15 2009-07-23 Invista Technologies S.A.R.L. Hydrocyanation of pentenenitriles
US8722079B2 (en) * 2008-04-18 2014-05-13 Warsaw Orthopedic, Inc. Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
AU2009241847B2 (en) 2008-04-28 2014-07-10 Zogenix, Inc. Novel formulations for treatment of migraine
EP2303393A4 (en) * 2008-05-07 2011-10-19 Obj Ltd METHOD AND APPARATUS FOR ENHANCED TRANSDERMAL DIFFUSION
US9095404B2 (en) * 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
AU2008359989A1 (en) * 2008-07-30 2010-02-04 Nitto Denko Corporation Drug carriers
WO2010068827A1 (en) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
WO2011046515A1 (en) 2009-10-14 2011-04-21 Nanyang Technological University Antiproliferative agent
EP2575950A4 (en) 2010-05-25 2014-07-09 Internat Scient Pty Ltd ADMINISTRATION OF ORAL CARE PRODUCTS
EP2582424A4 (en) 2010-06-17 2014-08-06 Internat Scient Pty Ltd DISTRIBUTION OF SKIN CARE PRODUCTS
WO2013142152A1 (en) * 2012-03-23 2013-09-26 Regents Of The University Of Minnesota Semi-solid delivery systems
US8945827B2 (en) 2013-03-13 2015-02-03 Awareness Technology, Inc. Serological methods and diagnostic tests for syphilis antibodies
CN105358129A (zh) * 2013-03-15 2016-02-24 赫伦治疗有限公司 聚原酸酯和质子惰性溶剂的组合物
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
US20160324798A1 (en) * 2013-12-31 2016-11-10 Heron Therapeutics, Inc. Polymer-based compositions for extended release of proteins
EP3154552B1 (en) 2014-06-11 2021-03-24 International Scientific Pty Ltd Device and method to treat or prevent joint degeneration
WO2018200425A1 (en) 2017-04-24 2018-11-01 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
CA3067558A1 (en) 2017-06-16 2018-12-20 Avery Therapeutics, Inc. Three dimensional tissue compositions and methods of use
US10687023B1 (en) 2017-08-14 2020-06-16 Visualimits, Llc Gaming table events detecting and processing
EP3829719B1 (en) 2018-07-27 2025-04-02 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
CN113286793B (zh) 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
KR102890706B1 (ko) 2018-10-17 2025-11-24 코크리스탈 파마, 아이엔씨. 인플루엔자 바이러스 복제 억제제의 조합물
EP3887355A1 (en) 2018-11-26 2021-10-06 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
WO2021188620A1 (en) 2020-03-17 2021-09-23 Cocrystal Pharma Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
CN115698035A (zh) 2020-04-10 2023-02-03 共晶制药公司 诺如病毒及冠状病毒复制的抑制剂
US12558415B2 (en) 2020-04-14 2026-02-24 The Regents Of The University Of California Broad-spectrum multi-antigen pan-coronavirus vaccine
WO2021211749A1 (en) 2020-04-14 2021-10-21 The Regents Of The University Of California Multi-epitope pan-coronavirus vaccine compositions
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
JP2024530920A (ja) 2021-08-03 2024-08-27 コクリスタル ファーマ，インコーポレイテッド コロナウイルスに対する阻害剤
US20240409530A1 (en) 2023-04-12 2024-12-12 Centennial Therapeutics, Llc Disubstituted Pyrimidine Compounds for Ketohexokinase Inhibition
WO2024249612A1 (en) 2023-05-31 2024-12-05 Centennial Therapeutics, Llc Bicyclic compounds for ketohexokinase inhibition

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US130472A (en) * 1872-08-13 Improvement in hinges for sewing-machine tables
US37300A (en) * 1863-01-06 Improvement in window-blind fastenings
US138474A (en) * 1873-05-06 Improvement in wave-powers
US152630A (en) * 1874-06-30 Improvement in cars for transporting coal
US82362A (en) * 1868-09-22 Samuel swes
US90398A (en) * 1869-05-25 Improvement in tree-boxes
US176844A (en) * 1876-05-02 Improvement in beer-taps
US3268550A (en) 1963-08-26 1966-08-23 Ibm Nu-butenyl carbazoles
US4180064A (en) 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
FR2238477B1 (https=) 1973-07-27 1976-12-03 Roussel Uclaf
US4014987A (en) 1974-06-04 1977-03-29 Alza Corporation Device for delivery of useful agent
US4180646A (en) 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4131648A (en) 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4079038A (en) 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
FR2352547A1 (fr) 1976-05-25 1977-12-23 Viridis Ets Nouvelle resine anionique a action hypocholesterolemiante, son procede de preparation et compositions therapeutiques la contenant
US4261969A (en) 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4502976A (en) 1982-10-25 1985-03-05 Bend Research, Inc. Water soluble polyesters
US4513143A (en) 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4690682A (en) 1983-04-15 1987-09-01 Damon Biotech, Inc. Sustained release
US5449670A (en) 1983-05-20 1995-09-12 Skinner; Wilfred A. Composition and method for the transdermal delivery of bioactive peptides
US4710497A (en) 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US5128376A (en) 1983-07-01 1992-07-07 Nitto Denko Corporation Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator
US4590190A (en) 1983-07-01 1986-05-20 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4752612A (en) 1983-07-01 1988-06-21 Nitto Electrical Industrial Co., Ltd. Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4548990A (en) 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4605670A (en) 1984-02-01 1986-08-12 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering metoclopramide
US4639366A (en) 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4765973A (en) 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4549010A (en) 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4690825A (en) 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US4738932A (en) 1985-12-03 1988-04-19 Advanced Polymer Systems, Inc. Reaginic test for syphilis
US5879716A (en) 1985-12-18 1999-03-09 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of benzoyl peroxide
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
US5955109A (en) 1985-12-18 1999-09-21 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of retinoic acid
US4764364A (en) 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4855132A (en) 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4713441A (en) 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4801457A (en) 1986-08-01 1989-01-31 Sandoz Pharm. Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
DE3789956T2 (de) 1986-08-15 1994-11-10 Advanced Polymer Systems Inc Polymere trägerzubereitungen, herstellung und verwendung.
US4849426A (en) 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US5013553A (en) 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US4806360A (en) 1987-10-23 1989-02-21 Advanced Polymer Systems Synthetic melanin aggregates
US4855144A (en) 1987-10-23 1989-08-08 Advanced Polymer Systems Synthetic melanin aggregates
US4923645A (en) 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
SE8705136D0 (sv) 1987-12-22 1987-12-22 Pharmacia Ab Oral doseringsenhet for lekemedel och dess anvendning och framstellning
US4898928A (en) 1988-03-07 1990-02-06 Sandoz Pharmaceuticals Corp. Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols
ZA892859B (en) 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
US5041713A (en) 1988-05-13 1991-08-20 Marinelon, Inc. Apparatus and method for applying plasma flame sprayed polymers
WO1989010947A1 (en) 1988-05-13 1989-11-16 Advanced Polymer Systems, Inc. Protective coating for boat hulls and method of applying the same
US4957998A (en) 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5632727A (en) 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5725491A (en) 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5840293A (en) 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
US5324520A (en) 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US4963369A (en) 1989-01-19 1990-10-16 Wm. Wrigley Jr. Co. Gum composition containing dispersed porous beads containing active chewing gum ingredients and method
US5287588A (en) * 1989-01-31 1994-02-22 U.S. Products, Inc. Upholstery and carpet cleaning equipment including external heat exchanger
US5108755A (en) 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5028435A (en) 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US4946931A (en) 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
KR920702383A (ko) 1989-08-28 1992-09-03 원본미기재 치료제의 방출을 조절하는데 유용한 생부식성 중합체
US5030457A (en) 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5217712A (en) 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
KR920703016A (ko) 1989-10-03 1992-12-17 데이비드 더블유, 라이트 용해성의 마이크로다공성 하이드로겔 입자 및 그것의 제조방법
KR920702928A (ko) 1989-11-09 1992-12-17 원본미기재 향이 첨가된 경구-전달 조성물 및 그 제조방법
IL98087A (en) 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
EP0574383B1 (en) 1990-05-14 1996-10-23 Advanced Polymer Systems, Inc. Color modified melanins and methods for their preparation and use
US5240715A (en) 1990-05-14 1993-08-31 Advanced Polymer Systems Color modified melanins and methods for their preparation and use
US5188844A (en) 1990-05-14 1993-02-23 Advanced Polymer Systems, Inc. Color modified melanins and methods for their preparation and use
JP3286315B2 (ja) 1990-06-20 2002-05-27 アドバンスト ポリマー システムズ，インコーポレイティド 可溶性活性物質の調節された放出のための組成物及び方法
SE9002339L (sv) 1990-07-04 1992-01-05 Kabi Pharmacia Ab Terapeutisk komposition och foerfarande foer dess framstaellning
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
NZ239370A (en) 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
MX9101786A (es) 1990-10-30 1992-06-05 Alza Corp Sistema para el suministro de droga y metodo
US5422121A (en) 1990-11-14 1995-06-06 Rohm Gmbh Oral dosage unit form
DE9015551U1 (de) 1990-11-14 1992-03-12 Röhm GmbH, 6100 Darmstadt Orale Arzneiform und Überzugsmittel, enthaltend ein im Colon abbaubares Polysaccarid
