DE60228182D1 - 3-hydroxymethylbenzo b thiophen-derivate und verfahren zu deren herstellung - Google Patents

3-hydroxymethylbenzo b thiophen-derivate und verfahren zu deren herstellung

Info

Publication number
DE60228182D1
DE60228182D1 DE60228182T DE60228182T DE60228182D1 DE 60228182 D1 DE60228182 D1 DE 60228182D1 DE 60228182 T DE60228182 T DE 60228182T DE 60228182 T DE60228182 T DE 60228182T DE 60228182 D1 DE60228182 D1 DE 60228182D1
Authority
DE
Germany
Prior art keywords
group
carbons
hydroxymethylbenzo
production
trihalomethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60228182T
Other languages
English (en)
Inventor
Hirosi Saitou
Tsuyoshi Mizuno
Naoki Tsuchiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Pharma Ltd
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Application granted granted Critical
Publication of DE60228182D1 publication Critical patent/DE60228182D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
DE60228182T 2001-05-07 2002-05-02 3-hydroxymethylbenzo b thiophen-derivate und verfahren zu deren herstellung Expired - Fee Related DE60228182D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001135928 2001-05-07
PCT/JP2002/004383 WO2002090345A1 (en) 2001-05-07 2002-05-02 3-hydroxymethylbenzo[b]thiophene derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
DE60228182D1 true DE60228182D1 (de) 2008-09-25

Family

ID=18983308

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228182T Expired - Fee Related DE60228182D1 (de) 2001-05-07 2002-05-02 3-hydroxymethylbenzo b thiophen-derivate und verfahren zu deren herstellung

Country Status (13)

Country Link
US (1) US6774245B2 (de)
EP (1) EP1298130B1 (de)
JP (1) JP3999131B2 (de)
KR (1) KR20030031486A (de)
CN (1) CN1205204C (de)
AT (1) ATE404551T1 (de)
CA (1) CA2414298A1 (de)
DE (1) DE60228182D1 (de)
HK (1) HK1052352B (de)
NO (1) NO20030058L (de)
NZ (1) NZ523407A (de)
PL (1) PL358478A1 (de)
WO (1) WO2002090345A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1792614A1 (de) * 2001-02-22 2007-06-06 Teijin Pharma Limited Benzo[b]thiophenderivate
CL2004001034A1 (es) * 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
KR20060120601A (ko) * 2003-08-22 2006-11-27 데이진 화-마 가부시키가이샤 키마제 저해제를 유효 성분으로서 함유하는 약제
JPWO2006052026A1 (ja) * 2004-11-12 2008-05-29 帝人ファーマ株式会社 ベンズイミダゾール誘導体の酸性塩及びその結晶
CN101300247A (zh) 2005-10-27 2008-11-05 帝人制药株式会社 3-羟甲基苯并[b]噻吩衍生物及其制备方法
US20090299074A1 (en) 2005-10-27 2009-12-03 Teijin Pharma Limited BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
CN102850246B (zh) * 2012-07-10 2015-04-22 江西理工大学 一种苯胺类衍生物引入巯基的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69925992T2 (de) * 1998-03-31 2006-05-24 Shionogi & Co., Ltd. Verfahren zur Herstellung von 5-Hydroxybenzo[b]thiopen-3-carbonsäurederivaten
EP1249450B1 (de) 2000-01-17 2007-10-10 Teijin Pharma Limited Benzimidazol-derivate als menschliche chymase - inhibitoren

Also Published As

Publication number Publication date
WO2002090345A1 (en) 2002-11-14
JPWO2002090345A1 (ja) 2004-08-26
EP1298130B1 (de) 2008-08-13
AU2002255294C1 (en) 2002-11-18
US20030191325A1 (en) 2003-10-09
NZ523407A (en) 2005-04-29
EP1298130A1 (de) 2003-04-02
CN1205204C (zh) 2005-06-08
US6774245B2 (en) 2004-08-10
NO20030058L (no) 2003-03-05
EP1298130A4 (de) 2005-03-30
CA2414298A1 (en) 2002-12-30
ATE404551T1 (de) 2008-08-15
HK1052352A1 (en) 2003-09-11
HK1052352B (zh) 2008-11-07
CN1462271A (zh) 2003-12-17
PL358478A1 (en) 2004-08-09
NO20030058D0 (no) 2003-01-06
JP3999131B2 (ja) 2007-10-31
KR20030031486A (ko) 2003-04-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee