ATE517079T1 - Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung - Google Patents

Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung

Info

Publication number
ATE517079T1
ATE517079T1 AT04020517T AT04020517T ATE517079T1 AT E517079 T1 ATE517079 T1 AT E517079T1 AT 04020517 T AT04020517 T AT 04020517T AT 04020517 T AT04020517 T AT 04020517T AT E517079 T1 ATE517079 T1 AT E517079T1
Authority
AT
Austria
Prior art keywords
schaemic
antidepressors
adamantande
neuroprotectors
derivatives
Prior art date
Application number
AT04020517T
Other languages
English (en)
Inventor
Francesco Makovec
Roberto Artusi
Simona Zanzola
Lucio Claudio Rovati
Original Assignee
Rottapharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Spa filed Critical Rottapharm Spa
Application granted granted Critical
Publication of ATE517079T1 publication Critical patent/ATE517079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT04020517T 2003-09-02 2004-08-30 Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung ATE517079T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000668A ITTO20030668A1 (it) 2003-09-02 2003-09-02 Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.

Publications (1)

Publication Number Publication Date
ATE517079T1 true ATE517079T1 (de) 2011-08-15

Family

ID=34131246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04020517T ATE517079T1 (de) 2003-09-02 2004-08-30 Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung

Country Status (9)

Country Link
US (1) US7145037B2 (de)
EP (1) EP1512679B1 (de)
JP (1) JP5116207B2 (de)
AT (1) ATE517079T1 (de)
AU (1) AU2004206990A1 (de)
CA (1) CA2479613A1 (de)
ES (1) ES2369888T3 (de)
IT (1) ITTO20030668A1 (de)
PT (1) PT1512679E (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7982070B2 (en) 2006-03-21 2011-07-19 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
US7977511B2 (en) * 2006-04-07 2011-07-12 Ssv Therapeutics, Inc. Carnitine conjugates of adamantanamines and neramexane derivatives as dual prodrugs for various uses
WO2008103421A1 (en) * 2007-02-21 2008-08-28 Ssv Therapeutics, Inc. Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids
DE102007022007A1 (de) * 2007-05-08 2008-11-13 Schebo Biotech Ag Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes
WO2010019712A1 (en) * 2008-08-12 2010-02-18 The Trustees Of The University Of Pennsylvania Modulation of influenza virus
WO2010033339A1 (en) 2008-09-16 2010-03-25 The Trustees Of The University Of Pennsylvania Inhibition of influenza m2 proton channel
US8592216B2 (en) 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
WO2011022191A1 (en) * 2009-08-21 2011-02-24 The Trustees Of The University Of Pennsylvania Adamantane analogs
US20110065762A1 (en) * 2009-09-11 2011-03-17 Jizhou Wang Methods of use of antiviral compounds
US8440720B2 (en) * 2009-09-11 2013-05-14 Influmedix, Inc. Methods of use of antiviral compounds
JP5562716B2 (ja) * 2010-05-12 2014-07-30 花王株式会社 電位依存性カチオンチャネル抑制剤
US9884832B2 (en) 2011-12-06 2018-02-06 The Trustees Of The University Of Pennsylvania Inhibitors targeting drug-resistant influenza A
JP2021504303A (ja) * 2017-11-22 2021-02-15 パノラマ リサーチ，インコーポレイティド Ｃｎｓ疾患を治療するためのアミノアダマンチルナイトレート化合物およびそれらの使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28836A (en) * 1860-06-26 Improvement in plows
GB1274652A (en) 1968-08-27 1972-05-17 Lilly Industries Ltd Adamantanyl-alkylamine derivatives and their preparation
US4007181A (en) * 1974-02-11 1977-02-08 The Upjohn Company Adamantyl containing guanidines
EP0392059B1 (de) 1989-04-14 1993-09-15 Merz & Co. GmbH & Co. Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie
EP0532642A1 (de) 1990-05-25 1993-03-24 STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON Substituierte guanidine, welche eine hohe sigma-rezeptor-bindungsaffinität besitzen, und ihre verwendung
WO1999020599A1 (en) 1997-10-21 1999-04-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
GB9726388D0 (en) * 1997-12-12 1998-02-11 Cerebrus Ltd Chemical compounds
GB9802225D0 (en) * 1998-02-02 1998-04-01 Cerebrus Ltd Chemical compounds
GB9803536D0 (en) 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
ITTO20010110A1 (it) * 2001-02-08 2002-08-08 Rotta Research Lab Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
AU2002326948A1 (en) 2001-09-18 2003-04-01 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
US7145037B2 (en) 2006-12-05
CA2479613A1 (en) 2005-03-02
AU2004206990A1 (en) 2005-03-17
EP1512679A1 (de) 2005-03-09
US20050049312A1 (en) 2005-03-03
JP5116207B2 (ja) 2013-01-09
ES2369888T3 (es) 2011-12-07
EP1512679B1 (de) 2011-07-20
JP2005075832A (ja) 2005-03-24
PT1512679E (pt) 2011-08-03
ITTO20030668A1 (it) 2005-03-03

Similar Documents

Publication Publication Date Title
ATE517079T1 (de) Adamantanderivate mit neuroprotektoren, antidepressoren und antiischaemischer wirkung, und verfahren zur ihrer herstellung
DE60124692D1 (de) Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
DE60119894D1 (de) Piperidinverbindungen und diese enthaltenden medikamente
DE69415319D1 (de) Verfahren zur herstellung von piperidinderivaten
DK1008592T3 (da) Cykliske amidderivater, som inhiberer cathepsin K
DE69231815T2 (de) Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
ATE381549T1 (de) Benzoxazol-derivative, verfahren zu ihrer herstellung und herbizide
ATE312150T1 (de) Electrochrome lösung, enthaltend eine hydrazonverbindung und mit dieser hergestellte vorrichtung
DE60316791D1 (de) Verfahren zur aufreinigung von lanzoprazol
ATE527228T1 (de) Verfahren zur herstellung von beta-santalol und derivaten davon
ATE383353T1 (de) Verfahren zur herstellung von 2-alkyl-3- aminothiophen derivate und 3-aminothiophen derivate
ATE424195T1 (de) Verwendung von 2-amino-1,3-propandiolderivaten zur herstellung eines medikaments zur behandlung von bestimmten schmerzen
WO2009044018A9 (fr) Dérivés de 1-0x0-1,2-dihydroisoquinoleine-5-carboxamides et de 4-oxo-3,4-dihydroquinazoline-8-carboxamides, leur préparation et leur application en thérapeutique
DE602006014054D1 (de) Verfahren zur Herstellung von Aminoadamantanen
MX2009004928A (es) Metodo para la produccion del derivado de 2-alquilo-3-aminotiofeno .
ATE315568T1 (de) Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ
DE602006003204D1 (de) Reinigungsverfahren von Moxonidine
MXPA05009338A (es) 7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen.
DE60228182D1 (de) 3-hydroxymethylbenzo b thiophen-derivate und verfahren zu deren herstellung
BRPI0414580A (pt) derivado do ácido fenilacético, processos para sua produção e uso
DE60136566D1 (de) Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungen
DE602007002639D1 (de) Neuartige epoxidverbindungen und verfahren zu ihrer herstellung
DE69810273D1 (de) Vitamin d 3? derivate und verfahren zur herstellung derselben
ATE364590T1 (de) Verfahren zur herstellung von1-acetoxy-3- (substituiertes phenyl)propenen
ATE6500T1 (de) 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1512679

Country of ref document: EP