WO1992018222A1 (en) 1991-04-18 1992-10-29 Advanced Polymer Systems, Inc. Preparation and use of solid beads having controlled characteristics
AU2261592A (en) 1991-06-20 1993-01-25 Pharmaceutical Delivery Systems, Inc. Pulsed release of high molecular weight therapeutic agents from bioerodible polymer compositions
JP3000732B2 (ja) 1991-07-05 2000-01-17 富士ゼロックス株式会社 コロナ放電装置
US5211951A (en) 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
US5261169A (en) 1991-10-11 1993-11-16 Advanced Polymer Systems, Inc. System and method for deodorant delivery in footwear
AU2605592A (en) 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
WO1993007862A1 (en) 1991-10-21 1993-04-29 Advanced Polymer Systems, Inc. Ionic beads useful for controlled release and adsorption
US5256400A (en) 1991-12-04 1993-10-26 Advanced Polymer Systems, Inc. Pressurized product delivery systems
EP0560014A1 (en) 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
AU3941493A (en) 1992-03-30 1993-11-08 Alza Corporation Viscous suspensions of controlled-release drug particles
US5334640A (en) 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
WO1993025077A1 (en) 1992-06-17 1993-12-23 Advanced Polymer Systems, Inc. Antimicrobial dry paper product
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
GB2273874A (en) 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix
IL110787A0 (en) 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
JPH09509403A (ja) 1993-12-15 1997-09-22 エイボン プロダクツ インコーポレイテッド 新規なレチノイド共役体化合物及び皮膚老化を処置するための方法
ATE317690T1 (de) 1994-04-08 2006-03-15 Qlt Usa Inc Flüssige zusammensetzungen zur arzneistoffabgabe
DE4415204A1 (de) 1994-04-30 1995-11-02 Carl Heinrich Dr Weischer Neue Retinol (Vitamin A) -Derivate, deren Herstellung und Verwendung als Arzneimittel und Kosmetika
JP3005419U (ja) 1994-06-20 1994-12-20 精 武田 スナップファスナーの雌型嵌合体
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5607686A (en) 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US6281015B1 (en) 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
US5627187A (en) 1995-04-12 1997-05-06 Katz; Bruce E. 5-FU for treating actinic kerotoses
US5811510A (en) 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
EP0850051A2 (en) 1995-08-31 1998-07-01 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
AU1284897A (en) 1995-12-04 1997-06-27 Advanced Polymer Systems Inc. Retinyl esters of alpha-hydroxy acids for topical improvement of skin function and appearance
US5851538A (en) 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
DE69703430T2 (de) 1996-01-05 2001-05-03 Advanced Polymer Systems, Inc. Polymere mit kontrolliertem physikalischen zustand und bioerodierbarkeit
US5968543A (en) 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
KR19990077278A (ko) 1996-01-16 1999-10-25 마이클 오코넬 약물의 하부 위장관으로의 국소적 전달
WO1997027843A2 (en) 1996-01-30 1997-08-07 Advanced Polymer Systems, Inc. Targeted delivery of drugs to the lower gastrointestinal tract
AU2804297A (en) 1996-04-22 1997-11-12 Advanced Polymer Systems Inc. Method of and composition for treating disorders of the skin using vitamin k
IL118235A0 (en) 1996-05-13 1996-09-12 Univ Ben Gurion Composition and method for forming biodegradable implants in situ and uses of these implants
ATE203157T1 (de) 1996-12-20 2001-08-15 Alza Corp Injizierbare depotgelzubereitung und herstellungsverfahren
US5993856A (en) 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
UA54505C2 (uk) 1997-04-03 2003-03-17 Гілфорд Фармасьютікалз Інк. Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання
US6193991B1 (en) 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
US6228894B1 (en) 1998-04-17 2001-05-08 Enhanced Derm Technologies, Inc. Softgel-compatible composition containing retinol
US5891470A (en) 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
WO2000000159A2 (en) 1998-06-26 2000-01-06 Dermik Laboratories Inc. Method of treatment for dermatological disorders
US6245345B1 (en) 1998-07-07 2001-06-12 Atrix Laboratories, Inc. Filamentous porous films and methods for producing the same
US6261583B1 (en) 1998-07-28 2001-07-17 Atrix Laboratories, Inc. Moldable solid delivery system
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6159491A (en) 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
ES2253381T3 (es) 2000-05-11 2006-06-01 Ap Pharma, Inc. Vehiculo de administracion semi-solida y composiciones farmaceuticas.
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
EP1315777B1 (en) 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
EP1395626A1 (en) 2001-05-11 2004-03-10 AP Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
DE10157163A1 (de) 2001-11-22 2003-06-18 Gfe Gmbh & Co Kg Ges Fuer Ents Verfahren und Vorrichtung zur Entsorgung von hochenergetische Stoffe enthaltenden Materialien, insbesondere von Granaten

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